JPH08198767A - Excess body fat storage agent and composition containing the same - Google Patents

Abstract

(57) [Summary] [Structure] An agent for suppressing excess body fat accumulation consisting of fruits or essences of a plant of the genus Prunus cherries and an obesity preventive food, an obesity improving food, a pharmaceutical composition for obesity prevention, and obesity treatment. Composition for use. [Effect] Since the agent for suppressing excess body fat accumulation of the present invention is excellent in the effect of suppressing the accumulation of excessive nutrients as fat, foods and pharmaceuticals containing this agent are excellent in improving and preventing obesity.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an agent for suppressing excess body fat accumulation comprising fruits of the genus Prunus genus Prunus genus, foods for preventing obesity, foods for improving obesity, pharmaceutical compositions for preventing obesity, which contain the same. It relates to a pharmaceutical composition for treating obesity.

[0002]

2. Description of the Related Art The modern age is an era of overnutrition, and obesity resulting from this is becoming a serious problem for modern people. Especially in Japan, obesity, which is caused by excessive intake of fats due to excessive intake of body fat, is associated with Westernization of eating habits and causes obstruction of arteries and compression of circulatory organs. As a result, the number of patients suffering from adult diseases, which are socially problematic, is increasing, and improvement of these has become a major issue.

Reflecting such a situation, slimming foods such as various dietary fibers and eicosapentaenoic acid, foods for improving lipid metabolism and the like have been developed, and antilipemic drugs such as mevalotene have been developed.

However, slimming foods have a mechanism of physically reducing the absorption area, and lipid metabolism improving foods increase lipid metabolism but energy generated by lipid metabolism is stored in the body. However, it cannot be said that antilipemic drugs can suppress the amount of fat in the blood, but cannot fundamentally suppress the absorption of fat into the body. I couldn't get the effect. Therefore, there is a need for a substance that promotes obesity prevention or obesity improvement by a mechanism different from these.

On the other hand, it has not been known that the fruits of the genus Prunus rosacea have an obesity-preventing action or an obesity-improving action.

[0006]

The present invention has been made under these circumstances, and an object thereof is to provide a food or pharmaceutical composition having an obesity-preventing action or an obesity-improving action.

[0007]

In view of such circumstances, the inventors of the present invention have conducted repeated research for a substance having an obesity-preventing action or an obesity-improving action, and as a result, an excess amount was found in the fruits of the plant of the genus Rosaceae. Contains a substance that interferes with the accumulation of body fat, and due to this excessive body fat accumulation inhibitory action, such obesity-preventing action or obesity-improving action is possessed by the fruit of the genus Rosaceae plant or its essence. It was found that the invention was completed and the invention was completed. Hereinafter, the present invention will be described in detail.

(1) Inhibitor of excess body fat accumulation of the present invention The inhibitor of excess body fat accumulation of the present invention comprises the fruit of a plant of the genus Prunus genus Rosaceae or its essence. Here, the essence refers to a processed product of fruit, specifically, dried fruit, smoked fruit, crushed fresh fruit or its dried product, ground fruit, fruit or Examples thereof include those obtained by extracting the dried product with a solvent or the like.
Among the plants belonging to the genus Prunus of the family Rosaceae, ume is the most preferable when used as the agent for suppressing excess body fat accumulation of the present invention. A number of closely related plants such as white plum, red plum, and Nanko plum are known for plums, and these fruits are eaten. Any of these can be used as an agent for suppressing excess body fat accumulation of the present invention. Can be done.

When these fruit extracts are used as an excess body fat accumulation suppressor, the method is to obtain an extract from the fruit. A polar solvent in an amount of 1 to 100 times is added to the fruit or a processed product thereof, and the temperature is kept at room temperature. Or it may be immersed at a temperature near the boiling point. You may add stirring as needed. Examples of polar solvents include water, alcohols such as ethanol, ethers such as diethyl ether and tetrahydrofuran, ketones such as acetone and methyl ethyl ketone, nitriles such as acetonitrile, and halogenated hydrocarbons such as methylene chloride and chloroform. . These solvents may be used alone or in combination of two or more. The preferred polar solvent is highly safe water or ethanol. The extract thus obtained may be used as it is, or may be used after removing the solvent by distillation under reduced pressure.
Furthermore, these extracts may be purified by liquid-liquid extraction or column chromatography before use. In the present invention, the extract means a generic name of these.

(2) Action The fruit of the above-mentioned plant of the genus Prunus genus Prunus or its essence has an action of suppressing excess body fat accumulation. The excessive body fat accumulation inhibitory action referred to in the present invention means suppressing the accumulation of energy as fat that occurs due to absorption of excess energy, converting these energy into proteins such as muscle, obesity, hyperlipidemia of blood. The effect of improving and preventing symptoms such as. Therefore, the excessive body fat accumulation suppressive action does not mean a dangerous action that suppresses energy absorption more than necessary and causes weight loss, but converts excess energy into a protein form and prevents body fat accumulation. It is a thing. This is, as shown in the Examples below, when the group administered with the agent for suppressing excess body fat accumulation of the present invention is fed with a high-nutrient diet, the average body weight does not change from the non-administered group, but as body fat, It is also clear from the fact that the accumulation of fat is suppressed. The over-nutrition absorption inhibitor of the present invention suppresses fat accumulation and works to prevent obesity when administered in a fattening situation, and when administered in an already obese situation, proteins such as fat muscle It promotes the conversion to and helps improve obesity. Furthermore, the agent for suppressing excess body fat accumulation of the present invention has excellent safety, as shown in Examples described later, and as is clear from the fact that Japanese apricots have been eaten since ancient times.

(3) Composition of the present invention The composition of the present invention is obtained by combining the above-described excess body fat accumulation suppressor and optional components for formulation into a conventional method. Compositions include food compositions and pharmaceutical compositions. The type of the formulation is not particularly limited as long as it is generally used in food compositions and pharmaceutical compositions.

The food composition can be formulated into juice, candy, jelly, bread, noodles and the like by a conventional method together with optional components such as a flavoring agent, a preservative, a stabilizer, an excipient and a food material. The preferable blending amount is 1 to 50% by weight, more preferably 1 to 20% by weight. The dose of the excessive body fat accumulation inhibitor per day varies depending on the type of preparation, the processing state, the weight, height, age, etc. of the recipient, but it is preferable to administer 100 to 100000 mg in several divided doses. .

The pharmaceutical composition includes an excipient, a disintegrant, a binder, a stabilizer, an emulsifying dispersant, a coating agent, a lubricant, a flavoring agent, a coloring agent, a pH adjusting agent, an isotonic agent, and a sugar coating agent. In addition to the above, it can be formulated into granules, powders, tablets, capsules, injections, rectal agents and the like by a conventional method. Examples of the route of administration of the injection include intravenous injection, arterial injection, portal vein injection, subcutaneous injection, intramuscular injection and the like. The dose of the excessive body fat accumulation inhibitor per day varies depending on the type of preparation, the processing situation, the symptoms of the recipient, the physical condition, the height, the weight, etc., but 100 to 100000 mg
It is suitable to administer the drug in several divided doses.

[0014]

The present invention will be described in more detail below with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Example 1 Production Example Ume fruit was extracted with warm water and freeze-dried to obtain an excess body fat accumulation inhibitor. That is, 5 l of water was added to 500 g of ume fruit, and the mixture was extracted by heating at 90 ° C. for 3 hours, insoluble matter was removed by filtration, and then freeze-dried to obtain 16 parts of the excess body fat accumulation inhibitor 1.
5.4 g was obtained.

Example 2 Acute Toxicity Acute toxicity by oral administration was examined using 6 5-week-old ICR mice (male, 20 to 30 g). That is, Example 1
The excessive body fat accumulation inhibitor 1 was orally administered at a dose of 1000 mg / Kg, and life or death was determined 14 days later. As a result, no death was observed, and it was found that the LD50 was higher than 1000 mg / Kg.

Example 3 Inhibitory Action on Excess Body Fat Accumulation (High Nutrient Diet Model) With respect to Inhibitor 1 for excess body fat accumulation, an inhibitory action on excess body fat accumulation under high nutrition diet was performed using ICR male mice (6 weeks old). I checked about. That is, from the 8th week after birth, mice that had been preliminarily bred for 2 weeks after arrival were bred for 4 weeks with a well-kneaded feed containing 85% of commercially available powdered feed, 10% of lard, and 5% of excess body fat accumulation inhibitor 1. The body weight and the weight of the epididymal fat were measured, and the fat amount around the epididymis was divided by the body weight to calculate the weight percentage of the epididymal fat to the body weight. On the other hand, in parallel with this, as a control, 90% of commercially available powdered feed was used.
The percentage of epididymal fat amount per body weight was also calculated for the group similarly bred with the kneaded feed containing 10% and lard. The percentage of epididymal fat per body weight in the administration group was divided by that value in the control group and multiplied by 100 to obtain 79.84.
%, And it was revealed that the agent for suppressing excess body fat accumulation of the present invention suppressed accumulation of body fat. On the other hand, the change in body weight before and after the experiment was examined. As a result, the experimental group showed an increase of 16.67%, whereas the control group showed an increase of 15.38%. It turns out that the increase is not suppressed. That is, it can be seen that the agent for suppressing excess fat accumulation of the present invention has an action of converting energy accumulation form into muscles other than fat.

Example 4 Effect of suppressing excess body fat accumulation (pathological obesity model) The effect of the agent for suppressing excess body fat accumulation of the present invention on pathological obesity was examined using MSG mice, which is a model of pathological obesity. That is, 1-day-old ICR mice were administered with sodium L-glutamate at a dose of 2 mg / g · day for 5 days to destroy the hypothalamus to prepare MSG mice. The mother was raised for 1 month and weaned at the 4th week after birth. From the 6th week after birth, 5% of the excess body fat accumulation inhibitor of the present invention was added to the powdered feed.
The kneaded feed was bred for 4 weeks. The control group was bred only with powdered feed. The body weight was measured at the end of 4 weeks of breeding and divided by the body weight at the start to obtain the weight gain rate. As a result, the increase rate in the control group was 8.76%, whereas that in the group administered with the excess body fat accumulation inhibitor was 5.00%.
Was an increase. That is, in MSG mice, which is a body fat accumulation type pathological model in which it is difficult to convert energy into muscles and the like, the excess body fat accumulation inhibitor of the present invention suppresses the accumulation of body fat, and therefore increases body weight. I know that it will be suppressed.

Examples 5-7 Formulation Examples Candy was prepared according to the formulation shown in Table 1.
That is, the component A was melted by heating at 150 ° C., cooled to 120 ° C., then the component B was added, and the mixture was stirred, homogenized and cooled to obtain a candy.

[0020]

[Table 1]

Examples 8-10 Formulation Examples Gummies were prepared according to the formulations shown in Table 2. That is, component A in Table 2 was heated and dissolved at 110 ° C., and separately swelled and dissolved in component B
The ingredients were added, and further the ingredient C was added, and the mixture was poured into a mold and allowed to stand for a whole day and night.

[0022]

[Table 2]

Examples 11 to 12 Formulation Examples Juices were prepared according to the formulations shown in Table 3. That is, the formulation ingredients were dissolved by stirring, sterilized, aseptically filled, and sealed to obtain juice.

[0024]

[Table 3]

Example 13 Formulation Example Bread was prepared based on the formulation shown in Table 4. That is, the A component was well stirred and mixed, and the B component heated to 40 ° C. was added and kneaded well, and after primary fermentation at 37 ° C. for 1 hour, degassing was performed and molding was performed at 37 ° C. for 30 minutes. Secondary fermented. This was baked in a 250 ° C. oven for 25 minutes to obtain a baked bread.

[0026]

[Table 4]

Examples 14 to 16 Formulation Example Granules were prepared according to the formulation shown in Table 5. That is, the prescription A
The components were mixed well, and component B dissolved in 20 times the amount of ethanol aqueous solution was gradually added thereto with stirring to granulate. This was blow-dried at 40 ° C. for 2 days to obtain granules.

[0028]

[Table 5]

[0029]

The agent for suppressing excess body fat accumulation of the present invention has an excellent effect of suppressing the accumulation of excess energy in the form of body fat. It is very useful for prevention and improvement.

Claims (6)

[Claims] 1. An excess body fat accumulation suppressor comprising the fruit of the genus Rosaceae plant or its essence. 2. The agent for suppressing excess body fat accumulation according to claim 1, wherein the plant of the genus Prunus of the family Rosaceae is plum. 3. A food for obesity prevention comprising the agent for suppressing excess body fat accumulation according to claim 1 or 2. 4. A food for improving obesity, which comprises the agent for suppressing excess body fat accumulation according to claim 1 or 2. 5. A pharmaceutical composition for preventing obesity, comprising the agent for suppressing excess body fat accumulation according to claim 1 or 2. 6. A pharmaceutical composition for treating obesity, which comprises the agent for suppressing excess body fat accumulation according to claim 1 or 2.