JPH0928768A - Drug containing sheet - Google Patents

Abstract

(57) [Abstract] [PROBLEMS] In a drug-containing sheet containing a drug,
It is an object to make it easy to install and to effectively apply it to the entire processing range such as indoors. A porous metal body having a large number of pores is formed in a sheet shape, and a skeleton portion covering the large number of pores in the porous metal body includes a large number of internal fine pores having a diameter smaller than the pores therein. A technique is employed in which at least one kind of chemical is contained in the pores or the internal fine pores.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a chemical-containing sheet having insect repellent and deodorizing effects.

[0002]

2. Description of the Related Art In order to maintain a good indoor environment, the following various treatments and devices are generally performed. For example, in a Japanese-style room, mites (such as mosquito mites) may propagate on the tatami mat material. For this reason, the tatami mat is often dried in the sun and dried, and chemicals such as fenitrothion are sprayed or injected to kill insects and insect repellants. It is processing.
Then, in clothes to be preserved, in order to exterminate harmful insects such as cuticle beetles attached to the clothes and the like, pesticides such as paradichlorobenzene, naphthalene, and camphor can be put in cellophane wrapping etc. and stored together with clothes and the like. Has been done.

Further, in order to take off the odor in the room or the like, measures such as installing a container containing a deodorant in the room or the like are taken. Further, in a room or a container where humidity is disliked, a treatment such as adding a desiccant is performed.

[0004]

However, the following problems remain in the above treatments and the like. With insect repellent treatment of tatami mats, it is difficult to effectively and sustainably treat the entire tatami mat, which is a large area, with a drug.
In the insect repellent treatment for pests attached to clothes, etc., it is necessary to install chemicals in a plurality of places so that the insect repellent effect is effectively exerted on the entire interior such as a chest and a storage box in which clothes are stored. Since the drug evaporates, it needs to be replaced regularly, which takes time to install and replace.
When deodorizing or absorbing moisture in a room, etc.
In order to effectively absorb moisture, it is necessary to install the drug-containing containers in multiple locations, and the effects of the drug gradually decrease, so periodic replacement is necessary. It was hanging.

The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to provide a drug-containing sheet which is easy to install and has an effective effect on the entire processing range such as indoors.

[0006]

Means for Solving the Problems The present inventors have conducted research on a porous metal sintered body having a novel structure which has not been known so far, and the following research results have been obtained. Generally, when a surfactant and a water-insoluble organic solvent are added to water and mixed, colloidal droplets called fine micelles and sized micelles containing the water-insoluble organic solvent are formed by the surfactant, This becomes evenly dispersed and distributed in water, but in addition to the surfactant and the non-water-soluble organic solvent, the addition of metal powder and mixing also form the micelles, which is in water together with the metal powder. The mixture is uniformly distributed. In this case, the water-insoluble organic solvent has 5 to 5 carbon atoms.
Using the water-insoluble hydrocarbon organic solvent of No. 8, a molded body of a predetermined shape is molded from the mixture by a known method such as a doctor blade method or a slip casting method, and the molded body is heated at a temperature of 5 ° C. or higher. When kept at, the water-insoluble hydrocarbon-based organic solvent having 5 to 8 carbon atoms has a vapor pressure larger than that of water, and this vaporizes and becomes a gas to evaporate from the molded body. A large number of fine and sized bubbles are generated to form a porous molded body. Further, when a water-soluble resin is added to the mixture as a binder, the porous molded body has a strength capable of being handled, and at least one kind of polyhydric alcohol, oil and fat, ether and ester is added to the mixture. When added, the porous molded body becomes plastic. When the porous compact in such a state is sintered, a porous metal body composed of a skeleton portion (skeleton) covering the pores is obtained, and the skeleton portion has an internal fine particle smaller than the pores therein. The research result was obtained that it was formed of a porous metal sintered body containing a large number of pores.

In order to solve the above problems, the present invention adopts the following configuration based on the above research results. That is, in the drug-containing sheet according to claim 1, a drug-containing sheet containing a drug, wherein a porous metal body having a large number of pores is formed into a sheet shape, and the porous metal body has a large number of pores. A skeleton part covering the inside is formed of a porous metal sintered body including a large number of internal fine pores having a diameter smaller than the pores, and the pores or the internal fine pores contain at least one kind of agent. Existing technology is adopted. The drug-containing sheet according to claim 2 is the drug-containing sheet according to claim 1, wherein the perforated metal sintered body forming the skeleton portion contains at least one of silver and copper. .

In the drug-containing sheet according to claim 1, since at least one kind of drug is formed in a sheet shape and the pores or the internal fine pores are contained, the installation is completed only by laying, and the drug is The specific medicinal effect of is effectively applied to the entire surface of the sheet. In addition, air permeability is simultaneously ensured by pores containing no drug or internal fine pores. Furthermore, since the drug is contained in a large number of pores or internal fine pores, the amount of drug contained per unit area is large and the drug effect is highly durable. Further, since it is sheet-shaped and has plasticity, it can be arranged along the installation surface even in a portion other than a plane. In the chemical | medical agent containing sheet of Claim 2, since at least 1 side of silver and copper is contained in the perforated metal sintered body which forms a skeleton part, generation | occurrence | production of a bacterium by silver and copper which are high antibacterial properties. Suppressed.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION A first embodiment of the present invention will be described below with reference to FIGS. In these figures, reference numeral 1 is a drug-containing sheet, 2 is a floor, 3 is a porous metal body, and T is a tatami mat.

The drug-containing sheet 1 is, as shown in FIG.
It is laid on the entire surface of the floor 2, and the tatami T is laid on it. As shown in FIG. 2, the drug-containing sheet 1 is formed by forming a porous metal body 3 having a large number of pores A into a sheet shape, and the porous metal body 3 covers the large number of pores A. The skeleton portion 3a is formed of a perforated metal sintered body including a large number of internal fine pores a having a smaller diameter than the pores A therein. The internal fine pores a contain, as the drug Y, an insect repellent for mites, such as fenitrothion, pyrethroid, phenyl salicylate, which are typical low-toxic organophosphorus insecticides. Further, the effective metal sintered body forming the skeleton portion 3a contains at least one of silver and copper.

In the above-mentioned drug-containing sheet 1, the drug Y is formed in a sheet shape and the internal fine pores a contain the drug Y. Therefore, the installation is completed by simply laying it as described above, and The medicinal effect extends to the entire lower surface of the tatami T laid on the tatami mat. Further, the air permeability is simultaneously secured by the pores A that do not contain the drug Y. Furthermore, since the drug Y is contained in a large number of internal fine pores a, the amount of the drug contained per unit area is large and the drug effect is highly durable.

Further, at least one of silver and copper is contained in the perforated metal sintered body forming the skeleton portion 3a, and the generation of bacteria is suppressed by the highly antibacterial metal silver and copper. .

Next, an example of an apparatus for manufacturing the drug-containing sheet 1 according to the present invention will be described with reference to FIG. In these drawings, reference numeral 10 is a drug-containing sheet manufacturing apparatus, 11A is a carrier sheet supply roll, 11B is a carrier sheet take-up roll, 12 is a foam metal slurry storage tank, 13 is a drafter, and 14 is a metal body sheet take-up roll. Shows a roll.

The drug-containing sheet manufacturing apparatus 10 employs the doctor blade method, and the carrier sheet 11 is used.
carrier sheet supply roll 11 for sending a in the horizontal direction
A, a carrier sheet winding roll 11B that winds the carrier sheet 11a supplied from the carrier sheet supply roll 11A at the downstream end, and a foam metal slurry S that is arranged and stored above the carrier sheet 11a that moves in the horizontal direction. And a foam metal slurry storage tank 12 for coating the surface of the carrier sheet 11a with the foam metal slurry storage tank 12.
A plurality of drafters 13 which are arranged downstream of the foamed metal slurry S to dry the foamed metal slurry S into a sheet-shaped porous metal body 3.
A sheet peeling member 14a for peeling the carrier sheet 11a from the porous metal body 3 and a metal body sheet winding roll 14 for winding the separated porous metal body 3 are provided.

The foamed metal slurry storage tank 12 is provided with a discharge port 12a for the foamed metal slurry S on the downstream side of its lower end, and a doctor blade section 12b on the upper side thereof. Further, a cutter 12c for cutting the discharged metal foam slurry S into a predetermined length is attached to the side surface of the doctor blade portion 12b so as to be vertically movable. The drafter 13 is a fan 1 that blows high-temperature air sent from an oven (not shown) connected to the upper part of the drafter 13 onto the applied foam metal slurry S.
3a.

Next, the above-mentioned drug-containing sheet manufacturing apparatus 10
An example of one step of the method for producing the drug-containing sheet 1 according to the present invention will be described with reference to FIGS. 2 to 4.

[Slurry Coating Step] First, in the foam metal slurry storage tank 12, a water-insoluble hydrocarbon organic solvent having 5 to 8 carbon atoms and having a weight percentage of 0.05 is used.
-10%, surfactant: 0.05-5%, water-soluble resin binder: 0.5-20%, average particle size: 0.5-500 μm metal powder: 5-80%, if necessary , A polyhydric alcohol, a fat, an ether, and an ester, and one or more kinds of plasticizers: 0.1 to 15%, water: the rest, a foamed metal slurry S that is a mixture having a composition composition of Save.

The foamed metal slurry S is shown in FIG.
As shown in, a surfactant forms fine colloidal droplets called a micelle 15a, which are finely sized and contain a water-insoluble organic solvent, and are dispersed uniformly in water. In addition to the surfactant and the water-insoluble organic solvent, the metal powder 15b is further added and mixed to form the micelle 15a, which is uniformly dispersed in water together with the metal powder 15b. . The metal powder 15b contains metal powder made of silver, copper, or an alloy thereof.

The carrier sheet supply roll 11A and the carrier sheet winding roll 11B are rotationally driven to move the carrier sheet 11a to the foamed metal slurry storage tank 12 side. Along with the movement of the carrier sheet 11a, the cutter 12c is moved upward, the discharge port 12a is opened, and the foam metal slurry S moves from the discharge port 12a below the storage tank 12 for the foam metal slurry 11a.
Ejected on the surface of, and applied directly.

At this time, the foamed metal slurry S is molded by the doctor blade portion 12b to a constant thickness.
As a result, as shown in FIG. 4A, a sheet-shaped slurry compact 15 is formed on the surface of the carrier sheet 11a. When the slurry compact 15 having a predetermined length is formed, the cutter 12c is moved downward to stop the discharge and application of the foam metal slurry S.

[Slurry Drying Step] Thereafter, the slurry molded body 15 is transferred to the lower side of the drafter 13 by the movement of the carrier sheet 11a, and the drafter 1 is also moved.
A drying process is performed according to 3. At this time, as shown in FIG. 4B, when the slurry molded body 15 is held at 5 ° C. or higher and dried, the water-insoluble hydrocarbon organic solvent having 5 to 8 carbon atoms is larger than water. Since it has a vapor pressure, it is vaporized and becomes a gas to evaporate from the slurry compact 15. After that, degreasing is further performed in a high temperature state.
Therefore, a large number of fine and sized bubbles are generated in the slurry molded body 15 to form a porous molded body, and after drying, a large number of pores A covered by the skeleton portion 3a.
The porous molded body 16 having the is formed.

[Sheet peeling step] Carrier sheet 11a
In order to peel off the upper porous metal body 3, the sheet peeling member 1
The carrier sheet 11a and the porous metal body 3 are branched in two directions by 4a. The carrier sheet 11a is
The porous metal body 3 is wound around and stored in the carrier sheet winding roll 11 </ b> B.
It is wound and stored.

[Sintering Porous Formed Body] Thereafter, the porous metal body 3 housed in the metal body sheet winding roll 14 is placed.
Is placed in a sintering furnace (not shown) and subjected to a sintering process. At this time, as shown in FIG. 4C and FIG.
A porous metal body 3 composed of a skeleton part 3a covering the above is obtained, and the skeleton part 3a becomes a perforated metal sintered body including a large number of internal fine pores a having a diameter smaller than the pores A therein.

[Drug Impregnation / Drying Step] When the drug is an insect repellent for mites, a drug solution storage tank in which the drug solution in which the drug Y is dissolved in an organic solvent or the like is stored in the sheet-like porous metal body 3 is stored. To impregnate the inside with the drug solution. Thereafter, when the porous metal body 3 is pulled up from the drug solution storage tank, the drug solution remains in the small internal pores a having a small diameter, but the drug solution falls out from the pores A having a large diameter to form a vacant state. Become. In this state, when the porous metal body 3 is appropriately dried under the temperature condition in which only the solvent evaporates and the medicine Y does not evaporate, the medicine Y remains inside the internal fine pores a, and the medicine-containing sheet 1 is manufactured. It

Next, a second embodiment of the present invention will be described with reference to FIG. In the drug-containing sheet in the second mode, the drug-containing sheet 1 in the first mode contained the drug Y inside the internal fine pores a, whereas as shown in FIG. The difference is that is included. Therefore, the air permeability is ensured by the internal fine pores a in a vacant state.

The method for producing a drug-containing sheet according to the second embodiment is the same as the drug-containing sheet 1 according to the first embodiment described above.
The manufacturing process is different from the manufacturing process described above in that the drug solution in which the porous metal body 3 is immersed in the drug impregnation / drying process holds the drug Y in a granular state and has a low viscosity. That is, when the porous metal body 3 immersed in the suspension is pulled up, the granular drug Y remains in the pores A having a large diameter, and the low-viscosity liquid component falls out from the pores A and the internal fine pores a. The drug-containing sheet of the second form is manufactured. Examples of such a drug and a drug solution include a desiccant which is a mixture of powdered silica gel, which absorbs moisture but is hardly soluble in water, stirred and mixed in water.

In the foam metal slurry according to the present invention,
The reason why the composition is limited as described above will be explained.

(A) Water-insoluble hydrocarbon organic solvent having 5 to 8 carbon atoms (hereinafter, simply referred to as an organic solvent) In the above organic solvent, micelles are formed by the action of a surfactant, and 5 ° C. or more after molding. Evaporate by keeping the temperature of
It has the function of forming fine and sized bubbles in the slurry compact, but if the proportion is less than 0.05%, the generation of bubbles is insufficient, and the desired porous metal sintering with high porosity is obtained. The body cannot be manufactured, while the ratio exceeds 10%. The size of the micelle increases, and the bubbles formed in the slurry compact also increase in size, which causes the strength of the slurry compact and porous metal sintered body to drop sharply. Was set to 0.05 to 10%, preferably 0.5 to 5%. Further, the carbon number of the organic solvent is set to 5 to 8 because the value of 4 or less and the liquid one does not exist under normal temperature and pressure (all are gases), while the value is 9
This is based on the reason that the vapor pressure becomes small and it becomes extremely difficult to form bubbles in the above cases. further,
As the organic solvent, it is preferable to use neopentane, hexane, isohexane, heptane, isoheptane, benzene, octane, and toluene.

(B) Surfactant The surfactant has a function of forming micelles encapsulating an organic solvent as described above, but if the ratio is less than 0.05%, the formation of the micelle becomes unstable, Due to this, it is not possible to form finely sized micelles, and on the other hand, even if the proportion exceeds 5%, further improvement effect does not appear due to the above action, so the proportion is 0.05 to 5%. , Preferably 0.5 to 3%. As the surfactant, generally, a detergent may be used, and a commercially available kitchen neutral synthetic detergent (for example, a 28% mixed aqueous solution of alkyl glucoside and polyoxyethylene alkyl ether) is sufficient.

(C) Water-Soluble Resin Binder The water-soluble resin binder has the function of improving the strength of the porous body and allowing its handling, but its proportion is less than 0.5%. However, the desired strength-improving effect cannot be obtained. On the other hand, if the ratio exceeds 20%, it becomes difficult to form a desired shape.
%, Preferably 2 to 10%. Further, as the water-soluble resin, it is desirable to use methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose ammonium, ethyl cellulose, and polyvinyl alcohol.

(D) Metal powder Since the metal powder constitutes a perforated metal sintered body after sintering, a metal material applied to a porous metal body including a conventional perforated metal sintered body. However, if the average particle size is less than 0.5 μm, it becomes difficult to increase the porosity of the sintered body, while if the average particle size exceeds 500 μm, the dispersibility in the mixed raw material decreases. However, since it becomes impossible to manufacture a homogeneous sintered body, the average particle size is set to 0.5 to 500 μm, preferably 5 to 100 μm. The ratio of the metal powder is preferably 5 to 80%, which is 5%.
If it is less than%, the strength of the sintered body will decrease sharply,
On the other hand, it is based on the reason that it is difficult to increase the porosity when the ratio exceeds 80%.
% Ratio is desirable.

(E) Plasticizer The polyhydric alcohol, fats and oils, ethers, and esters added as plasticizers have the function of imparting plasticity to the slurry compact. If the proportion of this plasticizer is less than 0.1%, the desired effect on the above-mentioned action cannot be obtained, while the proportion is 1%.
If it exceeds 5%, the strength of the porous molded article will suddenly decrease. Therefore, the ratio was set to 0.1 to 15%, preferably 2 to 10%. Further, as the polyhydric alcohol, ethylene glycol, polyethylene glycol,
And glycerin, sardines oil, rapeseed oil,
And olive oil, petroleum ether as the above ether,
Further, it is preferable to use diN-octyl phthalate, sorbitan monooleate, sorbitan trioleate, sorbitan palmitate, and sorbitan stearate as the ester.

Further, when a combustible material is added to the mixture,
Combustion disappears during degreasing and sintering of the porous molded body,
The formation of pores can be further promoted. Therefore, the combustible material is not particularly limited in terms of material as long as it burns and disappears at a temperature of 300 ° C. or higher and at a temperature of sintering temperature of the metal powder or lower. For example, 0.1 to 200 μm, preferably 20 to 10
Those having an average particle size of 0 μm are preferable, and if they are fibrous, the length thereof is 200 μm or less, preferably 30 to 12
It is preferably 0 μm. On the other hand, if the proportion is less than 0.1%, the desired effect of promoting pore formation cannot be obtained. On the other hand, if the proportion exceeds 40%, unevenness is likely to occur on the surface of the porous molded article during drying, Since the surface property is deteriorated, the ratio is set to 0.1 to 40%, preferably 5 to 20%. Furthermore, as combustible materials, pulp,
It is preferable to use cotton, lint, corn starch, carboxymethyl cellulose, water-insoluble cellulose resin, polyvinyl butyral resin, polyvinyl resin, acrylic resin, polyethylene resin and the like.

In each of the above-mentioned embodiments, only one medicine-containing sheet 1 of the present invention is laid under the tatami mat T, but a large number of sheets may be laid over each other. In this case, the medicinal effect of the drug Y can be maintained for a longer period of time. Furthermore, when a deodorant or a desiccant is included as a drug, the deodorizing / hygroscopic effect is effectively exerted in the entire room. Further, as another form, as an insect repellent for pests and the like attached to clothing, for example, by incorporating naphthalene or the like in a porous metal body, the agent of the present invention on the bottom of a chest or storage box for storing clothing or the like. When the containing sheet is laid, the insect repellent effect is effectively applied to the entire interior of the chest of drawers, storage box and the like, and periodical replacement becomes easy. The drug to be included may be a drug other than those listed above. For example, an antibacterial agent or a rust preventive agent may be included. Further, in the above-described method for producing the drug-containing sheet 1 of the present invention, the sheet-shaped porous metal body is dipped in the drug solution containing the drug to take in the drug inside.
The drug may be included by other methods. For example, a sheet-shaped porous metal body may be placed in a container containing a drug in the form of powder, which is smaller than the pores, and the surface may be rubbed well to allow the drug to be contained in the pores inside.

[0035]

EXAMPLES Next, the drug-containing sheet according to the present invention will be specifically described with reference to Examples. First, as metal powder,
Various metal powders having an average particle size and composition shown in
As an organic solvent, neopentane (hereinafter referred to as A-1), hexane (also referred to as A-2, the same hereinafter), isohexane (A-3), heptane (A-4), isoheptane (A-5), benzene (A) -6), octane (A-
7), and toluene (A-8), the above-mentioned commercially available kitchen neutral synthetic detergent as a surfactant, methylcellulose (hereinafter referred to as B-1) and hydroxypropylmethylcellulose (also B-) as a water-soluble resin binder. 2
The same shall apply hereinafter), hydroxyethyl methylcellulose (B-
3), carboxymethyl cellulose ammonium (B-
4), ethyl cellulose (B-5), and polyvinyl alcohol (B-6), as a plasticizer, polyethylene glycol (hereinafter referred to as C-1), olive oil (also referred to as C-2, hereinafter the same), petroleum ether (C). -3),
DiN-butyl phthalate (C-4) and sorbitan monooleate (C-5) were prepared respectively, and these are shown in Table 1.
Each of the mixed raw materials A to P was prepared as a foamed metal slurry by mixing it with water in the composition shown in No. 2 and mixing them under normal conditions.

[Table 1]

[Table 2]

Next, these various mixed raw materials are applied to the surface of the carrier sheet 11a by the above-described drug-containing sheet manufacturing apparatus 10 to form the slurry molded body 15, and the slurry molded body 15 is provided with Table 3 respectively. By carrying out bubble formation (formation of a porous molded body), degreasing and sintering under the conditions shown in 4, each of the drug-containing sheets having the porous metal bodies 1 to 16 formed on the surface was manufactured.

[Table 3]

[Table 4]

Next, with respect to the drug-containing sheets on which these porous metal bodies 1 to 16 were formed, the porosity of the perforated metal sintered body was measured, and arbitrary 10 points in the longitudinal section were magnified 200 times with a metallurgical microscope. Observe at magnification, measure the maximum and minimum pore size of the pores at each observation point,
The average was determined. Table 5 shows the results of these measurements.

[Table 5]

For the drug-containing sheets on which these porous metal bodies 1 to 16 were formed, the total porosity of the porous metal bodies was measured by using an image analysis device together, and B
The total specific surface area of the porous metal body was measured by the ET method, and the porosity of internal fine pores in the skeleton part of the porous metal sintered body forming the porous metal body was also measured. The results of these measurements are shown in Table 6 as the average values of 30 measurement points.

[Table 6]

[0039]

According to the present invention, the following effects can be obtained. (1) According to the drug-containing sheet of the present invention, the drug is formed in a sheet shape and the drug is contained in the pores or the internal fine pores. The medicinal effect is effective over the entire surface of the sheet, and a uniform medicinal effect can be obtained over a wide range. Further, air permeability is simultaneously ensured by the pores or internal fine pores that do not contain the drug, and the aeration promotes the diffusion of the drug. Furthermore, since the drug is contained in a large number of pores or internal fine pores, the amount of the drug contained per unit area is large and the drug effect is highly durable, so that a certain drug effect can be obtained over a long period of time.
The frequency of replacement can be reduced. And because it is formed into a sheet shape, it is arranged along the installation surface even in parts other than flat surfaces, has various installation application ranges on steps and curved surfaces, and can be folded and wound for easy storage. Becomes In addition, by mixing and incorporating multiple kinds of drugs, it is possible to obtain a plurality of drug effects at the same time. (2) Further, by containing at least one of silver and copper in the perforated metal sintered body forming the skeleton part, the generation of bacteria is suppressed by silver and copper, which are highly antibacterial metals, and the antibacterial effect is obtained. Can be added.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing a first form of a drug-containing sheet according to the present invention.

FIG. 2 is an enlarged cross-sectional view of a porous metal body in a second form of the drug-containing sheet according to the present invention.

FIG. 3 is a schematic cross-sectional view for explaining an example of a drug-containing sheet manufacturing apparatus according to the present invention.

FIG. 4 is a conceptual diagram for explaining one process example of a method for producing a drug-containing sheet according to the present invention.

FIG. 5 is an enlarged cross-sectional view of a porous metal body in a second form of the drug-containing sheet according to the present invention.

[Explanation of symbols]

 1 Drug-Containing Sheet 3 Porous Metal Body 3a Skeleton Part 15 Slurry Molded Body 15a Micelle 15b Metal Powder 16 Porous Molded Body A Pores a Internal Micropores S Foamed Metal Slurry Y Chemicals

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Koji Hoshino 1-297 Kitabukurocho, Omiya City, Saitama Prefecture Mitsubishi Materials Corporation

Claims (2)

[Claims] 1. A drug-containing sheet containing a drug, wherein a porous metal body having a large number of pores is formed into a sheet shape, and the porous metal body has a skeleton portion covering the large number of pores,
It is formed of a perforated metal sintered body including a large number of internal fine pores having a diameter smaller than that of the pores, and the pores or the internal fine pores contain at least one kind of chemical agent. Drug containing sheet. 2. The drug-containing sheet according to claim 1, wherein the perforated metal sintered body forming the skeleton portion contains at least one of silver and copper.