JPH09253185A - Volatile drug sustained release device - Google Patents

Abstract

(57) 【Abstract】 PROBLEM TO BE SOLVED: To reliably prevent excessive discharge of a drug to a volatilizing body due to temperature change in a volatile drug sustained-release device. SOLUTION: A substantially sealed inverted type container 2 which contains a liquid fragrance A inside and whose mouth 2a faces downward, a volatile paper 3 which is arranged below the mouth 2a, and a liquid aroma In the fragrance | flavor agent sustained release apparatus 1 provided with the supply body 10 which supplies the agent A to the volatilization paper 3, the upper end is opened to the upper space 9 above a liquid level in the container 2, and according to temperature change. A pipe 4 for guiding the gas in the upper space 9 to the mouth 2a through the opening 4a at the upper end and letting the gas escape to the outside of the container 2 is provided.
Is a penetrating support hole 11 for fitting and supporting the pipe 4, and the liquid fragrance A contained in the container 2 is vaporized on the paper 3.
And a liquid supply small hole 12 penetrating therethrough.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a volatile drug releaser.

[0002]

2. Description of the Related Art Conventionally, as a volatile drug sustained-release device, a substantially sealed container containing a liquid drug and having a mouth portion facing downward, and a volatilizing body disposed at a position below the mouth portion. And a supply body that supplies the drug in the container to the volatilization body through the mouth portion is known.

This type of release device is generally called an inverted type, and like the upright type with its mouth facing upward,
It is widely used in general. As conventional examples of the inverted type sustained-release device, there are No. 1-93039 and No. 61-39.
No. 82637, No. 61-194536, No. 6
No. 1-194537, No. 61-194538, No. 56-6444, No. 63-135644, etc.

Usually, this type of inverted volatilizable drug sustained-release device transfers a drug from a feeder located at the bottom of the container to a volatilizer below the container. Compared to an upright type that sucks up the drug, the drug is better supplied to the volatilizer via the feeder, and the inflow of air into the container due to the decrease in the drug is smoother. Is excellent in.

[0005]

However, in the conventional inverted type volatile drug sustained-release device, as described above, while air can be easily introduced into the container, the gas (air Since it is difficult to discharge the amount of chemicals and the amount of evaporated chemicals), when the temperature rises in the summer and the atmospheric pressure in the upper space of the container rises, the gas in this upper space pushes more chemicals than usual through the feeder. May be discharged to the volatilizer. In that case, there arises inconveniences such as a chemical such as an aromatic agent being diffused into the atmosphere more than necessary, and the consumption of the chemical is extremely fast. For this reason, there has been a strong demand for the development of a volatile drug sustained-release device that sufficiently considers the ambient temperature change.

The present invention has been made in view of the above-mentioned conventional problems, and provides a volatile drug sustained-release device for surely preventing excessive discharge of a drug to a volatile substance due to a change in ambient temperature. The purpose is to do.

[0007]

The present invention has the following configuration to achieve the above object. The invention according to claim 1 is a substantially sealed inverted container for containing a liquid drug therein and having a mouth portion facing downward, a volatilizer disposed below the mouth portion, In a volatile drug sustained-release device provided with a supply body for supplying the drug in a container to the volatile substance, in the container, an upper end is opened in an upper space above the liquid surface, and depending on a temperature change. A pipe is provided through which the gas in the upper space is guided from the opening of the upper end to the mouth portion and escapes to the outside of the container, and the supply body is formed with a through hole for fitting the pipe. It is a volatile drug releaser.

The invention of claim 2 is characterized in that the supply body is made of an injection-molded product having water repellency and has a through hole for supplying the drug in the container to the volatilization body. It is the volatile drug releaser described.

A third aspect of the present invention is the volatile drug releaser according to the first aspect, which is a porous sintered body made of a polyolefin resin.

According to the present invention, when the temperature rises in summer and the atmospheric pressure in the upper space in the container rises, the gas (air and vaporized chemicals) in the upper space reaches the mouth through the pipe. It is guided and released to the outside of the container. This allows
The gas in the upper space is maintained at normal pressure without being affected by the ambient temperature change. Therefore, according to the present invention, it is possible to reliably prevent the excessive discharge of the drug to the volatilization body due to the change in the ambient temperature.

Further, the drug in the container is supplied to the volatilizing body via the supplying body, whereby the medicine is saturated inside the supplying body and the volatilizing body. Then, in accordance with the volatilization of the drug in the volatilizer, the drug in the container is replenished to the volatilizer via the supplier, so that the drug in the container is gradually released into the atmosphere as in the conventional case.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings. In this embodiment, the volatile drug sustained-release device of the present invention is applied to a liquid fragrance sustained-release device.

(First Embodiment) As shown in FIGS. 1 and 2, a liquid fragrance sustained-release apparatus 1 of the first embodiment contains a liquid fragrance (an example of a liquid medicine) A therein, And, a substantially sealed inverted container 2 with the mouth 2a facing downward,
It is provided with a volatilization paper (corresponding to a volatilization body) 3 disposed below the mouth portion 2a and a supply body 4 for supplying the liquid aromatic agent A in the container 2 to the volatilization paper 3.

Further, the liquid fragrance sustained-release device 1 has a pedestal 5 having a volatilized paper 3 on its upper surface, a pedestal 5 fitted around the pedestal 5 to support the container 2, and a plurality of window holes 6a. It includes a cover 6, a lower cap 7 that is screwed into the mouth 2a from below and is fitted into a recess 6b in the center of the cover 6 from above, and an upper cap 8 that is fitted into the upper end of the container 2. ing.

In the first embodiment, the upper end of the container 2 is opened in the upper space 9 above the liquid surface, and the gas in the upper space 9 is opened from the opening 4a at the upper end according to the temperature change. A pipe 4 that guides to the outside 2a and escapes to the outside of the container 2 is provided, and further, the supply body 10 has a penetrating support hole 11 for fitting and supporting the pipe 4 and a liquid contained in the container 2. It has a liquid supply small hole 12 that penetrates to supply the fragrance A to the volatilization paper 3.

The supply member 10 is not particularly limited as long as it has water repellency, but from the viewpoint of production, an injection molded product of a thermoplastic or thermosetting resin is preferable. The inner diameter of the support hole 11 of the supply body 10 is 1.0 to 10.0 mm.
And the inner diameter of the liquid supply small hole 12 of the supply body 10 is within the range of 0.1 to 0.8 mm.

The configuration of each section will be described in detail below. As shown in FIG. 2, the container 2 is a synthetic resin molded product, and is procured by blow molding, for example. The mouth portion 2a of the container 2 is formed to have a smaller diameter than the body portion, and a male screw portion that is screwed into a female screw on the inner circumference of the lower cap 7 is provided on the outer circumference thereof. A circular hole 7a is provided in the center of the bottom portion of the lower cap 7 for allowing the substantially convex supply member 10 to project.
Is formed.

The cover 6 is provided with a concave portion 6b which is open upward to accommodate the mouth portion 2a and the lower cap 7, and the lower cap 7 is provided at the center of the bottom portion of the concave portion 6b.
The circular hole 6b1 having a diameter larger than that of the circular hole 7a is formed. Further, a tapered slope 6b2 that expands upward is formed at the upper edge of the recess 6b.
A taper-shaped step portion 2b formed in the lower portion of the container 2 is supported by the container 2.

Next, the assembly of the liquid fragrance gradual release device 1 will be described. First, the pipe 4 is the support hole 1 of the supply body 10.
After being fitted in 1, the supply body 10 is adhered to the bottom portion of the lower cap 7 so that the convex portion thereof contacts the volatilization paper 3. On the other hand, the container 2 in an upright state is filled with a predetermined amount of the liquid fragrance A, and in this state, the cover 6 including the lower cap 7 and the supply body 10 allows the pipe 4 to be inserted into the container 2. Is fitted into the container 2 from above, and the mouth portion 2a and the lower cap 7 are screwed together. Then, the container 2 integrated with the cover 6 is turned upside down, and the upper cap 8 is fitted on the upper end portion of the container 2, whereby the liquid fragrance sustained-release device 1 is completed.

As shown in FIG. 2, the volatilized paper 3 is laid on the upper surface of the bottom of the pedestal 5 according to the inner shape of the pedestal 5. Examples of the volatilization paper 3 include porous materials such as porous sintered bodies and foams, filter papers, and the like, but are not particularly limited as long as they have liquid absorbability.

According to the first embodiment having the above structure, the following actions and effects can be obtained. The liquid fragrance A in the container 2 is supplied to the volatilization paper 3 through the liquid supply small hole 12 of the supply body 10. As a result, the liquid fragrance A is saturated inside the supply body 10 and the volatile paper 3. And
As the liquid fragrance A in the container 2 is supplied to the volatile paper 3 through the liquid supply small holes 12 of the supply body 10 in accordance with the volatilization of the liquid fragrance A in the volatile paper 3, the liquid in the container 2 The fragrance A is gradually released into the atmosphere through the window 6a of the cover 6 as in the conventional case.

Then, when the atmospheric pressure in the upper space 9 in the container 2 increases due to an increase in temperature, the gas (air and evaporated fragrance) in the upper space 9 enters the pipe 4 through the opening 4a. While being guided by the pipe 4, it is guided to the space formed between the supply body 10 and the volatile paper 3. And
The gas transported to the lower end of the supply body 10 is discharged into the atmosphere through the gap between the bottom of the recess 6b of the cover 6 and the volatilization paper 3 or the inside of the volatilization paper 3. As a result, the upper space 9
The gas is kept at normal pressure without being affected by changes in ambient temperature. Therefore, according to the first embodiment,
Excessive discharge of the liquid fragrance A onto the volatilization paper 3 due to temperature change can be reliably prevented.

(Second Embodiment) Next, the liquid fragrance sustained-release device of the second embodiment will be described. In addition, about the same structure as the liquid fragrance | flavor extended release device of 1st Embodiment, the same code | symbol as 1st Embodiment is attached | subjected and description is abbreviate | omitted.

In the liquid fragrance sustained-release device 21 of the second embodiment, as shown in FIG. 3, in the basic structure of the first embodiment, the supply body 13 made of a porous sintered body having a liquid absorbing property is used. Is used. Similar to the first embodiment, this supply body 13 is formed with a support hole 14 for fitting and supporting the pipe 4, but the liquid fragrance A in the container 2 is transferred to the volatilization paper 3. No through hole for supply is formed. That is, since the supply body 13 is a porous sintered body having a liquid absorbing property, the liquid fragrance A passes through the supply body 13 and is discharged to the volatile paper 3. Therefore, according to the second embodiment, the same operation and effect as those of the first embodiment can be obtained.

The liquid fragrance sustained-release device 2 of the second embodiment
In 1, the supply body 13 made of a porous sintered body was used, but a foam body, pulp, or the like may be used. However, when comparing the porous sintered body and the foamed body, the porous sintered body is preferable because the porosity can be easily adjusted.

The porous sintered body is prepared by sintering thermoplastic resin powder. Examples of the thermoplastic resin include polyethylene, polypropylene, ethylene / butene-1 copolymer, ethylene / 4-methylpentene-1 copolymer, ethylene / vinyl acetate copolymer and other polyolefins, polystyrene, acrylonitrile / styrene copolymer. , Acrylonitrile / butadiene / styrene copolymer, polycarbonate, polymethylmethacrylate, polyamide, polyester, polyphenylene oxide, polyacrylonitrile, polyvinyl chloride, polyvinylidene chloride and the like. Among them, a polyolefin resin is desirable because it has excellent chemical resistance, does not cause dimensional change due to water absorption, does not cause strength reduction due to water absorption, and has sufficient strength as a sintered compact.

The liquid fragrance A used in the liquid fragrance sustained release devices 1 and 21 of the first and second embodiments is not particularly limited, and mainly contains a fragrance, a surfactant, a solvent and water. It can be obtained by blending at an appropriate composition ratio. When preparing the liquid fragrance A from the above components,
You may mix | blend arbitrary components as needed. Examples of the optional components include dyes, ultraviolet absorbers, deodorants, preservatives and the like.

As described above, the fragrance used in the preparation of the liquid fragrance A is not particularly limited, and can be appropriately selected from natural fragrances and synthetic fragrances. As the natural fragrance, for example, orange oil, lemon oil, lime oil, petitgrain oil, yuzu oil, neroli oil, bergamot oil, lavender oil, lavandin oil, abies oil, bay oil, poad rose oil, ylang ylang oil, citronella oil,
Geranium oil, peppermint oil, peppermint oil, spearmint oil, eucalyptus oil, lemongrass oil, patchouli oil, jasmine oil, rose oil, cedar oil, vetiver oil, carbam oil, oak moss oil, pine oil, camphor oil, white dough oil, Essential oils such as scented oil, turpentine oil, clove oil, clove leaf oil, cassia oil, nutmeg oil, cananga oil, and thyme oil, and animal flavors such as musk, spirit cat scent, raccoon scent, and spicy scent are used.

Examples of synthetic fragrances include linalool, linalyl acetate, geraniol, citronellol, C _{4 to} C ₁₂ various aliphatic aldehydes, phenylethyl alcohol, benzyl acetate, geranyl acetate, geranyl formate, vanillin, nitromusks, Galaxolid, tonalide, phantolide, Santarex, amyl salicylate, amyl acetate, γ-
Undecalactone, ethyl methylphenylglycidate,
Heliotropin etc. are mentioned. These fragrances may be used alone or as a mixed fragrance prepared by mixing two or more kinds.

Surfactants are roughly classified into nonionic surfactants, anionic surfactants and cationic surfactants. Nonionic surfactants include polyoxyethylene alkyl ether and polyoxyethylene. Alkyl phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene hydrogenated castor oil, and the like, and particularly, the average addition mole number of ethylene oxide is 1 to 30, preferably 5 to 2.
The polyoxyethylene-based nonionic surfactant of 5 can be preferably used. Also, alkylamine oxide and the like can be used. Examples of the anionic surfactant include alkyl sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl phenyl ether sulfate, polyoxyethylene alkyl phenyl ether sulfonate, and the like. Oxyethylene alkylphenyl ether sulfate and polyoxyethylene alkylphenyl ether sulfonate are preferable. Further, examples of the cationic surfactant include alkyl trimethyl ammonium salt and polyoxyethylene alkyl trimethyl ammonium salt. These surfactants may be used alone or in combination of two or more kinds.

Finally, as the solvent, ethanol, propanol, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, dipropylene. Examples include glycol monomethyl ether, dipropylene glycol monoethyl ether, 3-methoxy-3-methylbutanol, isoparaffin, dipentene and the like.

[0032]

EXAMPLES Next, the liquid fragrance A to be filled in the liquid fragrance sustained release devices 1, 12 and 15 of the present embodiment was mixed and prepared in various composition ratios as described below according to the examples. (Example 1) Perfume 2% by weight Polyoxyethylene alkyl ether 2 Polyoxyethylene hydrogenated castor oil 1 Ethanol 5 BHT trace Yellow No. 1 trace water balance Total 100

[0033] (Example 2) Perfume 1 wt% alkylphenol ethoxylate 1.5 Sodium alkyl benzene sulfonate 0.5 Ethanol 3 dihydroxybenzophenone trace Green No. 201 trace water Balance Total 100.0

[0034] (Example 3) Perfume 10 wt% ethanol 20 3-methoxy 3-methyl-butanol 40 BHT trace Green No. 201 trace water balance Total 100

(Example 4) Fragrance 6% by weight Propylene glycol 10 Isoparaffin 40 BHT Trace amount Red No. 106 Trace amount 3-Methoxy-3-methylbutanol Total residual amount 100

The liquid fragrances obtained in Examples 1 to 4 were filled in liquid fragrance sustained release devices 1 and 21, which are embodiments of the volatile drug sustained release device according to the present invention, and the changes with time were observed. However, it was confirmed that the temperature decreased by a fixed amount at every predetermined time without being affected by the temperature change around the container 2.

[0037]

As described above, according to the present invention, in the volatile drug sustained-release device, it is possible to reliably prevent the excessive drug from being discharged to the volatile substance due to the temperature change.

[Brief description of drawings]

FIG. 1 is a perspective view of a liquid fragrance sustained-release device according to a first embodiment.

FIG. 2 is a vertical cross-sectional view of the liquid fragrance sustained releaser according to the first embodiment.

FIG. 3 is a vertical cross-sectional view of a liquid fragrance sustained-release device according to a second embodiment.

[Explanation of symbols]

 1 Liquid fragrance sustained release device (an example of a volatile drug sustained release device) 2 Container 2a Mouth portion 3 Volatile paper (corresponding to a volatile substance) 4 Pipe 9 Upper space 10 Feeder 10a Top opening 11 Support hole 12 Liquid supply small Pore A Liquid fragrance

Claims (3)

[Claims] 1. A substantially sealed inverted container for containing a liquid drug therein and having a mouth portion facing downward, a volatilizer disposed below the mouth portion, and the inside of the container. A volatile drug sustained-release device provided with a supplier for supplying the drug to the volatile substance, wherein the container has an upper end opened in an upper space above the liquid surface, and the upper end according to a temperature change. Is provided with a pipe that guides the gas in the upper space to the mouth portion and escapes to the outside of the container, and the supply body is formed with a through hole for fitting the pipe. Volatile drug releaser. 2. The volatile chemical according to claim 1, wherein the supply body is made of an injection-molded article having water repellency and has a through hole for supplying the chemical in the container to the volatilization body. Releaser. 3. The volatile drug releaser according to claim 1, wherein the supply body is a porous sintered body made of a polyolefin resin.