JPH08322934A - Nasal drug dispenser - Google Patents

Abstract

(57) [Summary] [Purpose] In a nasal drug dispenser that administers medication into the nasal cavity of a patient, the air sprayed from the drug dispenser is made into a spiral flow, and the drug is conveyed by this spiral flow having straightness, The patient can be reliably dosed. [Structure] A straight passage portion 17B serving as an acceleration passage is formed in the left and right medicine passages 17 formed in the medicine spraying portion 14.
A spiral groove 19 is formed on the tip side of the linear passage portion 17B. As a result, the air containing the chemicals passes through the chemical passage 17
The linear flow path 17B is accelerated, and the spiral groove 19 forms a spiral flow having straightness. As a result, the drug can be reliably transported to the inner wall of the nasal cavity of the patient's nasal cavity.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nasal drug dispenser suitable for use in the nasal administration of powdered medicines filled in capsules.

[0002]

2. Description of the Related Art In general, a method of treating a patient with nasal allergy, asthma or the like by administering a powdered drug through the nasal cavity has been adopted. Further, in this treatment method, a powdery medicine filled in a capsule is administered into the nasal cavity by using a dedicated sprayer.

Further, as a sprayer used in this treatment method, there is known one shown in Japanese Patent Laid-Open No. 59-34267 (hereinafter referred to as prior art).

In this atomizer according to the prior art, a pump portion is provided on the air inflow side of the cylindrical member, a concave portion into which a capsule is inserted is formed on the air outflow side of the cylindrical member, and the tip end of the cylindrical member is formed. A distal end portion having an opening serving as a chemical spray port is detachably provided on the side, and the capsule housing portion is formed inside by fitting the distal end portion to the cylindrical member. Further, the cap has a cap that is detachably fitted to the cylindrical member, and a needle extending in the axial direction is provided in the cap, and the cap is mounted with the distal end fitted to the cylindrical member. As a result, the capsules accommodated in the capsule accommodating portion are perforated.

According to the prior art thus constructed, when the capsule is to be pierced in preparation for drug administration, the capsule filled with the drug in powder form is first inserted into the concave portion of the cylindrical member and then the distal end portion of the cylindrical member is inserted. The capsule is accommodated in the capsule accommodating portion by fitting, and the needle is inserted into the opening portion of the distal end portion so that the cap is attached from the distal end portion. Make holes on both sides.

Next, at the time of administration of the medicine, the cap is removed from the cylindrical member, the tip portion is inserted into one nasal cavity of the patient, and the pump portion is pressed, so that the air from the pump portion passes through the air introduction passage. The drug is circulated in the capsule, the drug in the capsule is sprayed into the nasal cavity of the patient through the opening, and the insertion into the nasal cavity is alternately exchanged to repeat the operation so that the drug is administered to the patient. ing.

Further, in the prior art, since the nasal cavity is dosed alternately to the left and right nasal cavities, a gap is provided between the capsule container and the capsule, and the pump section is pressed only once. The medicine in the capsule is not entirely administered by the operation, and the medicine in the capsule is administered by the operation of about 4 times only in one nasal cavity.

[0008]

By the way, in the above-mentioned conventional atomizer, when the drug in the capsule is administered (sprayed), air from the pump unit causes the drug in the capsule to enter the nasal cavity of the patient from the opening. Since it is sprayed on, the drug is diffused from the opening to the nasal cavity, and there is a problem that the drug adheres to the entrance part on the way to the nasal cavity and cannot reliably administer the drug. .

Further, in the conventional atomizer, since the distance from the capsule to the opening is short, the medicine discharged toward the opening is not sufficiently accelerated, and the medicine conveyed to the nasal cavity is small. Therefore, there is a problem that the administration efficiency is further reduced.

The present invention has been made in view of the above-mentioned various problems of the prior art, and an object of the present invention is to provide a nasal drug dispenser capable of reliably performing drug administration into the nasal cavity.

[0011]

A nasal drug dispenser according to the present invention supplies a capsule holding portion for holding a capsule filled with a powdery medicine inside, and air to the capsule in the capsule holding portion. And a drug spraying part having a drug passage for spraying the drug in the capsule from the spraying port to the nasal cavity of the patient by the air supplied from the pumping part in a state where a hole is formed in the capsule. .

Then, in order to solve the above-mentioned problems,
The feature of the configuration adopted by the invention of claim 1 is that a spiral groove is formed at least in the vicinity of the spray port in the drug passage of the drug spray portion.

According to a second aspect of the present invention, a linear portion is formed in the chemical passage of the chemical spraying portion, and the spiral groove is formed on the tip side of the linear portion.

[0014]

According to the structure of the first aspect of the present invention, the air containing the chemical that has flowed out of the capsule to the medicine passage side by the air supplied from the pump portion is formed in the spiral groove formed near the spray port of the medicine passage. It is discharged as a spiral flow from the spray port by this, and the spiral flow imparts a straight-line property to the chemicals in the air,
The drug can be delivered to the inner wall of the patient's nasal cavity.

According to the second aspect of the present invention, by forming a straight line portion in the drug passage and providing a spiral groove on the tip side of this straight line portion, the drug released from the capsule is straightened while passing through the drug passage. Since the swirling flow is accelerated in the part and swirled in the swirling groove, the straightening property of the drug is enhanced, and the drug can be jetted toward the nasal cavity of the patient in an accelerated state.

[0016]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A nasal drug dispenser according to an embodiment of the present invention will be described below with reference to FIGS.

In the figure, reference numeral 1 shows a nasal cavity drug dispenser according to the present embodiment. The nasal cavity drug dispenser 1 comprises a drug dispenser main body 2 integrally formed with a capsule holder 4 and a drug spraying section 14 described later, and the drug dispenser. A pump unit 12 for supplying air toward a capsule housed in the main body 2, and provided in the drug dispenser main body 2,
It is generally composed of a punch tool 20 for punching a capsule.

Reference numeral 2 denotes a drug dispenser main body, which is made of a resin material in a stepped cylindrical shape, and a lower side (air inflow side) thereof is a small diameter portion 2A, and an outer peripheral surface of the small diameter portion 2A. A male threaded portion 3 to which a female threaded portion 7 of a pump holder 6 to be described later is screwed is formed therein, and the small diameter portion 2A serves as a capsule holder 4. The upper side (air outflow side) of the drug dispenser body 2 is a large diameter portion 2B, and the large diameter portion 2B is a chemical spraying portion 14.

Reference numeral 4 denotes a capsule holder which is formed in the small diameter portion 2A of the drug dispenser body 2 and constitutes a capsule holding portion.
The capsule holder 4 is formed in a cylindrical shape having a small diameter, and a capsule housing hole 5 that opens toward the end face is formed inside the capsule holder 4. After the capsule K is inserted into the capsule housing hole 5, a pump to be described later is formed. Capsule holding protrusion 6E of holder 6
The capsule K is held in the capsule accommodating hole 5 by inserting.

Reference numeral 6 denotes a pump holder for holding the capsule K in the capsule accommodating hole 5, and the pump holder 6 is formed in a bottomed cylinder shape from a cylinder portion 6A, an opening portion 6B and a bottom portion 6C. Further, the pump holder 6 has a partition wall 6D that defines a supply valve chamber 8 to be described later with the bottom 6C, and a partition wall 6D that projects from the partition wall 6D toward the opening 6B and is inserted into the capsule housing hole 5. As a result, a capsule pressing protrusion 6E for pressing the capsule K is formed.

On the inner peripheral surface of the cylindrical portion 6A, a female screw portion 7 screwed to the male screw portion 3 is engraved, and the bottom portion 6C is formed.
And a partition 6D, a supply valve chamber 8 is defined between the bottom 6 and
An air supply passage 9 for supplying air from the pump portion 12 into the supply valve chamber 8 is formed in C. Further, a small-diameter capsule inflow side passage 10 communicating with the supply valve chamber 8 is formed from the partition wall portion 6D to the capsule pressing projection 6E, and a medicine capturing portion 25 described later is formed in the partition wall portion 6D. .

Reference numeral 11 denotes a supply valve which is located in the supply valve chamber 8 of the pump holder 6 and is openably and closably provided in the air supply passage 9. The supply valve 11 is provided when air is supplied from the pump portion 12. Air supply passage 9
Is closed.

Reference numeral 12 is for accommodating the pump holder 6.
The pump portion provided on the outer periphery of the pump holder 6 is shown,
The pump portion 12 is formed of a rubber material into an opening 12A, a bottom portion 12B, and an ellipsoidal shape having a pressing portion 12C on the peripheral surface, and the opening 12A is formed by welding, bonding, or the like to form the opening 6B of the pump holder 6. Is integrally fixed to the bottom 1
A suction valve 13, which will be described later, is attached to the center of 2B.

Reference numeral 13 denotes a suction valve. The suction valve 13 is formed on the bottom portion 12B of the pump portion 12, and is closed when air is supplied from the pump portion 12 and opened when sucked, and the pump portion 12 is supplied from the outside. It is designed to take in air.

Reference numeral 14 denotes a medicine spraying portion formed on the large diameter portion 2B of the drug dispenser main body 2. The medicine spraying portion 14 is formed in a cylindrical shape having a large diameter, and a pair of end surfaces of the large diameter portion 2B are provided. The nasal cavity insertion portions 15 and 15 are formed to project. In addition, in the chemical spraying section 14, the capsule housing hole 5 of the capsule holder 4 is provided.
A capsule outflow side passage 16 and two drug passages 17, 17 branched from the capsule outflow side passage 16 to the left and right and extending in a substantially U shape are formed.
On the tip side of the, there are independent spray ports 18, 18 located inside the nasal cavity insertion portion 15.

Here, the chemical passages 17 and 17 are branched passage portions 17A and 17A which branch left and right from the capsule outflow side passage 16 and are curved upward, and the branch passage portions 17 and 17, respectively.
It is composed of linear passage portions 17B and 17B which are acceleration passages extending from A and 17A toward the nasal cavity insertion portions 15 and 15. Since each of the straight passage portions 17B is formed linearly and long, the air flow from the pump portion 12 can be provided with straightening and straightening properties while passing through the straight passage portion 17B. Therefore, the chemical can be vigorously ejected from the spray port 18 in an accelerated state.

Reference numerals 19 and 19 denote spiral grooves, and the respective spiral grooves 1
9 is formed on the tip side of the linear passage portion 17B of each chemical passage 17. As shown in FIG. 4, each of the spiral grooves 19 gives a spiral flow to the medicine accelerated in the linear passage portion 17B of the medicine passage 17 so that the spiral flow is ejected from the spray port 18 toward the nasal cavity of the patient. It has become.

Reference numeral 20 denotes a hole-piercing tool provided in the chemical spraying section 14 in the axial direction. The hole-piercing tool 20 is substantially coaxial with the pusher 21 slidably provided in the axial direction and the capsule receiving hole 5. 2 is fixed to the pusher 21 as described above, and the tip side extends downward and becomes a cut needle that is inclined
It is composed of a pin 22 having 2A.

Reference numeral 23 denotes a seal rubber located below the perforated portion 22A of the pin 22. The seal rubber 23 is made of an elastic material and surrounds the pin 22 so that the capsule outflow side passage 16 and each chemical passage are formed. It is powder-tight with respect to the chemical flowing in 17, and slidable with respect to the pin 22.

Reference numeral 24 denotes a diffusion chamber located in the middle of the capsule outflow side passage 16 and provided in the chemical spraying section 14. The diffusion chamber 24 is formed so as to have a diameter larger than that of the capsule outflow side passage 16. There is. The diffusion chamber 24 has a radial dimension different from that of the capsule outflow side passage 16, and an air flow collides with the diffusion chamber 24 in the diffusion chamber 24, so that the chemicals and the air are well mixed and the mixing degree is made uniform.

Further, 25 is a partition wall portion 6 of the pump holder 6.
D is a drug catching portion provided in the supply valve chamber 8 so as to be coaxial with the capsule pressing protrusion 6E and to face the supply valve 11, and the capsule inflow side passage 10 is provided in the diameter direction of the drug catching portion 25. A capture passage 25A that communicates with the supply valve chamber 8 is formed. Then, the medicine capturing unit 25 is configured to capture the medicine, which drops to the supply valve 11 side when the perforated portion 22A of the pin 22 penetrates the capsule K at the time of drilling, in the capture passage 25A.

The pump holder 6 and the pump portion 12 are integrated by fixing the opening 6B and the opening 12A to each other by means such as welding or adhering.
1. The pump unit 26 is configured with the suction valve 13, and the entire pump unit 26 is attachable to and detachable from the capsule holder 4 of the medication device main body 2.

The nasal drug dispenser 1 according to the present embodiment has the above-mentioned structure. Next, the handling operation will be described.

First, the medicine dispenser body 2 and the pump unit 26
In the separated state, the capsule K is inserted into the capsule accommodating hole 5, and the pump unit 26 is screwed and attached to the medication device main body 2 again. As a result, the capsule K is firmly fixed between the capsule housing hole 5 and the capsule pressing protrusion 6E of the pump holder 6 in the axially pressed state.

Next, when the capsule K is fixed in the capsule accommodating hole 5, the pin 22 of the punch 20 is moved downward through the pusher 21, and the hole 22A of the pin 22 causes the capsule in the capsule accommodating hole 5 to move. Through holes H, H penetrating in the axial direction are formed in K (see FIG. 2). Then, after forming the through holes H, H in the capsule K, the pin 22 is returned upward, and the drilling operation of the capsule K is completed.

At the time of this drilling work, the capsule K is used.
Although the medicine drops from the through hole H formed in the above, the medicine is captured by the medicine capturing unit 25.

Next, in order to spray the drug in the capsule K, the left and right nasal cavity insertion parts 15 and 15 are inserted into the left and right nasal cavities of the patient, respectively, and as shown in FIG. 1
The second pressing portion 12C is pressed in the arrow P direction.

As a result, the air flow from the pump section 12 flows into the capsule K from the capsule inflow side passage 10 through the through hole H while opening the supply valve 11 that has closed the air supply passage 9. Then, the air flowing into the capsule K stirs the chemical in the capsule K and, together with the chemical, the through hole H, the capsule outflow side passage 16, the diffusion chamber 24.
Since it flows into the left and right drug passages 17 side from the left, the drug in the capsule K is sprayed from the spray ports 18, 18 of the drug passages 17, 17 to the left and right nasal cavity of the patient together with the air supplied from the pump unit 12. be able to. The pump unit 12
Is elastically returned in the direction of the arrow R indicated by the chain double-dashed line by removing the pressing force applied to the pressing portion 12C. At this time, the supply valve 11 is closed and the suction valve 13 is opened, and the pump portion 12 is opened. Outside air is sucked in.

Here, in the nasal drug dispenser 1 according to the present embodiment, the air containing the medicine is straightened while being rectified while passing through the straight passage portion 17B of each medicine passage 17. . Moreover, the linear passage portion 17 of each chemical passage 17
Since the spiral groove 19 is formed on the tip side of B, the air flow accelerated in the straight passage portion 17B of each chemical passage 17 becomes a spiral flow having straightness due to the spiral groove 19, and the spray port 1
Emitted from 8. As a result, the air flow containing the drug ejected from the spray port 18 can be vigorously ejected to the inner wall of the patient's nasal cavity.

As a result, the air jetted from the spray port 18 is accelerated while passing through the straight passage portion 17B of the chemical passage 17, and is also spirally formed by the spiral groove 19 formed near the spray port 18 of the chemical passage 17. It is discharged from the spray port 18 as a straight flow spiral flow. This makes it possible to impart straightness to the medicine sprayed from the spray port 18, prevent the medicine from adhering to the entrance of the nasal cavity, and reliably transport the medicine to the inner wall of the inner part of the nasal cavity of the patient.

On the other hand, at the time of the above-mentioned administration, the air flowing out from the capsule K together with the medicine flows into the diffusion chamber 24 through the capsule outflow side passage 16, so that the diameter difference between the capsule outflow side passage 16 and the diffusion chamber 24 is different. The diffusion chamber 2
The air flow collides with each other in 4 and the degree of mixing with the chemical becomes uniform.

Further, when the capsule K is punched, the drug that has fallen out of the capsule K and has been captured in the drug capturing section 25 is returned to the capsule K side by the air flow supplied from the pump section 12 at the time of administration, and is then returned to the patient. Be administered to.

Thus, according to the present embodiment, each of the chemical passages 17 is provided with the linear passage portion 17B which is formed linearly and long toward the spray port 18 side. Since the acceleration including air is applied to the air, and the spiral groove 19 is formed on the distal end side of the linear passage portion 17B, the medicine is directed from the spray ports 18 toward the inner wall of the left and right nasal cavity of the patient. Can be sprayed vigorously, and the dosing efficiency can be improved.

On the other hand, since the diffusion chamber 24 is formed in the middle of the capsule outflow side passage 16, the air containing the chemicals flowing out from the capsule K is made to collide in the diffusion chamber 24 to make the chemicals mixed with the air uniform. Can be made to flow to each drug passage 17 side, and the amount of the drug to be administered to the left and right nasal cavities of the patient can be made uniform to improve the drug administration efficiency.

Further, a medicine catching section 25 is provided below the capsule accommodating hole 5 so that the medicine falling from the capsule K is caught by the medicine catching section 25 and the medicine caught by the medicine catching section 25 is Since it is returned to the capsule K side during the dispensing operation, the amount of the drug left in the nasal drug dispenser 1 can be reduced, and the prescribed amount of the drug filled in the capsule K can be reliably administered to the patient. At the same time, the frequency of cleaning the nasal medication device 1 can be reduced.

In each of the above embodiments, the pump holder 6
Capsule retainer protrusion 6E, supply valve chamber 8, drug catching section 25
Although the case where these members are integrally formed is illustrated, these members may be provided separately and assembled.

The pump holder 6, the pump portion 12 and the like are integrated to form the pump unit 26. The opening 6B of the pump holder 6 is formed in the capsule holder 4 of the main body 2 of the medicine dispenser.
Removably attached to the outer periphery, the opening 12A of the pump unit 12
The pump holder 6 and the pump unit 12 are separately mounted on the outer circumference of the medicine spraying unit 14 by attaching the pump holder 6 and the pump unit 6 separately.
It may be attached to.

Further, in the above-mentioned embodiment, the spiral groove 19 is formed in the straight passage portions 17B of the left and right chemical passages 17, but the present invention is not limited to this, and the entire length of the chemical passage 17 is formed. Of course, a spiral groove may be formed.

Further, in the main body 2 of the dispenser according to the above-described embodiment, the left and right nasal cavities of the patient can be simultaneously dosed, but the present invention is not limited to this, and one drug passage is alternately provided to the left and right sides. It may be applied to a nasal drug dispenser that inserts a nasal cavity insertion portion into the right nasal cavity and administers medication.

[0050]

As described in detail above, according to the first aspect of the invention, the air containing the drug that has flowed out from the capsule to the drug passage side is formed at least by the spiral groove formed near the spray port of the drug passage. A spiral flow is sprayed from the spray port, and by this spiral flow having linearity, it can be reliably conveyed to the inner part of the nasal cavity, and the administration efficiency can be improved.

According to the second aspect of the present invention, a linear portion is formed in the drug passage, and a spiral groove is provided on the tip side of the linear portion, so that the drug released from the capsule is formed in the straight portion while passing through the drug passage. Since it is accelerated and becomes a swirling flow in the swirling groove, the rectifying property and straightness of the drug are enhanced, and the drug can be vigorously transported to the inner wall of the patient's nasal cavity in an accelerated state, and the drug dosing efficiency is improved. be able to.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing a nasal drug dispenser according to an embodiment of the present invention.

FIG. 2 is a cross-sectional view at the same position as in FIG. 1, showing a state where a pump portion is pressed to spray a chemical from a chemical passage.

FIG. 3 is an enlarged cross-sectional view of a main part in FIG. 2, showing a chemical spraying unit according to an embodiment of the present invention.

FIG. 4 is an enlarged cross-sectional view showing a state in which a chemical is being sprayed from a spray port.

[Explanation of symbols]

 1 Nasal Medicater 4 Capsule Holder (Capsule Retaining Part) 5 Capsule Receiving Hole 12 Pump Part 14 Chemical Spraying Part 17 Chemical Passage (Drug Diffusing Means) 17B Straight Passage (Straight) 18 Spray Port 19 Spiral Groove K Capsule

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Kazunori Ishizeki 1370 Onna, Atsugi, Kanagawa Pref. Within Unisia Jecs Co., Ltd. (72) Akira Yanagawa 5-3 Fujimigaoka, Tsuzuki-ku, Yokohama, Kanagawa

Claims (2)

[Claims] 1. A capsule holding part for holding a capsule filled with a powdery medicine inside, a pump part for supplying air to the capsule in the capsule holding part, and a state in which a hole is formed in the capsule. In the nasal drug dispenser, which comprises a drug spray unit having a drug passage for spraying the drug in the capsule from the spray port toward the nasal cavity of the patient by the air supplied from the pump unit, the drug passage of the drug spray unit The nasal medication device is characterized in that a spiral groove is formed at least near the spray port. 2. The nasal drug dispenser according to claim 1, wherein a linear portion is formed in the drug passage of the drug spraying portion, and the spiral groove is formed on the tip side of the linear portion.