JPH09110708A - Nutritional tonic crude drug combination preparation - Google Patents

Abstract

(57) [Summary] [Purpose] To improve the feeling of ingestion of a drug containing a nutritional tonic crude drug. [Constitution] (a) one or more kinds of herbal medicine for nutritional tonic, (b) one or more kinds of ingredients selected from the group consisting of vitamin B group, nicotinamide and caffeine, and (c) stevia. Which has a bitterness ingredient content and a stevia compounding ratio of 1 part by weight of the bitterness ingredient content in the range of 0.001 parts by weight to 0.1 parts by weight of stevia. Tonic crude drug formulation.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a flavor improvement of a medicine containing a nutritional tonic crude drug.

[0002]

BACKGROUND OF THE INVENTION Stevia is a Stevia Rebau.
diana Bertoni is a sweetener mainly composed of a sweetening ingredient contained in leaves of a perennial plant of the Asteraceae family.

On the other hand, a nutritional tonic crude drug mixture preparation usually contains active ingredients such as vitamin B group, nicotinic acid amide, biotin, ammonium ferric citrate, and caffeine in addition to the nutritional tonic crude drug. Many of the nutritional tonic crude drugs have a bitter taste, and even if a nutritional tonic crude drug that does not have bitterness is compounded, the vitamin B group that is simultaneously compounded,
The nicotinic acid amide, caffeine and the like had a bitter taste, and thus the herbal medicine for nutritional tonic formulation had a poor feeling of ingestion. In order to improve this, conventionally, sucrose was blended to mask the bitterness, but the bitterness masking effect is not sufficient, and the flavor becomes poor (for example, sucrose was blended). In some cases, there was inconvenience, such as sweetness remaining after administration and dullness, or excessive intake of calories), and improvement in the feeling of administration was not sufficient.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to improve the feeling of ingestion of a nutritional tonic crude drug mixture preparation.

[0005]

[Means for Solving the Problems] In order to solve the above problems, the present inventors have conducted various studies using various sweeteners, and as a result, have used stevia as a sweetening ingredient and blended a nourishing tonic crude drug having a bitter taste. When blended in a specific proportion in the formulation,
The present invention has been completed by discovering that a formulation that is easy to take can be obtained.

That is, the present invention comprises (a) one or more kinds of nutritional tonic crude drugs (b) vitamin B group, nicotinic acid amide, biotin, ammonium ferric citrate, calcium pantothenate, and caffeine. A preparation containing one or more selected ingredients and (c) stevia, wherein the bitterness ingredient content and the stevia content in the preparation are 0.001 parts by weight of stevia per 1 part by weight of the bitterness ingredient content. To 0.1 part by weight, which is a herbal herbicide formulation for nutritional tonicity.

[0007] The herbal medicine for nutritional tonicity used in the present invention means akako, inchinko, fennel, oyster, ougi, ousei, oataku, ouren, kaiba, gauze, kanzo, kyoukou, kokushi, kujin, keihi, ketsumei, kouka, gokai, Kobushi, kokotsu, goshuyu, kotonin, saffron, sanshyu, hawthorn,
Sansho, Sansonin, Sanyaku, Zio, Zikoppi, Sikon, Civet, Peonies, Shajin (Rhododendron ginseng), peony, Jukujiou, Shuksha, Joteishi, Shinkyku, Jinkou, Hawthorn, Sakinayo, Sekoku, Sengoku, Senso, Daitai, Taio, Musk Root, Taksha, Clove, Chorei, Chinpi, Tenmondou, Tojin,
Eucommia ulmoides, euglena, spruce, horsetail, eucommia, pearl oyster, bayite, hazelnut, bakumondou, bald, hub, hampi, sandalnut, fukubonshi, bukuryou, safflower, bowfish, kokushi, button pie, matabi, makuryuu, mokko, koukou.
It is one kind or two or more kinds selected from the group consisting of Ryukotsu, antelope, and rennik, among which, bitter melon, sardine, oxoamidine (garlic), onji, kaizin, cashew, guarana, kojin, gooh, gokahi (shigoka), which have bitterness, Oxamidine has a large effect of improving the feeling of ingestion when one or more kinds selected from the group consisting of garlic, carrot, psycho, jashikoushi, ginger, touki, muirapuama, yutan, yokinin, ryuno, ryutan and roquejo are used. The effect of improving ingestion is greatest when one or more selected from the group consisting of (garlic), gohwa, gokahi (shigoka), carrot, psycho, muirapuama and roquejo are used.

The vitamin B group means vitamin B ₁ ,
Refers to vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ and derivatives thereof. Stevia is Stevioside, Rebaudioside A, Zulcoside A, Zulcoside B, Rebaudioside E, Rebaudioside D, Steviorbioside, Rebaudioside B, Steviol, etc.
It refers to a mixture of known Stevia extracts or one obtained by isolating one of these components, and it also includes the above-mentioned known Stevia extracts that have been subjected to an enzyme treatment in order to increase the sweetness.
Among these, those having a high content of rebaudioside A are preferable.

The preparation of the present invention contains, in addition to the above-mentioned active ingredients, other known additives, such as excipients and disintegrants, if necessary.
Binder, lubricant, antioxidant, coating agent, colorant,
Oral preparations such as granules, powders, capsules, tablets, dry syrups, and liquids can be prepared by mixing a flavoring agent, a surfactant, a plasticizer and the like by a conventional method.

Examples of the excipient include mannitol, xylitol, sorbitol, glucose, white, lactose, crystalline cellulose, crystalline cellulose / carboxymethyl cellulose sodium, calcium hydrogen phosphate, wheat starch, rice starch, corn starch, potato starch, Sodium carboxymethyl starch,
Dextrin, α-cyclodextrin, β-cyclodextrin, carboxyvinyl polymer, light anhydrous silicic acid, titanium oxide, magnesium aluminometasilicate,
Examples thereof include polyethylene glycol and medium chain fatty acid triglyceride. As the disintegrant, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose,
Examples include carboxymethyl cellulose calcium, carboxymethyl cellulose sodium, croscarmellose sodium type A (actisol), starch, crystalline cellulose, hydroxypropyl starch, partially pregelatinized starch and the like.

Examples of the binder include methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, gelatin, gum arabic, ethyl cellulose, polyvinyl alcohol, pullulan, pregelatinized starch, agar, taragant, sodium alginate, propylene glycol alginate, etc. Is mentioned.

Examples of the lubricant include stearic acid, magnesium stearate, calcium stearate, cetanol, talc, hardened oil, sucrose fatty acid ester, microcrystalline wax, beeswax, and beeswax.

Examples of the antioxidant include dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), α-tocopherol,
Citric acid and the like.

Examples of the coating agent include hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose, cellulose acetate phthalate, polyvinyl acetal diethylaminoacetate, aminoalkyl meta. Examples thereof include acrylate copolymer, hydroxypropylmethyl cellulose acetate succinate, methacrylic acid copolymer, cellulose acetate trimellitate (CAT), polyvinyl acetate phthalate, shellac and the like.

Examples of colorants include tar dyes and titanium oxide. Examples of the surfactant include polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymer, polysorbates, sodium lauryl sulfate, macrogol, sucrose. Examples thereof include fatty acid esters.

Examples of the plasticizer include triethyl citrate, triacetin, cetanol and the like. Also, if desired, other physiologically active ingredients, hormones, nutritional ingredients, flavors and the like may be mixed to impart palatability. As all of these pharmaceutically acceptable additives, those generally used in preparations can be used.

[0017]

EFFECTS OF THE INVENTION According to the present invention, it is resistant to heat, relatively stable to acid, highly safe, can be used with confidence, has a mild sweetness, a low aftertaste, and is non-fermentable.
It has become possible to provide a nourishing and tonic crude drug formulation having an excellent ingestion feeling that does not cause a browning effect by heat treatment. Therefore, the nutritional tonic crude drug combination preparation of the present invention is a nutritional tonic, weak constitution, physical fatigue, post-disease illness, gastrointestinal disorder (weakness), loss of appetite, poor blood color, coldness, nutritional disorders, febrile wasting disease, pregnancy and lactation. It is useful for prevention or treatment such as nutritional supplementation in cases such as periods.

[0018]

EXAMPLES The present invention will be specifically described below with reference to examples and test examples. Example 1 (Prescription example 1) Shigoka extract (amount of crude drug equivalent: 400 mg) 16 mg Gomishi extract (amount of equivalent of crude drug: 200 mg) 0.2 mg Eucommia ulmoides extract (amount of equivalent of crude drug: 200 mg) 0.2 ml Vitamin B1 4 mg Vitamin B2 4 mg Vitamin B6 4 mg Vitamin B12 6.5 μg Nicotinamide 15 mg Carnitine chloride 50 mg Calcium pantothenate 5 mg Biotin 200 μg Inositol 30 mg Calcium gluconate 450 mg Taurine 800 mg The above drug and stevia (15 mg), A D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water were mixed to give a 50 ml solution.

Example 2 (Prescription example 2) Shigoka extract (raw drug equivalent: 400 mg) 16 mg Gomishi extract (raw drug equivalent: 200 mg) 0.2 mg Eucommia ulmoides extract (raw drug equivalent: 200 mg) 0.2 ml Vitamin B1 4 mg Vitamin B2 4 mg Vitamin B6 4 mg Nicotinamide 15 mg Carnitine chloride 50 mg Calcium pantothenate 5 mg Calcium gluconate 450 mg Magnesium aspartate 100 mg Ammonium iron citrate 10 mg Taurine 800 mg The above drugs and Stevia (15 mg) ), D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil, and distilled water were mixed to prepare a 50 ml solution.

Example 3 (Formulation Example 3) Muirapuama extract (amount of crude drug equivalent: 300 mg) 15 mg Carrot extract (amount of crude drug equivalent: 600 mg) 90 mg Ougi extract (amount of crude drug equivalent: 300 mg) 0.3 ml licorice extract (Original drug equivalent: 200 mg) 50 mg Bukuro extract (Original drug equivalent: 300 mg) 9.6 ml Jukujyou extract (Original drug equivalent: 600 mg) 300 mg Touki extract (Original drug equivalent: 400 mg) 0.4 ml Peony extract (amount of crude drug equivalent: 120mg) 12 mg Keihi extract (amount of crude drug equivalent: 300mg) 0.3 ml Yokuinin extract (amount of crude drug equivalent: 600mg) 0.6 ml Ginger extract (amount of crude drug equivalent: 300 mg) 1.5 ml Taurine 500 mg Vitamin B1 5 mg Vitamin B2 5 mg Vitamin B6 5 mg Calcium pantothenate 5 mg Caffeine 50 mg The above drug and stevia (15 mg), D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water were mixed to give a 50 ml liquid preparation.

Example 4 (Prescription example 4) Psycho extract (amount of crude drug equivalent: 200 mg) 12 mg Taizo extract (amount of crude drug equivalent: 100 mg) 0.3 ml Ginger extract (amount of crude drug equivalent: 75 mg) 18. 75 mg licorice extract (converted amount of crude drug: 150 mg) 7.2 mg carrot extract (converted amount of crude drug: 400 mg) 400 mg peony extract (converted amount of crude drug: 45 mg) 0.3 ml Keihi extract (converted amount of crude drug: 100 mg) 0.3 ml Taurine 500 mg Vitamin B1 4 mg Vitamin B2 4 mg Vitamin B6 4 mg Nicotinic acid amide 15 mg Calcium pantothenate 5 mg Carnitine chloride 50 mg The above drug and stevia (15 mg), D-sorbitol solution, benzoic acid , Sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water are mixed, and 50 ml liquid And the.

Example 5 (Formulation Example 5) Muirapuama extract (amount of crude drug equivalent: 300 mg) 15 mg Carrot extract (amount of crude drug equivalent: 600 mg) 90 mg Sun yak extract (amount of crude drug equivalent: 300 mg) 0.3 ml Bukyou extract (amount of crude drug equivalent: 300mg) 9.6 mg dio extract (amount of equivalent of crude drug: 300mg) 150 mg Cistanche salsa extract (amount of crude drug equivalent: 500mg) 151.6 mg eucommia extract (amount of equivalent crude drug: 300mg) ) 0.3 ml Jashoushi extract (amount of crude drug equivalent: 300 mg) 600 mg Toshishi extract (amount of crude drug equivalent: 300 mg) 33 mg Goshishi extract (amount of crude drug equivalent: 300 mg) 0.3 ml Sanshuyu extract (amount of original drug equivalent) : 500 mg) 0.5 ml Onji extract (amount of crude drug equivalent: 300 mg) 0.3 ml Bakmondou extract (amount of crude drug equivalent: 300 mg) 300 μg Extract (Original drug equivalent: 300 mg) 1.08 mg Chinese cabbage extract (Original drug equivalent: 100 mg) 100 mg Caixin extract (Original drug equivalent: 100 mg) 500 mg Eucommia ulmoides extract (Original drug equivalent: 330 mg) 0.33 ml Hampi extract (raw drug equivalent: 250 mg) 1.25 ml Taurine 500 mg Vitamin B1 5 mg Vitamin B2 5 mg Vitamin B6 5 mg Calcium pantothenate 5 mg Caffeine 50 mg The above drug and stevia (15 mg), D -Sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water were mixed to make a 50 ml solution.

Example 6 (Prescription Example 6) Muirapuama extract (amount of crude drug equivalent: 300 mg) 15 mg Carrot extract (amount of equivalent of crude drug: 600 mg) 90 mg Ougi extract (amount of equivalent of crude drug: 600 mg) 0.6 ml Raw drug equivalent: 600 mg) 0.6 ml Licorice extract (raw drug equivalent: 150 mg) 37.5 mg Taizo extract (raw drug equivalent: 300 mg) 91 mg Touki extract (raw drug equivalent: 50 mg) 0.05 ml Psycho extract (Amount of crude drug equivalent: 150 mg) 0.15 ml Ginger extract (Amount of crude drug equivalent: 75 mg) 0.375 ml Inyoukaku extract (Amount of crude drug equivalent: 1000 mg) 100 mg Hampitinki (Equivalent amount of crude drug: 250 mg) 1.25 ml Taurine 500 mg Vitamin B1 5 mg Vitamin B2 5 mg Vitamin B6 5 mg Vitamin B12 13 μg Caffeine 50 mg The agent was mixed with stevia (15 mg), D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water to give a 50 ml solution.

Example 7 (Formulation Example 7) Muirapuama extract (amount of crude drug equivalent: 300 mg) 15 mg dio extract (amount of crude drug equivalent: 300 mg) 150 mg Kukoshi extract (amount of crude drug equivalent: 300 mg) 0.3 ml Toki extract ( Raw drug equivalent: 50 mg) 0.05 ml Carrot extract (active substance equivalent: 300 mg) 90 mg Astragalus extract (active substance equivalent: 300 mg) 0.3 ml Chinese radish extract (active substance equivalent: 300 mg) 0.3 ml Licorice Extract (raw drug equivalent: 150 mg) 37.5 mg Rokujou extract (raw drug equivalent: 300 mg) 1.08 ml Inyoukaku extract (raw drug equivalent: 1000 mg) 100 mg Hampi extract (raw drug equivalent: 250 mg) ) 1.25 ml Keihi extract (amount of crude drug equivalent: 150 mg) 0.15 ml Bukuro extract (amount of crude drug equivalent: 300 mg) 9.6 mg Taurine 500 mg Vitamin B15 mg Vitamin B2 5 mg Vitamin B6 5 mg Calcium pantothenate 5 mg Caffeine 50 mg The above drug and stevia (15 mg), D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water are mixed. , 50 ml liquid formulation.

Example 8 (Formulation Example 8) Muirapuama extract (amount of crude drug equivalent: 300 mg) 15 mg Cistanche salsa extract (amount of crude drug equivalent: 500 mg) 151.6 mg Jashoushi extract (amount of crude drug equivalent: 300 mg) ) 600 mg Toshishi extract (amount of crude drug equivalent: 300 mg) 33 mg Eucommia essence extract (amount of equivalent to crude drug: 300 mg) 0.3 ml Kaikijin extract (amount of equivalent to crude drug: 100 mg) 500 mg 300 mg) 1.08 ml Chinese cabbage extract (amount of crude drug equivalent: 1000 mg) 100 mg Carrot extract (amount of crude drug equivalent: 600 mg) 90 mg Sanyaku extract (amount of crude drug equivalent: 300 mg) 0.3 ml Ginger extract (raw substance) Crude drug equivalent: 300 mg) 150 mg Hampi extract (crude drug equivalent: 250 mg) 1.25 ml Sanshuyu extract (crude drug equivalent: 500 mg) 0.5 ml Garlic extract (primitive drug) Medication equivalent: 300 mg) 0.3 ml Bukyou extract (Amount of crude drug equivalent: 300 mg) 9.6 mg Taurine 500 mg Vitamin B1 5 mg Vitamin B2 5 mg Vitamin B6 5 mg Vitamin B12 13 μg Caffeine 50 mg Stevia (15 mg), D-sorbitol solution, benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water were mixed to give a 50 ml solution.

Example 9 (Prescription example 9) Taurine 2000 mg Shigoka extract (amount of crude drug equivalent: 600 mg) 24 mg Kukushi extract (amount of crude drug equivalent: 600 mg) 0.6 ml Nikujo extract (amount of crude drug equivalent: 600 mg) 182 mg Arginine hydrochloride 300 mg Vitamin B1 derivative 7 mg Vitamin B2 5 mg Vitamin B6 5 mg Nicotinamide 30 mg Inositol 100 mg Caffeine 50 mg The above drug and stevia (15 mg), D-sorbitol solution, benzoic acid, sodium citrate, Polyoxyethylene hydrogenated castor oil and distilled water were mixed to prepare a 100 ml liquid agent.

Example 10 (Prescription example 10) Taurine 2000 mg Arginine hydrochloride 300 mg Inositol 100 mg Vitamin B1 10 mg Vitamin B2 5 mg Vitamin B6 5 mg Nicotinic acid amide 20 mg Carrot dry extract (amount of active ingredient: 630 mg) 90 mg anhydrous caffeine 50 mg The above drug and stevia (5 mg), D-sorbitol solution,
Benzoic acid, sodium citrate, polyoxyethylene hydrogenated castor oil and distilled water were mixed to prepare a 100 ml solution.

Test Example 1 (Experimental Material) As the experimental material, the liquid preparation of Stevia-containing liquid (Sample A) of Prescription Example 1 and the liquid preparation of Example 1 without Stevia (Sample B) were used. (Test method) Questionnaire survey regarding flavor 1) Panel: healthy children 9 to 14 years old: 21 (breakdown: male: 13, female: 8). 2) Content: A method was used in which the sample A using stevia and the sample B not using stevia were drunk, and then the questionnaire was answered. As for the evaluation method of the questionnaire, each evaluation item on the panel (odor smell, sourness, scent, and horse mackerel, and (i) taste / favorite (ii) taste /
7 steps (very good, relatively good, somewhat good, neither, slightly bad, relatively bad, very good) I got it judged separately. In addition, the sample administration is performed by double blind, and the contents are not understood on the panel. An absolute evaluation method based on the SD method was used for data analysis.

(Test Results) Samples A and B were prepared using the panel.
About smell, sweetness, sourness, dryness,
Nigasa, Jibusa, and horse mackerel were evaluated as desired. The result is shown in FIG. Specimen A, which used stevia as a preference, showed a tendency of improving effect with respect to specimen B in all evaluation groups. In particular, bittern (p <0.0
5) showed a significant improvement effect.

Further, the taste was evaluated as to whether it is favorite / favorite, deliciousness / delicious, repeated use / drinking again, purchase motive / want to buy. The result is shown in FIG. The improvement tendency was obtained for the sample A with respect to the sample B. In particular, regarding the palatability, a significant difference was generated (p <0.05).

Test Example 2 (Experimental Material) As the experimental material, the liquid preparation of Stevia-containing liquid preparation (Sample C) and the liquid preparation of Example 2 without Stevia (Sample D) were used. (Test method) Questionnaire survey on flavor 1) Panel: healthy adults in their 20s to 50s: 43 (breakdown: male: 18 female: 25). 2) Content: A method was used in which the sample C using stevia and the sample D not using stevia were drunk, and then the questionnaire was answered. The evaluation method of the questionnaire is as follows: [Smell / Aroma Sweetness Sour Spicy Bitterness Astringency, astringent aftertaste, and (i) Deliciousness (ii) Medicinality (iii)
Efficacy (iv) Repeated drinking (v) Purchase motive (vi) Comprehensive evaluation] to 7 levels (very good, relatively good, moderately good, neither, slightly bad, relatively bad, very bad) I had them judged separately. In addition, the sample administration is performed by double blind, and the contents are not understood on the panel. An absolute evaluation method based on the SD method was used for data analysis.

(Test Results) Samples C, D
About odor / aroma, sweetness, sourness, spiciness, bitterness, astringency, acridness, body, and aftertaste, preference was evaluated. The result is shown in FIG. As for preference, the sample C using stevia showed a tendency of improving effect with respect to the sample D in all the evaluation groups. In particular, in terms of taste, sweetness (p <0.05) showed a significant improvement effect. further,
As a flavor evaluation, deliciousness, medicinalness, effectiveness,
Repeated drinking, purchase motivation, and overall evaluation were evaluated. FIG. 4 shows the results. The sample C showed an improvement tendency with respect to the sample D. In particular, there was a significant difference (p <0.05) in terms of taste and purchase motive.

[Brief description of the drawings]

FIG. 1 is a graph showing flavor evaluation when a sample A and a sample B are taken.

FIG. 2 is a graph showing flavor evaluation when the sample A and the sample B are taken.

FIG. 3 is a graph showing flavor evaluation when the samples C and D are taken.

FIG. 4 is a graph showing flavor evaluation when the samples C and D are taken.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 31/425 ADD A61K 31/425 ADD 31/455 31/455 31/495 31/495 31/51 31/51 31/52 31/52 31/525 31/525 31/70 31/70 33/06 33/06 33/26 33/26 47/26 47/26 L

Claims (2)

[Claims] 1. A compound selected from the group consisting of (a) one or more kinds of herbal medicine for nutritional tonic (b) vitamin B group, nicotinic acid amide, biotin, ammonium iron citrate, calcium pantothenate and caffeine, or A formulation containing two or more components and (c) stevia, wherein the content ratio of the bitterness component and stevia in the formulation is 0.001 to 0.1 parts by weight of stevia per 1 part by weight of the bitterness component content. A blended herbal medicine for nutritional tonics characterized by being in the range of parts by weight. 2. A herbal medicine for nutritional tonics is eucalypt, sorghum, oxoamidine (garlic), onsi, calyxine, cashew, guarana, kojin, gooh, gokahi (shigoka), gojishi, carrot, saiko, jazoushi, ginger, gall, toki ,. The herbicide-containing preparation for nutritional tonic according to claim 1, which is one or more selected from the group consisting of muirapuama, yutan, yokinin, ryuno, ryutan, and roquejou.