JPH082784B2 - Medical patch - Google Patents

Description

TECHNICAL FIELD The present invention relates to a medical patch that is used by being stuck to an affected area for anti-inflammatory or analgesia.

(Prior Art) Conventionally, in this type of medical patch, a plaster layer containing a medicinal component is provided on a support such as sfumosulin, flannel, and a non-woven fabric.

Supports made of these woven or non-woven fabrics have good heat retention, breathability, and water absorption, and are particularly thin and flexible, and stretchable so as to follow the movement of the body and not give discomfort. The one with good properties is used (for commercial patches, JIS
A support made of a woven or non-woven fabric having a bending resistance of about 17 to 28 mm according to L 1005 is used).

(Problems to be Solved by the Invention) None of the conventional medical patches using such a woven or non-woven fabric as a support has an effect of fixing or supporting an affected area.

An object of the present invention is to provide a medical patch having a so-called corset effect, which is fundamentally different from the conventional medical patches as described above and particularly fixes or supports the affected area.

(Means for Solving the Problems) The medical patch of the present invention has a bending resistance according to JIS L 1005.
Tensile elastic stress at 40% or more and 20% elongation is 0.7kg / 25
On a support made of woven fabric or non-woven fabric having a width of mm or more, a plaster layer containing a medicinal component is provided,
Thereby, the above object is achieved.

The support used in the present invention is made of woven or non-woven fabric,
Generally, its thickness is 0.1 to 7 mm. As woven cloth, cotton,
Woven cloth made of fibers such as suf, nylon and rayon is used. As the non-woven fabric, rayon, polyester,
A non-woven fabric of fibers such as cellulose and nylon is used.

And, among such woven or non-woven fabrics, weaving method,
A material having a flexural rigidity of 40 mm or more according to JIS L 1005 and a tensile elastic stress at a 20% elongation of 0.7 kg / 25 mm width or more is used by density, binder, needle punching, heat treatment, or the like.

Here, the bending resistance according to JIS L 1005 is a 25 mm wide × 150 mm long sample extruded in the direction of the slope from a smooth horizontal table with a slope of 45 ° at the tip under conditions of 23 ° C and 65% RH. ,
When the tip of the sample comes into contact with the slope, it is represented by the extruded distance. When this value is less than 40 mm, the feeling of fixing or supporting the affected area is reduced. therefore,
In the present invention, the bending resistance must be 40 mm or more.

Also, the tensile elastic stress at 20% elongation is 65
% RH, 25mm width x 150mm length sample (mark line distance 100
mm) was pulled by a tensile tester at a speed of 300 mm / min,
It is expressed by the tensile stress within the elastic limit at% elongation.
If this value is less than 0.7 kg / 25 mm width, the elasticity is too large, and the feeling of fixing or supporting the affected area is reduced. Therefore, in the present invention, the tensile elastic stress at 20% elongation is
Must be 0.7kg / 25mm or wider.

A plaster layer containing a medicinal component is provided on the support as described above. The plaster layer is generally a mixture of medicinal components and an adhesive, which is used in a conventional manner. The thickness of the plaster layer is generally 100 to 350 μm.

As the medicinal component, salicylates such as methyl salicylate and glucose salicylate; arnica, yellow oak,
Herbal medicines such as aloe, sanshin, chamomile; analgesic and anti-inflammatory agents such as indomethacin, ketoprofen, chlorbiflofen; antihistamines such as diphenhydramine hydrochloride, chlorpheniramine maleate, etc .; Menthol, peppermint oil,
Examples thereof include thymol, capsicum extract, nonyl acid vanillyl amide, and vitamin E.

The adhesive may be lipophilic or hydrophilic.
The lipophilic one is generally used for a warm feeling type, and the hydrophilic one is generally used for a cold feeling type.

As the lipophilic pressure-sensitive adhesive, styrene-isoprene-styrene block copolymer, polyacrylic acid ester-based polymer, lipophilic polymer such as natural or synthetic rubber, if necessary, terpene-based resin, alicyclic synthetic resin, Examples thereof include those containing a tackifier such as rosin resin and a softening agent such as liquid paraffin and polybutene.

Further, as the hydrophilic adhesive, a hydrophilic polymer such as sodium alginate, gelatin, corn starch, casein, methyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, sodium polyacrylate, methoxyethylene-maleic anhydride copolymer, if necessary. Moisturizers such as glycerin and propylene glycol,
Examples include those containing a swelling agent such as water and a cross-linking agent such as methyl ethyl ketone.

The adhesive may be blended with an inorganic filler such as titanium oxide or zinc oxide, an antiaging agent such as BHT, or the like.

The plaster layer containing such a medicinal component is provided on the support made of the above woven or non-woven fabric by the following method by a hot melt method, a solvent method, a calender method or the like.

First, a pressure-sensitive adhesive is used as it is, or a solvent is added to the pressure-sensitive adhesive as needed, and the mixture is heated or made into a viscous liquid at room temperature.

Next, this plaster is applied on a support by a coater. At this time, a plaster layer may be continuously provided on the entire surface of the support, or the plaster may be partially provided in a streak-like, mesh-like or spot-like manner by dividing the coating portion. . When the plaster layer is continuously provided on the entire surface of the support, a perforating process or the like is generally performed finally to provide air permeability.

When a solvent is used in the production of the plaster, the solvent is volatilized with a dryer or the like after coating the plaster.

Finally, a release paper is attached to the entire surface of the plaster to protect the plaster layer, and the product is cut into a predetermined sheet shape and packaged. Further, a roll-wound body can be formed without cutting into a predetermined sheet shape. It can also be manufactured by applying a plaster on a release paper and attaching a support to it.

(Operation) In the present invention, a woven or non-woven fabric is used as a support, and the physical properties of the woven or non-woven fabric are as follows: JIS L 1005 has a bending resistance of 40 mm or more and a tensile elastic stress at 20% elongation of 0.7 kg. When the width is set to be / 25 mm or more, the obtained patch has rigidity enough to fix or support the affected area, moderate touch and moderate heat retention effect.

When the support is made of woven or non-woven fabric and a plaster layer is provided on the support, a part of the plaster penetrates into the gap between the woven or non-woven fabric, and the anchor effect strongly adheres to the support and the plaster. To do.

(Example) Hereinafter, the Example and comparative example of this invention are shown.

Example 1 A non-woven fabric produced by a dry method in which rayon fibers were distributed on one side and polypropylene fibers were distributed on the other side (weighing 210 g
/ m ² , rayon fiber 45% by weight, polypropylene fiber 55% by weight) was passed through a pair of heating rollers to form a support made of a nonwoven fabric in which polypropylene fibers were partially melt-bonded to each other.

The obtained support (nonwoven fabric) has a bending resistance of 75 mm according to JIS L 1005 and a tensile elastic stress of 2.4 kg / 25 at 20% elongation.
The width and thickness were 1.2 mm.

In addition, 100 parts by weight of styrene-isoprene-styrene block copolymer, 150 parts by weight of liquid paraffin, 90 parts by weight of alicyclic resin, 4 parts by weight of titanium oxide, 1.0 part by weight of dry extract of sanshishi as a medicinal ingredient, 6% of pepper Extract 0.0
2 parts by weight were blended and stirred and mixed by a hot melt method at a temperature of 150 to 170 ° C. so that the whole was uniform, to prepare a lipophilic plaster.

First, a release paper made of a polyester film having a silicone layer on one side was prepared, and the above-mentioned paste was applied to the silicone layer side of the release paper to a thickness of 250 by a hot melt coating machine.
μm, coating width 10 mm, non-coating width 10 mm, applied in a number of stripes parallel to each other, and immediately after that, the paste is made of the above non-woven fabric while maintaining the temperature of 80 to 90 ° C. It was laminated with the polypropylene fiber side of the support and wound into a roll.
From this roll-shaped material, a patch having a length of 215 mm × width 100 mm with rounded corners was punched and cut to produce a patch.

Volunteers (10 males, 12 females, ages 22 to 55 years old) with this patch were attached to the lumbar region along the spine vertically, and the performance was evaluated in a questionnaire.

As a result, it was found that the lumbar region was always supported, it provided a psychological relief, and it was superior not only in medicinal properties but also in physical and psychological effects. Further, it was also good in terms of heat retention (warmth), breathability (no rash), and water absorbency (no accumulation of sweat).

 Met.

Example 2 As a support, the bending resistance according to JIS L 1005 is 92 mm, 20%
Tensile elastic stress at elongation is 3.5kg / 25mm width, thickness is 1.
A wool felt having a weight of 1 mm and a weight of 140 g / m ² was used. Other than that was performed like Example 1. The evaluation result was the same as in Example 1.

Example 3 2 parts by weight of polyvinyl alcohol, 4 parts by weight of gelatin,
7 parts by weight of glycerin, 33 parts by weight of zinc white, 50 parts by weight of water,
2 parts by weight of peppermint oil and methyl salicylate 2 as medicinal ingredients
Parts by weight were mixed and kneaded at a temperature of 40 ° C. so that the whole was uniform to make a hydrophilic plaster.

This plaster was applied on the entire surface of the support made of the non-woven fabric used in Example 1 on the rayon fiber side with a knife coater to a thickness of 250.
Immediately after that, a liner made of a polyethylene film was attached to the plaster surface, wound in a roll shape, and aged for 24 hours. 215 mm length x 100 width from this roll
A patch was manufactured by punching into a sheet with rounded corners of mm and cutting.

The performance of the patch was evaluated in the same manner as in Example 1. The evaluation result was the same as in Example 1.
In this case, since the adhesive strength of the plaster was weak, it was fixed to the lumbar region using a breathable pressure-sensitive adhesive sheet that was 1 cm wider than the patch size. Further, in this case, the plaster layer was provided on the entire surface of the support, but since the plaster itself absorbed sweat, the sweat did not stay on the pasting surface.

Example 4 The same procedure as in Example 3 was carried out except that the hydrophilic plaster used in Example 3 was applied in a number of stripes parallel to each other with a coating width of 10 mm and a non-coating width of 3 mm. . The evaluation result was the same as in Example 3. In this case, the balance between sweat divergence and appropriate water retention was good.

Comparative Example A commercially available patch (Nobinobi Salonship and Salon Cup: manufactured by Hisamitsu Pharmaceutical Co., Ltd.) was used as a control patch. In the patch of this control, the support of the former salon ship consisted of omnidirectional expansion flannel, and the bending resistance according to JIS L 1005 was 18 mm. The latter salon cup was made of sufmusulin and had a bending resistance of 25 mm. This control patch was constructed so as to fit the stretch and contraction of muscles.

When the patch of this control was applied to the lower back and evaluated in the same manner as in Examples 1 to 3, the same performance as in Examples 1 to 3 was observed in terms of heat retention, air permeability, and water absorption. The supportive feeling on the lower back was poor, and a significant difference from the patch of the present invention was observed.

(Effects of the Invention) As described above, the medical patch of the present invention has a plaster layer provided on a support made of a woven or non-woven fabric, and the woven or non-woven fabric is flexible according to JIS L 1005. 40 degrees or more,
Tensile elastic stress at 20% elongation is 0.7 kg / 25 mm width or more, such a woven or non-woven fabric, the rigidity or moderate touch and moderate breathability and water absorption, which can fix or support the affected area, Has a heat retention effect.

Therefore, the medical patch of the present invention, compared with the conventional medical patch of this type, gives a psychological relief by the so-called corset effect of fixing or supporting the affected area,
It has excellent therapeutic effects such as anti-inflammatory and analgesia due to its medicinal properties, warmth, no rash, no sweat accumulation, etc. In particular, it is suitable for low back pain and sprains.

In addition, the support made of woven or non-woven fabric and the plaster are strongly adhered to each other due to the anchor effect, etc., so that the plaster is prevented from peeling off from the support even when sweating, and also when peeling and removing after use. It also prevents the plaster from remaining on the skin.

Claims (1)

[Claims] [Claim 1] The bending resistance according to JIS L 1005 is 40 mm or more, 20%
A medical patch, wherein a plaster layer containing a medicinal component is provided on a support made of a woven or non-woven fabric having a tensile elastic stress at an elongation rate of 0.7 kg / 25 mm width or more.