JPH09315930A - Cosmetic material for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic material for skin capable of expressing excellent aging-preventing effect on skin and skin-beautifying effect by using mevalonic acid, mevalonolactone together with a specific plant-extract or a specific material obtained from yeasts or mammals. SOLUTION: In this cosmetic material for skin, (a) one or more of mevalonic acid and mevalonolactone are combined with (b1 ) an extract of one or more of plants selected from a group consisting of loquats, peaches, Kokuryo ginsengs, dishcloth gourds, herbaceous peonies, goldthreads, etc. One or more of powdery yeasts (b2 ), extracts of yeasts are combined together with the component (a). One of a deproteinized extract from the blood of a mammal (b3 ) or collagen is combined together with the component (a). A dose of the component (a) in a cosmetic material is preferably about 0.001-10wt.% based on the total weight of the cosmetic material. The dose of the components (b1 ), (b2 ) and (b3 ) are preferably about 0.01-10wt.%, 0.01-5.0wt.% and 0.01-5.0wt.%, respectively.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin cosmetic, and more specifically, it exhibits an excellent anti-aging effect on skin (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover speed), and beautiful skin effect. The present invention relates to a skin cosmetic which is excellent in giving.

[0002]

2. Description of the Related Art Aged skin becomes rough and dry without smoothness, and keratinocyte exfoliation is observed. It is said that aging skin has a slow turnover speed, and that when the antiaging effect is exerted and imparted to the skin, the turnover speed of the skin increases. Conventionally, various cosmetics that impart a suitable moist feeling and flexibility to the skin surface have been proposed. For example, in Japanese Patent Application Laid-Open No. 4-99707, R-
(-) Skin cosmetics containing mevalonic acid have been proposed. In addition, propylene glycol, 1,3-butylene glycol, glycerin, polyglycerin, and the like have been added as a humectant in skin cosmetics to give a moist feeling to the skin. Has a drawback that stickiness is caused because these humectants are incorporated in a large amount of 5% by weight or more. In addition, the skin cosmetics and the like act on the epidermis of the skin tissue, but rarely act on the dermis, which is a tissue below the epidermis, and thus have a sufficient effect on the prevention of skin aging as described above. There was nothing.

[0003]

DISCLOSURE OF THE INVENTION The object of the present invention is to develop and impart an anti-aging effect (rough skin improving effect, keratin improving effect, turnover speed increasing effect), beautiful skin effect, and excellent feeling of use. To provide cosmetics.

[0004]

[Means for Solving the Problems] The above objects are (a) one or more of mevalonic acid and mevalonic acid lactone, and (b) loquat, peach, aloe, ginseng, loofah, peony, oleen, psyllium, button pi, Gentian ginger, tea, spruce, sardine, sage, hamamelis, birch, garlic, chinpi, chamomile, chazensou, bellflower, keihi, fennel, hops, valerian, sardine, purple, sage, ginkgo, bamboo, sowaku, senburi, camellia, camellia It is achieved by a skin cosmetic containing a plant extract selected from one or more of:

Further, it is achieved by a skin cosmetic containing (a) one or more of mevalonic acid and mevalonic acid lactone and (b) one or more of yeast powder and yeast extract.

Further, it is achieved by a skin cosmetic composition containing (a) one or more kinds selected from mevalonic acid and mevalonic acid lactone, and (b) one or more kinds of deproteinized protein extract from mammalian blood and collagen. .

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the mevalonic acid used as the component (a) is also referred to as pyroclastic acid (molecular formula: C ₆ H ₁₂ O ₄ ), and true fire bacillus (Lactobac) mixed in sake.
illushomochio and L. hetero
chichi), and lactic acid bacteria (L. a.
Cidophilus), a substance found as a growth-promoting factor, and is used as a biosynthesis precursor for isoprenoid compounds such as sterols, or as a raw material for chemically or enzymatically synthesizing various optically active substances. Mevalonic acid has two isomers [R (-)-mevalonic acid, S (+)
-Mevalonic acid] and R (-)
-Mevalonic acid, any of which can be used in the present invention, but R (-)-mevalonic acid, which is easily available, is preferable. R (-)-mevalonic acid is disclosed in, for example, JP-A-63-2
No. 16484, JP-A-63-216485,
JP-A-63-216486, JP-A-63-216
No. 487 can be produced by a microbial fermentation method. Alternatively, it can be produced as a racemate (mixture of isomers) by a chemical synthesis method, and can be isolated into each isomer, and any of them can be used in the present invention.
Further, mevalonic acid lactone (molecular formula: C ₆ H ₁₀ O) which is a derivative of mevalonic acid used as the component (a) in the present invention.
₃ ) is a compound having the property of being easily converted to mevalonic acid by hydrolysis.

The amount of the above mevalonic acid or mevalonic acid lactone to be added to the skin cosmetics is based on the total amount of the skin cosmetics.
0.001 to 10% by weight (hereinafter abbreviated as wt%)
Is preferred. If it is less than 0.001 wt%, the effect of the present invention is not sufficiently exhibited, and if it is compounded in excess of 10 wt%, the effect commensurate with the increase of the compounding amount may not be expected.

On the other hand, examples of the above-mentioned plant extract used as the component (b) in the present invention include loquat, peach, aloe, leaves in ginkgo, tea leaves or fruits, ginseng, peony, valerian root, purple mulberry. , Bellflowers are roots, loofah, genus ginger, odorum serrata, bamboo are aboveground parts, oren are rhizomes, psyllium, cinnamon bark, sage, senburi, psyllium (psyllium) are whole plants, hamamelis leaves, bark or roots, birch leaves or Bark, garlic bulbs, chamomile flowers, fennel, camellia fruits, hops female spikes, chimpi (citrus peels), button pi (button roots), kujin (clara roots), sohakuhi (mulberry roots), Scuttlefish (root of Scutellaria baicalensis), water, alcohol (methanol, ethanol, etc.), hydrous alcohol, polyhydric alcohol (propylene glycol, 1,3 Renglycol, polyethyleneglycol, etc.), hydrous polyhydric alcohol, other organic solvent solvents (petroleum ether, cyclohexane, acetone, benzene, carbon tetrachloride, etc.) extracted and / or further purified extract, Alternatively, it is a product obtained by further fractionating a purified product, and in the present invention, any of an extract, a concentrate, and a dried powder can be blended. Of these, preferably, 1,3 butylene glycol extract of peach leaves, root of ginseng root, loofah leaves, aloe leaves, root of algonum, ethanol extract of tea, tea fruit extracted with hydrous lower alcohol An extract obtained by further fractionating an ion-exchange column (Japanese Patent Publication No. 5-52287),
An extract obtained by subjecting camellia seeds extracted with hydrous lower alcohol to fractionation with an ion exchange column (Patent Literature 6
-693).

The amount of the above-mentioned plant extract to be added to the skin cosmetics (calculated as dry residue) is 0.0.
1 to 10 wt% is preferable. If the amount is less than 0.01 wt%, the effect of the present invention is not sufficiently exerted, and if the amount exceeds 10 wt%, the effect commensurate with the increase in the amount of the compound may not be expected, and the skin trouble may occur. There are cases.

Further, used as the component (b) in the present invention,
As the yeast powder and yeast extract, (1) a spray-dried product of a digestive solution obtained by autolysis of yeast such as brewer's yeast and baker's yeast, (2) a microfilter of the digestive solution obtained by autolysis of dry yeast. By aseptic filtration, lyophilized, diluted with purified water, and (3) propylene glycol, 1,3 butylene glycol, obtained by concentrating and drying the digested liquid obtained by yeast autolysis.
The product obtained by extracting with water, (4) the product obtained by drying yeast cells into powder, and extracting with a mixed solution of water and concentrated glycerin, (5) hydrolyzing yeast with acid. After disassembling,
It is obtained by centrifugation, dialysis, filtration, and concentration, and various amino acids, vitamins, nucleic acid-related substances, proteins,
Contains a lot of sugars and lipids. As commercially available products, yeast extract A-33 (manufactured by Nikko Chemicals), L
p yeast (manufactured by SunRade) and the like.

The amount of the yeast powder and the solvent extract of yeast described above (converted to the dry residue) is 0.
01-5.0 wt% is preferable. If it is less than 0.01 wt%, the effect of the present invention is not sufficiently exerted, and if it exceeds 5 wt%, the effect commensurate with the increase of the blending amount may not be expected, and there is a concern of skin trouble. There are cases.

Further, the deproteinized extract from mammalian blood used as the component (b) in the present invention is Japanese Patent Publication No.
It is a water-soluble component obtained by deproteinizing fresh blood of cattle, pigs, etc. by an ultrafiltration method and the like, which is produced by JP-A-4-13956, and amino acids, peptides, organic acids and sugars. Contains a lot of quality. Examples of commercially available products include Stimulusel (manufactured by Petafarm) and Solcoceryl (manufactured by Toryo Yakuhin). Further, the collagen used in the present invention is a main protein of connective tissue of animals, and soluble collagen and hydrolyzate obtained by subjecting the skin or dermis layer of cattle or the like to an extraction treatment or hydrolyzing the same. Collagen, or a product obtained by further treating it with succinylation or the like can be mentioned. As commercially available products,
Protein CAA S.M. F. (Manufactured by Croda), Promois W (manufactured by Seiwa Kasei), and Atelocollagen SS (manufactured by Koken Co.).

The amount of the deproteinized protein extract from the blood of mammals and the collagen content (calculated as dry residue) is preferably 0.01 to 5.0 wt% with respect to the total amount of the skin cosmetic.
If it is less than 0.01 wt%, the effect of the present invention is not sufficiently exerted, and even if it exceeds 5.0 wt%, the effect commensurate with the increase of the blended amount may not be expected, and there is a concern of skin trouble. May occur.

The dosage form of the skin cosmetic of the present invention is not particularly limited, and may be cream, emulsion, lotion,
Ointments, powders, etc. of ordinary pharmaceuticals, quasi-drugs,
It can be applied to cosmetic formulations. In the external preparation for skin of the present invention, as other components, an emulsifier, an oily substance, a moisturizer, a thickener, a fragrance, an antiseptic, an antioxidant, a colorant and the like are appropriately added within a range to achieve the object of the present invention. It may be blended.

[0016]

The present invention will be described below in detail based on examples and comparative examples. In the Examples, (1) the method for measuring the turnover speed of the stratum corneum, (2) the method for measuring the effect of improving rough skin, (3) the method for measuring the effect of improving stratum corneum, and (4) the sensory test are as follows. .

(1) Method for measuring turnover rate of stratum corneum 5 wt% of dansyl chloride as a fluorescent dye in white petrolatum
% Ointment was prepared and occluded and applied to the skin of the forearm of 20 subjects for 24 hours, and dansyl chloride was osmotically bonded to the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day.
The number of days until the fluorescence disappeared was defined as the skin stratum corneum turnover speed. The measurement results were shown as an average of the number of days for each subject. The normal skin stratum corneum turnover is 1
4-16 days, but extends around 18 days in aged skin. On the other hand, when the anti-aging effect appears, 12
It is shortened to around days.

(2) Method for measuring the effect of improving rough skin The effect of continuous application was investigated for 20 weeks for 20 middle-aged and elderly subjects who have rough skin on their lower legs. That is, the test sample was applied twice a day (morning and evening) to the left lower leg test site of the test subject, and the skin condition before and after the test was judged according to the criteria shown in Table 1 below. The lower leg on the right side was used as a control without applying the test sample.

[0019]

[Table 1]

Then, the judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two stages or more (for example: + →-, ++ → ±), it is “effective” and improved by one stage. When the result is "slightly valid", when there is no change, it is considered "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(3) Method for measuring the effect of improving keratin (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is adhered to the skin of the test area before and after the start of and the end of the rough skin improvement measurement test. When this is peeled off, the state of keratinocytes attached to the tape is examined in detail by a scanning electron microscope,
The stratum corneum exfoliating property was classified according to the criteria shown in Table 2 below, and the effect of improving the keratin was determined.

[0022]

[Table 2]

The judgment is “effective” when the difference between the evaluation points of the test site and the control site after continuous application for 4 weeks is 2 or more, “effective”, 1 or more is “slightly effective”, and 0 is 0. "Invalid" The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(4) Sensory test (Beautiful skin effect) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
Test sample twice a day (morning, evening) for 20 persons 3
The coating was applied for 1 month, and the effect after 1, 2 and 3 months was evaluated.
The test results are shown by the number of people who responded that "the skin was moisturized" and "the skin became smooth" for each of the items of wettability, smoothness, and elasticity of the skin.

Examples 1 to 6 and Comparative Examples 1 to 9 (skin cream) (a) component mevalonic acid, mevalonic acid lactone, (b)
Aloe leaf extract, peach leaf extract, camellia seed extract, tea seed extract, sardine root extract, loquat leaf extract as ingredients are blended as shown in Tables 3 to 4, and each skin is blended. Creams were prepared and the above experiments were carried out.

(1) Composition

[0027]

[Table 3]

(2) Preparation Method The raw material (A) in Table 3 above was melted at 70 ° C., mixed with the raw material (B), and then heated to 78 ° C. Next, this was gradually added to the raw material (C) heated to 75 ° C. while stirring, and preliminarily emulsified. Thereafter, the mixture was completely emulsified with a homogenizer, cooled to 50 ° C., added with the raw material (D), and cooled to 30 ° C. to prepare a skin cream. The R (-)-mevalonic acid lactone blended as the component (a) is considered to be present in the skin cream in equilibrium with R (-)-mevalonic acid.

(3) Characteristics Various tests were conducted on each of the above skin creams, and the results are shown in Tables 4 and 5.

[0030]

[Table 4]

[0031]

[Table 5]

As shown in Tables 4 and 5, (a) component mevalonic acid, mevalonic acid lactone, (b) component aloe leaf extract, peach leaf extract, camellia fruit extract, tea fruit The skin creams of Comparative Examples 1 to 9 which did not contain the extract, the root extract of Scutellaria basil, and the loquat leaf extract, or which contained the extract alone, did not show sufficient effects in various properties, while the Examples of the present invention were used. 1 to 6 of (a) mevalonic acid and mevalonic acid lactone, and (b) component of aloe leaf extract, peach leaf extract, camellia fruit extract, tea fruit extract, sorghum root extract The skin creams of Examples 1 to 6 which were used in combination with the loquat leaf extract were found to have a remarkable effect on rough skin improving effect, keratin improving effect, quick turnover speed effect, that is, the effect of preventing skin aging. , Sensory test, 2 months after application, wetting, smooth , Elasticity was observed.

Example 7, Comparative Examples 10 to 11 (Skin Lotion) Each skin lotion was prepared according to the composition shown in Table 6 below, and various tests were carried out. In addition, yeast extract A-33 (manufactured by Nikko Chemicals Co., Ltd.) was used as the yeast extract (compounding amount converted to dry residue).

(1) Composition

[0035]

[Table 6]

(2) Preparation Method Each of the raw materials shown in Table 6 above was stirred and uniformly dissolved to prepare a skin lotion. (3) Characteristics The skin lotion of Example 7 had excellent skin beautifying effect and skin aging preventing effect (rough skin improving effect, keratin improving effect, effect of accelerating turnover speed) as compared with Comparative Examples 10 to 11. .

Example 8 (Skin Cream) A skin cream having the composition shown in Table 7 below was prepared. Deproteinized extract of mammalian blood (blending amount converted to dry residue)
Solcoceryl (manufactured by Tohryo Pharmaceutical Co., Ltd.) was used as.

[0038]

[Table 7]

(2) Preparation method The raw material (A) and the raw material (B) shown in Table 7 were uniformly heated and melted to bring the temperature to 80 ° C. Then, during (A),
After injecting and emulsifying (B), it was cooled to 30 ° C. with stirring to prepare a skin cream.

Example 9 (makeup base) A makeup base having the composition shown in Table 8 below was prepared.
As the hydrolyzed collagen (compounding amount was calculated as dry residue), Promois W (manufactured by Seiwa Kasei Co., Ltd.) was used. (1) Composition

[0041]

[Table 8]

(2) Preparation method The raw material (A) and the raw material (B) shown in Table 8 were uniformly heated and melted to bring the temperature to 80 ° C. Next, while stirring the liquid (B) with a homomixer, the liquid (A) was injected and emulsified, and then cooled to 30 ° C. to prepare a makeup base.

Example 10 (skin milk) A skin milk having the composition shown in Table 9 below was prepared. still,
The blending amount of the plant extract of the component (b) is in terms of dry residue. (1) Composition

[0044]

[Table 9]

(2) Preparation method The raw material (A) and the raw material (B) shown in Table 9 were uniformly heated and melted to bring the temperature to 80 ° C. Then, in the (A) liquid,
After injecting and emulsifying the liquid (B), it was cooled to 30 ° C. with stirring to prepare skin milk.

Components (a) and (b) of Examples 8 to 10 above
The combined use of the components has a superior effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover speed), and beautiful skin, as compared with those in which only component (a) or component (b) is blended. Showed the effect.

[0047]

As described above, the present invention provides a useful skin cosmetic excellent in skin aging prevention effect (rough skin improvement effect, keratin improvement effect, turnover speed increasing effect) and skin beautiful effect. Is clear.

Claims (3)

[Claims] 1. (a) one or more of mevalonic acid and mevalonic acid lactone, and (b) loquat, peach, aloe, ginseng, loofah, peony, oleen, psyllium, button pi, gem ginger, tea, kujin, sardine, sage. , Plant extract selected from one or more of the group consisting of, hamamelis, birch, garlic, chimpanzee, chamomile, chazensou, bellflower, cinnamon, fennel, hop, valerian, dragonfly, murasaki, sage, ginkgo, bamboo, sowakuhi, senburi, camellia. A skin cosmetic containing and. 2. A skin cosmetic containing (a) one or more of mevalonic acid and mevalonic acid lactone, and (b) one or more of yeast powder and yeast extract. 3. A skin cosmetic containing (a) one or more of mevalonic acid and a mevalonic acid lactone, and (b) one or more of a deproteinized extract from mammalian blood and collagen.