JPH07227256A - Liquid agent for oral administration - Google Patents

Abstract

PURPOSE:To stabilize ascorbic acid in a liquid agent for oral administration and to improve the drinkability of the liquid. CONSTITUTION:This liquid agent for oral administration contains ascorbic acid or its edible salt in an amount of about 0.05-5%(W/V) in terms of ascorbic acid and has pH of 4.5-7. The liquid agent may contain an edible organic acid other than ascorbic acid or its edible salt in an amount of about 0.005-5%(W/V) in terms of the edible organic acid. The agent may further contain about 0.001-0.5%(W/V) of unstable free a-tocopherol having high activity.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral liquid preparation which can be easily drunk without causing pain.

[0002]

2. Description of the Related Art Conventionally, oral liquid preparations containing vitamin C have been marketed. However, this solution has a problem with the stability of vitamin C. Vitamin C, that is, ascorbic acid, is in a reduced form and is extremely easily oxidized. It was considered that ascorbic acid was relatively stable in the strongly acidic (pH 2 or less) and neutral to alkaline regions, but was particularly unstable in the acidic to slightly acidic region. Further, in order to exert the effect of vitamin C, a large amount of ingestion is required, so that the content of ascorbic acid is often increased in the oral liquid preparation containing vitamin C. However, if the content of ascorbic acid is increased, the solution becomes sour in the acidic region and has a strong salty taste in the slightly acidic to neutral region, and even if a flavoring agent such as a sweetener is added, it is difficult to drink. As described above, the liquid agent containing ascorbic acid is considered to be in a region not suitable for drinking at pH 4.5 to 6.

Further, in an oral liquid preparation containing ascorbic acid, the stability of ascorbic acid in an aqueous solution is impaired, and when an additive such as a flavoring agent is added, the stability of ascorbic acid is further impaired. Therefore, in an oral liquid preparation containing ascorbic acid, the content of ascorbic acid cannot be maintained for a long period of time, sacrificing stability, imparting a taste that is easy to drink and securing the content of ascorbic acid. , The amount has been increased (additional preparation).

[0004] Although such an oral solution can secure the content of ascorbic acid, it cannot fundamentally solve the stability within the quality guarantee period, and also has a problem of ingesting decomposition products. . In particular, oral liquids called drinks are not under the control of doctors and are intended for an unspecified large number of people. Therefore, the stability of ascorbic acid is further likely to decrease in oral liquid preparations such as drink preparations.

Oral liquid preparations containing vitamin E are also commercially available. However, vitamin E is also easily oxidized and easily decomposed with oxidation. Free α-tocopherol, which is particularly active, has low stability. Therefore, as vitamin E, it is unavoidable to use an ester which has lower activity than that of free α-tocopherol, but has good stability.

[0006]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide an oral liquid preparation which has high stability of ascorbic acid and can be easily taken without causing a feeling of strangeness.

[0007] Another object of the present invention is to provide an oral liquid preparation with further improved ease of swallowing.

Yet another object of the present invention is to include ascorbic acid and free α-tocopherol,
An object of the present invention is to provide an oral liquid preparation which is highly stable and can be drunk without causing pain.

[0009]

Means for Solving the Problems As a result of intensive studies to achieve the above object, the present inventors have found that when the pH of an oral solution containing ascorbic acid is adjusted to a specific pH range, the ascorbic acid becomes relatively stable. Moreover, they have found that they are suitable for drinking and completed the present invention.

That is, the oral liquid preparation of the present invention contains ascorbic acid or an edible salt thereof and has a pH of 4.5 to 7. The pH of the oral liquid preparation can be selected within the above range, and may be, for example, about pH 4.5 to 5. Moreover, the oral liquid preparation may contain an edible organic acid other than ascorbic acid or an edible salt thereof. The content of ascorbic acid or its edible salt is, for example, 0.05 in terms of ascorbic acid.
The content of the edible organic acid other than ascorbic acid or its edible salt may be, for example, 0.005 to 5% (W / V) in terms of edible organic acid. It may be about V).

The oral solution of the present invention may further contain free α-tocopherol, which has high activity but is considered to be unstable. The content of free α-tocopherol may be, for example, about 0.001 to 0.5% (W / V).

Further, the oral liquid preparation of the present invention includes, for example,
(1) A liquid agent containing ascorbic acid or an edible salt thereof and free α-tocopherol and having a pH of 4.5 to 6.0, (2) an ascorbic acid or an edible salt thereof, or an ascorbic acid other than ascorbic acid. Contains an edible organic acid or an edible salt thereof and free α-tocopherol, and has a pH of 4.5 to
Also included is a solution that is 6.0. Furthermore, oral liquid preparation (1)
In (2), about 0.1 to 3% (W / V) of ascorbic acid or its edible salt in terms of ascorbic acid, and 0.01 to 0.1% (W / V) of free α-tocopherol.
Degree, edible organic acid other than ascorbic acid or its edible salt is converted to edible organic acid 0.007 to 2% (W / V)
The degree may be included.

Examples of the ascorbic acid and the edible salt thereof include salts of ascorbic acid, ascorbic acid and an inorganic base (for example, alkali metal salts of ascorbic acid such as sodium ascorbate and potassium ascorbate, calcium ascorbate, Examples thereof include alkaline earth metal salts of ascorbic acid such as magnesium ascorbate, ammonium ascorbate), salts of ascorbic acid with organic bases (eg, arginine, histidine, triethanolamine, meglumine).
Of these ascorbic acid and edible salts thereof, for example, alkali metal salts of ascorbic acid such as ascorbic acid, sodium ascorbate and potassium ascorbate are frequently used. These components may be used alone or in combination of two or more, and ascorbic acid and its edible salt may be used in combination.

The content of ascorbic acid and its edible salt can be selected according to the purpose and application of the oral liquid preparation. For example, the content of ascorbic acid in the oral liquid preparation is 0.05 to 5%.
(W / V), preferably 0.05 to 4% (W / V), and more preferably 0.1 to 3% (W / V).

The oral solution of the present invention has a pH of 4.5 to 7,
It is preferably 4.5 to 6, and more preferably about 4.5 to 5. The oral solution adjusted to such a pH range has a feature that ascorbic acid is relatively stable and can be easily taken without causing pain or discomfort.
When the pH of the oral liquid is out of the above range, the stability of ascorbic acid is impaired, and discomfort or discomfort is likely to occur during drinking.

The pH of the oral liquid preparation is, if necessary,
Acids (for example, organic acids, inorganic acids such as hydrochloric acid and phosphoric acid described later), bases (for example, sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, inorganic bases such as ammonia) Or an organic base such as arginine, histidine, triethanolamine, meglumine) or the like.

The oral solution of the present invention may further contain an edible organic acid other than ascorbic acid or an edible salt thereof in order to further improve ease of drinking. Examples of the edible organic acid and its edible salt include oxycarboxylic acids such as citric acid, tartaric acid, malic acid, lactic acid and gluconic acid, saturated aliphatic carboxylic acids such as acetic acid and succinic acid, and unsaturated compounds such as fumaric acid. Aromatic carboxylic acids such as aliphatic carboxylic acids and benzoic acids, aromatic organic acids such as tannic acid; salts thereof (for example, alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium) Salt etc.). Preferred edible organic acids include edible oxycarboxylic acids (eg citric acid, tartaric acid, malic acid, etc.) and alkali metal salts of edible oxycarboxylic acids. These components may be used alone or in combination of two or more.

The content of the edible organic acid and the edible salt thereof can be appropriately selected within a range that does not impair the stability of ascorbic acid, drinking ability, and the like. 0.005-5% (W / V), preferably 0.005-3% (W / V), more preferably 0.0
It is about 07 to 2% (W / V).

The oral liquid preparation of the present invention may contain free α-tocopherol. Free α-tocopherol includes, for example, d-α-tocopherol, dl-α-
Includes tocopherols. The content of free α-tocopherol can be used within a range in which it can be solubilized or dispersed, and, for example, 0.001 to 0.5% (W / V) in an oral solution,
It is preferably 0.005 to 0.2% (W / V), and more preferably about 0.01 to 0.1% (W / V).

The free α-tocopherol is (1)
The ascorbic acid or the edible salt thereof may be used in combination, or (2) the ascorbic acid or the edible salt thereof and an edible organic acid other than ascorbic acid or the edible salt thereof may be used in combination.

Liquid formulation (1) containing ascorbic acid or its edible salt in combination with free α-tocopherol
In, the proportion of each component can be selected within the above range, and the content of ascorbic acid or an edible salt thereof is 0.05 to 5% (W / V) (preferably 0.1) in terms of ascorbic acid.
~ 3% (W / V)), and the content of free α-tocopherol is 0.001 to 0.5% (W / V) (preferably 0.01 to 0.1% (W / V)). It is a degree. The pH of this liquid agent can be selected in the range of 4.5 to 7 as described above,
Preferably 4.5-6.0, more preferably 4.5-
It is about 5.

In a liquid preparation (2) containing ascorbic acid or an edible salt thereof, an edible organic acid other than ascorbic acid or an edible salt thereof, and free α-tocopherol, ascorbic acid or an edible salt thereof is used. Content of 0.05 to 5% (W / V) in terms of ascorbic acid
(Preferably about 0.1 to 3% (W / V)), the content of the edible organic acid and its salt is 0.0 in terms of the edible organic acid.
05-5% (W / V) (preferably 0.007-2%)
(W / V)), the content of free α-tocopherol is 0.001 to 0.5% (W / V) (preferably 0.0).
It is about 1 to 0.1% (W / V)). PH of this solution
Also, similarly to the above, it can be selected in the range of 4.5 to 7, preferably 4.5 to 6.0, and more preferably about 4.5 to 5.

In the present specification, in addition to the oral liquid preparation containing ascorbic acid (hereinafter referred to as oral liquid preparation (A)) having the above composition, an oral liquid preparation containing free α-tocopherol and containing no ascorbic acid (hereinafter referred to as oral liquid preparation). Liquid agent (sometimes referred to as B)) is also disclosed. This oral liquid preparation (B) is novel in that it contains free α-tocopherol instead of an ester form of α-tocopherol.

In the oral liquid preparation (B), free α-
The content of tocopherol can be selected within a range that does not impair the stability, and for example, 0.001 to 0.5% (W / V) (preferably 0.005 to 0.2% (W / V), It is preferably about 0.01 to 0.1% (W / V).

The oral liquid preparation (B) containing the free α-tocopherol contains the edible organic acid and its salt in an amount of 0.005 to 5% (W / V) (preferably 0) in terms of the edible organic acid. 0.005 to 3% (W / V), and more preferably 0.007 to 2% (W / V)).
Furthermore, if necessary, ascorbic acid or an edible salt thereof is added in an amount of 0.05 to 5% (W / V) in terms of ascorbic acid.
(Preferably about 0.1 to 3% (W / V)) may be included.

PH of oral liquid preparation (B) containing free α-tocopherol and not containing ascorbic acid or a salt thereof.
Is a range that does not impair ease of drinking, for example, 2 to 7, preferably about 3 to 5.

The oral liquid preparation (A) of the present invention and free α-
The oral liquid preparation (B) containing tocopherol includes other medicinal ingredients such as water-soluble vitamins and fat-soluble vitamins, flavoring agents, flavoring agents, flavoring agents, coloring agents, suspending agents, thickening agents, preservatives, and interfacial agents. An activator, a solubilizer, dietary fiber, an antioxidant, a solubilizing agent, fruit juice and the like may be added.

The water-soluble vitamins include, for example, vitamin B ₁ such as thiamine hydrochloride, vitamin B ₁ derivative such as fursultiamine and thiamine disulfide, vitamin B ₂ such as riboflavin, riboflavin phosphate and riboflavin sodium phosphate. , Vitamin B ₆ such as pyridoxine, pyridoxine hydrochloride, pyridoxal phosphate, pyridoxamine phosphate, cobalamin, cyanocobalamin,
Vitamin B group such as vitamin B ₁₂ such as hydroxocobalamin, hydroxocobalamin acetate and mecobalamin,
Nicotinic acid and its salts, nicotinic acid amide, pantothenic acid and its salts, carnitine chloride, panthenol,
Pantethine, folic acid and its salts, biotin, etc. are included. These water-soluble vitamins can be used alone or in combination of two or more, and the amount generally added to an oral liquid preparation can be added.

Examples of fat-soluble vitamins include vitamins A such as etretinate, retinol acetate, retinol palmitate, liver oil and β-carotene; cholecalciferol, ergocalciferol, dihydrotachysterol, alfacalcidol, calcitriol and the like. Vitamin Ds of tocopherol succinate; vitamin Es consisting of ester derivatives of tocopherols such as calcium tocopherol succinate, tocopherol acetate, tocopherol butyrate, and tocopherol nicotinate; and vitamin Ks such as phytonadione and menaterein. These fat-soluble vitamins can be used alone or in combination of two or more, and the amount generally added to the oral liquid preparation can be added.

Oral liquid preparations include caffeine, chondroitin sulfate, royal jelly, herbal medicine components (eg, carrot, rockfish, eucommia, guarana, psyllium, hops, homika, maou, mokutou, mokko, ryutan, gentian, luzonka, forsythia, auspicious, It may be contained in an amount generally contained in an oral liquid preparation such as kokushi, dio, touki, armature, cuckoo, liquorice, kyounin, kukushi, keihi, ginger, tokyo).

Examples of the corrigent include sucrose, glucose, fructose, lactose, sorbitol,
Palatinose, reduced maltose, corn syrup, sorbitol and other sugar alcohols, isomerized sugar, starch syrup, glycyrrhizin, natural or artificial sweeteners such as honey, etc. are included, and the amount generally added to an oral liquid preparation can be added.

Examples of the suspending agent and thickening agent include polysaccharides such as gum arabic, tragacanth, pullulan, locust bingham, bingham, xanthan gum and guar gum, methyl cellulose, carboxymethyl cellulose,
Polyvinyl alcohol, polypinylpyrrolidone, acrylic acid copolymer, carboxyvinyl polymer, acrylic acid-vinyl alcohol copolymer, starch acrylate, partially pregelatinized starch, soluble starch, colloidal microcrystalline cellulose and the like are mentioned, which are generally blended in oral liquid preparations. Amount can be added.

Preservatives include preservatives and antibacterial agents such as benzoic acid, benzoic acid salts such as sodium benzoate, paraoxybenzoic acid esters such as ethyl paraoxybenzoate, propyl paraoxybenzoate and butyl paraoxybenzoate, sorbic acid. , Sorbate salts such as sodium sorbate, dehydroacetic acid, dehydroacetate salts such as sodium dehydroacetate, chlorhexidine, chlorobutanol and the like, which can be added in an amount generally mixed in an oral solution.

Oral liquid preparations include amino acids such as L-aspartic acid or salts thereof (eg, sodium salt), sodium glutamate, sodium succinate,
It may contain a flavoring agent such as sodium inosinate and taurine (flavoring agent), and the amount generally added to an oral liquid preparation can be added.

The oral liquid preparation of the present invention can be directly used for drinking, but it is preferable to add a flavor (flavoring agent, flavoring agent) in order to give a taste and flavor more suitable for drinking. Examples of flavors include various flavors, for example, fruit-like flavors such as citrus flavors, herb flavors (for example, flavors such as rosemary, thyme and lemongrass used as spices for cooking) and the like. To be Preferred flavors include fruity (citrus) flavors.

Flavors may be added alone, but if a plurality of flavors are added in combination, an oral liquid preparation with further improved taste and flavor can be obtained. In particular,
The combination of fruity (citrus) flavors and herbal flavors further improves the taste and flavor of oral solutions.

The amount of flavor to be added can be selected within a range capable of imparting a taste and flavor suitable for drinking, but usually a trace amount (for example, 0.002 to 1% (V / V in the case of containing a solvent)).
V) about 0.00002 as a perfume component excluding the solvent
It is about 0.01% (W / V)).

The oral liquid preparation can be prepared by a conventional method, and the method is not particularly limited. Usually, each component is mixed with a part of purified water, the remaining purified water is added, and if necessary,
It can be prepared by filtration or sterilization. Note that α-
When it contains a fat-soluble component such as tocopherol, for example, it is emulsified or solubilized with a suitable surfactant, a solubilizer such as alcohols, or dissolved in an edible oil or fat, and then added by emulsification. Good. Further, the fat-soluble component may be adsorbed on a carrier and suspended in the suspending agent to be added. The compounding amount of the solubilizer may be the amount generally used for oral liquid preparations.

Examples of the surfactant include polyoxyethylene sorbitan fatty acid esters such as monooleyl polyoxyethylene sorbitan, sorbitan fatty acid esters such as sorbitan sesquioleate, and polyoxyethylene fatty acid esters such as polyoxyethylene stearate. , Glycerin fatty acid esters such as glycerin monostearate, polyoxyethylene-based surfactants such as lauromacrogol, oxyethyleneoxypropylene block copolymers such as pluronic surfactants (such as Pluronic F68), polyoxyethylene cured castor Polyoxyethylene derivatives such as oils, nonionic surfactants such as polyoxyethylene alkyl ethers and polyoxyalkyl aryl ethers, fatty acid salts, Anionic surfactants such as Le sulfate and the like.

Examples of the alcohols include ethanol, cetyl alcohol, propylene glycol, ethylene glycol, polyethylene glycol, glycerin,
It includes sorbitol, mannitol, xylitol and the like.

The oral liquid preparation of the present invention is not limited to oral liquid preparations such as drinks, syrups, extracts, elixirs and limonades, and medicinal drinks, but also functional drinks (eg health drinks). It can be used as various beverages such as.

When the oral liquid preparation of the present invention is used as an oral liquid preparation or a medicinal drink, for example, relief of pigmentation due to spots, freckles, sunburns, rashes, etc.,
Prevention of bleeding from gums and nosebleeds, physical fatigue, pregnancy /
It is useful for vitamin C supplementation during lactation, during physical illness after illness, and during old age. Further, an oral solution containing free α-tocopherol, for example, due to peripheral blood circulation, shoulder / neck muscle numbness, limb numbness, coldness, relief of burns, shoulder / neck muscle stiffness in menopause, limb numbness, relief of hot flashes, It can be used for irregular menstruation, supplementation of vitamin E in old age, etc.

[0043]

EFFECTS OF THE INVENTION Since the oral liquid preparation of the present invention is adjusted to a specific pH, it has a high stability of ascorbic acid and can be easily taken without causing any discomfort. In addition, when an edible organic acid or a salt thereof is contained, the ease of drinking the oral liquid preparation can be further improved. Further, when it contains free α-tocopherol, it has high stability and can be drunk without pain, even though it contains ascorbic acid and free α-tocopherol.

[0044]

The present invention will be described in more detail based on the following examples, but the invention is not intended to be limited by these examples.

Example 1 An oral liquid preparation having the following composition was prepared.

Ascorbic acid 1000 mg d-α-tocopherol 10 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 25 mg Nicotinic acid amide 30 mg Purified white sugar 5 g Citric acid 50 mg Polyoxyethylene hydrogenated castor oil 50 10 mg Flavor (citrus) Trace sodium hydroxide (pH) Adjusting agent) Proper amount Purified water (total amount) 50 ml pH 5.0 The obtained oral liquid preparation was stored at 40 ° C. for 6 months, and the residual ratio of ascorbic acid and d-α-tocopherol was examined. 1% and 95.5% of d-α-tocopherol remained, ascorbic acid was remarkably stabilized, and it was conventionally difficult to compound d.
It was found that -α-tocopherol can also be stably mixed.

Example 2 An oral liquid preparation having the following composition was prepared.

Ascorbic acid 500 mg dl-α-tocopherol 10 mg Riboflavin sodium phosphate 15 mg Pyridoxine hydrochloride 25 mg Nicotinic acid amide 30 mg Anhydrous caffeine 50 mg Taurine 500 mg Purified white sugar 5 g Citric acid 200 mg Sodium citrate 200 mg Sodium benzoate 30 mg Polyoxyethylene hardened polyoxyethylene Oil 60 10 mg Flavor (citrus type) Trace amount sodium hydroxide (pH adjuster) Appropriate amount Purified water (total amount) 50 ml pH 4.7 And the oral solution is stored at 25 ° C for 6 months, and ascorbic acid and dl-α-tocopherol are stored. The residual ratio of ascorbic acid was 96.8% and dl-α-tocopherol was 99.5%. Ascorbic acid was significantly stabilized, and dl-alpha-tocopherol had been flame also were found to be stably formulated.

Example 3 An oral liquid preparation having the following composition was prepared.

Ascorbic acid 500 mg dl-α-tocopherol 10 mg Riboflavin sodium phosphate 15 mg Pyridoxine hydrochloride 50 mg Nicotinic acid amide 30 mg Anhydrous caffeine 50 mg Taurine 500 mg Purified white sugar 8 g Citric acid 400 mg Sodium benzoate 35 mg Polyoxyethylene hydrogenated castor oil 60 Sodium oxide (pH adjuster) Appropriate amount Purified water (total amount) 50 ml pH 4.5 The obtained oral liquid preparation was stored at 25 ° C. for 6 months, and the residual ratio of ascorbic acid and dl-α-tocopherol was examined. It was found that 91.7% of the acid and 100% of the dl-α-tocopherol remained, the ascorbic acid was remarkably stabilized, and the dl-α-tocopherol could also be stably mixed.

Example 4 An oral liquid preparation having the following composition was prepared.

Ascorbic acid 1000 mg Sodium ascorbate 1000 mg dl-α-tocopherol 50 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 30 mg Pantothenic acid 10 mg Purified white sugar 8 g Polyoxyethylene hydrogenated castor oil 60 100 mg Flavor (citrus) Trace amount purified water (total amount) 100 ml pH 4.5 Example 5 An oral solution having the following composition was prepared.

Ascorbic acid 500 mg d-α-tocopherol 10 mg Riboflavin sodium phosphate 15 mg Pyridoxine hydrochloride 50 mg Nicotinic acid amide 30 mg Anhydrous caffeine 50 mg Taurine 500 mg Purified white sugar 4 g Reduced maltose starch syrup 0.5 g Honey 0.5 g sodium citrate 250 mg 100 mg Sodium benzoate 35 mg Polyoxyethylene hydrogenated castor oil 60 50 mg Flavor (citrus) Trace sodium hydroxide (pH adjuster) Appropriate amount Purified water (total amount) 50 ml pH 4.5 Obtained oral liquid formulation at 25 ° C for 12 months When preserved and examined the residual ratio of ascorbic acid and d-α-tocopherol, 90.8% of ascorbic acid and 100% of d-α-tocopherol remained.

Example 6 An oral liquid preparation having the following composition was prepared.

Ascorbic acid 100 mg Sodium ascorbate 100 mg dl-α-tocopherol 10 mg d-α-tocopherol 10 mg Riboflavin sodium phosphate 5 mg Pyridoxine hydrochloride 30 mg Nicotinamide 30 mg Anhydrous caffeine chloride 100 mg Inositol 10 mg Purified ginseng extract 10 ginseng flow g Honey 5 g Citric acid 200 mg Sodium citrate 200 mg Benzoic acid 30 mg Polyoxyethylene hydrogenated castor oil 60 100 mg Flavor (citrus type) Trace amount purified water (total amount) 100 ml pH 4.8 Comparative example 1 Obtain a commercially available oral liquid composition of the following composition did.

Ascorbic acid 500 mg Vitamin B ₂ Phosphate ester 5 mg Vitamin B ₆ 10 mg Vitamin E acetate 10 mg Nicotinic acid amide 25 mg Anhydrous caffeine 30 mg Purified water (total amount) 30 ml pH 4.3 Comparative example 2 A commercially available oral liquid composition having the following composition I got.

Ascorbic acid 500 mg Vitamin B ₆ 5 mg Nicotinic acid amide 15 mg Anhydrous caffeine 50 mg Taurine 1000 mg Carnitine chloride 50 mg Pantothenyl alcohol 15 mg Inositol 100 mg Purified water (total amount) 100 ml pH 4.0 Comparative example 3 A commercially available oral solution having the following composition was used. obtained.

Ascorbic acid 500 mg Vitamin B ₁ nitrate 10 mg Vitamin B ₂ phosphate 5 mg Anhydrous caffeine 50 mg Taurine 1000 mg Carnitine chloride 100 mg Inositol 100 mg Sodium pantothenate 10 mg Purified water (total amount) 100 ml pH 2.7 And Comparative Examples 1 to 3 Oral liquid formulation at 40 ℃ for 3 months,
When the residual ratio of ascorbic acid was examined by storing at 25 ° C. for 4 months, the results shown in Table 1 were obtained.

[0059]

[Table 1] Sensory test The oral liquid preparations obtained in Example 2 and the oral liquid preparations of Comparative Examples 1 and 2 were subjected to a sensory test as a drink preparation by 10 panelists. Sourness, vitamin C drink-likeness, and ease of drinking were selected as sensory test items, and each item was evaluated according to the following five-grade evaluation criteria, and an average score was calculated. The results are shown in Table 2.

Acidity: 0: None 2.5: Weak 5: Slightly weak 7.5: Slightly strong 10: Strong Vitamin C drink-likeness: 0: Not felt 2.5: Not felt 5: Neither can be said 7. 5: Feel 10: Feel strongly Ease of drinking: 0: Difficult to drink 2.5: Difficult to drink 5: Neither can be said 7.5: Easy to drink 10: Very easy to drink

[0061]

[Table 2] In the sensory test results of the oral liquid preparation of Example 2 and the oral liquid preparations of Comparative Examples 1 and 2, a significant difference was observed at a significance level of 1%, and as is clear from Table 2, the oral liquid preparation of Example 2 contained vitamin It had a sour taste similar to that of C-drink and had an easy-to-drink taste.

Examples 7 and 8 An oral liquid preparation containing no flavor was prepared with the composition of Example 5 as a base liquid, and a fruity (citrus) flavor was added in an amount of 0.14% (V / V) [solvent 0.025% (W / V)] as an aromatic component to be removed] added oral liquid formulation (Example 7), and fruit (citrus) flavor and herb flavor (mixed flavor of rosemary, thyme and lemongrass). , 0.14 each added
% (V / V) [0.025% as perfume component excluding solvent
(W / V)] and 0.02% (V / V) [0.00016% (W / V) as a perfume component excluding the solvent] were added to prepare an oral liquid preparation (Example 8).

Then, the above-mentioned base solution, Examples 7 and 8
The oral sensation of the oral liquid preparation was evaluated by a sensory test by 10 panelists. In addition, the drinking sensation was evaluated on the basis of the same criteria as the above-mentioned ease of drinking on a five-point scale, the average score was calculated, and the drinking sensation was commented. The results shown in Table 3 were obtained.

[0064]

[Table 3] As is clear from Table 3, the addition of the fruit-like flavor improves the drinking sensation, and the combined addition of the fruit-like flavor and the herb flavor significantly improves the drinking sensation.

Claims (10)

[Claims] 1. An oral liquid preparation containing ascorbic acid or an edible salt thereof and having a pH of 4.5 to 7. 2. The oral liquid preparation according to claim 1, which has a pH of 4.5 to 5. 3. The oral liquid preparation according to claim 1, further comprising an edible organic acid other than ascorbic acid or an edible salt thereof. 4. The oral liquid preparation according to claim 1, which contains 0.05 to 5% (W / V) of ascorbic acid or an edible salt thereof in terms of ascorbic acid. 5. An edible organic acid other than ascorbic acid or an edible salt thereof is 0.005 to 5% in terms of edible organic acid.
The oral liquid preparation according to claim 1, comprising (W / V). 6. The oral liquid preparation according to claim 1, which further contains free α-tocopherol. 7. Free 0.001 of α-tocopherol
The oral liquid preparation according to claim 1, which comprises ˜0.5% (W / V). 8. Ascorbic acid or an edible salt thereof and free α-tocopherol are contained, and the pH is 4.5 to 6.
The oral liquid preparation according to claim 1, which is 0. 9. Ascorbic acid or an edible salt thereof, an edible organic acid other than ascorbic acid or an edible salt thereof, and free α-tocopherol, and having a pH of 4.5 to 4.5.
The oral liquid preparation according to claim 1, which is 6.0. 10. Ascorbic acid or an edible salt thereof is 0.1 to 3% (W / V) in terms of ascorbic acid, and an edible organic acid other than ascorbic acid or an edible salt thereof is 0 in terms of an edible organic acid. The oral liquid preparation according to claim 9, which comprises 0.007 to 2% (W / V) and 0.01 to 0.1% (W / V) of free α-tocopherol.