JPH07242539A - Composition having laxative effect - Google Patents

Abstract

(57) [Summary] [Structure] An organic acid and an amount of sugar alcohol and calcium salt that do not have a laxative effect by themselves are contained. [Effect] It is a composition that is safe and has a good feeling when ingested or taken, and has a laxative effect that does not cause any unpleasant symptom while having naturalness so that it can be ingested as a food or drink. It has a synergistic laxative effect with a smaller amount than when used alone, and is highly safe, and moreover, it is an unpleasant symptom that is observed when sugar alcohol such as abdominal bloating, flatus, and guru is used. Since it has almost no urine, it is extremely effective as a composition having a defecation-promoting effect and laxative effect, and also has the characteristic that it does not easily cause adverse effects on diabetic patients, and can be used for a wider range of subjects than conventional products. .

Description

Detailed Description of the Invention

[0001]

[Industrial applications]

The present invention relates to a composition having a laxative effect, and more specifically, it is safe with few restrictions when ingested or taken, and various unpleasant symptoms such as abdominal pain or bloating after ingestion or administration are safe. The present invention relates to a composition having a laxative effect which does not exhibit

[0003]

[Prior art]

[0004] Constipation is a symptom caused by lifestyle, diet, exercise, defecation habits, psychological influences, etc., and excretes dry and hard small fecal masses or the frequency of defecation.

Constipation, which is often seen in women, is caused by a decrease in nerve excitability of the large intestine, resulting in relaxation of the intestinal tract, stagnation of intestinal contents and increased water absorption, stiffening of stool, and retention of stool in the ascending colon and rectum. Drugs caused by functional constipation such as spasmodic constipation, rectal constipation and functional constipation such as rectal constipation and stenosis due to adhesion after surgery, and suppression of intestinal motility such as antitussives. Divided into sexual constipation.

[0006] The laxatives or substances having a laxative effect that have been conventionally used to reduce the symptoms of constipation such as these include colon-stimulating anthraquinone-based crude drug laxatives,
There are small intestinal irritating castor oil, swelling laxatives such as carboxymethylcellulose, salt laxatives such as magnesium sulfate, and sugar laxatives such as sugar alcohols.

[0007]

[Prior Art and Problems to be Solved by the Invention]

However, various problems remain in conventional laxatives.

[0009] For example, the above-mentioned anthraquinone type crude drug laxative causes pelvic hyperemia, so that it is not suitable for use in patients with hemorrhoidal disease and pregnant women, and there is a problem that those that transfer milk cannot be used during lactation. It was

The castor oil described above has the advantage that the time required for the onset of action is short, but it has a very poor feeling of administration and requires a large dose of 20 to 30 ml at a time. There is a problem that it is necessary to pay attention to the poisoning caused by the absorption enhancement of the fat-soluble drug while taking the drug.

The above-mentioned swelling laxatives such as carboxymethylcellulose must be taken with a large amount of water, and induce uterine contraction along with unpleasant symptoms such as nausea, vomiting and abdominal bloating. Therefore, there was a problem that it cannot be administered to pregnant women.

Although the above-mentioned salt laxatives such as magnesium sulfate have the advantage that they have few side effects, they are not effective and have a weak effect, and they need to be taken with a large amount of water. Since there is a large amount, it is difficult for the elderly to take.

Further, the above-mentioned sugar alcohols are widely used in foods as non-cariogenic, low-calorie, indigestible sweeteners, and are known to have a laxative effect when taken in large amounts. Therefore, when used in foods, the laxative effect of each sugar alcohol is adjusted to be less than the maximum no-effect level, but among these sugar alcohols, sorbitol and lactitol are used as laxatives for pharmaceuticals. There is.

These sugar alcohols have the advantage that they are highly safe and have a sweet taste and therefore have a good feeling when ingested or taken, but in order to exert a laxative effect, it is necessary to take a relatively large amount. If the maximum ineffectiveness of laxative action was exceeded, there was a problem that unpleasant symptoms such as abdominal bloating, sensation of swelling, glistening, ejaculation, abdominal pain, and nausea were exhibited.

On the other hand, various organic acids are used not only as foods but also as medicines as sour agents for beverages and the like, but are considered to be absorbed and used as energy in the living body, which is a safety problem. However, it is not known to have a laxative effect.

It is known that some of the above metal salts such as magnesium sulfate, sodium sulfate and magnesium oxide have a laxative effect, but calcium salts are ingested for the purpose of supplementing calcium, and Although it is different, it is also said that about 60% is absorbed in the test using rats, and if a large amount remains in the digestive tract, it may have the same effect as the hardly absorbable metal salts,
The effect is considered to be low, it has not been used as a component of a composition having a laxative effect or as a laxative, and
It was not even recognized as a laxative.

In summary, constipation is caused by various causes, and depending on the cause, colon-stimulating anthraquinone-based crude drug laxatives, diphenylmethane-based drugs, small intestinal-stimulating castor oil, salts and sugar laxatives are used. However, since these laxatives have various side effects, they cannot be taken if pregnant women or have symptoms such as hemorrhoids, cardiac dysfunction, renal dysfunction, etc. There is a problem that it is necessary to limit the drugs and the like, and even in the case of a highly safe laxative, the feeling of ingestion is uncomfortable, and an unpleasant symptom such as a bloating of the abdomen and a glistening noise is accompanied.

Under these circumstances, there is a demand for the development of a composition which is safe and has a good feeling when ingested or taken, and has a laxative effect which is natural enough to be ingested as a food or drink and does not cause unpleasant symptoms. It was

[0019]

[Means for Solving the Problems]

In order to solve the above-mentioned problems, the inventors of the present invention have conducted extensive studies and as a result, when ingested together with an organic acid and a sugar alcohol in an amount which does not have a laxative effect when taken alone, It was found that organic acid and sugar alcohol act synergistically to produce a laxative effect without showing symptoms such as abdominal bloating observed when a large amount of sugar alcohol is taken alone. It was found that the synergistic laxative effect was further increased by adding calcium salt in addition to the sugar alcohol and sugar alcohol, and succeeded in preparing a composition having an excellent laxative effect, thus completing the present invention. Came to do.

That is, the means for solving the problems of the present invention are as follows.

First, a composition having a laxative effect, which comprises an organic acid and an amount of sugar alcohol which does not have a laxative effect by itself.

Secondly, a composition having a laxative effect, which comprises an organic acid and an amount of sugar alcohol and calcium salt which do not have a laxative effect by themselves.

Third, the sugar alcohol is xylitol,
The above-mentioned first or second, which is one kind or a mixture of two or more kinds selected from the group consisting of sorbitol, mannitol, maltitol, lactitol, palatinit, erythritol, reduced starch hydrolyzate and isomaltosyl oligosaccharide alcohol. A composition having a laxative effect.

Fourth, the organic acids are citric acid, succinic acid,
The composition having a laxative effect according to any one of the first to third aspects, which is one kind or a mixture of two or more kinds selected from the group consisting of lactic acid, fumaric acid, malic acid, acetic acid and tartaric acid.

Fifth, sugar alcohol intake is 1 to 150 mg in the case of sorbitol per 1 kg of human body weight,
1-300 mg for maltitol, 1-175 mg for lactitol, 1-3 for palatinit
00 mg, 1 to 760 mg for erythritol, 1 to 350 mg for reduced starch hydrolyzate, and 1 to 375 mg for isomaltosyl oligosaccharide alcohol. The composition having a laxative effect according to any one of the first to fourth aspects.

Sixth, sugar alcohol intake is 1 to 30 g in the case of xylitol, 1 to 20 g in the case of mannitol, and a mixture of two or more kinds of sugar alcohol per adult per day. The first to the first, which are prepared so as to fall within any range of the laxative action less than the maximum no-effect amount.
A composition having a laxative effect according to any one of the fourth.

Seventh, the sugar alcohol intake is 1 to 100 mg in the case of sorbitol per 1 kg of human body weight,
1-200 mg for maltitol, 1-117 mg for lactitol, 1-2 for palatinit
00 mg, 1-507 mg in the case of erythritol, 1-230 mg in the case of reduced starch hydrolyzate, and 1-250 mg in the case of isomaltosyl oligosaccharide alcohol. The composition having a laxative effect according to any one of the first to fourth aspects.

Eighth, the sugar alcohol intake is 1 to 20 g in the case of xylitol, 1 to 14 g in the case of mannitol, and a mixture of two or more kinds of sugar alcohol per adult per day. The composition having a laxative effect according to any one of the first to fourth aspects, which is prepared so as to fall within a range of less than 60% of a maximum laxative ineffective amount.

Ninth, it has the laxative effect according to any one of the above second to eighth, which is prepared such that the calcium salt intake is 1 to 15 mg of calcium per 1 kg of human body weight. Composition.

Further, an example of concrete means for solving the problems of the present invention will be shown below.

The composition having a laxative effect according to the above 1st or 2nd, wherein the organic acid is a food or a substance designated as a food additive.

Organic acids as foods include acetic acid as a chemical component of rice vinegar, apple vinegar, wine vinegar and the like, and these are contained in foods.

Organic acids designated as food additives include acetic acid prepared by diluting glacial acetic acid, citric acid, succinic acid, lactic acid, fumaric acid, malic acid, tartaric acid and the like.

The above-mentioned first or second organic acid is lactic acid
A composition having a laxative effect according to 1.

The composition having a laxative effect according to the above 1st or 2nd, wherein the organic acid is malic acid.

The composition having a laxative effect according to the first or second aspect, wherein the organic acid is citric acid.

The composition having a laxative effect according to the first or second aspect, wherein the organic acid is a mixture of lactic acid and citric acid.

The composition having a laxative effect according to the above first or second aspect, wherein the organic acid is a mixture of citric acid and malic acid.

The composition having a laxative effect according to the above 1st or 2nd, wherein the sugar alcohol is a food or a substance designated as a food additive.

Examples of sugar alcohol which is a food include maltitol, lactitol, palatinit, reduced starch hydrolyzate, isomaltosyl oligosaccharide alcohol and the like.

Sugar alcohols designated as food additives include xylitol, sorbitol, mannitol, erythritol and the like.

The composition having a laxative effect according to the above 1st or 2nd, wherein the sugar alcohol is sorbitol.

The composition having a laxative effect according to the above 1st or 2nd, wherein the sugar alcohol is a reduced starch hydrolyzate.

The composition having a laxative effect according to the above 1st or 2nd, wherein the sugar alcohol is isomaltosyl oligosaccharide alcohol.

The composition having a laxative effect according to the above 1st or 2nd, wherein the organic acid is a mixture of lactic acid and citric acid, and the sugar alcohol is a reduced starch hydrolyzate.

The composition having a laxative effect according to the above 9th, wherein the calcium salt is a food or a substance designated as a food additive.

The calcium salt which is a food includes components contained in calcium-containing foods such as various bone meals and egg shells, and foods such as milk.

Calcium salts designated as food additives include calcium citrate, calcium gluconate, calcium lactate, calcium dihydrogen pyrophosphate,
Examples include tricalcium phosphate, calcium monohydrogen phosphate, and calcium dihydrogen phosphate.

A composition having a laxative effect according to the above second, wherein the organic acid is a mixture of lactic acid and citric acid, the sugar alcohol is a reduced starch hydrolyzate, and the calcium salt is calcium chloride. .

A composition having a laxative effect, characterized in that it contains calcium lactate and maltitol adjusted to have no laxative effect alone.

The composition having a laxative effect according to the above 1st or 2nd, wherein the organic acid is citric acid and the sugar alcohol is sorbitol.

The composition having a laxative effect according to the first or second aspect, wherein the organic acid is lactic acid and the sugar alcohol is isomaltosyl oligosaccharide alcohol.

Examples of the sugar alcohol used in the present invention include xylitol, erythritol, sorbitol, mannitol, maltitol, lactitol, palatinit, reduced starch hydrolyzate and isomaltosyl oligosaccharide alcohol, and these sugar alcohols have sweetness and viscosity. Can be used alone or in combination of two or more in the sense of adjusting.

Further, the quality of the sugar alcohol used in the present invention is sufficient that it is commercially available as a food or a food additive, and there is no particular limitation, and its form is liquid according to the shape of the composition. Any of powder, granule, slurry and solid can be adopted.

The amount of sugar alcohol used in the present invention is
It is necessary to adjust the amount of sugar alcohol alone without causing unpleasant symptoms such as abdominal bloating and glistening noise, and the maximum no-effect level of the laxative effect of each sugar alcohol. If the mixture of two or more sugar alcohols is used, it is preferable that the laxative action of the mixture is less than the maximum ineffective amount.

Specifically, the intake of various sugar alcohols is preferably adjusted as follows per 1 kg of human body weight.

In the case of sorbitol, the amount is 1 to 150 mg. In the case of maltitol, it is 1 to 300 mg.
In the case of lactitol, the amount is 1-175 mg. In the case of palatinit, it is 1 to 300 mg. In the case of erythritol, the dose is 1 to 760 mg. In the case of reduced starch hydrolyzate, the amount is 1 to 350 mg. In the case of isomaltosyl oligosaccharide alcohol, the amount is 1 to 375 mg.

The following sugar alcohol intake is preferably adjusted as follows per adult day.

In the case of xylitol, the amount is 1 to 30 g. In the case of mannitol, the amount is 1 to 20 g.

Further, the intake of various sugar alcohols is
It is more preferable to prepare as follows per 1 kg of human body weight.

In the case of sorbitol, the amount is 1-100 mg. In the case of maltitol, it is 1 to 200 mg.
In the case of lactitol, the amount is 1-117 mg. In the case of palatinit, it is 1 to 200 mg. In the case of erythritol, the dose is 1 to 507 mg. In the case of reduced starch hydrolyzate, the amount is 1-230 mg. In the case of isomaltosyl oligosaccharide alcohol, the amount is 1-250 mg.

Further, the following intake of sugar alcohol is more preferably adjusted as follows per adult day.

In the case of xylitol, the amount is 1 to 20 g. In the case of mannitol, the amount is 1 to 14 g.

When a mixture of two or more sugar alcohols is used, the amount present in the ingested composition is adjusted so as to fall within any range of less than 60% of the maximum ineffectiveness of the laxative effect of the mixture. Most preferably, or controlling the intake of the composition.

If the amount of sugar alcohol used is less than the lower limit of each of the above ranges, the laxative effect, which is the effect of the present invention, may not be exhibited, and if it exceeds the upper limit of each range, for example, Even if the amount is less than the maximum no-effect amount of each sugar alcohol, unpleasant symptoms such as abdominal bloating, tingling sensation, glistening, erecting, abdominal pain, and nausea may be exhibited, which is not preferable.

The organic acids used in the present invention include citric acid, succinic acid, lactic acid, fumaric acid, malic acid, acetic acid and tartaric acid, and these organic acids are used alone for the purpose of controlling sourness and sweetness. It is also possible to use two or more types in combination.

Among the above-mentioned organic acids, lactic acid is most preferable in order to remarkably exhibit the effects of the composition of the present invention.

There are no particular restrictions on the form of the organic acid used in the present invention, and various forms of acid may be adopted according to the shape of the composition of the present invention.

The amount of organic acid used in the present invention is most preferably about 1/50 to 2 times the amount of sugar alcohol used,
When the sugar alcohol and the organic acid are used in combination, the excellent effect of the present invention can be expected even if the above range is slightly exceeded unless the composition is excessively blended to significantly impair the feeling of ingestion.

As the calcium salt used in the present invention, in addition to inorganic calcium salts such as various calcium phosphates such as calcium chloride, calcium carbonate, calcium sulfate and calcium pyrophosphate, calcium salts of various organic acids can be used.

When calcium salts of various organic acids are used, the organic acid and calcium can be simultaneously mixed as calcium citrate, calcium gluconate, calcium lactate, calcium malate and the like.

The quality of the calcium salt used in the present invention can be adopted as a food or drug having a laxative effect, which is the object of the present invention, that is, as a pharmaceutical material, food or food additive. There is no particular limitation so long as the calcium salt used in the present invention has any suitable form depending on the form of the composition of the present invention.

The amount of calcium salt used in the present invention is preferably 1 to 15 mg per 1 kg of human body weight as calcium.
It is more preferably in the range of / 50 to 1/2, and more preferably in the range of 1/25 to 1 with respect to the amount of the organic acid.

If the amount of the calcium salt used is outside the above preferred range, the synergistic effect of the present invention due to the calcium salt may be slightly reduced or the feeling of ingestion may be deteriorated. There is no point in using an amount of calcium salt outside the preferred embodiment.

According to the knowledge of the present inventors, the composition of the present invention in which a sugar alcohol and an organic acid are used in combination has a laxative effect further enhanced by further using a calcium salt. The effective usage ratio is 1% by weight of the organic acid when the amount of calcium used in the calcium salt is 1 part by weight.
25 parts by weight and sugar alcohol 2 to 50 parts by weight. The most effective use ratio is 5 to 20 parts by weight of organic acid and 10 to 30 parts of sugar alcohol when the amount of calcium used in the calcium salt is 1 part by weight. Parts by weight.

The composition of the present invention is used as a food, a beverage, a favorite product, a feed, or a medicine for health and beauty purposes, such as a syrup or a drink, a liquid, a slurry, a powder, a granule or a solid. Although it can be formed into various known shapes such as, it can be mixed with various materials other than those used in the composition of the present invention at any ratio, and can be used in combination, for example, kneading, kneading, dissolving, dipping, penetrating, The composition of the present invention can be contained in any step until the product is completed by known methods such as spraying, coating, coating, spraying, pouring, crystallization, and solidification.

The composition of the present invention described above eliminates the unpleasant symptoms that remain after taking sugar alcohol alone while increasing the sugar alcohol laxative effect by an organic acid that has no laxative effect alone. On the contrary, it has an excellent property that the laxative effect is further enhanced by the calcium salt which may promote constipation by itself, and a good feeling of ingestion is exhibited.

Hereinafter, the present invention will be described more specifically with reference to Test Examples and Examples, but the technical scope of the present invention is not limited to the following examples.

In the following examples,% means% by weight unless otherwise specified.

[0081]

[Test example]

Male ddY, 5 weeks old, weighing 20-25 g
Strain mouse [manufactured by Japan SLC Co., Ltd.] was used as an individual, and as shown in the sample prescription list in Table 1, for the tests of Sample 1 to Sample 5 having different components, an experiment was conducted using 20 mice per sample. Was allowed food and water ad libitum.

[0083]

[Table 1]

Then, 0.4 ml of each sample was intragastrically administered to each mouse using a sonde, followed by fasting and water-free, and feces were discharged on a filter paper.

Collect this in a glass container and use the method of Niwa et al. Pharmacy, 4
0, 32-41 (1980)], the laxative effect of each sample was evaluated as a group of 20 animals according to the appearance evaluation criteria of feces in Table 2, and the laxative effect was evaluated as a laxative effect. The occurrence rate (%) is shown in Table 3.

[0086]

[Table 2]

[0087]

[Table 3]

As shown in the results shown in Table 3, the laxative effect is produced by adding an organic acid to an amount of sugar alcohol which does not have a laxative effect by itself, and this effect is more effective by adding a calcium salt. Met.

[0089]

[Example 1]

Reduced starch hydrolyzate [Towa Kasei Co., Ltd.
Made, product name PO-40] 8000 mg, lactic acid (50%)
2000 mg and citric acid 2000 mg were dissolved in purified water, and Na benzoate 50 mg was dissolved therein, and then an appropriate amount of Na hydroxide was added to adjust the pH to 4.0.

The standard sugar composition of the reduced starch hydrolyzate [Product name: PO-40, manufactured by Towa Kasei Kogyo Co., Ltd.] used above is as follows.

1 to 5% of saccharide (sorbit), 50 to 55% of 2 saccharide (maltitol), 17 to 25% of 3 saccharide (maltotriitol), 4 or more saccharide (oligosaccharide alcohol)
Is 23 to 30%.

The total amount of this aqueous solution was adjusted to 100 ml with purified water, filtered through a filter paper, the total amount was filled in a glass bottle, an aluminum cap was closed, and heat sterilization was performed to obtain a composition 1 (internal liquid preparation) of the present invention.

[0094]

Example 2

Reduced starch hydrolyzate [Towa Chemical Industry Co., Ltd.
Made, product name PO-60] 8000 mg, lactic acid (50%)
2000 mg, citric acid 2000 mg, calcium chloride 2000 mg were dissolved in purified water, and Na5 benzoate was added to the solution.
After dissolving 0 mg, an appropriate amount of sodium hydroxide was further added to adjust the pH to 4.0.

The standard sugar composition of the reduced starch hydrolyzate [product name: PO-60, manufactured by Towa Kasei Co., Ltd.] used above is as follows.

1 to 4 sugars (sorbit) 2 to 4%, 2 sugars (maltitol) 63 to 67%, 3 sugars (maltotriitol) 13 to 18%, 4 sugars or more (oligosaccharide alcohol)
Is 13 to 18%.

This aqueous solution was made up to 100 ml with purified water, and then the composition 2 of the present invention was processed in the same manner as in Example 1.
(Liquid for internal use) was obtained.

[0099]

Example 3

37 parts by weight of cocoa base, 1 cocoa butter
1 part by weight, calcium lactate 15 parts by weight, maltitol [manufactured by Towa Kasei Kogyo KK, product name Amarti MR] 36.
After mixing 4 parts by weight and passing through a refiner to adjust the particle size, put in a contier, add 0.6 parts by weight of lecithin and knead at 47 ° C for 2 days and nights, then bring the temperature to 30 ° C, and bubble with a shaker. After removing enough, pour into a mold,
After cooling for 1 minute and removing from the mold, the composition 3 (chocolate) of the present invention was obtained by packaging 20 g as one package.

[0101]

Example 4

0.21 parts by weight of lemon oil, 8.93 parts by weight of alcohol for beverages, 10.00 parts by weight of citric acid, 0.21 parts by weight of sodium saccharin, 10.65 parts by weight of water,
6 parts by weight of carbonated water was added to 1 part by weight of an aqueous solution consisting of 70.00 parts by weight of a 35% sorbitol aqueous solution [Product name: Solbit D-70, manufactured by Towa Kasei Kogyo Co., Ltd.], and the mixture was filled in a 250 ml bottle and sealed. A composition 4 (soft drink) of the present invention was obtained.

[0103]

Example 5

6 parts by weight of whey protein, 10 parts by weight of milk fat, 0.25 part by weight of gelatin, 0.25 part by weight of emulsifier [Atomos 150, manufactured by Kao Corporation], isomaltosyl oligosaccharide alcohol [Towa Chemical Industry Co., Ltd. ), PO-500] 21.5
While heating 62 parts by weight of water and 60 parts by weight of water to 60 ° C., the components are mixed and dissolved, and the mixture is strongly stirred with a homogenizer to emulsify and then heat sterilized at 90 ° C. for 3 minutes to add a small amount of vanilla essence. Divide into 100 g cups, put a mixture of 3 g of calcium citrate and 1 g of sodium malate and 20 g of commercially available strawberry jam on the cream, slowly cool at 5 ° C below zero, and then quickly freeze at 30 ° C below zero. Cured and stored at 20 ° C. below zero, composition 5 of the present invention
I got (frozen dessert).

[0105]

[Comparative Example 1]

Reduced starch hydrolyzate [Towa Kasei Co., Ltd.
Manufactured, product name PO-40] 8000 mg was dissolved in purified water, ethyl paraoxybenzoate 10 mg was dissolved in this, and the total amount of this aqueous solution was further adjusted to 100 ml with purified water, and thereafter, in the same manner as in Example 1. Comparative product 1 was obtained.

[0107]

[Comparative Example 2]

2000 mg of calcium chloride was dissolved in purified water, to which 10 g of sucrose and 1 part of paraoxybenzoate were added.
After dissolving 0 mg, the total amount of the aqueous solution was further adjusted to 100 ml with purified water, and then Comparative Example 2 was obtained in the same manner as in Example 1.

[0109]

[Comparative Example 3]

2000 mg of lactic acid (50%) and 2000 mg of citric acid were dissolved in purified water, 10 g of sucrose and 50 mg of Na benzoate were dissolved therein, and then an appropriate amount of sodium hydroxide was added to adjust the pH to 4.0. Then, the total amount of this aqueous solution was made up to 100 ml with purified water, and then Comparative Example 3 was obtained in the same manner as in Example 1.

[0111]

[Comparative Example 4]

Reduced starch hydrolyzate [Towa Kasei Co., Ltd.
Manufactured, product name PO-60] 8000 mg and calcium chloride 2000 mg were dissolved in purified water, ethyl paraoxybenzoate 10 mg was dissolved in this, and the total amount of this aqueous solution was 100 ml with purified water, and thereafter the same as in Example 1. Comparative product 4 was obtained.

[0113]

[Comparative Example 5]

Lactic acid (50%) 2000 mg, citric acid 2
000 mg and 2000 mg of calcium chloride were dissolved in purified water, 10 g of sucrose and 50 mg of Na benzoate were dissolved therein, and then an appropriate amount of sodium hydroxide was added to pH 4.0.
The total amount of this aqueous solution was adjusted to 100 ml with purified water, and then Comparative Example 5 was obtained in the same manner as in Example 1.

[0115]

[Comparison test]

Compositions 1 to 5 of the present invention obtained in Examples 1 to 5 and comparative products 1 to 1 obtained in Comparative Examples 1 to 5
Comparative product 5 was orally administered to 20 healthy adult men and women with a body weight of 56 ± 8.4 kg, and by 24 hours, the number of laxative effects, abdominal bloating, sensation of feeling, flatus, A test was conducted to compare the effects of laxative effects and side effects by examining the number of people who exhibited unpleasant symptoms such as whirring, abdominal pain, and nausea.

The order of the tests was randomized, the test preparations were given random numbers, and blind tests were conducted.

The results of the tests are shown in Table 4.

[0119]

[Table 4]

As is clear from Table 4, no laxative effect was observed in the comparative examples, whereas the laxative effects were high in all of the Examples. There were no unpleasant symptoms such as feeling, flatus, and guru.

[0121]

【The invention's effect】

The composition having a laxative effect of the present invention is a composition which is safe and has a good feeling when ingested or taken, and has a natural laticity that can be ingested as a food or drink, but has no laxative effect. It has a synergistic laxative effect with a smaller amount than the case of using sugar alcohol and other components alone, and is highly safe, and moreover, the abdominal bloating, flatus, glistening noise, etc. Since there is almost no unpleasant symptom seen when using sugar alcohol, it is extremely effective as a composition having a defecation promoting effect and laxative effect, and also has a characteristic that a diabetic patient is unlikely to be adversely affected.
It can be used for a wider range of subjects than conventional products.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number within the agency FI technical indication location (A61K 31/19 31: 045 33:06) (72) Inventor Hidetomo Sakurai Konan Town, Osato County, Saitama Prefecture 2512-1 Numagami Oshikiriji Central Research Institute, Zeria Shinyaku Kogyo Co., Ltd. (72) Inventor, Yuko Kaneko 2-8-7 Yaesu, Chuo-ku, Tokyo Towa Kasei Kogyo Co., Ltd. (72) Inventor, Kazuaki Kato Central Tokyo 2-8-7 Yaesu-ku, Towa Kasei Kogyo Co., Ltd.

Claims (9)

[Claims] 1. A composition having a laxative effect, which comprises an organic acid and an amount of sugar alcohol which does not have a laxative effect by itself. 2. A composition having a laxative effect, which comprises an organic acid and an amount of sugar alcohol and calcium salt which do not have a laxative effect by themselves. 3. The sugar alcohol is xylitol, sorbitol, mannitol, maltitol, lactitol,
Palatinit, erythritol, reduced starch hydrolyzate,
The composition having a laxative effect according to claim 1 or 2, which is one kind or a mixture of two or more kinds selected from the group consisting of isomaltosyl oligosaccharide alcohols. 4. The organic acid is citric acid, succinic acid, lactic acid,
4. One or a mixture of two or more selected from the group consisting of fumaric acid, malic acid, acetic acid and tartaric acid.
A composition having a laxative effect according to any one of 1. 5. The intake of sugar alcohol is 1 kg of human body weight.
In the case of sorbitol, 1 to 150 mg, in the case of maltitol, 1 to 300 mg, in the case of lactitol, 1 to 175 mg, in the case of palatinit, 1 to 300 m.
g, 1 to 760 mg in the case of erythritol, 1 to 350 mg in the case of reduced starch hydrolyzate, and 1 to 375 mg in the case of isomaltosyl oligosaccharide alcohol. Item 5. A composition having a laxative effect according to any one of Items 1 to 4. 6. The intake of sugar alcohol per adult per day is 1 to 30 g in the case of xylitol, 1 to 20 g in the case of mannitol, and laxative of the mixture when a mixture of two or more sugar alcohols is used. The composition having a laxative effect according to any one of claims 1 to 4, which is prepared so as to have a range of less than the maximum no-effect level of action. 7. The intake of sugar alcohol is 1 kg of human body weight.
So, 1-100 mg for sorbitol, 1-200 mg for maltitol, 1-117 mg for lactitol, 1-200 m for palatinit.
g, 1 to 507 mg in the case of erythritol, 1 to 230 mg in the case of a reduced starch hydrolyzate, and 1 to 250 mg in the case of isomaltosyl oligosaccharide alcohol. Item 5. A composition having a laxative effect according to any one of Items 1 to 4. 8. The intake of sugar alcohol per adult per day is 1 to 20 g in the case of xylitol, 1 to 14 g in the case of mannitol, and laxative of the mixture when a mixture of two or more sugar alcohols is used. Maximum no effect of action 6
The composition having a laxative effect according to any one of claims 1 to 4, which is prepared so as to fall within a range of less than 0%. 9. The calcium salt intake is 1 kg of human body weight.
The composition having a laxative effect according to any one of claims 2 to 8, which is prepared to have a calcium content of 1 to 15 mg.