JPH09227310A - Acaricide for indoor dust mites - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the above acaricide having a sufficient exterminating effect at a low dose by using a specific compound having a wide and a potent acaricidal effect to an in house dust acarid singly or simultaneously with another insecticide. SOLUTION: This acaricide for an in house dust acarid contains chlorophenapyle*, i.e., 4-bromo-2-(4- chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrol-3-carbonitrile as an active ingredient, and also is used by blending the chlorophenapyle* with at least one or more kinds selected from a pyrethroide-based insecticide, an organophosphorus-based insecticide, an organic bactericide or an inorganic bactericide. The acaricidal composition is preferably further blended with a cooperating agent. In this preparation, 0.1-95% active ingredient is contained, and especially 0.5-20% in an oil preparation, 10-50% in art emulsion, 30-80% in a hydrated preparation, 5-40% in a powder, 10-50% in a granular preparation, 1-20% in a fumigating agent, 0.1-20% in an aerosol agent and 0.05-10g/m<2> in a sheet agent. Chlorophenapyle*: probably a gerneric name of the subject compound, spelling thereof is not clear.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an acaricide for indoor dust mites, and the acaricide of the present invention is extremely effective for exterminating various indoor dust mites.

[0002]

2. Description of the Related Art Indoor dust mites, which are hygiene pests, are said to be a cause of allergic asthma, childhood asthma, atopic dermatitis, etc. Also, various dermatitis due to bites, blood feeding, and scabies. Is the cause. In addition, these mites also cause damage such as discomfort due to abnormal occurrence and deterioration of the quality of foods. The spread of these mites is due to human hygiene,
It threatens and significantly impedes the maintenance of a healthy life, and there is a need for immediate and reliable killing. Conventionally, pyrethroid insecticides such as resmethrin, permethrin, and phenothrin against mites such as house dust mites, Dermatophagoides farinae, Dermatophagoides farinae, horn ticks, Saladani, lice mites and dust mites (JP-A-63-290).
9, JP-A-60-142906), diazinon, dichlorvos, fenitrothion, trichlorfon, malathion, fenthion and other organophosphorus insecticides (Shirasaka et al., Sanitary animals, 22, 210-212, (197).
1)), various insecticides such as carbamate insecticide propoxur (Mr. Shiiyama, beautiful environment, 7, 65-7, (1982)).

In addition, chlorfenapyr (Japanese Patent Laid-Open No. 1-10
No. 4042) is known as an acaricide,
The target mites are outdoor spider mites, and indoor dust mites are not disclosed. Tick mites and house dust mites are taxonomically, ecologically, and physiologically different, and their sensitivities to drugs are also inconsistent. Therefore,
It is a completely different organism in terms of control.

[0004]

[Problems to be Solved by the Invention] Various indoor and indoor mites of various morphologically and physiologically different mites such as ascidians, prestigmatics, middle ascidians, and respirators are simultaneously present. . However, various pyrethroid-based, organophosphorus-, and carbamate-type insecticides conventionally used for controlling these mites have a high acaricidal effect on mites belonging to the midgastricial group such as house dust mites. However, it was not very effective against other mites, and it was difficult to simultaneously exterminate various kinds of indoor dust mites. In addition, when various pyrethroid-based, organophosphorus-based and carbamate-based insecticides that have been conventionally used to control indoor dust mites are treated indoors, even if they can be controlled, pests such as flies and cockroaches can be controlled. The application of these pesticides in a room where a person lives is problematic in terms of safety, because they require an incomparably large amount of drug compared to the amount required for the drug.

[0005]

[Means for Solving the Problems] As a result of intensive studies to solve the above problems, the present inventors found that chlorfenapyr was
Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Stag beetle mite, Dromedary spider mite, Dick mite,
It has been found that it has a broader and more powerful acaricidal effect than ever before against indoor dust mites such as Southern mites, dust mites, and Saladani, and found that it has a sufficient disinfecting effect even at low doses. The invention was completed.

That is, the gist of the present invention is an acaricidal composition for indoor dust mites, characterized by containing chlorfenapyr as an active ingredient. An acaricidal composition for indoor dust mites, which contains chlorfenapyr and at least one or more pest control agents selected from pyrethroid insecticides, organic phosphorus insecticides, organic fungicides or inorganic fungicides. Furthermore, there exists an acaricide for indoor dust mites, in which a synergist is added to these acaricidal compositions for indoor dust mites.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below.
Chlorfenapyr (4-bromo-2) used in the present invention
-(4-chlorophenyl) -1- (ethoxymethyl)-
5- (trifluoromethyl) pyrrole-3-carbonitrile (generic name), even if used alone as an active ingredient, it becomes an acaricidal composition for indoor dust mites having a sufficient acaricidal effect for indoor dust mites. By mixing with a pesticide, an acaricidal composition for indoor dust mites having a stronger acaricidal effect for indoor dust mites can be obtained.

Examples of the pest control agent include pyrethroid insecticides such as resmethrin, permethrin and phenothrin; organic phosphorus insecticides such as diazinon, dichlorvos and fenitrothion; and inorganic fungicides such as zinc oxide such as sodium dehydroacetate. To be Furthermore, for the acaricidal composition for indoor dust mites, octachlorodipropyl ether (abbreviation S-421), isobornyl thiocyanoacetate (abbreviation IBTA), piperonyl butoxide, N-
(2-Ethylhexyl) -bicyclo- [2,2,1]-
Hepta-5-ene-2,3-dicarboximide (abbreviation MGK-264), N- (2-ethylhexyl) -1-
Isopropyl-4-methylbicyclo- [2,2,2]-
By mixing and using a synergist such as octo-5-ene-2,3-dicarboximide (abbreviated as sinepyrine 500), an acaricide for indoor dust mites, which is further enhanced in efficacy, can be obtained. .

When chlorfenapyr and the pest control agent are used as the active ingredients of the acaricide or the acaricidal composition of the present invention, they are usually mixed with a solid carrier, a liquid carrier, a gaseous carrier, a bait or the like, or It is impregnated with mat, paper, cloth, leather, resin, etc., and if necessary, surfactants or other formulation auxiliary agents are added, and oils, emulsions, wettable powders, powders, granules, fumigants, azole agents, It is used after being formulated into a sheet or flowable agent.

As solid carriers used in these formulations, mineral powder or wood powder such as silicic acid, kaolin, talc, clay, calcium carbonate, bentonite, diatomaceous earth, etc.,
Vegetable powder such as soybean powder and starch powder can be used. Liquid carriers include alcohols such as ethyl alcohol and isopropyl alcohol; ketones such as acetone and methyl ethyl ketone; ethers such as tetrahydrofuran, dioxane and diethyl ether; hydrocarbons such as hexane kerosene, paraffin and petroleum benzine; oleic acid and the like. Fatty acids; esters such as ethyl acetate, methyl oleate, isopropyl myristate; aromatic hydrocarbons such as benzene and toluene; halogenated hydrocarbons such as chloroform and dichloroethane.

As the gaseous carrier, hydrocarbons such as propane and butane; ethers such as dimethyl ether; inert gas such as helium, neon and argon; oxygen; nitrogen;
Carbon dioxide gas; compressed air; hydrogen and the like. Examples of the surfactant include polyoxyethylene alkyl ethers such as soaps, polyoxyethylene oleyl ether, and polyoxyethylene nonylphenyl ether; polyoxyethylene fatty acid esters; fatty acid glycerides; sorbitan fatty acid esters; sulfuric acid esters of higher alcohols; dodecyl. Examples thereof include alkyl sulfonates such as sodium benzene sulfonate.

These formulations include the acaricidal composition of the present invention,
Alternatively, an acaricidal composition containing a pesticide is contained as an active ingredient in an amount of 0.1% to 95%. In particular, 0.5% to 20% as an oil agent, 10% to 50% as an emulsion,
30% -80% as a wettable powder, 5% -4 as a powder
0%, 10% -50% for granules, 1 for fumigants
% To 20%, as an aerosol agent 0.1% to 20%,
The sheet material ^{0.05g / m 2 ~10g / m 2} , as a flowable formulation being formulated to be 1% to 50% are common.

[0013]

EXAMPLES Next, the effects of the present invention will be specifically described by showing Examples and Test Examples, but the present invention is not limited to the following Examples unless it exceeds the gist. <Examples 1 to 5> Chlorfenapyr or a mixture of chlorfenapyr and various drugs shown in Table 1 was dissolved in a mixed solution of xylol and white kerosene to contain 0.5% as a drug substance, acaricide in the form of an oil agent. Each agent was prepared. <Comparative Examples 1 to 3> Pest repellent N, N-dimethyl-m-toluamide (abbreviated to DEET), a synergist MGK-264 or S-, which is conventionally known as an acaricide for indoor dust mites.
421 was dissolved in a mixed solution of xylol and white kerosene to prepare an acaricide in the form of an oil containing 0.5% as a drug substance. <Test Example 1> (filter paper contact test) A part of each of the oil solutions obtained in Examples 1 to 5 and Comparative Examples 1 to 3 was taken and diluted with acetone, and a predetermined size was applied to a filter paper (Toyo Filter Paper 5A) having a diameter of 9 cm. It was applied so that the dose would be evenly adhered. After drying, fold the filter paper in half, put about 50 Plutella xylostella mites or Dermatophagoides farinae in it, clip on three sides, forcibly contact it, and investigate the mortality of the test insects after 24 hours, The 50% lethal concentration (LC ₅₀ ) was calculated. Table 1 shows the results.

Chlorfenapyr has a higher acaricidal effect than known acaricides, and it is considered that chlorfenapyr should be contained in an actual concentration of about 0.5 g / m ^{2 in} practical use. In addition, a combination drug of chlorfenapyr and S-421,
Chlorfenapyr and 3-phenoxybenzyl DL
-Cis / trans-3- (2,2-dichlorovinyl)-
2,2-Dimethyl-1-cyclopropanecarboxylate (abbreviation permethrin) mixture, chlorfenapyr and O, O-dimethyl O- (3-methyl-4-nitrophenyl) phosphorothioate (abbreviation fenitrothion)
Each of these combinations showed a higher acaricidal effect than when used alone.

[0015]

[Table 1]

<Examples 6 to 8> Chlorfenapyr or a mixture of chlorfenapyr and various drugs shown in Table 2 was dissolved in ethanol and filled in an aerosol can together with a propellant gas, and the total dose was 1.0%. The respective acaricides in the form of aerosols were prepared. <Comparative Examples 4 to 7> As a comparative example, 2,2, -dichlorovinyl dimethyl phosphate (abbreviation dichlorvos),
DEET, MGK-264 or S-421 was dissolved in ethanol and filled in an aerosol can together with a propellant gas to prepare an acaricide in the form of an aerosol containing 1.0% as a total dose. <Test Example 2> (Aerosol Quasi-Field Test) A 20 cm × 20 cm × 6 cmH mini tatami mat was used at a temperature of 26 ±
Saturated potassium chloride aqueous solution (humidity 84% RH) at 2 ° C
The sample was stored in a container whose humidity was adjusted in 2., 2.0 g (approximately 20,000) of the mite, Plutella xylostella, were planted together with the medium, and stored again under the above conditions. About 2 weeks later, 10c on a mini tatami mat
Two pieces of black paper of m × 10 cm were placed for 10 minutes, and the number of mites that were active on the front and back of the black paper was examined. This mini tatami mat was placed on the bottom of a glass chamber having a side length of 1 m (1 m ³ ) and the aerosols of Examples 6 to 8 and Comparative Examples 4 to 7 were spray-applied for 10 seconds from a height of about 30 cm. After 5 minutes, the tatami mats were taken out and stored again under the above-mentioned conditions. The investigation of the number of live mites after the treatment was conducted after a predetermined number of days had passed, in the same manner as before the treatment. The test was repeated 3 times, the growth ratio for each test was calculated from the formula (1), and the decrease index was calculated from the average value from the formula (2). Table 2 shows the results
Shown in

[0017]

[Equation 1] (However, if the decrease index is negative (-), there is no effect (0))

[0018]

[Table 2]

<Test Example 3> (Aerosol Quasi-Practical Test) A pure-hair carpet cut to 20 cm × 20 cm was saturated sodium chloride solution (humidity 75% R at a temperature of 26 ± 2 ° C.).
It was placed in a container whose humidity was adjusted by H), 2.0 g (approximately 1,000) of the medium was planted with the Dermatophagoides farinae and stored. About 2 weeks later, 10 cm x 1 on a pure wool carpet
Two 0 cm pieces of black paper were placed for 30 minutes, and the number of ticks on the front and back of the black paper was examined, and this was taken as the number of live mites before treatment. This carpet was placed on the bottom of a glass chamber having a side length of 1 m (1 m ³ ) and the aerosols of Examples 6 to 8 and Comparative Examples 4 to 7 were spray-applied for 5 seconds from a height of about 30 cm. 5
After a minute, the carpets were removed and stored again under the above conditions. The investigation of the number of live mites after the treatment was conducted after a predetermined number of days had passed, in the same manner as before the treatment. The test was repeated 3 times, the growth ratio for each test was calculated from the formula (1), and the decrease index was calculated from the average value from the formula (2). Table 3 shows the results
Shown in

[0020]

[Table 3]

<Examples 9 to 11> Chlorfenapyr or a mixture of chlorfenapyr and various drugs shown in Table 4 was dissolved in toluene, and this was uniformly applied to kraft paper so that the total ratio was 1.0 g / m ^2. And then dried to prepare sheet-like acaricides. <Comparative Examples 8 to 11> As comparative examples, dichlorvos, DEE
Dissolve each of T, MGK-264 or S-421 in toluene, apply the solution evenly on kraft paper so that the total ratio is 1.0 g / m ² , and dry to prepare a sheet-like acaricide. did. <Test Example 4> (Semi-on-site test for sheet material) A 20 cm x 20 cm x 6 cmH mini tatami mat was placed at a temperature of 26 ±
It was stored in a container whose humidity was adjusted with a saturated potassium chloride aqueous solution (humidity 84% RH) at 2 ° C., and 2 g (approximately 20,000) of Plutella xylostella mites were planted together with the medium and stored again under the above conditions. About 2 weeks later, 10 cm x 1 on a mini tatami mat
Two 0 cm pieces of black paper were placed for 10 minutes, and the number of ticks that were active on the front and back of the black paper was examined. Next, 2 sheets of Examples 9 to 11 and Comparative Examples 8 to 10 were prepared.
It was cut into 0 cm x 20 cm, the surface of the tatami mat was covered with this sheet, and these were again stored under the above-mentioned conditions. The investigation of the number of live mites after the treatment was conducted after a predetermined number of days had passed, in the same manner as before the treatment. The test was repeated 3 times, the growth ratio for each test was calculated from the formula (1), and the decrease index was calculated from the average value from the formula (2). The results are shown in Table 4.

[0022]

[Table 4]

<Examples 12 to 14> Chlorfenapyr,
Alternatively, a mixture of chlorfenapyr and various chemicals shown in Table 5 is dissolved in ethanol, and an aerosol can is filled with a propellant gas, and a full amount injection type button is attached, and an aerosol type fumigation containing 1.0% as a total dose. Each agent was prepared. <Comparative Examples 12 to 16> As comparative examples, dichlorvos, DE
ET, MGK-264, S-421, 2-isopropoxyphenyl methyl carbamate (abbreviated as propoxer) are each dissolved in ethanol and filled in an aerosol can together with a propellant gas, and a total amount injection type button is attached, giving a total dose of 1 Aerosol fumigants containing 0.0% were prepared respectively.

Test Example 5 (Aerosol type fumigant quasi-field test) A 20 cm × 20 cm × 6 cmH mini tatami mat was placed at a temperature of 26 ±
It was stored in a container whose humidity was adjusted with a saturated potassium chloride aqueous solution (humidity 84% RH) at 2 ° C., 2 g (approximately 20,000) of Plutella xylostella was inoculated together with the medium, and stored again under the above conditions. About 2 weeks later, 10 cm x 1 on a mini tatami mat
Two 0 cm pieces of black paper were placed for 10 minutes, and the number of ticks on the front and back of the black paper was examined, and this was taken as the number of live mites before treatment. This mini tatami mat is placed in the four corners of a 6 tatami mat room, and examples 12 to 14 are used.
And 100 ml of the fumigant of Comparative Examples 12 to 16 was smoked in the center of the room. After 2 hours, the tatami mats were taken out of the room and stored again under the above-mentioned conditions. The number of live mites after the treatment was investigated in the same manner as before the treatment after the lapse of a predetermined number of days. The test was repeated 3 times, the growth ratio for each test was calculated from the formula (1), and the decrease index was calculated from the average value from the formula (2). Table 5 shows the results.

[0025]

[Table 5]

[0026]

EFFECTS OF THE INVENTION By using chlorfenapyr as an acaricide against indoor dust mites, it exhibits a sufficient control effect against a wide range of indoor dust mites with a low dose and unprecedented.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication (A01N 43/36 57:12) (A01N 43/36 57:14) (A01N 43/36 59: 16) (A01N 43/36 31:14 37:32 43:36 37:10 43:50)

Claims (3)

[Claims] 1. An acaricidal composition for indoor dust mites, which contains chlorfenapyr as an active ingredient. 2. An insecticidal agent for indoor dust mites, characterized by containing chlorphenapyr and at least one or more pesticides selected from pyrethroid insecticides, organophosphorus insecticides, organic fungicides or inorganic fungicides. Tick composition. 3. The acaricide for indoor dust mites according to claim 1 or 2, wherein a synergist is added to the acaricidal composition for indoor dust mites.