JPH07165252A - Vial container - Google Patents

Abstract

PURPOSE:To provide an inexpensive vial container by which the material therein can extremely easily be classified on incinerating in waste disposal and there is not in danger of floating-up of the plug and slipping-off thereof. CONSTITUTION:An aperture for piercing a needle 12 which is enclosed by a sealing means 13 easily opening or piercing it, is formed at the top wall. A plug 15 for reading between the inside face of the top wall and the bottle opening 20a is fitted in a plastic protector 11 having a ventilation means 17 to the bottle inside at the cylindrical part. And fixing means 18, 19 retaining a half-driven plug lyophilization posture of the protector 11 corresponding to the state on the way to a freeze dryer and the completely driven plug-sealing posture of the protector 11 corresponding to the state after lyophilization, are provided at the inside face of the cylindrical part constituting the protector 11.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to improvements in vial containers.

[0002]

2. Description of the Related Art In a conventionally known vial container, as shown in FIG. 35, a protector 1 made of an aluminum material is provided with a breaking portion 3 surrounded by an easy breaking line 2 such as a score, An engaging projection 5 formed on the inner surface of a synthetic resin lid body (hereinafter referred to as a flip-off cap) 4 is fixed to the breaking portion 3 with an eyelet structure, while the stopper portion 6a is vented to the inside of the protector 1. A rubber stopper 6 having a notch 7 formed therein is fitted, and the drug in the vial bottle 8 is freeze-dried in a posture in which the rubber stopper 6 is fitted in a bottle mouth 8a of the vial bottle 8 in a floating manner. The rubber stopper 6 is completely sealed, and the hem of the protector 1 is wound by a winding machine. In use, as shown in the figure, the breaking portion 3 is broken through the flip-off cap 4, the exposed upper portion of the rubber stopper 6 is sterilized, and a needle of a syringe is pierced through this portion to remove distilled water or the like. A liquid is poured into a vial 8 to dissolve a freeze-dried drug, and this drug solution is poured into a syringe or the like for administration.

[0003]

The conventional vial container has the following problems. (A) The vial container is composed of four types of glass, aluminum, synthetic resin, and rubber material, and it is necessary to separate the respective materials at the time of waste incineration processing, which requires much time and labor. (B) Keep the aluminum protector in the hopper,
During the process of crushing the vial via the feeder with this protector, aluminum scraps may be generated during the retention rolling in the hopper, and the aluminum scraps may contaminate the flip-off cap. (C) The rubber stopper may float up and fall off during transportation to the freeze-drying device. (D) It is difficult to inspect the bottle mouth because the vial mouth corresponding to the winding part of the aluminum protector is opaque. (E) When the lid is removed and the fractured part is exposed, a shearing part of aluminum is generated around the fractured part, and absorbent cotton for sterilization is caught and left on this, which hinders the sterilization of the exposed part of the upper surface of the rubber plug. You

It is an object of the present invention to provide a vial container at a low cost, which is extremely easy to sort by materials at the time of waste incineration processing, and on the other hand, in which there is no fear that the stopper will rise or fall during transportation.

[0005]

The structure of the present invention which solves the problems of the prior art is to form a needle passing window portion closed at the top wall by an opening or a sealing means for facilitating needle passing, and at the same time, bottle the bottle portion. In a protector made of synthetic resin having a ventilation means with the inside of the container, a stopper that seals between the inner surface of the top wall and the bottle mouth is fitted, and on the other hand, on the inner surface of the tubular portion constituting the protector,
Providing locking means for holding all stopper sealing postures of the protector, the inner surface of the tubular portion constituting the protector,
The locking means for holding the half-stopper freeze-drying posture of the protector is provided, the ventilation means is a groove provided on the inner surface of the tubular portion of the protector, and the ventilation means is a notch provided in the tubular portion of the protector. On the outer circumference of the bottle mouth of the bottle container to which the synthetic resin protector for forming the needle passage window part closed by the opening means or the sealing means for easily passing the needle is fitted on the top wall, the inside of the bottle container is exposed to the outside. Ventilation means for communication is provided, and on the other hand, a stopper for sealing between the protector and the bottle mouth is fitted on the inner surface of the top wall of the protector, and the protector is half-stopped on the inner surface of the protector. Provided with locking means for holding the dry posture and the corresponding full stopper sealing posture of the protector after freeze-drying, synthetic resin that forms a needle passage part closed on the top wall or closed by a sealing means for easy needle passage Made An outside diameter of the bottle mouth of the bottle container to which the protector is fitted is formed smaller than the inner diameter of the cylinder part that constitutes the protector, and the inside of the bottle container is communicated to the outside between the outer circumference of the bottle mouth and the inner surface of the cylinder part. On the other hand, while fitting a stopper for sealing between this and the bottle mouth on the inner surface of the top wall of the protector, on the inner surface of the tubular portion,
A half-stopper freeze-drying position of the protector and a locking projection with an intermittent structure that holds the corresponding full-stopper plugging position of the protector after freeze-drying are provided, and the plug is a sheet-like packing, and the freeze-drying position The retaining projections for holding are omitted.

[0006]

With the locking means having the ridge structure or the screw structure, it is possible to prevent the protector from rising and falling during transport to the freeze-drying means and to ensure the sealing after freeze-drying. By means of a groove provided on the inner surface of the tubular body that constitutes the protector or a notch on the tubular portion of the protector, and a means for communicating between the projection, the groove, the notch provided on the outer peripheral portion of the bottle mouth and the inside of the vial container, Can be effectively freeze-dried. Since non-combustible metals such as aluminum are not used at all, the work of separating the materials is omitted in the waste incineration process.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, details of embodiments of the present invention will be described with reference to the drawings. 1, 2 and 5 show a first embodiment, FIGS. 3, 4 and 5 show a second embodiment, FIGS. 6 to 9 show another embodiment of a protector, and FIGS. The third embodiment,
12 and 13 show the fourth embodiment, and FIGS. 14 and 15 show the fifth embodiment.
16 to 18, the sixth embodiment is shown in FIGS. 16 to 18, the seventh embodiment is shown in FIGS. 19 and 20, and the eighth embodiment is shown in FIGS.
24 and 25 show the ninth embodiment, and FIGS. 26 to 28 show the first embodiment.
0 embodiment, FIGS. 29 and 30 show the eleventh embodiment, and FIG.
1, FIG. 32 shows the twelfth embodiment, and FIGS. 33 and 34 show the thirteenth embodiment.
An example is shown.

The first embodiment shown in FIGS. 1 and 2 will be described in detail. 11 is a synthetic resin protector,
A needle passing window portion 12 is formed in the central portion of the top wall of the protector 11, and a seal 13 for closing the needle passing window portion 12 is attached to the upper surface of the top wall of the protector 11. On the surface of the sticker 13, a display (not shown) for identifying the drug name, content, etc. is printed. A stopper 15 made of rubber or a synthetic resin material integrally formed with a stopper 15a provided with a ventilation cutout 14 so as to abut the inner surface of the protector 11 is fitted inside the protector 11, and the stopper 15
The periphery of the lower portion of the collar 15b formed in the above is the protector 1
It is locked to a small ridge 16 integrally formed on the inner surface of 1, and the thickness of the flange 15b is a. Reference numeral 17 in the drawing denotes a ventilation groove formed on the inner surface of the protector 11. Also,
On the inner surface of the protector 11, two parallel ridges 18, 19 are integrally formed below the ridge 16 at appropriate intervals, and the bottle mouth 20a of the vial bottle 20 is provided between the ridges 18, 19. By sandwiching the collar portion 20b formed in the portion, the protector 11 is held in the posture during freeze-drying as shown in FIG. That is, the lower end of the stopper portion 15a of the stopper 15 slightly intervenes in the bottle mouth 20a in a half stoppered state, and the ventilation groove 17 provided in the protector 11 and the ventilation notch 14 provided in the stopper portion 15a of the stopper 15 are electrically connected. Is in a state. The lowermost protrusion 19 prevents the protector 11 from rising and falling off, and the next protrusion 18 prevents the protector 11 from inadvertently descending, so that the freeze-drying posture is reliably maintained. There is.
The distance b between the protrusion 16 and the protrusion 18 is substantially the same as the outer peripheral thickness of the collar portion 20b of the bottle mouth 20a. Tsuba 1 of the plug 15
The sum of the thickness a of 5b and the interval b between the ridges 16 and 18 is formed to be slightly larger than the distance L between the inner surface of the top wall of the protector 11 and the upper edge of the ridge 18 of the next stage. With this dimensional condition, as shown in FIG. 2, after the drug is freeze-dried, the upper surface of the protector 11 is pressed by a top plate (not shown) provided in the freeze-drying chamber, and the stopper 15 is in a sealed posture, that is, the collar of the stopper 15 is pressed. 15b is compressed and brought into close contact with the upper surface of the bottle mouth 20a, and when both are sandwiched and supported between the top wall of the protector 11 and the ridge 18 of the next stage, the sealing performance can be improved. As shown in FIGS. 2 and 5, the ridge 16 has a collar portion 20 of the bottle mouth 20a.
It is also possible to intervene in the step portion 21 formed on the outer periphery of the upper surface of the b.

Next, the details of the second embodiment shown in FIGS. 3 and 4 will be described. In this embodiment, the plug 15 having the plug portion 15a shown in FIGS. 1 and 2 is used as a sheet packing 22. For the purpose of improving the sealing property, the sheet-like packing 22 has the bottle mouth 20a.
It is also possible to use a plurality of ring-shaped sealing projections 23 integrally formed on the lower surface of the peripheral edge which abuts the upper surface of the periphery of the. Further, instead of the seal protrusion 23, a plurality of ring-shaped seal protrusions 24 can be integrally formed on the upper surface of the bottle mouth 20a as shown by the phantom line in FIG. The other structure is the same as that of the embodiment shown in FIGS. 1 and 2 described above, and the detailed description is omitted by giving the same symbols to the same components. The seal ridges 23 and 24 can be applied to the embodiment shown in FIG.

6-9, the protector 11
The details of another embodiment will be described. In this embodiment, in place of the seal 13 shown in FIGS. 1 and 3 described above, a seal film 25 for easily inserting a thin syringe needle is integrally formed on the needle passage window portion 12, and is shown in FIG. As described above, the seal film 25 is formed on the uppermost portion of the needle window portion 12 to flatten the upper surface of the protector 11, or the seal film 25 is provided on the lowermost portion of the needle window portion 12 as shown in FIG. Alternatively, as shown in FIG. 9, the seal film 25 is integrally formed in the middle portion of the needle window portion 12. In order to facilitate breakage of the seal film 25, an easy opening means such as a scorer (not shown) is provided on the seal film 25 portion in contact with the peripheral edge of the needle passing window portion 12, and the seal film 25 is pressed with a fingertip. It is also possible to make it possible to break the score portion cleanly and easily.

The third embodiment shown in FIGS. 10 and 11 will be described in detail. The embodiment shown in FIGS. 1 and 2 described above is
Although the protector 11 is held in the freeze-dried posture in the half stoppered state and kept in the sealed posture in the fully stoppered state by a plurality of stages of ridges 18 and 19 formed on the inner surface of the protector 11, this embodiment is a bottle. The female screw 26b of the protector 11 is screwed into the male screw 26a formed on the outer peripheral portion of the mouth 20a. The same applies to the fourth embodiment shown in FIGS. 12 and 13. The same structural parts as those shown in FIGS. 1 and 3 are designated by the same reference numerals, and detailed description thereof will be omitted. In the embodiment shown in FIGS. 1 and 3, a large number of protectors can be displaced from the freeze-drying posture to the sealing posture by pressing the top plate provided in the freeze-drying chamber. In the embodiment shown by, the protector 11 is brought into contact with a disk (not shown) that is rotationally driven, and the disk is pushed down or the vial 20 is pushed up, so that the protector 11 is screwed in, and the protector 11 is moved from the freeze-drying posture. It is displaced in a sealed position.

Next, details of the fifth embodiment shown in FIGS. 14 and 15 will be described. The embodiment described above is based on the protector 11
A groove 17 for ventilation is provided on the inner surface of the vial, and the inside of the vial 20 is communicated with the outside air through the ventilation groove 17 at the time of freeze-drying. However, the embodiment shown in FIG. A notch 27 for ventilation is provided in the portion 11a. When the protector 11 is in the half-capping freeze-drying posture, the upper end of the notch 27 is located above the upper edge of the bottle mouth 20a as shown in FIG. The upper end of the notch 27 is formed to be lower than the upper end of the bottle mouth 20a in the sealed posture in the state, as shown in FIG. The protector 11 shown in this embodiment can also be applied to the embodiments shown in FIGS. 1, 3, 10, and 13. By forming the protector 11 with a transparent synthetic resin material such as polycarbonate having a high heat resistance, the inside of the bottle mouth 20a can be seen through, the quality can be improved, and autoclave sterilization can be performed. Becomes

The details of the sixth to eleventh embodiments will be described with reference to FIGS. These examples are based on
In contrast to the fifth embodiment in which the protector is provided with the ventilation means, the ventilation means is formed on the outer periphery of the bottle mouth flange portion of the vial bottle. 16 to 18 show the sixth embodiment, and as shown in FIG. 16, at least three protrusions 28 are integrally formed on the outer periphery of the collar portion 20b of the bottle mouth 20a, and as shown in FIG. The protector 11 is fitted into the bottle mouth 20a so that the inner surface of the tubular portion 11a of the protector 11 contacts the outer end of the protrusion 28, and the flange portion 20b of the bottle mouth 20a is interposed between the protrusions 18 and 19. Between the surface of the cylindrical portion 11a of the protector 11 and the outer peripheral surface of the collar portion 20b,
A plurality of ventilation gaps 29 corresponding to the thickness of the protrusions 28 are formed, and the inside of the vial 20 is kept in communication with the outside to maintain the posture during freeze-drying. After lyophilization, as shown in FIG. 18, the aeration gap 29 is sealed by the stopper 15 by completely stoppering the protector 11, and the collar portion 2
The ridge 18 engages with the lower surface of 0b so that the stopper 15 and the protector 11 are held in a sealed posture. In the seventh embodiment shown in FIGS. 19 and 20, the plug 15 having the plug portion 15a of the sixth embodiment is a sheet-like packing 22, and other structures are the same as those of the sixth embodiment. Detailed description is omitted. However, in the case of this sheet-like packing 22,
Since there is no lifting phenomenon of the stopper itself, the ridges 19 for holding the freeze-drying posture are not particularly required as shown by imaginary lines.

The eighth embodiment shown in FIGS. 21-23 is shown in FIG.
As shown in FIG. 1, a ventilation groove 30 is formed in the outer periphery of the collar portion 20b of the bottle mouth 20a so as to penetrate therethrough in the vertical direction. Then, as shown in FIG. 22, the stopper 15a of the stopper 15 is half-capped with respect to the bottle mouth 20a of the vial bottle 20, and the lower ridge 19 provided on the tube portion 11a of the protector 11 is attached to the bottle mouth 20a. The freeze-drying posture in which the lower surface of the collar portion 20b is engaged is maintained, and the inside of the vial bottle 20 is covered with the ventilation groove 3
It is connected to the outside through 0. After freeze-drying, as shown in FIG. 23, the vent groove 30 is sealed by the stopper 15 by completely stoppering the protector 11.
The ridge 18 engages with the lower surface of the collar portion 20b to hold the stopper 15 and the protector 11 in a sealed posture. 24 and 25
In the ninth embodiment shown in FIG. 10, the plug 15 having the plug portion 15a of the eighth embodiment is a sheet-like packing 22, and the other structure is the same as that of the eighth embodiment. Therefore, detailed description thereof will be omitted. To do. However, in the case of this sheet-like packing 22, the lifting phenomenon of the stopper itself does not occur, so that the ridge 19 for holding the freeze-drying position does not need to be particularly provided unlike a virtual stopper.

26 to 28 show a tenth embodiment. In this embodiment, as shown in FIG. 26, a cut-off surface 31 obtained by vertically cutting the collar portion 20b is provided at a symmetrical portion of the collar portion 20b of the bottle mouth 20a. As shown in FIG. The stopper portion 15a is connected to the bottle mouth 20a of the vial bottle 20.
Half-stopped, and the lower ridge 19 provided on the inner surface of the tubular portion 11a of the protector 11 is held in the freeze-drying posture in which the lower surface of the collar portion 20b is engaged, and the inside of the vial bottle 20 is cut off. It is communicated with the outside through a ventilation gap 32 formed between the drop surface 31 and the inner surface of the tubular portion 11a. After freeze-drying, as shown in FIG. 28, the aeration gap 32 is closed by plugging the protector 11 completely.
The protrusions 18 are engaged with the lower surface of the collar portion 20b to hold the stopper 15 and the protector 11 in the sealed posture. 29 and 30 show an eleventh embodiment. In this embodiment, the plug 15 having the plug portion 15a shown in the tenth embodiment is replaced by a sheet-like packing 22, and the other structure is the tenth embodiment. The detailed description is omitted because it is the same as the embodiment. However, when the sheet-like packing 22 is used, since the phenomenon of lifting of the stopper itself does not occur, the ridge 19 for holding the freeze-drying posture is not particularly required as shown by a virtual line.

The twelfth embodiment shown in FIGS. 31 and 32 is the outer diameter of the bottle mouth 20a of the vial 20, that is, the collar portion 2.
The outer diameter of 0b is smaller than the inner diameter of the tubular portion 11a of the protector 11, and a ventilation gap 33 corresponding to the difference in diameter between the outer periphery of the collar portion 20b and the inner surface of the tubular portion 11a is formed. . In this embodiment, as shown in FIG. 31, the stopper 15a of the stopper 15 is half-capped into the vial 20a of the vial 20 and the lower ridge 19 provided on the inner surface of the tubular portion 11a of the protector 11 is used for the collar. The freeze-drying posture engaged with the lower surface of the portion 20b is maintained. At this time, since the ventilation gap 33 may be blocked by the protrusion 19, the protrusion 1
Reference numeral 9 is an intermittent structure provided with a ventilation part 34. The ridges 18 also have the same structure. Then, after freeze-drying, FIG.
As shown in FIG. 4, the ventilation gap 33 is sealed by the stopper 15 by completely stoppering the protector 11, and the projection 18 is engaged with the lower surface of the collar portion 20b to keep the stopper 15 and the protector 11 in a sealed posture. . 33 and 34
The thirteenth embodiment shown in FIG. 11 is the plug portion 15a shown in the twelfth embodiment.
Since the sheet-like packing 22 is used in place of the plug 15 having the above, and the other structure is the same as that of the twelfth embodiment, detailed description thereof will be omitted. However, when this sheet-like packing 22 is used, since the phenomenon of lifting of the stopper itself does not occur, the ridge 19 for holding the freeze-drying posture is not particularly required as shown by the phantom line.

[0017]

As described above, according to the structure of the present invention, the following effects can be obtained. (A) It is possible to secure the freeze-drying posture and the sealing posture of the protector with a simple configuration, and it is possible to completely prevent the protector from rising and falling off during transportation to the freeze-drying cabinet, and it is possible to improve work processing efficiency. (B) Since the vial container is made of three materials of glass, synthetic resin, and rubber, the waste incineration process becomes extremely easy as compared with the conventional case. (C) Since the protector is made of a synthetic resin material as compared with the prior art that uses an aluminum protector, no waste is generated during retention in the hopper and the like, and the protector is easy to manage. (D) Aeration between the vial and the outside air during lyophilization can be completely ensured, and proper and uniform lyophilization can be performed.

[Brief description of drawings]

FIG. 1 is a sectional view of a freeze-drying posture in a first embodiment in which a stopper having a locking means of a protector is used as a protrusion and a stopper having a stopper is used.

FIG. 2 is a sectional view of the embodiment shown in FIG. 1 in a sealed posture.

FIG. 3 is a cross-sectional view of a freeze-drying posture in a second embodiment in which a sheet-like packing is used with the locking means of the protector as a ridge.

FIG. 4 is a sectional view of the embodiment shown in FIG. 3 in a sealed posture.

FIG. 5 is an enlarged cross-sectional view of a main part.

FIG. 6 is a partially cutaway perspective view of an embodiment in which a needle passing window portion is closed by a sealing means which is integrated with a protector and which facilitates opening, and the ventilation means has a groove structure.

7 is a cross-sectional view showing another example of the protector provided on the upper portion of the needle window portion of the sealing means shown in FIG.

8 is a cross-sectional view showing another example of the protector provided in the lower portion of the needle window portion of the sealing means shown in FIG.

9 is a cross-sectional view showing another example of the protector provided in the intermediate portion of the needle window portion of the sealing means shown in FIG.

FIG. 10 is a sectional view of a freeze-drying posture in a third embodiment in which the locking means of the protector has a screw structure and a stopper having a stopper is used.

11 is a sectional view of the embodiment shown in FIG. 10 in a sealed posture.

FIG. 12 is a cross-sectional view of a freeze-drying posture in a fourth embodiment in which the locking means of the protector has a screw structure and a sheet-like packing is used.

13 is a sectional view of the embodiment shown in FIG. 12 in a sealed posture.

FIG. 14 is a partially cutaway front view of the freeze-drying posture in the fifth embodiment in which a ventilating means having a cutout structure is provided in the tubular portion of the protector.

FIG. 15 is a partially cutaway front view of the embodiment shown in FIG. 14 in a sealed posture.

FIG. 16 is a plan view showing a sixth embodiment in which ventilation means are formed in the bottle mouth.

FIG. 17 is a cross-sectional view showing a freeze-drying posture of the above-mentioned embodiment using a stopper having a stopper portion.

18 is a cross-sectional view showing the sealed posture of FIG.

FIG. 19 is a sectional view showing a freeze-drying posture of a seventh embodiment using a sheet-like packing.

20 is a cross-sectional view showing the sealed posture of FIG.

FIG. 21 is a plan view of an eighth embodiment in which a vent is formed on the bottle mouth.

FIG. 22 is a cross-sectional view showing a freeze-drying posture of the embodiment using a stopper having a stopper portion.

23 is a cross-sectional view showing the sealed posture of FIG.

FIG. 24 is a sectional view showing a freeze-drying posture of the ninth embodiment using a sheet-like packing.

FIG. 25 is a cross-sectional view showing the sealing posture of FIG. 24.

FIG. 26 is a plan view of a tenth embodiment in which a ventilation means is formed at the bottle mouth.

FIG. 27 is a cross-sectional view showing a freeze-drying posture of the above-mentioned embodiment using a stopper having a stopper portion.

28 is a cross-sectional view showing the sealed posture of FIG. 27.

FIG. 29 is a cross-sectional view showing a freeze-drying posture of the eleventh embodiment using a sheet-like packing.

30 is a cross-sectional view showing the sealed posture of FIG. 29.

FIG. 31 is a cross-sectional view of a freeze-drying posture using a stopper having a stopper, showing a twelfth embodiment in which the difference between the outer diameter of the bottle mouth and the inner diameter of the protector cylinder is used as the ventilation means.

32 is a cross-sectional view showing the sealing posture of FIG. 31.

FIG. 33 is a sectional view showing a freeze-drying posture of a thirteenth embodiment using a sheet-like packing.

FIG. 34 is a cross-sectional view showing the sealed posture of FIG. 33.

FIG. 35 is an exploded vertical sectional front view of a conventional vial container.

[Explanation of symbols]

 11 Protectors 12 Needle Window 13 Seals 14 Vent Notches 15 Plugs 15a Plugs 15b Collars 16 Projections 17 Ventilation Grooves 18 Projections 19 Projections 20 Vials 20a Bottles 20b Collars 21 Steps 22 Sheet-like packing 23 Seals Protrusions 24 Seal protrusions 25 Seal film 26a Male screw 26b Female screw 27 Notch 28 Protrusion 29 Ventilation gap 30 Ventilation groove 31 Cut-off surface 32 Ventilation gap 33 Ventilation gap 34 Ventilation part

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Ikuo Araki 166 Yamashita-cho, Naka-ku, Yokohama Araki Industry Co., Ltd.

Claims (7)

[Claims] 1. A synthetic resin protector having an opening or a needle passage window portion closed by a sealing means for facilitating needle passage, and a cylinder made of a synthetic resin protector having ventilation means for communicating with the inside of a bottle container. Fit a stopper that seals between the inner surface of the top wall and the bottle mouth,
On the other hand, a vial container characterized in that a locking means for holding the protector in a fully stoppered sealing posture is provided on the inner surface of the tubular portion constituting the protector. 2. The vial container according to claim 1, wherein a locking means for holding the half stopper stopper freeze-drying posture of the protector is provided on the inner surface of the cylindrical portion constituting the protector. 3. The vial container according to claim 1, wherein the ventilation means is a groove provided on the inner surface of the cylindrical portion of the protector. 4. The vial container according to claim 1, wherein the ventilating means is a notch provided in the tubular portion of the protector. 5. The inside of the bottle container is fitted to the outer circumference of the bottle container to which a synthetic resin protector for forming a needle passing window part which is closed on the top wall with an opening or a sealing means for easily passing the needle is fitted. Ventilation means for communicating with the outside is provided.On the other hand, a stopper that seals between the top wall of the protector and the bottle mouth is fitted on the inner surface of the protector, and the protector is struck halfway on the inner surface of the tubular portion constituting the protector. A vial container provided with a stopper freeze-drying posture and a locking means for holding a stopper stopper full-sealing posture of a corresponding protector after freeze-drying. 6. The bottle mouth outer diameter of a bottle container to which a synthetic resin protector for forming a needle passing portion closed by a closing means or a sealing means for easily passing the needle is formed on the top wall is It is formed to have a diameter smaller than the inner surface diameter, and a ventilation gap is formed between the outer periphery of the bottle mouth and the inner surface of the cylinder portion for communicating the inside of the bottle container to the outside, while the inner wall of the protector has a space between it and the bottle mouth. While fitting the sealing plug,
The vial container is characterized in that the inner surface of the cylindrical portion is provided with a locking protrusion having an intermittent structure for holding a half-stopper freeze-drying posture of the protector and a corresponding full-stopper stopper sealing posture of the corresponding protector after freeze-drying. 7. The vial container according to claim 6, wherein the stopper is a sheet-like packing, and the locking projection for holding the freeze-drying posture is removed.