JPH08295706A - Production of hydrogel containing calcium - Google Patents
Production of hydrogel containing calciumInfo
- Publication number
- JPH08295706A JPH08295706A JP12304095A JP12304095A JPH08295706A JP H08295706 A JPH08295706 A JP H08295706A JP 12304095 A JP12304095 A JP 12304095A JP 12304095 A JP12304095 A JP 12304095A JP H08295706 A JPH08295706 A JP H08295706A
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- water
- aqueous solution
- carboxyvinyl polymer
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011575 calcium Substances 0.000 title claims abstract description 28
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 28
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- 239000000017 hydrogel Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 21
- 239000002244 precipitate Substances 0.000 claims abstract description 11
- 239000003518 caustics Substances 0.000 claims abstract description 10
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000003513 alkali Substances 0.000 claims abstract description 9
- 239000001110 calcium chloride Substances 0.000 claims abstract description 9
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 9
- YFGAFXCSLUUJRG-WCCKRBBISA-M sodium;(2s)-2-amino-5-(diaminomethylideneamino)pentanoate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCCN=C(N)N YFGAFXCSLUUJRG-WCCKRBBISA-M 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract description 7
- 239000000661 sodium alginate Substances 0.000 abstract description 7
- 235000010413 sodium alginate Nutrition 0.000 abstract description 7
- 229940005550 sodium alginate Drugs 0.000 abstract description 7
- 239000002270 dispersing agent Substances 0.000 abstract description 6
- 239000000243 solution Substances 0.000 abstract description 6
- 239000002562 thickening agent Substances 0.000 abstract description 6
- 239000000839 emulsion Substances 0.000 abstract description 5
- 239000003381 stabilizer Substances 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 4
- 238000005406 washing Methods 0.000 abstract description 2
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 7
- 239000000920 calcium hydroxide Substances 0.000 description 7
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 7
- 210000003722 extracellular fluid Anatomy 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 4
- 235000011118 potassium hydroxide Nutrition 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 210000002977 intracellular fluid Anatomy 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000008279 sol Substances 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000001669 calcium Chemical class 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 241000473391 Archosargus rhomboidalis Species 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229940086737 allyl sucrose Drugs 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- -1 calcium halide Chemical class 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
Landscapes
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、化粧品製造用の原料と
して、経皮吸収の可能性の高い高濃度のカルシウムを含
有し、併せて増粘剤、分散剤、乳化安定剤などの目的に
使用される水性ゲルの製造法に関するものである。FIELD OF THE INVENTION The present invention contains a high concentration of calcium, which has a high possibility of percutaneous absorption, as a raw material for manufacturing cosmetics, and also serves as a thickener, a dispersant, an emulsion stabilizer and the like. The present invention relates to a method for producing an aqueous gel used.
【０００２】[0002]
【従来の技術】カルボキシビニルポリマーは、厚生省が
化粧品原料の規格として定めた「化粧品原料基準」に掲
載されており、カルボキシル基を有する水溶性のビニル
ポリマーで、アクリル酸を主とし、これに少量のアリル
ショ糖などを配した共重合体である。これは、濃化、分
散および乳化剤として、化粧品製造用の原料に広く利用
されている酸性の物質である。これにカルシウムを含有
させたカルボキシビニルポリマーの水性ゲルは、特に有
効な化粧品製造用の原料である。2. Description of the Related Art Carboxy vinyl polymers are listed in the "Cosmetic Raw Material Standards" established by the Ministry of Health and Welfare as standards for cosmetic raw materials. Carboxy vinyl polymers are water-soluble vinyl polymers having a carboxyl group, mainly acrylic acid, and a small amount of this. It is a copolymer in which allyl sucrose and the like are arranged. It is an acidic substance widely used as a thickening, dispersing and emulsifying agent as a raw material for cosmetic production. Aqueous gel of carboxyvinyl polymer containing calcium therein is a particularly effective raw material for manufacturing cosmetics.
【０００３】カルシウムを含有させたカルボキシビニル
ポリマーの水性ゲルの製造法としては、本出願人の出願
に係る特公昭６０−１７２０７号がある。この方法は、
カルボキシビニルポリマー水溶液に中和量以下の量の苛
性アルカリの水溶液を加え透明なゲル状態とし、これに
ハロゲン化カルシウムの水溶液を加え、析出するゴム状
物質を採取し水洗後、これを苛性アルカリ水溶液中に浸
漬放置することを特徴とするカルシウム含有カルボキシ
ビニルポリマーの水性ゲルの製造方法である。As a method for producing an aqueous gel of a carboxyvinyl polymer containing calcium, there is JP-B-60-17207 filed by the present applicant. This method
An aqueous solution of caustic alkali in an amount less than the neutralization amount is added to the aqueous solution of carboxyvinyl polymer to form a transparent gel state, and an aqueous solution of calcium halide is added to this, and the rubbery substance that precipitates is collected and washed with water, and then the aqueous solution of caustic alkali is added. A method for producing an aqueous gel of a calcium-containing carboxyvinyl polymer, which comprises immersing and standing in water.
【０００４】上記の方法により得られる水性ゲルは、組
成中にカルシウムを含有し、これを水で希釈することに
よって高粘度のゾルとなり、このゾルは、化粧品製造用
の増粘剤、分散剤、乳化安定剤、ｐＨ調整剤、湿潤剤な
どとして応用範囲の極めて広いもののように考察されて
いた。しかし、上記の方法においては、その製造過程で
得られるカルボキシビニルポリマーのカルシウム塩が、
多量の水分を含有する水性ゲルであるため、カルシウム
を多量に含有する最終生成物が得られない欠点があっ
た。The aqueous gel obtained by the above-mentioned method contains calcium in the composition, and by diluting this with water, it becomes a highly viscous sol. This sol is a thickener, dispersant, It has been considered as an emulsion stabilizer, a pH adjuster, a wetting agent, etc., which has a very wide range of application. However, in the above method, the calcium salt of the carboxyvinyl polymer obtained in the production process is
Since it is an aqueous gel containing a large amount of water, it has a drawback that a final product containing a large amount of calcium cannot be obtained.
【０００５】[0005]
【発明が解決しようとする課題】本発明は、化粧品製造
用の原料として、経皮吸収の可能性の高い高濃度のカル
シウムを含有し、併せて増粘剤、分散剤、乳化安定剤な
どの目的に使用される水性ゲルを製造する方法を提供す
る。The present invention contains a high concentration of calcium, which has a high possibility of percutaneous absorption, as a raw material for the production of cosmetics, and also contains a thickener, a dispersant, an emulsion stabilizer and the like. Provided is a method for producing an aqueous gel used for a purpose.
【０００６】[0006]
【課題を解決するための手段】本発明者は、上記の目的
を達成するため鋭意研究を重ねた結果、カルボキシビニ
ルポリマーをアルギン酸ナトリウムと併用することによ
り、特公昭６０−１７２０７号の方法による生成物より
も、遙かに高濃度のカルシウムを含有する水性ゲルが得
られることを知り、本発明を完成するに至った。Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned object, the present inventor has found that by using a carboxyvinyl polymer in combination with sodium alginate, it is produced by the method of JP-B-60-17207. It was found that an aqueous gel containing a much higher concentration of calcium than that of the product can be obtained, and the present invention has been completed.
【０００７】すなわち、本発明は、カルボキシビニルポ
リマーにアルギン酸ナトリウムを加えて水溶液とし、こ
れに苛性アルカリを加えて中和した後、塩化カルシウム
の水溶液を加え、生成する沈澱物を採取して水洗した
後、これに苛性アルカリを加えることを特徴とするカル
シウムを含有する水性ゲルの製造法である。That is, according to the present invention, sodium arginate is added to carboxyvinyl polymer to prepare an aqueous solution, and a caustic alkali is added to the solution to neutralize it, and then an aqueous solution of calcium chloride is added thereto, and the resulting precipitate is collected and washed with water. Then, a method for producing an aqueous gel containing calcium, which is characterized in that a caustic alkali is added thereto.
【０００８】カルボキシビニルポリマーに対して３〜２
０重量％、好ましくは５〜１５重量％のアルギン酸ナト
リウムを加えて水溶液とし、これに苛性アルカリを加え
て中和した後、生成する沈澱物を濾過により採取して水
洗した後、これに苛性アルカリを加えると、水性ゲルが
得られることが分かったのであるが、この水性ゲルは、
下記の反応式（１）および（２）によって得られるもの
と考察される。3 to 2 with respect to carboxyvinyl polymer
After adding 0% by weight, preferably 5 to 15% by weight, of sodium alginate to form an aqueous solution, and adding caustic alkali to neutralize the solution, the precipitate formed is collected by filtration and washed with water. It was found that an aqueous gel can be obtained by adding
It is considered to be obtained by the following reaction formulas (1) and (2).
【０００９】（１）カルボキシビニルポリマーの反応(1) Reaction of carboxyvinyl polymer
【化１】 Embedded image
【００１０】（２）アルギン酸ナトリウムの反応(2) Reaction of sodium alginate
【化２】 上記の反応によって得られる生成物は、無色透明の均一
な中性のゲルで、組成的にはカルボキシビニルポリマー
のナトリウム塩、アルギン酸カルシウムおよび水酸化カ
ルシウムの混合したコロイドと考えられるが、本生成物
中に含有する前記の水酸化カルシウムは、市販の水酸化
カルシウムの場合とは異なり、共存するカルボキシビニ
ルポリマーの存在によって、その電離が妨げられ、分子
状態として存在しているものと推察される。また、本生
成物が無色透明の中性のゲルであることから考察して、
この場合の水酸化カルシウムは、可溶化状態にあると考
えられる。Embedded image The product obtained by the above reaction is a colorless transparent uniform neutral gel, which is compositionally considered to be a mixed colloid of sodium salt of carboxyvinyl polymer, calcium alginate and calcium hydroxide. It is presumed that the above-mentioned calcium hydroxide contained therein is present as a molecular state, unlike the case of commercially available calcium hydroxide, because the coexisting carboxyvinyl polymer prevents its ionization. Also, considering that this product is a colorless and transparent neutral gel,
The calcium hydroxide in this case is considered to be in a solubilized state.
【００１１】本発明の生成物中に水酸化カルシウムが存
在していることは、上記の生成物を水とエタノールで希
釈し、これに炭酸アンモニウム試液を加える時、白濁す
る現象によって確認することができる。本発明において
は、カルボキシビニルポリマーをアルギン酸ナトリウム
と併用することにより、高濃度のカルシウムを含有する
生成物を得ることができるようにしたのであるが、その
理由について検討してみると、次のとおりである。The presence of calcium hydroxide in the product of the present invention can be confirmed by the phenomenon of white turbidity when the above product is diluted with water and ethanol and an ammonium carbonate reagent solution is added to it. it can. In the present invention, it was made possible to obtain a product containing a high concentration of calcium by using a carboxyvinyl polymer in combination with sodium alginate. The reason for this is as follows. Is.
【００１２】アルギン酸はコンブ、アラメ、カジメなど
の海草類中に含有されている天然の高分子体で、前記
（Ｄ）式の塩化カルシウムとの反応式によってカルシウ
ム塩は得られるが、これに（Ｃ）式の反応のように苛性
アルカリを作用させても、カルボキシビニルポリマーの
場合のような水性ゲルは得られない。しかし、本発明の
ように適量をカルボキシビニルポリマーと併用させるこ
とによって、水分の含有量の少ない、濾紙で濾過できる
ような沈澱物となり、したがって、水洗も容易で特公昭
６０−１７２０７号の方法の５〜８倍程度のカルシウム
分を含有する水性ゲルが得られる。[0012] Alginic acid is a natural polymer contained in seaweeds such as kelp, sea bream and squid. Calcium salt can be obtained by the reaction formula (D) with calcium chloride. Even if a caustic alkali is applied as in the reaction of the formula), an aqueous gel as in the case of carboxyvinyl polymer cannot be obtained. However, by using an appropriate amount together with carboxyvinyl polymer as in the present invention, a precipitate having a low water content which can be filtered with a filter paper is obtained, and therefore, it can be easily washed with water and the method of JP-B-60-17207 is used. An aqueous gel containing about 5 to 8 times more calcium is obtained.
【００１３】本発明によって得られる水性ゲルは、無
色、無味、無臭で水に可溶性の中性のゲルで、化粧品原
料の増粘剤、分散剤、乳化安定剤などとして有効である
他、前記のように多量のカルシウムを含有し、このカル
シウムの経皮吸収の可能性が、特公昭６０−１７２０７
号の方法の場合よりも大であることが次のように考察さ
れる。The aqueous gel obtained by the present invention is a colorless, tasteless, odorless and water-soluble neutral gel, which is effective as a thickener, a dispersant, an emulsion stabilizer, etc. for cosmetic raw materials. Since it contains a large amount of calcium as described above, the possibility of transdermal absorption of this calcium is
It is considered as follows that it is larger than that of the No. method.
【００１４】カルシウムは人体中に、ミネラル成分とし
て約１．５％含有している。その大部分は燐酸カルシウ
ムまたは炭酸カルシウムとして、骨および歯の主成分で
あるが、小部分は水溶性カルシウムとして、主に血液の
血清ならびに組織間液中に存在している。すなわち、こ
の水溶性カルシウムは、細胞外液中に存在するわけであ
るが、このカルシウムは、人体の健康上重要な作用を発
揮する。その作用とは、血液のアルカリ化に貢献するこ
とと、細胞外液の浸透圧を低下させることである。Calcium is contained in the human body as a mineral component in an amount of about 1.5%. Most of them are calcium phosphates or carbonates, the main constituents of bone and teeth, while some are mainly water-soluble calcium, which is mainly present in blood serum and interstitial fluid. That is, this water-soluble calcium exists in the extracellular fluid, but this calcium exerts an important effect on human health. Its action is to contribute to the alkalization of blood and to reduce the osmotic pressure of extracellular fluid.
【００１５】細胞外液のミネラルの組成は、ナトリウ
ム、カリウム、マグネシウムならびにカルシウムで、一
方、細胞内液のそれはナトリウム、カリウム、マグネシ
ウムであり、カルシウムは含まれていない。このミネラ
ルの組成上の相違によって、細胞外液と細胞内液との間
に浸透圧の差が生じ、その結果、細胞外液中の栄養分は
細胞内液に入ることができ、細胞に栄養が供給される。
表皮には血管がないため、表皮細胞は血液から栄養分を
受けついだ組織間液（リンパ液）によって養われてい
る。The mineral composition of extracellular fluid is sodium, potassium, magnesium and calcium, while that of intracellular fluid is sodium, potassium, magnesium and is calcium-free. This difference in the composition of minerals causes a difference in osmotic pressure between extracellular fluid and intracellular fluid, and as a result, nutrients in the extracellular fluid can enter the intracellular fluid, and the nutrients in the cells can be increased. Supplied.
Since there are no blood vessels in the epidermis, epidermal cells are nourished by interstitial fluid (lymph) that receives nutrients from blood.
【００１６】基礎化粧品は皮膚表面に塗布されるもので
あるため、カルシウムイオンを含有する化粧品は、経皮
吸収によって皮膚内に浸透し、表皮細胞の外液にカルシ
ウムを補給できるのではないかと考えられるが、これは
誤りである。その理由は、表皮の最上層である角質層
と、その内部の顆粒層との間にイオンの透過を阻む構造
があるためで、イオンは皮膚内には入って行くことはで
きない。経皮吸収はカルシウムイオンによっては行なわ
れない。Since the basic cosmetics are applied to the skin surface, cosmetics containing calcium ions may penetrate into the skin by percutaneous absorption to supplement calcium to the external fluid of epidermal cells. But this is wrong. The reason is that there is a structure that prevents the permeation of ions between the stratum corneum, which is the uppermost layer of the epidermis, and the granular layer inside the stratum corneum, and ions cannot enter the skin. Percutaneous absorption is not carried out by calcium ions.
【００１７】化粧品の配合成分が経皮吸収できる条件
は、次のとおりである。 (1) 水溶性またはコロイド性であること。 (2) イオンになる傾向が少ないこと。 (3) 分子量が２００〜３００以下であること。 上記の条件の全てを満たす物質でなければ、経皮吸収は
行なわれない。The conditions under which the compounding ingredients of cosmetics can be absorbed transdermally are as follows. (1) Water-soluble or colloidal. (2) Less tendency to become ions. (3) The molecular weight is 200 to 300 or less. Percutaneous absorption is not performed unless the substance satisfies all the above conditions.
【００１８】本発明の生成物中に存在する水酸化カルシ
ウムは、この条件の全てを満たしている。すなわち、水
溶液として存在し、イオンにならず、また、分子量が７
４．０９である。以上の結論として、本発明の水性ゲル
中の水酸化カルシウムには、経皮吸収の可能性が示唆さ
れるのである。The calcium hydroxide present in the product of the present invention meets all this requirement. That is, it exists as an aqueous solution, does not become an ion, and has a molecular weight of 7
It is 4.09. From the above conclusion, it is suggested that calcium hydroxide in the aqueous gel of the present invention may be percutaneously absorbed.
【００１９】[0019]
【実施例】以下に、本発明の実施例を挙げて説明する。
なお、特公昭６０−１７２０７号の実施例１および実施
例２を、それぞれ比較例１および比較例２として示す。 （比較例１）カルボキシビニルポリマー１０ｇを１００
０ｃｃの水に溶解し、これに苛性カリ５ｇ（中和量は８
ｇ）を１００ｃｃの水溶液としたものを攪拌しながら加
えると、透明なゲルが得られる。これに塩化カルシウム
（ＣａＣｌ2 ・２Ｈ2 Ｏ）１０ｇを１００ｃｃの水溶液
としたものを加えると、白色のゴム状物質が析出する。
この物質を採取し水洗した後、苛性カリ３ｇを１０００
ccの水溶液としたものの中に浸漬し、時々攪拌しつつ常
温に放置すると、前記ゴム状物質は漸次溶解して透明な
ゲルとなる。また、ｐＨは次第に低下して略中性とな
る。EXAMPLES Examples of the present invention will be described below.
Incidentally, Examples 1 and 2 of JP-B-60-17207 are shown as Comparative Example 1 and Comparative Example 2, respectively. (Comparative Example 1) 100 g of carboxyvinyl polymer 10 g
Dissolve in 0 cc of water and add 5 g of caustic potash (neutralize 8
A transparent gel is obtained by adding 100 g of g) in an aqueous solution with stirring. When a solution of 10 g of calcium chloride (CaCl 2 .2H 2 O) in 100 cc was added thereto, a white rubber-like substance was precipitated.
After collecting this substance and washing it with water, add 3 g of caustic potash to 1000 g.
When immersed in an aqueous solution of cc and left at room temperature with occasional stirring, the rubber-like substance gradually dissolves and becomes a transparent gel. Further, the pH gradually decreases and becomes almost neutral.
【００２０】（実施例１）カルホキシビニルポリマー５
０ｇとアルギン酸ナトリウム５ｇとを１０００ccの水に
溶解し、これに苛性カリ２５ｇの水溶液を攪拌しながら
加えると、透明なゾル状物質となる。これに塩化カルシ
ウム（ＣａＣｌ2 ・２Ｈ2 Ｏ）５０ｇの水溶液を加える
と、白色の沈澱物が析出する。この物質を濾過水洗した
後、苛性カリ２５ｇを５００ｃｃの水で水溶液としたも
のを加えて、前記の沈澱物と反応させ、さらに水を追加
して全量を１０００ｇとする。本物質はｐＨ７．３０の
中性のゲルである。Example 1 Carfoxy vinyl polymer 5
When 0 g and 5 g of sodium alginate are dissolved in 1000 cc of water and an aqueous solution of 25 g of caustic potash is added thereto with stirring, a transparent sol-like substance is obtained. When an aqueous solution of 50 g of calcium chloride (CaCl 2 .2H 2 O) is added to this, a white precipitate is deposited. This material is filtered and washed with water, and 25 g of caustic potash is made into an aqueous solution with 500 cc of water to react with the above-mentioned precipitate, and water is further added to bring the total amount to 1000 g. This substance is a neutral gel with a pH of 7.30.
【００２１】これを比較例１と比較すると、この場合に
は、塩化カルシウムとの反応物が多量の水を含有してい
るために、その反応物が１０００ｇを遙かに超過する量
となってしまい、したがって、本発明の場合のような濃
厚なカルシウムを含有する生成物とすることはできな
い。本発明の前記の生成物は、比較例１の生成物の５倍
に相当するカルシウム分を含有する。Comparing this with Comparative Example 1, in this case, since the reaction product with calcium chloride contains a large amount of water, the reaction product has an amount far exceeding 1000 g. Therefore, it cannot be a product containing rich calcium as in the present invention. The product of the invention contains 5 times the calcium content of the product of Comparative Example 1.
【００２２】（比較例２）カルボキシビニルポリマー１
０ｇを１０００ｃｃの水に溶解し、これに苛性ソーダ
３．６ｇ（中和量は５．８ｇ）を１００ｃｃの水溶液と
したものを常温で攪拌しながら加えると、透明なゲルが
得られる。これに塩化カルシウム（ＣａＣｌ2 ・２Ｈ2
Ｏ）１０ｇを１００ｃｃの水溶液としたものを加える
と、白色のゴム状物質が析出する。この物質を採取して
水洗した後、苛性ソーダ２．２ｇを１０００ｃｃの水溶
液としたものの中に浸漬し、時々攪拌しつつ常温に放置
すると、前記ゴム状物質は、漸次溶解して透明なゲルと
なる。また、ｐＨは次第に低下して略中性となる。Comparative Example 2 Carboxyvinyl Polymer 1
A transparent gel is obtained by dissolving 0 g of water in 1000 cc of water and adding 3.6 g of caustic soda (neutralized amount of 5.8 g) in 100 cc of aqueous solution with stirring at room temperature. Calcium chloride (CaCl 2 · 2H 2
When 10 g of O) in 100 cc of an aqueous solution was added, a white rubber-like substance was precipitated. After this substance was collected and washed with water, it was immersed in a solution of 2.2 g of caustic soda in an amount of 1000 cc and left at room temperature with occasional stirring, and the rubber-like substance gradually dissolved to form a transparent gel. . Further, the pH gradually decreases and becomes almost neutral.
【００２３】（実施例２）カルボキシビニルポリマー８
０ｇとアルギン酸ナトリウム８ｇとを１０００ｃｃの水
に溶解し、これに苛性ソーダ２８．８ｇの水溶液を加え
ると、透明なゾルが得られる。これに塩化カルシウム
（ＣａＣｌ2 ・２Ｈ2 Ｏ）８０ｇの水溶液を加えると、
白色の沈澱物を生じ、この物質を濾過水洗した後、苛性
ソーダ２８．８ｇの水溶液を加えて、前記の沈澱物を溶
解させ、さらに水を追加して全量を１０００ｇとする。
本ゲル状物質はｐＨ７．４４である。これを比較例２と
比較した場合には、本発明の実施例１と同様に、比較例
２の方法によっては得られない、その８倍に相当する濃
厚なカルシウム分を含有する生成物が得られる。(Example 2) Carboxyvinyl polymer 8
A transparent sol is obtained by dissolving 0 g and 8 g of sodium alginate in 1000 cc of water and adding an aqueous solution of 28.8 g of caustic soda. When 80 g of calcium chloride (CaCl 2 .2H 2 O) is added to this,
A white precipitate is formed, and this substance is filtered and washed with water, and then an aqueous solution of 28.8 g of caustic soda is added to dissolve the precipitate, and water is further added to make the total amount 1000 g.
The gel substance has a pH of 7.44. When this is compared with Comparative Example 2, as in Example 1 of the present invention, a product containing a calcium component which is 8 times as much as that obtained, which is not obtained by the method of Comparative Example 2, is obtained. To be
【００２４】[0024]
【発明の効果】本発明によれば、カルボキシビニルポリ
マーにアルギン酸ナトリウムを併用することにより、特
公昭６０−１７２０７号の方法による生成物よりも、遙
かに高濃度のカルシウムを含有する、化粧品製造用の原
料として有用な水性ゲルを得ることができる。EFFECTS OF THE INVENTION According to the present invention, by using sodium arginate in combination with carboxyvinyl polymer, a cosmetic preparation containing much higher concentration of calcium than the product produced by the method of Japanese Patent Publication No. 60-17207. It is possible to obtain an aqueous gel useful as a raw material for use.
Claims (1)
ナトリウムを加えて水溶液とし、これに苛性アルカリを
加えて中和した後、塩化カルシウムの水溶液を加え、生
成する沈澱物を採取して水洗した後、これに苛性アルカ
リを加えることを特徴とするカルシウムを含有する水性
ゲルの製造法。1. A sodium arginate is added to a carboxyvinyl polymer to form an aqueous solution, and a caustic alkali is added to the aqueous solution for neutralization, and then an aqueous solution of calcium chloride is added, and the resulting precipitate is collected and washed with water. A method for producing an aqueous gel containing calcium, which comprises adding caustic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12304095A JPH08295706A (en) | 1995-04-25 | 1995-04-25 | Production of hydrogel containing calcium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12304095A JPH08295706A (en) | 1995-04-25 | 1995-04-25 | Production of hydrogel containing calcium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08295706A true JPH08295706A (en) | 1996-11-12 |
Family
ID=14850726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12304095A Pending JPH08295706A (en) | 1995-04-25 | 1995-04-25 | Production of hydrogel containing calcium |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH08295706A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005085406A1 (en) * | 2004-02-27 | 2005-09-15 | Reckitt Benckiser (Uk) Limited | Method of treatment of a surface |
-
1995
- 1995-04-25 JP JP12304095A patent/JPH08295706A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005085406A1 (en) * | 2004-02-27 | 2005-09-15 | Reckitt Benckiser (Uk) Limited | Method of treatment of a surface |
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