JPH08280807A - Spray container dissolving when necessary and spray dissolving when necessary using the container - Google Patents

Abstract

PURPOSE: To provide a spray container which has both long-term stability of a liquid medicine and quickness when necessary. CONSTITUTION: A spray container dissolving when necessary is provided with a lower bottle body 4 in which a freeze-dried medicine is stored and a chamber 2 in which a liquid component is stored, and has such a constitution that both of the lower bottle body and the chamber are connected by means of a locking member 3. This locking member 3 has semi-plugging keeping effect when the liquid medicine is filled in the lower bottle body 4 to be freeze-dried. The bottom of the chamber 2 is formed out of an aluminum foil 6, therefore the liquid component in the chamber 2 flows down into the lower bottle body 4 and thereby the solid medicine stored in the lower bottole body 4 is dissolved to form the liquid medicine, when a liquid ejecting member 10 is attached on the upper part of the chamber 2 and the aluminum foil is broken through. Therefore, the liquid component and the solid medicine are separately stored and can be mixed by easy operation and ready for using medicine when the engaging member 3 is used in a semi-plugged condition in the lower bottle body 4 in which the liquid medicine is stored and the liquid medicine is freeze-dried.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a structure of a spray container in which a solid component and a liquid component are separately housed in different containers, and both are mixed and used at the time of use. Regarding spray. More specifically, the present invention is a spray that is stored in a state where the solid component and the liquid component are separated so as not to be mixed at the time of storage / transportation, etc., and is sprayed by using a mixed liquid obtained by mixing the two when used. And a spray container, particularly a spray and a spray container suitable for spraying a drug into the nasal cavity.

[0002]

2. Description of the Prior Art Sprays having a pump mechanism are already used for applying a drug to the nasal cavity. Conventionally, in this type of spray, a liquid medicine in which a solid drug component is dissolved or dispersed in a solvent such as water is stored in a bottle as it is, and a jetting device equipped with a pump mechanism is provided at the opening of the bottle filled with the liquid medicine. It is generally installed and used.

However, many solid drug components are more stable when stored in a dry state. Further, in the case of a drug component showing only low solubility in a solvent, it cannot be used without being dissolved in a solvent. Where
If this dispersion is left for a long period of time, the dispersed drug components may precipitate and aggregate.

Therefore, such a drug in solution is freeze-dried for long-term stability. The freeze-drying procedure is, for example, as shown in FIG. 8, after the lower bottle 4 is filled with a liquid (solution or dispersion) drug (mixed liquid agent) 54, it is housed inside the lower bottle 4. In order to prevent the vapor of the solvent for the existing chemicals from evaporating to the outside of the lower bottle body 4, that is, to prevent the air permeability from being impaired, a rubber stopper 55 is half-stopped in the opening portion of the lower bottle body 4 and inside the freeze dryer. To house.

Next, as shown in FIG. 8, when the solvent is removed by freeze-drying and the drug is solidified, the rubber stopper 55 is press-fitted into the lower bottle body 4 and sealed, and then taken out from the freeze-dryer. . That is, a plurality of vertical grooves are formed in the lower end portion of the rubber stopper 55 used for freeze-drying in order to ensure air permeability in the half stoppered state, while the rubber stopper 55 is used.
A collar is formed on the upper portion of the lower bottle body 4 so that the hermeticity is ensured when the lower portion is pushed into the opening portion of the lower bottle body 4. Further, in order to ensure the airtightness, the rubber cap 55 is pushed in, and then the aluminum cap is wound and tightened so that the flange portion 21 located at the upper end of the lower bottle body 4 and the flange portion of the rubber plug 55 are integrated. It is crimped.

In order to use the drug thus freeze-dried together with the lower bottle body 4 as a nasal spray,
As shown in FIG. 8, the aluminum caulks are removed, the rubber stopper 55 is removed, and the separately prepared solvent 52 is added into the lower bottle body 4 as shown in FIG. The lower vial 4 is shaken well as shown in FIG. 9 to prepare a liquid 54 in which the solid drug is dissolved or dispersed in the solvent 52.

The lower bottle body 4 is usually a glass bottle having the same shape as a bottle for containing an injection solution or the like, and a screw groove for screwing the liquid jetting member 10 to fix the same is provided on the outer surface thereof. Generally not formed. Therefore, the solution 54 in which the solid drug is dissolved by adding the solvent 52 is transferred to the outer periphery of the upper opening portion as shown in FIG. 9 and to the lower bottle body 64 into which the liquid ejection member 10 can be screwed. As shown in FIG. 10, the liquid ejection member 1 is attached to the lower bottle body 64.
It is used by fixing 0 by screwing.

By freeze-drying the drug dissolved in the liquid in the lower bottle body 4 as described above, the shelf life of the drug can be extended as a result of improving the storage stability of the medicinal component.

However, when using the freeze-dried solid drug, the aluminum caulking used for fixing the rubber stopper and the lower bottle body 4 as described above is removed, and the rubber stopper is removed. However, it requires a very complicated operation of adding a separately prepared solution and shaking, and then transferring this drug liquid easily and separately for spraying.

In particular, when removing the caulking made of aluminum, there is a problem that the fingertip may be injured and the amount of the solution added is not constant. By the way, although it is a technique different from spraying using a solid drug prepared by freeze-drying as described above, a container for preparing a solution by mixing a solid drug and a liquid drug when used is actually used. According to Kaihei 7-9727, a container for solid components whose upper and lower bottoms are sealed with aluminum foil is formed in the vicinity of an opening at the top of a bottle-shaped container filled with a solvent, and a jetting device is used for storing solid components. There is disclosed a spray in which a solid drug is dropped into a solvent contained in a bottle-like container to be used by being pierced so as to penetrate the portion and attached.

[0011] However, although the above-mentioned publication discloses that a bottle-shaped container is filled with a liquid drug, it is not considered to be used as a container for freeze-drying. In addition, when the solid component is placed on the upper part of the container in this way, when the drug suction pipe of the ejection device passes through the solid component, the drug may enter the liquid suction pipe as a solid, and the solid drug may penetrate into the liquid suction pipe. The suction pipe may be blocked and the pump function may not be exhibited.

Further, in the container disclosed in this publication, the solid component is dropped into the liquid component, but in order to completely drop the solid component, it is necessary to form a considerably large breakage opening in the partition wall. In addition to this, in the case of powder chemicals, the amount of powder adhering to the wall surface of the vessel reaches a considerable amount, so use it as a chemical liquid only after thorough shaking (shaking). There is a problem of not getting.

[0013]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide a spray container in which a solid component and a liquid component are contained in a separated state, and both are mixed and used at the time of use, and a spray using this container. There is. Further, according to the present invention, the solid component and the liquid component are contained in a container in a separated state so as not to come into contact with each other at the time of storage / transportation, etc., and both are mixed to form a drug liquid (mixed liquid) when used. It is an object of the present invention to provide a spray container which is prepared and jets and uses this mixed solution, and a dissolution spray when using this container.

In particular, in the present invention, when a solid drug is prepared by freeze-drying, the opening of the lower bottle body 4 is covered in a freeze-dryable state (aeration-permissible state) instead of the conventional rubber stopper, and
A spray container which contains the solid drug in the lower bottle body 4 prepared by freeze-drying the solution or dispersion of the solid drug in a state separated from the liquid medium, and immediately mixes the two for use, and The aim is to provide a spray using a container, in particular a nasal spray.

[0015]

The in-use soluble spray container of the present invention is characterized by having the following constitution: a lower bottle body for containing a solid component and an easily breakable bottom portion. And a chamber for containing a liquid component, which is composed of a thin film and has a bottom portion having a bottom diameter substantially equal to the upper end opening of the lower bottle body, and an upper opening portion of the lower bottle body. The lower bottle body and the chamber, which are substantially cylindrical locking members having an inner peripheral surface having an engaging portion with a flange portion formed on the outer periphery and an engaging portion with a protrusion formed on the outer peripheral portion of the chamber. The lower bottle body and the chamber can be tightly fixed to each other by fitting, and when the locking member with which the chamber is fitted is placed in the upper opening of the lower bottle body, One or more vertical grooves on the inner surface of the cylinder that allow the gas of A liquid ejecting member having a locking member having the liquid ejecting port at the upper part of the pump part, and having a liquid agent suction pipe capable of supplying a liquid component from the lower bottle body to the pump at the lower part of the pump part, When the liquid agent suction pipe of the liquid ejecting member is inserted from the upper end of the chamber to set the liquid ejecting member, the liquid agent suction pipe is attached so as to break the easily breakable thin film at the bottom of the chamber. Dissolving spray container when used.

The in-use dissolving spray of the present invention is characterized by having the following constitution: a lower bottle body containing a freeze-dried solid component and an upper opening of the lower bottle body. And a liquid component that dissolves or disperses the freeze-dried solid component, and is placed in close contact with the lower bottle via a thin film. And a substantially cylindrical locking member that engages with a protrusion formed on the outer peripheral portion of the chamber and the lower bottle body to closely fix the chamber and the lower bottle body. And a liquid jet having a liquid jet port at the upper part of the pump part and a liquid agent suction pipe capable of supplying a liquid component from the lower bottle body to the pump at the lower part of the pump part when using a spray. Liquid absorption Insert from the upper end of the chamber in the direction in which the lifting pipe enters, break the thin film that separates the chamber and the lower bottle body with the liquid agent suction pipe, and let the liquid component contained in the chamber flow down into the lower bottle body. A spray for dissolving before use characterized in that a solid component contained in a lower bottle is dissolved or dispersed in a liquid component that has flowed down.

<Preferred Embodiment of the Invention> The in-use dissolution spray container of the present invention and the spray in which the container is filled with a medicine will be specifically described below based on Examples.

Since the vertical spray groove is formed in the lower inner peripheral surface of the engaging member between the lower bottle body and the chamber, the in-use soluble spray container of the present invention is filled with the drug liquid. When the locking member is placed on the upper opening of the lower bottle during freeze-drying, the liquid component evaporates well from the vertical groove (concave groove) formed on the inner peripheral surface of the locking member. It can be lyophilized. Furthermore, by providing a bottom of aluminum foil or the like at the lower end of the chamber, and inserting and engaging from the top of this locking member, this locking member and the chamber cooperate to open the upper opening of the lower bottle body. Acts as a cover to cover. After the freeze-drying is completed, the locking member with the chamber is pushed into the lower bottle body from above (including pushing up the lower bottle body from below) so that the chamber and the lower bottle body are separated from each other. It is integrated via a locking member. By thus filling the chamber with the liquid component after the chamber and the lower bottle body are integrated by the locking member, the solid component and the liquid component can be accommodated in the same container in a separated state.

Therefore, according to the in-use dissolution spray container of the present invention, for example, a freeze-dried solid drug and a liquid medium component for dissolving or dispersing this solid drug are held in the same container without contacting each other. Can be done.

Further, in the in-use dissolution spray of the present invention, since the liquid agent component is contained in the chamber arranged in the upper portion of the lower bottle body, the liquid agent suction pipe of the liquid jetting member is inserted from the upper portion of the chamber. By penetrating the bottom, the entire amount of the contained liquid drug component flows down into the lower bottle body, and the solid drug contained in the lower bottle body and the flowed down liquid drug component are rapidly mixed. Moreover, in this operation, there is an advantage that the liquid medicine suction pipe is not blocked by the solid medicine.

<< Description of Drawings >> FIG. 1 (a) is a vertical sectional view showing an example of the before-use dissolution spray container of the present invention, and FIG. 1 (b) constitutes the before-use dissolution spray container. It is a longitudinal cross-sectional view showing an example of a liquid jetting member. 2 is shown in FIG.
FIG. 6 is a vertical cross-sectional view showing a state in which a liquid ejection member is attached to the fresh-use dissolution spray container shown in (a) of FIG.

The in-use dissolution spray container of the present invention has a lower bottle body 4, a chamber 2, a locking means 3 for fixing the both, and a liquid jetting member 10 attached to the chamber 2.
The lower bottle body 4 is adapted to accommodate a solid component, usually a solid drug 13, while the chamber 2 is adapted to accommodate a liquid drug component.

The lower bottle body 4 has an opening at the upper end thereof, and a flange 21 which is a protrusion for engaging the locking member 3 is provided at the upper end where the opening is formed. Have
The lower bottle body 4 can be formed of, for example, glass, metal, or a thermoplastic resin such as polyolefin, polystyrene, or acrylic resin.

A solid medicine is accommodated in the lower bottle body 4. There is no particular limitation on the solid drug, but when the spray of the present invention is used as a nasal spray, for example, a freeze-dried preparation such as tranexamic acid or lysodium chloride is added to the lower bottle body 4. In addition to the drug, antibiotics, antihistamines, corticosteroids, etc. are filled as a drug liquid dissolved or dispersed in an aqueous medium or an organic solvent.

The solid drug consisting of the above-mentioned medicinal ingredients is usually filled in the lower bottle body 4 in a solution or dispersion state, and then the solvent or dispersion medium is removed to leave the solid drug. Freeze-drying is preferably used in the present invention as a method for removing a liquid medium such as water from the lower bottle body 4 filled with the above-mentioned medicinal ingredients and drying it.

In freeze-drying, the lower bottle body 4 filled with the liquid medicine as described above is free of foreign matter from the opening of the lower bottle body 4, and the water content in the lower bottle body 4 is volatilized. The lower bottle body 4 is housed in the freeze-drying device adjusted to about -80 to -20 ° C by capping the opening in a state in which air permeability is ensured so that the sex component evaporates. This is a method in which volatile components such as water contained in the drug in 4 are removed and then sealed.

Conventionally, the rubber stopper having the vertical groove formed in the opening portion of the lower bottle body 4 as described above is half-capped so as to ensure the air permeability. However, in the present invention, instead of this rubber stopper, the locking member 3 as shown in FIGS. 3B and 4 is placed on the opening of the lower bottle body 4.

The locking member 3 usually has a cylindrical shape, as shown in FIGS. 3 (b) and 4.
As shown in FIGS. 3 (a) and 3 (c), the upper portion of the locking member 3 is slightly slightly larger than the upper end portion of the cylindrical body so that the chamber 2 is fitted and closely fixed. Groove 3 on the lower inner surface
4 is formed, and the flange portion 21 formed on the outer peripheral surface of the chamber 2 is fitted and integrated.
That is, since the liquid agent component is contained in the chamber 2, the liquid component is retained in the locking member 3 and the chamber 2.
The lower end of the chamber 2 and the intermediate portion of the locking member 3 are formed with engaging concaves and convexes so that they are fitted to each other so as not to leak out from the joint portion with.

A protrusion 22 is formed on the outer peripheral surface of the chamber 2, and the protrusion 22 is engaged with a concave groove 31 formed in the inner peripheral surface of the engaging member 3 in the circumferential direction. The chamber 2 and the locking member 3 are joined. Further, in this locking member 3, an easily rupturable and impermeable thin film 6 such as an aluminum foil is arranged at the lower end of the chamber 2 and the thin film 6 is formed. A bottom material of the chamber 2 is formed, and a gasket 7 is arranged below the thin film 6 as necessary. A thin film 6 made of aluminum foil or the like is joined to the opening edge portion of the lower end portion of the chamber 2 by welding of resin or adhesion through an adhesive or the like to form the bottom portion of the chamber 2.

In this locking member 3, the lower bottle is so fitted that the flange portion 21 on the outer periphery of the upper opening edge of the lower bottle body 4 fits on the inner peripheral surface of the lower portion of the thin film 6 or the gasket 7. A recess 35 is formed corresponding to the shape of the collar 21 on the edge of the body 4. Further, at the lower part of the recess 35, a locking portion 36 is formed which is narrowed inwardly of the inner circumference of the locking member 3 so that the fitted lower bottle body 4 does not fall off.
The locking portion 36 is formed so as to protrude in the inner circumferential direction so that when the lower bottle body 4 is pushed into the locking member 3, the outer peripheral edge portion of the opening portion of the lower bottle body 4 passes through and is fitted into the concave portion 35. Alternatively, it may be placed on the lower bottle body 4, and in this case, the locking portion 36 serves as a stopper.

A vertical groove 32 is formed in the lower portion of the inner peripheral surface of the locking portion 36 of the locking member 3, and when the locking member 3 is placed on the lower bottle body 4, As shown in FIG. 5 (a), the vaporized liquid agent component contained in the liquid mixture (medicinal liquid) 14 in the lower bottle body 4 passes through the vertical groove 32 and evaporates to the outside of the lower bottle body 4, The medicine in the lower bottle body 4 is gradually dried. It is sufficient that at least one vertical groove 32 is provided in the lower portion of the inner peripheral surface of the locking member 3, but a plurality of vertical grooves 32 may be provided as shown in FIG.

As described above, the locking member 3 in which the chamber 2 having the bottom formed of the thin film 6 of aluminum foil or the like is fitted and fixed from above is placed so as to cover the upper opening of the lower bottle body 4. By doing so, like the rubber temporary stopper in the conventional freeze-drying, the locking member 3 allows the gas in the lower bottle body 4 to flow to the outside, but can prevent foreign matter from entering from the outside.

Thus, after the liquid component in the lower bottle body 4 is removed by freeze-drying and the solid drug containing the medicinal component is dried, the chamber 2 is pushed in from above as shown in FIG. 5 (b). Then, the upper end of the lower bottle body 4 is fixed in contact with the thin film 6 such as an aluminum foil via the gasket 7. Next, as shown in FIG. 5C, the chamber 2 is filled with the liquid agent component, and the upper end of the chamber 2 is sealed as necessary.

The liquid medicine component 12 filled in the chamber 2 can dissolve or disperse the liquid medicine or the solid medicine 13 which can dissolve or disperse the solid medicine 13 filled in the lower bottle body 4. At the same time, the liquid drug component 12 itself can be used as a medium having a medicinal effect. As such a liquid agent component 12,
Examples thereof include water, an aqueous medium containing water and alcohols, a water retention agent such as glycerin or ethylene glycol, and the like. Particularly when the spray of the present invention is used as a nasal spray, it is preferable to use water or a mixture of water and alcohol as the liquid component.

The upper end of the chamber 2 is an upper sealing member 5 made of an easily rupturable and impermeable material for sealing the liquid agent component 12 filled in the chamber 2.
Can be sealed with. The upper sealing member 5 can be formed of various materials, for example, the thermoplastic resin or the metal foil forming the chamber 2 can be formed. In order to seal the chamber 2 using such a material so as to be easily broken, it is preferable that the thickness of the upper sealing member 5 be within the range of 10 to 300 μm.

As shown in FIG. 1 (a), the solid component is contained in the lower bottle body 4 as described above, and the chamber 2
After accommodating the liquid medicine components inside, if necessary, the cap 1
Protects the upper end of the chamber 2.

The main body of the chamber 2 as described above can be formed of, for example, a thermoplastic resin. Further, the locking means 3 is also preferably formed of a thermoplastic resin. It should be noted that the cap 1 for protecting the sealing portion formed of the easily breakable material on the upper portion of the chamber 2 is usually provided on the outer periphery of the upper portion of the chamber 2 when storing or transferring (transporting) the spray of the present invention. And a screw groove for screwing a liquid ejection member 10, which will be described later, are formed.

The spray of the present invention can be stored or transferred in a state in which the cap 1 is screwed into the chamber 2 in addition to the state in which the liquid ejection member 10 is removed. And
When using this spray, remove the cap 1,
Instead, the liquid ejection member 10 is attached and used.

The liquid ejecting member 10 is movable up and down, and an actuator 8 for ejecting the liquid agent from the tip, a pump section 9 for arranging the actuator 8 at the lower portion for ejecting the liquid agent by the vertical movement of the actuator 8, and further the pump The portion 9 has a liquid agent suction pipe 16 for supplying a liquid agent, and the liquid jetting member 10 usually has a thread groove that can be screwed into the chamber 2.

As shown in FIG. 2, the liquid agent suction pipe 16 of the liquid ejecting member 10 is connected to the upper end portion 5 of the chamber 2.
The liquid component 12 so as to penetrate through the thin film 6 below the liquid component 12 as well.
Let it run down. Then, the liquid jetting member 10 is screwed and fixed to the upper portion of the chamber 2 by the screw groove provided on the liquid jetting member 10 and the screw groove provided on the outer peripheral wall of the chamber 2.

By inserting the liquid jetting member 10 in this way, the liquid drug component 12 flowing down into the lower bottle body 4 is mixed with the solid drug 13 previously contained in the lower bottle body 4, and this solid drug 13 is mixed with the liquid drug component 12. A mixed liquid (medicine liquid) 14 dissolved or dispersed in is prepared.

In the present invention, the thin film 6 is pierced and broken by inserting the liquid agent suction pipe 16 provided on the liquid ejecting member 10 as described above, and the liquid agent component 12 contained in the chamber 2 is removed from the lower bottle. Since the liquid agent suction pipe 16 is made to flow down into the body 4, it is preferable to provide the liquid agent suction pipe 16 with a dip cover 11 that spreads the opening of the thin film 6. FIG.
In (b) and FIG. 2, a dip cover 11 continuous from the pump 9 is formed on the outer wall of the liquid agent suction pipe 16 extending downward from the pump 9, and the dip cover 11 includes the chamber 2 and the lower part. Separation from the bottle body 4 is to cut the thin film 6 so that the liquid component 12 can easily flow down into the lower bottle body 4, and for example, reference numeral 1 in FIG.
As shown by 5, it may be in the form of a slitting blade that spreads from the lower side to the upper side of the liquid medicine suction pipe 16. That is, the liquid ejecting member 10 is provided with the dip covers 11 and 15 for breaking the thin film 6 below the liquid agent suction pipe 16 and / or the pump portion 9.

Unlike the embodiment shown in FIG. 1, the thin film 6 is provided in the upper opening of the lower bottle body 4 in the upper portion 5 of the chamber 2 in FIG. 6 (a). An embodiment is shown with pre-opened openings. In this embodiment, a gasket (gasket) 7 is arranged below the chamber 2 to seal a liquid component (not shown) in the chamber 2. In addition, in (a) and (b) of FIG. 6 and FIG.
The same members as those shown in FIGS. 1A and 1B and FIG. 2 are designated by the same reference numerals.

In this embodiment, the thin film 6 does not adhere to the upper edge of the lower bottle body 4 during freeze-drying, and the chamber 2 is dried after drying.
The thin film 6 is adhered to the upper edge of the lower bottle body 4 when the is pushed.

In the in-use dissolving spray of the present invention, the tubular portion of the liquid jetting member 10 is pierced from the upper end portion 5 of the chamber 2 to break through the thin film 6 for separating the chamber 2 and the lower bottle body 4, The liquid drug component 12 contained in the chamber 2 flows down into the lower bottle body 4 and is mixed with the solid drug 13 contained therein to form a mixed liquid 14.

After the liquid agent component 12 flows down, the liquid jetting member 10 is screwed into the chamber 2 to seal the upper end portion 5 of the chamber 2, and then the entire spray is shaken to sufficiently mix the liquid component and the solid drug. To mix.

After the mixed medicine is prepared by the above-mentioned operation, the actuator 9 is pushed down so that the pump 9 operates. As a result, the mixed liquid 14 sucks the liquid medicine sucking pipe 16.
It is sucked up from and is ejected from the tip of the actuator 8. The liquid ejecting member 10 can be arranged so that the liquid agent suction pipe 16 of the liquid ejecting member 10 contacts the liquid agent component 12 but does not contact the solid drug.

Due to the contribution, the situation which may occur in the prior art, that is, the situation where the solid medicine 14 invades the lower end of the liquid medicine suction pipe 16 to close the liquid medicine suction pipe 16 does not occur. Further, since the liquid agent component is contained in the chamber 2 and the thin film 6 is broken by the liquid agent suction pipe 16, almost all the liquid component 12 flows down into the lower bottle body 4.

The spray of the present invention can be used for various purposes by changing the combination of the liquid drug component and the solid drug, and is particularly suitable as a spray used for inhalation therapy such as asthma and rhinitis. Is.

[0050]

EFFECTS OF THE INVENTION In the in-use dissolution spray container of the present invention, a locking member for a chamber and a bottle can be used in place of the half stoppered rubber stopper which has been conventionally used for freeze-drying. . By using the spray container of the present invention, caulking by an aluminum plate or the like becomes unnecessary, and the manufacturing is very easy.

The in-use dissolution spray of the present invention can be easily used by simply inserting the liquid jetting member from the upper end of the chamber. In the in-use dissolution spray of the present invention, the liquid agent suction pipe is not blocked by the solid component.

In the in-use dissolution spray of the present invention, no liquid component remains in the chamber. With the spray of the invention, the concentration of the mixture formed is constant and highly uniform.

In the in-use dissolution spray of the present invention, the liquid drug component and the solid drug are stored in a stable state. In the in-use dissolution spray of the present invention, even when a drug having a low storage stability when used as a mixed solution is used, the usable period can be extended.

[Brief description of drawings]

FIG. 1 is a vertical sectional view schematically showing a spray of the present invention.

FIG. 2 is a vertical cross-sectional view schematically showing a state in which a liquid ejection member is attached from above the chamber.

FIG. 3 is a schematic vertical cross-sectional view showing a combined state of a locking member and a chamber.

FIG. 4 is a partially enlarged sectional perspective view showing a locking member.

FIG. 5 is a process drawing showing an operation when preparing a solid component by freeze-drying.

FIG. 6 is a schematic vertical sectional view showing another embodiment of the easy-dissolving spray container of the present invention.

FIG. 7 is a schematic vertical cross-sectional view showing another embodiment of the in-use dissolution spray container with a liquid ejection member attached from above the chamber.

FIG. 8 is an operation procedure diagram for explaining a method for preparing a before-use dissolution spray that employs the freeze-drying method.

FIG. 9 is an operation procedure diagram for explaining a method for preparing a before-use dissolution spray adopting the freeze-drying method.

FIG. 10 is a schematic longitudinal sectional view of a new embodiment of the spray spray container before use, which comprises a locking member of another aspect and a lower bottle body of another aspect.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... Cap 2 ... Chamber 3 ... Locking means 4 ... Lower bottle body 5 ... Upper sealing member 6 ... Thin film 7 ... Gasket 8 ... Actuator 9 ...・ Pump 10 ・ ・ ・ Liquid ejection member 11 ・ ・ ・ Dip cover 12 ・ ・ ・ Liquid component 13 ・ ・ ・ Solid drug 14 ・ ・ ・ Mixed liquid (medicine liquid) 15 ・ ・ ・ Dip cover 16 ・ ・ ・ Liquid suction pipe 21 ... Collar part 24 ... Engagement unevenness 31 ... Recessed groove 32 ... Vertical groove 34 ... Engagement unevenness 35 ... Recess 36 ... Engagement part 52 ... Solvent 53・ ・ ・ Solid medicine 54 ・ ・ ・ Mixed liquid (medicine liquid) 55 ・ ・ ・ Rubber stopper 64 ・ ・ ・ Lower bottle body that can be screwed with the liquid ejection member

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location B65D 83/36

Claims (8)

[Claims] 1. A bottomed bottle body for accommodating a solid component, and a bottomed cylinder formed at the bottom with an easily rupturable thin film and having a diameter of the bottom portion substantially equal to the upper end opening of the lower bottle body. A chamber, which is made of a body, for accommodating a liquid component, an engaging portion with a flange portion formed on the outer periphery of the upper opening of the lower bottle body, and an engaging portion with a protrusion formed on the outer peripheral portion of the chamber. Is a substantially cylindrical locking member having an inner peripheral surface, and by fitting the lower bottle body and the chamber, the lower bottle body and the chamber can be closely fixed, and the engagement of the chamber A locking member having at least one vertical groove on the inner peripheral surface of the cylinder, through which the gas inside the lower bottle body flows when the stopper member is placed in the upper opening of the lower bottle body, and the pump portion upper part It has a liquid outlet in the lower part of the pump and the lower part of the pump. A liquid ejecting member having a liquid agent sucking pipe capable of supplying a liquid component from a bottle body, and when the liquid agent sucking pipe of the liquid ejecting member is inserted from the upper end of the chamber to set the liquid ejecting member, the liquid agent sucking pipe Is attached so that the easily breakable thin film on the bottom of the chamber can be broken. 2. The easily breakable thin film is an aluminum foil, and the aluminum foil is welded or adhered to an opening edge portion of a lower end portion of the chamber to close the opening portion, and the lower bottle body and the chamber. The in-use dissolution spray container according to claim 1, wherein the aluminum foil is closely attached to the lower portion of the aluminum foil closely attached to the opening edge of the lower end of the chamber via a gasket. 3. A lower bottle body accommodating a freeze-dried solid component, and a close contact with the lower bottle body in a state of being separated from the lower bottle body through a thin film at an upper opening portion of the lower bottle body. A chamber containing a liquid component for dissolving or dispersing the freeze-dried solid component and having a lower end opening approximately equal to the opening diameter of the lower bottle body, and the chamber and the outer peripheral portion of the lower bottle body. It has a substantially cylindrical locking member that engages with the formed projection and tightly fixes the chamber and the lower bottle body, and has a liquid ejection port on the upper part of the pump section when using a spray. A liquid ejecting member having a liquid agent suction pipe capable of supplying a liquid component from the lower bottle body to the pump portion is inserted from the upper end of the chamber in the direction in which the liquid agent suction pipe enters, and the chamber and the lower bottle body are inserted. And The thin film to be separated is broken by the liquid agent suction pipe, the liquid component contained in the chamber is made to flow down into the lower bottle body, and the solid component contained in the lower bottle body is dissolved or dispersed in the liquid component flowed down. Dissolving spray before use, characterized by 4. The before-use dissolution spray according to claim 3, wherein an upper end opening of the chamber is sealed with a breakable material. 5. A thin film for separating the lower bottle body and the chamber is an aluminum foil.
Or the in-use dissolution spray described in 4 above. 6. The liquid ejecting member has a pump section for ejecting a liquid, a liquid ejection port for ejecting a mixed liquid agent sent out from the pump section upward, and a liquid agent suction pipe for supplying the mixed liquid agent to the pump section. The dip cover for breaking a thin film is attached to a lower portion of the liquid agent suction pipe and / or the pump portion, The in-use dissolution spray according to any one of claims 3 to 5, wherein. 7. A screw groove is formed on an outer periphery of an upper portion of the chamber so as to be screwed with the liquid jetting member, and the upper portion of the chamber is a screwed cap before the liquid jetting member is inserted into the chamber. 7. The before-use dissolution spray according to any one of claims 3 to 6, which is hermetically sealed, and the chamber and the liquid jetting member are screwed together after the liquid jetting member is inserted. 8. The nasal spray, wherein the spray contains a lyophilized drug in a lower vial and a solution for dissolving or dispersing the lyophilized drug in a chamber. The third to the seventh aspects.
The in-use dissolution spray described in any one of 1.