JPH09169618A - Emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an O/W type emulsified composition, capable of reducing the particle size of an emulsion to an ultrafine one and excellent in especially emulsification stability with time by using a surfactant as an emulsifying agent and further an emulsion stabilizing assistant in combination. SOLUTION: This emulsified composition is obtained by using a surfactant as an emulsifying agent and further an alkyl glyceryl ether and cholesteryl N-acylglutamate as an emulsification stabilizing assistant in combination. Glycerol monostearyl ether, etc., are cited as the alkyl glyceryl ether and a compound, etc., of the formula (R<1> and R<2> are each cholesteryl, 2-octyldodecyl, etc.) are cited as the cholesteryl N-acylglutamate. Various surfactants can be selected as the surfactant according to the objective substance. The blending ratio thereof is preferably about 2-8wt.% based on the total amount of the composition. The blending ratio of the emulsification stabilizing assistant of the alkyl glyceryl ether:cholesteryl N-acylglutamate (expressed in terms of weight) is preferably 1:(0.5-10), especially preferably 1:(1-5).

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an O / W type emulsion composition which is excellent in emulsion stability and can be used as a liquid, creamy or other cosmetics, a base for external use of pharmaceuticals and the like.

[0002]

BACKGROUND OF THE INVENTION Emulsified compositions are widely used in cosmetics, medicines, foods, etc., and in addition to emulsifiers in order to secure the emulsion stability over time, various studies have been made on emulsion stabilizers. There is. Nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants are generally used as emulsifiers. When these emulsifiers are used, an emulsion with a particle size of about 10μ is usually obtained. ing. It is generally recognized that the smaller the particle size of the emulsion is, the better it is for the evaluation of emulsion stability, and recently, various composite emulsifiers and emulsion stabilizers that combine multiple emulsifiers have been proposed to improve the emulsion stability. Has been done.

However, the fact is that little is known about the conventionally proposed complex-type emulsifiers and emulsion stabilizers that are capable of obtaining emulsions having a particle size of less than 1 μm. In particular, in the case of cosmetics and the like that are desired to be penetrated into individual hairs such as hair treatment, those having a smaller particle size of emulsion are desired.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide an emulsified composition in which the particle size of an emulsion can be adjusted to a very small value and which is particularly excellent in emulsion stability over time.

[0005]

According to the present invention, an O / W
In a type emulsion composition, a surfactant as an emulsifier,
An emulsion composition comprising an alkyl glyceryl ether as an emulsion stabilizer and N-acyl glutamic acid cholesteryl ester is provided.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The emulsified composition of the present invention contains, in addition to a surfactant as an emulsifier, a combination of an alkyl glyceryl ether and an N-acylglutamic acid cholesteryl ester as an emulsion stabilizer. With these combinations, the particle size of the obtained emulsion can be made very small, and excellent emulsion stability is exhibited. The particle size of the emulsion can be preferably 1 μm or less, particularly preferably 0.8 μm or less. The smaller the lower limit of the particle size, the more preferable, but it is usually about 0.08μ. The emulsion having such a small particle size is obtained, although the alkyl glyceryl ether is insoluble in water, it is an oil phase component having a strong interaction with water, and contains water to show a liquid crystal, On the other hand, N-acylglutamic acid cholesteryl ester has an excellent low interfacial tension, and these properties interact with each other to enhance the emulsification assisting function, forming a fine emulsion and stabilizing the formed micelles. It is thought that it is because it has contributed to. The mixing ratio of these is in order to obtain a sufficient emulsion stability effect, alkyl glyceryl ether: N
-Acylglutamic acid cholesteryl ester in terms of weight is preferably 1: 0.5 to 10, and particularly preferably 1: 1 to 5. The blending ratio of the mixture of the alkyl glyceryl ether and the N-acyl glutamic acid cholesteryl ester in the emulsion composition can be appropriately selected according to the blending amount of the oil described below, but preferably 100 parts by weight of the contained oil. On the other hand, it is in the range of 5 to 40 parts by weight, particularly preferably 10 to 20 parts by weight.

Examples of the alkyl glyceryl ether include glycerin monostearyl ether, glycerin monocetyl ether and monooleyl glyceryl ether. Also, the product name "Batyl Alcohol EX",
"Batyl alcohol 100", "Chimyl alcohol 10"
Commercially available products such as "0" and "Ceraquil alcohol" (all manufactured by Nippon Surfactant Industry Co., Ltd.) can also be used.

Examples of the N-acylglutamic acid cholesteryl ester include compounds having a cholesterol structure represented by the following formula (1).

[0009]

Embedded image

(In the formula, R ¹ and R ² are the same or different groups and represent cholesteryl, 2-octyldodecyl or behenyl, provided that at least one of R ¹ and R ² represents cholesteryl.) N-acyl As glutamic acid cholesteryl ester,
In particular, the compound represented by the above formula (1) is known as an oil base for cosmetics having high water retention and moisture retention, and is known to exhibit excellent emulsification aid and pigment dispersibility. However, it is not known that it exhibits a further excellent emulsion stabilizing auxiliary action in combination with alkyl glyceryl ether.

The emulsified composition of the present invention contains a surfactant as an emulsifier. As the surfactant, various kinds can be selected from nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants according to the intended product. Specifically, for example, propylene glycol monostearate, glyceryl monostearate, glyceryl monomyristate, glyceryl monooleate, polyoxyethylene glyceryl monostearate,
Polyoxyethylene glyceryl monooleate, diglyceryl monoisostearate, tetraglyceryl monostearate, hexaglyceryl monostearate, decaglyceryl monostearate, sorbitan monostearate, polyoxyethylene sorbitan monostearate, polyoxytetraoleate Ethylene sorbit,
Polyoxyethylene hydrogenated castor oil, polyethylene glycol monostearate, ethylene glycol monostearate, polyoxyethylene cetyl ether, polyoxyethylene oleyl ether, polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene phytophterol, etc. be able to. The mixing ratio of the surfactant is preferably 2 with respect to the total amount of the emulsion composition.
８8% by weight.

The emulsion composition of the present invention is an O / W type emulsion composition, and the form thereof is liquid, cream or the like.
It can be applied to cosmetics known as such O / W type emulsions, external bases for pharmaceuticals, etc.
Materials other than oil and water for forming a / W type liquid material, creamy material, etc. can be appropriately selected and blended.

As the oil used in the present invention, any of vegetable oil, animal oil and synthetic oil can be used according to the purpose. Specifically, for example, beef tallow, pork oil, mink oil, jojoba oil, avocado oil, olive oil, evening primrose oil, grape seed oil, sasanqua oil, safflower oil, almond oil, corn germ oil, sunflower oil, macadamia nut oil,
Meadow home oil, palm oil, coconut oil, squalene, squalane, glycerin tri (caprylic / capric acid), liquid paraffin, cetyl isooctanoate, isopropyl myristate, isocetyl myristate, cetyl alcohol, isostearyl alcohol, behenyl alcohol, Examples thereof include methylpolysiloxane, methylphenylpolysiloxane, cyclic dimethylpolysiloxane, stearic acid, palmitic acid, behenic acid, octyldodecyl myristate, and octyldodecyl erucate. The blending ratio of the oil can be appropriately selected according to the intended product, as long as the emulsion composition can be stable as an O / W type. For example, when it is used as a cosmetic emulsion, it is 5 to 15% by weight in the emulsion composition, and when it is used as a cream,
It is preferably compounded in the emulsion composition in the range of 15 to 50% by weight.

As the water used in the present invention, usually purified water can be used. The mixing ratio of water is 0 for the emulsified composition.
/ W type can be appropriately selected according to the intended product as long as it is in a stable range. For example, when used in a milky lotion of cosmetics, it is preferably added in an amount of 60 to 80% by weight in the emulsion composition, and when used in a cream, it is preferably added in an amount of 40 to 75% by weight in the emulsion composition.

When the emulsion composition of the present invention is used as a cosmetic or a base for external use of medicines, it is usually preferable to add a polyhydric alcohol or the like. As the polyhydric alcohol, 3-methyl-1,3-butanediol, ethylene glycol, diethylene glycol, water-soluble polyethylene glycol,
Propylene glycol, dipropylene glycol, water-soluble polypropylene glycol, 1,3-butylene glycol, propylene glycol monocaprylate, propylene glycol dicaprate, glycerin, diglycerin, triglycerin, glycerin tri-2-ethylhexanoate, tri (capryl. Capric acid) glyceryl, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, decaglyceryl decastearate, decaglyceryl decaisostearate, water-soluble polyglycerin, mannitol, Examples thereof include sorbitol, pentaerythritol, glucose, trehalose, maltitol and the like. The blending ratio of the polyhydric alcohol is 25 in the emulsion composition.
It is preferable to blend in an amount of not more than 5% by weight, particularly 5 to 25% by weight.

The emulsion composition of the present invention further comprises various agents having anti-inflammatory action, whitening action, anti-wrinkle action, cleaning action, treatment action and the like, an ultraviolet absorber, a preservative, an antioxidant, depending on the purpose. Colorants, fragrances, etc. can also be added.

To prepare the emulsion composition of the present invention, the oil component and the water component are dissolved at a temperature equal to or higher than the melting point of the emulsion stabilizer, and then the water component is gradually added to the oil component with stirring to emulsify the composition. It can be obtained by a method or the like.

[0018]

The emulsion composition of the present invention contains, in addition to a surfactant as an emulsifier, an alkyl glyceryl ether and an N-acylglutamic acid cholesteryl ester as an emulsion stabilizer, and therefore, the emulsion particles. The diameter can be made extremely small, the emulsion stability is excellent, and it is useful for various cosmetics, external pharmaceutical bases, and the like. In particular, since the particle size of the emulsion is small, it is useful for hair care products such as rinses and treatments in which it is preferable to contact each hair individually.

[0019]

The present invention will be described below in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.
In addition, "part" in an example shows a "weight part."

[0020]

Example 1 Squalane 8 parts, methyl polysiloxane 1.6 parts, octyldodecyl myristate 4.8 parts, behenyl alcohol 3.2 parts, monooleyl glyceryl ether 0.8 parts, N-lauroyl-L-glutamic acid diester.
(Cholesteryl-octyldodecyl) 1.6 parts, polyethylene glycol monostearate (25EO) 3.6
Parts, 0.4 parts of ethylene glycol monostearate and 0.2 parts of paraoxybenzoic acid ester, and mixed at 80 ° C.
Heated. Then, 75.8 parts of purified water at 80 ° C. was gradually added with stirring, and then cooled with stirring to obtain an emulsion. The obtained emulsion was subjected to measurement of particle size distribution and emulsion stability test.

The particle size distribution is measured by a Shimadzu Corporation laser diffraction type particle size distribution measuring device (trade name, "SALD-2000").
It measured using. In the emulsion stability test, the separated state after standing for 3 months at 40 ° C. was visually observed, and a 10 wt% solution of the obtained emulsion was prepared and centrifuged (35
(00 rpm, 10 minutes), and the separated state after centrifugation was also visually observed. Table 1 shows the results.

[0022]

Example 2 Squalane 8 parts, methylpolysiloxane 1.6 parts, octyldodecyl myristate 4.8 parts, behenyl alcohol 3.2 parts, monooleyl glyceryl ether 1.6 parts, N-lauroyl-L-glutamic acid diester.
(Cholesteryl-octyldodecyl) 1.6 parts, polyethylene glycol monostearate (25EO) 3.6
Parts, 0.4 parts of ethylene glycol monostearate and 0.2 parts of paraoxybenzoic acid ester, and mixed at 80 ° C.
Heated. Subsequently, 75 parts of 80 ° C. purified water was gradually added with stirring, and then cooled with stirring to obtain an emulsion. The same measurement as in Example 1 was performed on the obtained cream.
Table 1 shows the results.

[0023]

Example 3 Squalane 8 parts, methylpolysiloxane 1.6 parts, octyldodecyl myristate 4.8 parts, behenyl alcohol 5 parts, monooleyl glyceryl ether 0.8 parts, N-lauroyl-L-glutamic acid (cholesteryl octyl An oil component was prepared by mixing 0.8 parts of dodecyl), 3.6 parts of polyethylene glycol monostearate (25EO) and 0.4 parts of ethylene glycol monostearate. On the other hand, 3 parts of 3-methyl-1,3-butanediol, 0.02 part of hinokitiol, 0.5 part of cationized dextran and 71.48 parts of purified water were mixed to prepare a water component. The oil component and the water component were heated to 80 ° C., the water component was gradually added while stirring the oil component, and the mixture was stirred and cooled to obtain a cream. The same measurement as in Example 1 was performed on the obtained cream. Table 1 shows the results.

[0024]

Example 4 Squalane 6.5 parts, methyl polysiloxane 1.3 parts, octyldodecyl erucate 4 parts, stearyl alcohol 3.2 parts, monooleyl glyceryl ether 1.6 parts, N-lauroyl-L-glutamic acid ( Cholesteryl octyldodecyl) 1.6 parts, polyethylene glycol monostearate (20) sorbitan 3.6
Parts, 0.4 parts of sorbitan monostearate and 0.2 parts of paraoxybenzoic acid ester were mixed to prepare an oil component. On the other hand, 3 parts of 3-methyl-1,3-butanediol,
A water component was prepared by mixing 0.5 part of cationized dextran, 3 parts of cationized collagen polypeptide and 71.1 parts of purified water. After heating the oil component and the water component to 80 ° C. and gradually adding the water component while stirring the oil component,
The hair treatment was obtained by stirring and cooling. The same measurement as in Example 1 was performed on the obtained hair treatment. Table 1 shows the results.

[0025]

Example 5 Liquid paraffin 5 parts, methyl polysiloxane 1 part, cetyl isooctanoate 3 parts, cetanol 2 parts,
Glycerin monostearyl ether 0.5 part, N-lauroyl-L-glutamate di (cholesteryl octyldodecyl) 1 part, polyoxyethylene (20) sorbitan monostearate 4 parts, sorbitan monostearate 0.5 parts and paraoxybenzoic acid An oil component was prepared by mixing 0.2 part of the acid ester. On the other hand, a water component was prepared by mixing 0.1 part of dipotassium glycyrrhizinate as an anti-inflammatory component, 5 parts of glycerin and 77.7 parts of purified water. The oil component and the water component were heated to 80 ° C., the water component was gradually added while stirring the oil component, and the mixture was stirred and cooled to obtain a cream. The same measurement as in Example 1 was performed on the obtained cream. Table 1 shows the results.

[0026]

Example 6 Liquid paraffin 10 parts, methyl polysiloxane 5 parts, isopropyl palmitate 3 parts, cetanol 5 parts, stearic acid 1 part, monooleyl glyceryl ether 1 part, N-lauroyl-L-glutamic acid di (cholesteryl octyl). Dodecyl) 2 parts, polyoxyethylene (15) cetyl ether 4 parts, glyceryl monostearate 1 part, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl 3 parts as a UV absorber, neopentyl glycol dioctanoate An oil component was prepared by mixing 3 parts and 0.2 part of paraoxybenzoic acid ester.
On the other hand, 5 parts of 1,3-butanediol and 56.8 of purified water.
The parts were mixed to prepare a water component. 8 oil and water components
The mixture was heated to 0 ° C., the water component was gradually added while stirring the oil component, and the mixture was cooled with stirring to obtain a cream. The same measurement as in Example 1 was performed on the obtained cream. Table 1 shows the results.

[0027]

Example 7 Squalane 10 parts, methylpolysiloxane 5 parts, glyceryl tri-2-ethylhexanoate 5 parts, behenyl alcohol 3 parts, glycerin monocetyl ether 1.5 parts, N-lauroyl-L-glutamic acid di (cholesteryl octyl). An oil component was prepared by mixing 1.5 parts of dodecyl), 3.2 parts of polyoxyethylene (15) cetyl ether, 0.8 part of sorbitan monostearate and 0.2 part of paraoxybenzoic acid ester. On the other hand, magnesium phosphate L-ascorbyl as a whitening ingredient 0.
A water component was prepared by mixing 5 parts and 69.3 parts of purified water. The oil component and the water component were heated to 80 ° C., the water component was gradually added while stirring the oil component, and the mixture was stirred and cooled to obtain a cream. The same measurement as in Example 1 was performed on the obtained cream. Table 1 shows the results.

[0028]

Example 8 Liquid paraffin 10 parts, polyether modified silicon 5 parts, isocetyl myristate 3 parts, cetyl palmitate 3 parts, polyoxyethylene (9) lauryl ether 10 parts as a cleaning component, monooleyl glyceryl ether 1. 6 parts, N-lauroyl-L-glutamate di (cholesteryl octyldodecyl) 1.6 parts, polyoxyethylene (20) cetyl ether 4.5 parts, diglyceryl monoisostearate 0.5 parts and paraoxybenzoate 0 The oil component was prepared by mixing 2 parts. Meanwhile, 5 parts of glycerin, 5 parts of 1,3-butylene glycol and 53.8 parts of purified water were mixed to prepare a water component. The oil component and the water component were heated to 80 ° C., the water component was gradually added while stirring the oil component, and the mixture was stirred and cooled to obtain a face wash. The same measurement as in Example 1 was performed on the obtained face wash. Table 1 shows the results.

[0029]

Example 9 3 parts of jojoba oil, 7 parts of glyceryl tri-2-ethylhexanoate, 5 parts of cetyl palmitate, 2 parts of stearic acid, 5 parts of behenyl alcohol, 0.1 part of vitamin A oil as an anti-wrinkle component, monooleyl 1 part of glyceryl ether, 1.5 parts of di (cholesteryl octyldodecyl) N-lauroyl-L-glutamate, 4 parts of polyethylene glycol monostearate (40EO), 1 part of diethylene glycol stearate and 0.2 part of paraoxybenzoic acid ester. An oil component was prepared by mixing. on the other hand,
A water component was prepared by mixing 5 parts of glycerin, 2 parts of sodium hyaluronate solution, 3 parts of glycolic acid as an anti-wrinkle component, and 61.2 parts of purified water. 80 parts oil and water
The mixture was heated to ° C, the water component was gradually added while stirring the oil component, and the mixture was cooled with stirring to obtain a cream. The same measurement as in Example 1 was performed on the obtained cream. Table 1 shows the results.

[0030]

Comparative Example 1 An emulsion was prepared in the same manner as in Example 1 except that the monooleyl glyceryl ether was not blended and the amount of purified water was 76.6 parts. The obtained emulsion was measured in the same manner as in Example 1. Table 1 shows the results.

[0031]

Comparative Example 2 Monooleyl Gluceryl Ether and N-
The amount of purified water blended was 78. without adding lauroyl-L-glutamate di (cholesteryl-octyldodecyl).
An emulsion was prepared in the same manner as in Example 1 except that the amount was 2 parts. The obtained emulsion was measured in the same manner as in Example 1. Table 1 shows the results.

[0032]

COMPARATIVE EXAMPLE 3 An emulsion was prepared in the same manner as in Example 1 except that N-lauroyl-L-glutamate di (cholesteryl-octyldodecyl) was not blended and the amount of purified water was 77.4 parts. The obtained emulsion was measured in the same manner as in Example 1. Table 1 shows the results.

[0033]

Comparative Example 4 An emulsion was prepared in the same manner as in Example 1, except that polyoxyethylene (20) sorbitan monostearate was used instead of monooleyl glyceryl ether. The obtained emulsion was measured in the same manner as in Example 1. Table 1 shows the results.

[0034]

[Table 1]

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication B01F 17/52 B01F 17/52

Claims (1)

[Claims] 1. An O / W emulsion composition comprising a surfactant as an emulsifying agent, an alkyl glyceryl ether and an N-acyl glutamic acid cholesteryl ester as an emulsion stabilizing aid. .