JPH08511936A - 多発性硬化症ウィルス - Google Patents
多発性硬化症ウィルスInfo
- Publication number
- JPH08511936A JPH08511936A JP7500386A JP50038694A JPH08511936A JP H08511936 A JPH08511936 A JP H08511936A JP 7500386 A JP7500386 A JP 7500386A JP 50038694 A JP50038694 A JP 50038694A JP H08511936 A JPH08511936 A JP H08511936A
- Authority
- JP
- Japan
- Prior art keywords
- hmsv
- genome
- polypeptide
- antibody
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000006417 multiple sclerosis Diseases 0.000 title claims abstract description 34
- 241000700605 Viruses Species 0.000 title claims abstract description 28
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 53
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 53
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- 241000894007 species Species 0.000 claims description 8
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- 210000004027 cell Anatomy 0.000 description 29
- 108020004414 DNA Proteins 0.000 description 13
- 235000001014 amino acid Nutrition 0.000 description 13
- 239000002299 complementary DNA Substances 0.000 description 12
- 235000018102 proteins Nutrition 0.000 description 10
- 239000012634 fragment Substances 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 230000027455 binding Effects 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 241001430294 unidentified retrovirus Species 0.000 description 5
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
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- 241001493065 dsRNA viruses Species 0.000 description 2
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- 230000002452 interceptive effect Effects 0.000 description 2
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- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 241000004176 Alphacoronavirus Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000714198 Caliciviridae Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
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- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 241000709664 Picornaviridae Species 0.000 description 1
- 241000712907 Retroviridae Species 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000555745 Sciuridae Species 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 210000000349 chromosome Anatomy 0.000 description 1
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- 238000012258 culturing Methods 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- 210000000416 exudates and transudate Anatomy 0.000 description 1
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- 230000004927 fusion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 150000002669 lysines Chemical class 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
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- 230000007659 motor function Effects 0.000 description 1
- 210000003007 myelin sheath Anatomy 0.000 description 1
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- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 108010091748 peptide A Proteins 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 108700004029 pol Genes Proteins 0.000 description 1
- 101150088264 pol gene Proteins 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 102220201851 rs143406017 Human genes 0.000 description 1
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- 238000002424 x-ray crystallography Methods 0.000 description 1
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4-130828 | 1992-05-22 | ||
| GB939310657A GB9310657D0 (en) | 1993-05-24 | 1993-05-24 | Retrovirus |
| GB9310657.3 | 1993-05-24 | ||
| PCT/GB1994/001129 WO1994028138A1 (en) | 1993-05-24 | 1994-05-24 | Multiple sclerosis virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO1993024121A1 JPWO1993024121A1 (ja) | 1994-06-02 |
| JPH08511936A true JPH08511936A (ja) | 1996-12-17 |
Family
ID=10736021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7500386A Pending JPH08511936A (ja) | 1993-05-24 | 1994-05-24 | 多発性硬化症ウィルス |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6136528A (de) |
| EP (1) | EP0700441B1 (de) |
| JP (1) | JPH08511936A (de) |
| AT (1) | ATE274584T1 (de) |
| AU (1) | AU676568B2 (de) |
| CA (1) | CA2163641C (de) |
| DE (1) | DE69433964T2 (de) |
| ES (1) | ES2227525T3 (de) |
| GB (1) | GB9310657D0 (de) |
| WO (1) | WO1994028138A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727428B1 (fr) * | 1994-11-24 | 1997-04-30 | Bio Merieux | Virus msrv1 associe a la sclerose en plaques et ses constituants nucleiques |
| FR2715937A1 (fr) * | 1994-02-04 | 1995-08-11 | Bio Merieux | Virus MSRV1 et MSRV2 associés ensemble à la sclérose en plaques et leurs constituants nucléiques. |
| FR2728585A1 (fr) * | 1994-12-23 | 1996-06-28 | Bio Merieux | Virus msrv1 et agent pathogene et/ou infectant msrv2 associes a la sclerose en plaques et leurs constituants nucleiques |
| FR2689520B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
| FR2689521B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede d'obtention et maintien d'une culture cellulaire viable, infectee par un virus associe a la sclerose en plaques, et produits biologiques derives de ladite culture. |
| NZ279855A (en) * | 1994-02-04 | 1998-05-27 | Bio Merieux | Msrv1 and msrv2 pathogenic and/or infectious agents associated with ms, nucleic acids encoding them and diagnostic and therapeutic applications |
| FR2716198B1 (fr) * | 1994-02-15 | 1996-04-19 | Bio Merieux | Facteur cytotoxique tel qu'associé à la sclérose en plaques, sa détection et sa quantification. |
| FR2731356B1 (fr) * | 1995-03-09 | 1997-04-30 | Bio Merieux | Virus msrv-1 et agent pathogene et/ou infectant msrv-2 associes a la polyarthrite rhumatoide |
| FR2737500B1 (fr) | 1995-08-03 | 1997-08-29 | Bio Merieux | Materiel viral et fragments nucleotidiques associes a la sclerose en plaques, a des fins de diagnostic, prophylactiques et therapeutiques |
| WO1998023755A1 (en) * | 1996-11-26 | 1998-06-04 | Bio Merieux | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes |
| FR2765588A1 (fr) | 1997-07-07 | 1999-01-08 | Bio Merieux | Materiel nucleique retroviral et fragments nucleotidiques notamment associes a la sclerose en plaques et/ou la polyarthrite rhumatoide, a des fins de diagnostic, prophylactiques et therapeutiques |
| JP2002511277A (ja) * | 1998-04-08 | 2002-04-16 | エムエス・リサーチ・アクティーゼルスカブ | 多発性硬化症および他の脱髄性疾患の診断 |
| FR2788784A1 (fr) | 1999-01-21 | 2000-07-28 | Bio Merieux | Fragment nucleique endogene associe a une maladie auto-immune, procede de marquage et reactif |
| EP1029917A1 (de) * | 1999-02-15 | 2000-08-23 | Bio Merieux | Die LTR-Region von MSRV und die durch sie kodierten Proteine, und Sonden und Methoden für Detektion des MSRV-1 Retrovirus |
| FR2791140B1 (fr) * | 1999-03-19 | 2002-03-22 | Bio Merieux | Procede de detection d'une activite superantigenique dans un echantillon et composition therapeutique ou prophylactique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ218050A (en) * | 1985-11-13 | 1989-05-29 | Wistar Inst | Test for the presence of htlv-1v |
| CA2095539A1 (en) * | 1990-11-14 | 1992-05-15 | Robert D. Cook | Diagnosis and treatment of multiple sclerosis |
-
1993
- 1993-05-24 GB GB939310657A patent/GB9310657D0/en active Pending
-
1994
- 1994-05-24 EP EP94915674A patent/EP0700441B1/de not_active Expired - Lifetime
- 1994-05-24 US US08/553,411 patent/US6136528A/en not_active Expired - Fee Related
- 1994-05-24 AU AU67600/94A patent/AU676568B2/en not_active Ceased
- 1994-05-24 AT AT94915674T patent/ATE274584T1/de not_active IP Right Cessation
- 1994-05-24 CA CA002163641A patent/CA2163641C/en not_active Expired - Fee Related
- 1994-05-24 WO PCT/GB1994/001129 patent/WO1994028138A1/en not_active Ceased
- 1994-05-24 JP JP7500386A patent/JPH08511936A/ja active Pending
- 1994-05-24 DE DE69433964T patent/DE69433964T2/de not_active Expired - Fee Related
- 1994-05-24 ES ES94915674T patent/ES2227525T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU676568B2 (en) | 1997-03-13 |
| GB9310657D0 (en) | 1993-07-07 |
| AU6760094A (en) | 1994-12-20 |
| CA2163641A1 (en) | 1994-12-08 |
| WO1994028138A1 (en) | 1994-12-08 |
| ES2227525T3 (es) | 2005-04-01 |
| US6136528A (en) | 2000-10-24 |
| DE69433964T2 (de) | 2005-09-08 |
| EP0700441B1 (de) | 2004-08-25 |
| CA2163641C (en) | 2003-12-30 |
| EP0700441A1 (de) | 1996-03-13 |
| ATE274584T1 (de) | 2004-09-15 |
| DE69433964D1 (de) | 2004-09-30 |
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