JPH07508009A - クリングル含有タンパク質及び特にｔ−ＰＡの精製 - Google Patents

クリングル含有タンパク質及び特にｔ−ＰＡの精製

Info

Publication number
JPH07508009A
JPH07508009A JP6501963A JP50196393A JPH07508009A JP H07508009 A JPH07508009 A JP H07508009A JP 6501963 A JP6501963 A JP 6501963A JP 50196393 A JP50196393 A JP 50196393A JP H07508009 A JPH07508009 A JP H07508009A
Authority
JP
Japan
Prior art keywords
plasminogen
kringle
acid
protein
elution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6501963A
Other languages
English (en)
Japanese (ja)
Inventor
ヨハネッセン，マリー
ハルケール，エリク
ペテルセン，ラース　クリスティアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JPH07508009A publication Critical patent/JPH07508009A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP6501963A 1992-06-23 1993-06-23 クリングル含有タンパク質及び特にｔ−ＰＡの精製 Pending JPH07508009A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK92825A DK82592D0 (da) 1992-06-23 1992-06-23 Fremstilling af proteiner
DK0825/92 1992-06-23
PCT/DK1993/000206 WO1994000483A1 (en) 1992-06-23 1993-06-23 PURIFICATION OF KRINGLE CONTAINING PROTEINS, AND ESPECIALLY t-PA

Publications (1)

Publication Number Publication Date
JPH07508009A true JPH07508009A (ja) 1995-09-07

Family

ID=8097981

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6501963A Pending JPH07508009A (ja) 1992-06-23 1993-06-23 クリングル含有タンパク質及び特にｔ−ＰＡの精製

Country Status (11)

Country Link
EP (1) EP0672051A1 (da)
JP (1) JPH07508009A (da)
KR (1) KR950702204A (da)
AU (1) AU4311893A (da)
CA (1) CA2137779A1 (da)
CZ (1) CZ328594A3 (da)
DK (1) DK82592D0 (da)
FI (1) FI946031A0 (da)
HU (1) HUT71326A (da)
NO (1) NO944981D0 (da)
WO (1) WO1994000483A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210906B1 (en) 1998-01-20 2001-04-03 Abbott Laboratories Specific antibodies to kringle 5 of apo(a) and methods of use therefor
NZ518692A (en) * 1999-12-23 2004-08-27 Csl Ltd Purified fibrinogen free of destabilising levels of plasminogen and other proteases obtained from a Fraction I paste
AU8591901A (en) 2000-09-05 2002-03-22 Karolinska Innovations Ab Materials and methods relating to endothelial cell growth inhibitors
AU2002314081B2 (en) * 2001-05-21 2007-04-05 Omrix Biopharmaceuticals S.A. Removal pf plasmin(Ogen) from protein solutions
CN110770340B (zh) * 2017-05-31 2023-09-19 Brain生物科技股份公司 在宿主细胞中丝氨酸蛋白酶的表达的优化

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法

Also Published As

Publication number Publication date
DK82592D0 (da) 1992-06-23
KR950702204A (ko) 1995-06-19
WO1994000483A1 (en) 1994-01-06
FI946031L (fi) 1994-12-22
CA2137779A1 (en) 1994-01-06
CZ328594A3 (en) 1995-06-14
EP0672051A1 (en) 1995-09-20
NO944981L (no) 1994-12-22
NO944981D0 (no) 1994-12-22
FI946031A7 (fi) 1994-12-22
FI946031A0 (fi) 1994-12-22
HUT71326A (en) 1995-11-28
AU4311893A (en) 1994-01-24

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