JPH0789963A - 三置換ピリミド［５，４−ｄ］ピリミジン、これらの化合物を含む医薬組成物及びそれらの調製方法 - Google Patents

三置換ピリミド［５，４−ｄ］ピリミジン、これらの化合物を含む医薬組成物及びそれらの調製方法

Info

Publication number
JPH0789963A
JPH0789963A JP6179359A JP17935994A JPH0789963A JP H0789963 A JPH0789963 A JP H0789963A JP 6179359 A JP6179359 A JP 6179359A JP 17935994 A JP17935994 A JP 17935994A JP H0789963 A JPH0789963 A JP H0789963A
Authority
JP
Japan
Prior art keywords
group
piperidino
methyl
pyrimido
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6179359A
Other languages
English (en)
Japanese (ja)
Inventor
Armin Heckel
ヘッケル アルミン
Uwe Bamberger
バンベルガー ウーヴェ
Annerose Mauz
マウツ アンネローゼ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of JPH0789963A publication Critical patent/JPH0789963A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP6179359A 1993-08-02 1994-08-01 三置換ピリミド［５，４−ｄ］ピリミジン、これらの化合物を含む医薬組成物及びそれらの調製方法 Pending JPH0789963A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4325900:6 1993-08-02
DE4325900A DE4325900A1 (de) 1993-08-02 1993-08-02 Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
JPH0789963A true JPH0789963A (ja) 1995-04-04

Family

ID=6494272

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6179359A Pending JPH0789963A (ja) 1993-08-02 1994-08-01 三置換ピリミド［５，４−ｄ］ピリミジン、これらの化合物を含む医薬組成物及びそれらの調製方法

Country Status (22)

Country Link
US (1) US5618814A (2)
EP (1) EP0645390A1 (2)
JP (1) JPH0789963A (2)
KR (1) KR950005828A (2)
CN (1) CN1041091C (2)
AU (1) AU683888B2 (2)
BG (1) BG98931A (2)
CA (1) CA2129179A1 (2)
CZ (1) CZ184594A3 (2)
DE (1) DE4325900A1 (2)
EE (1) EE9400255A (2)
FI (1) FI943574A7 (2)
HU (1) HUT70957A (2)
IL (1) IL110509A (2)
NO (1) NO301479B1 (2)
NZ (1) NZ264133A (2)
PL (1) PL304512A1 (2)
RO (1) RO113557B1 (2)
RU (1) RU94028278A (2)
SK (1) SK91594A3 (2)
TW (1) TW251286B (2)
ZA (1) ZA945689B (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517827A (ja) * 2004-01-17 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療のための置換ピリミド［５，４−ｄ］ピリミジンの使用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
NZ544472A (en) 2003-07-03 2009-04-30 Myriad Genetics Inc Compounds and therapeutical use thereof
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
CN115650827B (zh) * 2022-10-27 2024-03-15 戊言医药科技（上海）有限公司 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE2931573A1 (de) * 1979-08-03 1981-02-26 Thomae Gmbh Dr K Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3833392A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517827A (ja) * 2004-01-17 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療のための置換ピリミド［５，４−ｄ］ピリミジンの使用

Also Published As

Publication number Publication date
PL304512A1 (en) 1995-02-06
FI943574A7 (fi) 1995-02-03
KR950005828A (ko) 1995-03-20
HU9402253D0 (en) 1994-09-28
CN1106405A (zh) 1995-08-09
US5618814A (en) 1997-04-08
NZ264133A (en) 1996-05-28
EP0645390A1 (de) 1995-03-29
AU683888B2 (en) 1997-11-27
RO113557B1 (ro) 1998-08-28
HUT70957A (en) 1995-11-28
NO301479B1 (no) 1997-11-03
CZ184594A3 (en) 1995-02-15
ZA945689B (en) 1996-02-01
NO942853D0 (2) 1994-08-01
SK91594A3 (en) 1995-04-12
IL110509A0 (en) 1994-10-21
CN1041091C (zh) 1998-12-09
RU94028278A (ru) 1996-08-27
NO942853L (no) 1995-02-03
IL110509A (en) 1998-01-04
BG98931A (en) 1995-09-29
AU6881394A (en) 1995-02-09
TW251286B (2) 1995-07-11
CA2129179A1 (en) 1995-02-03
FI943574A0 (fi) 1994-08-01
EE9400255A (et) 1996-02-15
DE4325900A1 (de) 1995-02-09

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