JPH0848619A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic excellent in the remedying effect for chapped and dried skin developed as skin aging goes, also in usability and presenting pigmentation-remedying effect, etc., containing, as active ingredient, methyl methionine sulfonium chloride. CONSTITUTION:This skin cosmetic contains pref. 0.05-5.0wt.%, based on the whole cosmetic, of methyl methionine sulfonium chloride of the formula, and can be made into a form of lotion, cream, milky lotion or pack. This cosmetic has significant chapped skin-remedying effect, being excellent in usability. Besides, this cosmetic has the suppressive effect against melanogenesis due to ultraviolet light and rapid fading effect for pigmentation, causing no onset of skin irritancy due to ultraviolet light, and also being good in preservability.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic excellent in preventing skin aging and whitening skin. More specifically, skin cosmetics that are excellent in the effect of improving rough skin and dry skin caused by aging of the skin, and are also excellent in usability,
The present invention also relates to a skin cosmetic having excellent skin safety, an effect of improving skin pigmentation due to ultraviolet rays, an effect of quickly lightening dark skin, and an excellent storage stability.

[0002]

2. Description of the Related Art Aged skin is dry and non-smooth rough skin in which keratinocyte exfoliation phenomenon is observed. It is said that aging skin has a slow turnover speed, and that the turnover speed increases when the skin has an antiaging effect.

Conventionally, there are many skin anti-aging cosmetics containing various anti-aging agents in the market. However, these skin anti-aging cosmetics are generally slow in the effects of anti-aging and the like, and the effects appear only after continuous use for a long period of time, which is not sufficiently satisfactory and leaves room for improvement. It was the reality.

In view of such circumstances, the inventors of the present invention have made earnest researches to improve the difficulties of the prior art, and as a result,
A skin cosmetic characterized by containing methylmethionine sulfonium chloride improves the rough skin early by densifying and promoting the structure of rough skin caused by aging, and is also excellent in terms of usability. As a result, the present invention has been completed.

On the other hand, the skin is inflamed (erythema) by ultraviolet rays and various factors are released to stimulate melanocytes.
As a result, the color tone changes and blackens. This blackening is due to the overproduction of melanin produced in melanocytes and delivered to epidermal cells.

[0006] Conventionally, whitening cosmetics containing various whitening agents such as L-ascorbic acid are often found in the market in order to prevent blackening, stains and freckles of the skin and maintain the original white skin. .

However, in many cases, the storage stability in the preparation is insufficient, and the effect of improving pigmentation and whitening effect by ultraviolet rays are not sufficiently observed in many cases. As described above, it is difficult to obtain a whitening cosmetic composition which is excellent in pigmentation improving effect and whitening effect, has high skin safety, and is excellent in storage stability.

[0008] In view of such circumstances, the inventors of the present invention have made earnest researches to improve the difficulties of the prior art, and as a result,
It was found that a skin cosmetic characterized by containing methylmethionine sulfonium chloride has a pigmentation improving effect, an excellent whitening effect, a high skin safety, and an excellent storage stability, and has completed the present invention. It was

Methylmethionine sulfonium chloride used as an active ingredient of the skin cosmetic of the present invention is used in the field of medicine as a therapeutic agent for peptic ulcer or liver disease. However, the antiaging effect and the whitening effect of this compound have not been known at all. The chemical formula of this compound is represented by C ₆ H ₁₄ ClNO ₂ S, and its molecular weight is 199.70. Its appearance is white crystals or crystalline powder with a slight peculiar odor and a weak salty taste.
Hygroscopic, extremely soluble in water, easily soluble in glacial acetic acid or formic acid, almost insoluble in ethanol and ether. The melting point is about 140 ° C. Also, the pH is 4.0-
It is 5.0 (5% aqueous solution).

That is, the present invention provides a skin cosmetic which is excellent in improving rough skin and dry skin caused by aging of the skin, and is also excellent in usability, and is effective in improving pigmentation and whitening effect. It is an object of the present invention to provide a skin cosmetic having excellent skin stability, high skin safety, and excellent storage stability.

[0011]

In order to achieve the above object, the skin cosmetic of the present invention has the following constitution. That is, structural formula 2

Embedded image A skin cosmetic comprising a methylmethionine sulfonium chloride represented by:

The amount of methylmethionine sulfonium chloride incorporated into the skin cosmetic of the present invention is preferably 0.05 to 5.0% by weight, based on the total amount.

The skin cosmetic of the present invention can be formulated into lotions, creams, emulsions, packs and the like according to a conventional method.

The skin cosmetic of the present invention includes a tar pigment, a coloring pigment such as iron oxide, a preservative such as paraben,
Anionic surfactants such as fatty acid soap, sodium cetyl sulfate, sodium N-stearoyl-L-glutamate, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil , Polyhydric alcohol fatty acid ester, nonionic surfactant such as polyglycerin fatty acid ester, cationic surfactant such as tetraalkylammonium salt, amphoteric surfactant such as betaine type, sulfobetaine type, sulfoamino acid type, lecithin , Natural surfactants such as lysophosphatidylcholine, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents, various vitamins, various amino acids, various animal and plant extract extracts, etc. It can be appropriately blended within the range to achieve the target.

[0015]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The present invention is not limited to these. In addition,% used in Examples and Comparative Examples means% by weight.

Further, used in the present invention, (1) rough skin practical test, (2) sensory test (feeling of use), (3) tyrosinase activity inhibition test, (4) skin color lightness recovery test,
The test methods of (5) whitening practical test, (6) optical patch test, and (7) storage stability test are as follows.

(1) Practical test for rough skin Female panelists (25 to 50 years old) who complain of rough and dry skin
Twenty people in each group were applied to the face with the Examples or Comparative Examples twice a day continuously for one month. The evaluation was shown by the number of people who answered that "rough skin was improved".

(2) Sensory test (feeling of use) 20 panelists from each group evaluated the characteristics after continuously using the example and the comparative example for 10 days on the face. The evaluation is shown by the number of respondents who answered “Affinity is good” to the questionnaire items regarding affinity.

(3) Tyrosinase activity inhibition test 0.3 mg / ml in McClubain buffer (pH 6.8)
Add the sample solution of each concentration to the tyrosine solution of ml concentration, and
Preliminary incubation was performed at 10 ° C for 10 minutes. To this was added 0.1 ml of 1 mg / ml tyrosinase (Sigma) and 37 ° C.
After heating for 15 minutes at 4 ° C using a spectrophotometer,
Absorbance (A) was measured at 75 nm. On the other hand, the absorbance (B) of 0.1 ml of buffer solution added in place of tyrosinase, the absorbance (C) of 0.1 ml of buffer solution in place of the sample solution, and the buffer solution 0.1% in place of sample solution and tyrosinase. The absorbance (D) of 2 ml was measured, and the inhibition rate (%) was calculated according to the following formula.

Inhibition rate (%) = [1- (AB) / (CD)] × 100

(4) Skin color lightness recovery test The skin of the left and right upper arms of 20 subjects was irradiated with the minimum erythema dose of UV rays in the UVA and UVB regions for 3 days. After the irradiation, the reference lightness (V
0 value, V0 'value) was measured. Subsequently, the examples and comparative examples were applied to the irradiation site three times a day for four consecutive weeks. 1, 2, and 4 weeks after the start of irradiation, the skin lightness (Vn value, Vn 'value) of the skin of the application part of the invention and the skin of the application part of the comparative example was measured, and the recovery of the skin color was evaluated according to the criteria shown in Table 1.

The brightness of the skin (V value of Munsell display system)
Was calculated from X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation was shown by the average value of the evaluation points of 20 subjects after 4 weeks.

[0023]

[Table 1]

(5) Practical Whitening Test A forearm flexion side skin of 20 subjects exposed to sunlight in summer for 3 hours (1.5 hours a day for 2 days) was applied to the left and right forearm flexion side skin. From the day of exposure to sunlight, the example and the comparative example were applied once in the morning and in the evening for eight consecutive weeks.

The evaluation was shown by the number of subjects for whom it was confirmed that the skin lightening effect of the application part of the example was stronger than that of the application part of the comparative example.

(6) Optical patch test Twenty-five subjects were tested with a patch test plaster of 1.0 cm in diameter, which was prepared by applying 0.05 g of the sample to the skin on the flexion side of the forearm.
Timed closed patch. After removal of the patch, it was exposed to summer sunlight for 1 hour (1 day total).

In the evaluation, the photopatch test was positive when the skin reaction (erythema, edema, etc.) was strong as compared with the non-coated part. The determination result was represented by the number of people who showed positive results.

(7) Storage stability test method The sample was placed in a thermostatic chamber at 45 ° C. and observed over time, and evaluated according to the criteria shown in Table 2. The term "abnormal" means a phenomenon in which discoloration or odor occurs, precipitation occurs in lotion, and phase separation occurs in an emulsion.

[0029]

[Table 2]

Examples 1 and 2, Comparative Example 1 [lotion] (prescription)

[0031]

[Table 3]

(Preparation method) After the components A and B shown in Table 3 were uniformly dissolved, the component B was uniformly mixed with the component A with stirring and dispersion to obtain a product.

Examples 3 to 4 and Comparative Example 2 [skin cream] (composition)

[0034]

[Table 4]

(Preparation method) The components A and B shown in Table 4 were uniformly heated and dissolved to bring the temperature to 80 ° C. Then,
After injecting and emulsifying the B component in the A component, stir 3
Cooled to 0 ° C.

The rough skin test and the sensory test were carried out on Examples 1 to 4 and Comparative Examples 1 and 2. The results are shown in Table 5.

[0037]

[Table 5]

As shown in Table 5, it is clear that each example is excellent in the rough skin improving effect and the feeling of use.

Test Example 1 (Tyrosinase activity inhibition test) Table 6 shows the tyrosinase activity inhibition rate of methylmethionine sulfonium chloride measured by this method.

[0040]

[Table 6]

From Table 6, it was found that methylmethionine sulfonium chloride has an anti-tyrosinase action.

With respect to Examples 1 to 4 and Comparative Examples 1 and 2, the skin lightness recovery test, the whitening practical test, the optical patch test and the storage stability test were carried out. The results are shown in Table 7.

[0043]

[Table 7]

As shown in Table 7, the lotions of Examples 1 and 2 showed remarkable results in all the tests. Similarly, the skin creams of Examples 3 to 4 also showed remarkable results in all the tests.

[0045]

Industrial Applicability As described above, the present invention provides a useful skin cosmetic having a remarkable rough skin improving effect and an excellent feeling of use, and further, an effect of suppressing the production of melanin pigment in the skin by ultraviolet rays, a skin It is clear that it provides an excellent skin cosmetic which has a rapid lightening effect of pigmentation, does not cause skin irritation due to ultraviolet rays, and has high storage stability.

Front page continuation (72) Inventor Toshio Hikima 5-3 28, Kotobuki-cho, Odawara-shi, Kanagawa Kanebo Co., Ltd.

Claims (1)

[Claims] 1. The following structural formula: A skin cosmetic comprising a methylmethionine sulfonium chloride represented by: