JPH10151115A - Catheter and manufacturing method thereof - Google Patents

Abstract

(57) Abstract: A catheter having a catheter main body, a sensor section and a wiring section provided on an outer wall of the catheter main body, and an insulating section covering the wiring section, and manufacturing the catheter. A method of manufacturing a catheter, wherein at least the wiring portion is formed of a conductive thin film pattern. [Effect] A catheter with a sensor that can have a wiring portion with high accuracy and can be used for injecting a drug solution or the like inside can be obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a catheter applied to a body cavity such as a blood vessel and a method for manufacturing the same, and more particularly, to a catheter equipped with functions such as sensing and manipulation and having wiring means for transmitting an electric signal thereof, and a catheter therefor. It relates to a manufacturing method.

[0002]

2. Description of the Related Art A catheter is an important medical device used for injecting a drug solution into a body cavity such as a blood vessel, removing a polyp, and opening an obstructed portion. In recent years, the development of highly functional catheters provided with a sensing function for monitoring in-vivo information, an active function in which the catheter itself performs arbitrary movements, a manipulation function, and the like has been actively performed.

[0003] As a catheter having a sensing function, there is a catheter having an enzyme electrode or a field effect transistor (ISFET) mounted at the distal end, or a microbiosensor type having a combination of an ISFET and an enzyme electrode. The signal from such a sensing part is converted into an electric signal or an optical signal, and transmitted by a conducting wire or an optical fiber.

[0004] Currently, these optical fiber cables and conductors are installed inside catheters. However, vascular catheters having an outer diameter of 2 mm or less, particularly intracerebral vascular catheters having an outer diameter of about 1 mm, are extremely thin, so that optical fiber cables and conducting wires cannot be installed inside these catheters. In addition, even when the inside of the catheter is used for transporting a drug solution, a lead wire or the like cannot be similarly provided inside.

Further, when an optical fiber cable or a conducting wire is installed inside the catheter as described above, there has been a problem that the catheter itself becomes rigid and the flexible movement of the catheter is hindered.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide a wiring part with high accuracy even when the outer diameter is as small as about 1 mm, and the inside can be used for injection of a chemical solution or the like. It is to provide a catheter and a method by which such a catheter can be manufactured.

[0007]

Means for Solving the Problems In view of the above problems, as a result of intensive studies, the present inventors have found that the sensor section and the wiring section are provided on the outer wall of the catheter body so that the sensor section and the wiring section can be formed even with a thin catheter. In addition to finding that it can be mounted and that the inside of the catheter can also be used for injecting a drug solution, it is necessary to form the wiring part etc. in a conductive thin film pattern by a predetermined method or to wrap a very thin metal wire around the catheter body As a result, the present inventors have found that a wiring portion can be formed with high accuracy, and have completed the present invention.

That is, the present invention is a catheter having a catheter main body, a sensor section and a wiring section provided on an outer wall of the catheter main body section, and an insulating section covering the wiring section. Further, according to the present invention, the sensor section has a substrate made of a conductive material, and the substrate and the wiring section are provided integrally, or the sensor section is provided on the wiring section. Characterized by the fact that
The above catheter.

Further, the present invention provides the above-mentioned method for manufacturing a catheter, wherein at least the wiring portion is formed by a conductive thin film pattern, or a metal wire is wound around the catheter body to form the wiring portion. A method for producing a catheter, which is characterized by the following.

Further, according to the present invention, after a positive resist is applied to the outer wall of the catheter body, at least the pattern of the wiring portion is exposed by laser drawing and developed to expose the pattern, and then the exposed pattern is exposed. The method for manufacturing a catheter according to the above-mentioned, wherein the conductive thin film pattern is formed by forming a conductive thin film so as to cover a pattern portion, and then removing the positive resist.

Further, the present invention provides a method for forming a metal thin film on the outer wall of the catheter body, applying a negative resist, exposing at least the pattern of the wiring portion by laser drawing, and developing the pattern. The method for manufacturing a catheter according to claim 1, wherein the metal thin film in the portion (1) is exposed, and then the exposed metal thin film is removed by etching to form the conductive thin film pattern.

Further, according to the present invention, the electroconductive thin film pattern is formed by applying a catalyst solution to the outer wall of the catheter main body so as to form at least a wiring pattern, and then performing electroless plating. A method for producing the above-mentioned catheter, characterized in that:

Further, according to the present invention, a conductive ink is applied on an insulating polymer film so as to form a wiring pattern, and then the obtained polymer film is attached to an outer wall of the catheter body. The method of manufacturing a catheter, wherein the wiring portion and the insulating portion are formed by attaching.

Further, according to the present invention, a pattern made of an insulating material is formed on a conductive substrate so as to constitute a portion other than the wiring portion or a portion other than the wiring portion and the sensor portion, and then the pattern is formed. After forming a conductive material in the portion that did not exist, an insulating adhesive material was further formed on the conductive material, and a plate was pressed against the outer wall of the catheter body, thereby forming the conductive material. A method for producing the catheter, comprising forming a conductive thin film pattern.

Further, the present invention is the above-mentioned method for producing a catheter, wherein the conductive thin film pattern is formed by applying the discharged ultrafine metal ink to the outer wall of the catheter body. . Further, the present invention is the above-mentioned method for producing a catheter, wherein the insulating portion made of an insulating material having a charge is coated on the wiring portion by an electrodeposition method.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
FIG. 1 shows a catheter according to an example of the present invention. The catheter 1 has a catheter main body 2, a sensor section 3 and a wiring section 4 provided on an outer wall of the catheter main body 2, and an insulating section 5 covering the wiring section 4. FIG. 2 is an enlarged cross-sectional view of the vicinity M of the sensor unit 3 in the catheter 1. In this embodiment, the sensor section 3 has a working electrode 31 and a reference electrode 32. The working electrode 31 is provided with a substrate 31a formed on the catheter body 2 and an enzyme fixing section 31b formed thereon.
However, the sensor section in the present invention is not particularly limited as long as it can read and detect information on the substance to be detected as an electric signal.

The catheter body 2 is formed of a normal catheter having no sensor, no wiring, and the like.
In the present invention, a catheter having an outer diameter of 0.2 to 20 mm and an inner diameter of 0.1 to 19 mm can be used. The material of the catheter body 2 is not particularly limited as long as it is a non-toxic polymer material, but segmented polyurethane or the like is preferably used in terms of biocompatibility and flexibility.

In this embodiment, a so-called enzyme electrode type biosensor is employed as the sensor section 3. The enzyme fixing part 31b generally contains an enzyme (conductive enzyme) modified and mixed with a mediator. Various enzymes are used depending on the substance to be detected, and examples thereof include oxidoreductases such as glucose oxidase, fructose oxidase, and alcohol dehydrogenase. The mediator is not particularly limited as long as it mediates the movement of electrons between the active site of the enzyme and the substrate 31a, and imparts conductivity to the enzyme by modifying or mixing the enzyme with the enzyme. Conductive polymers such as ferrocene and polypyrrole. The enzyme is immobilized on the substrate 31a by a method of directly immobilizing via a sulfide group or the like, a method of supporting it via a hydrogel or the like, and forms an enzyme immobilized portion 31b.

Here, the "substrate" in the present invention refers to a thin layer made of a conductive material formed on the catheter main body, which constitutes a connection part with the wiring part in the sensor part. Therefore, taking the catheter 1 as an example, the substrate 31a
Not only the reference electrode 32 but also the “substrate” may be used.
Examples of the conductive material forming the substrate include a conductive polymer such as polyacetylene, a metal such as aluminum, copper, silver, platinum, and gold, or indium oxide and carbon. Silver, gold, platinum and the like are more preferable.

When the sensor has a substrate as in this embodiment, the sensor substrate is provided integrally with the wiring portion 4 in a conductive thin film pattern from the viewpoint of simplifying the manufacturing process and reliability of connection. Is preferred. Further, even if the sensor does not have a substrate, the same effect can be obtained by providing a sensor unit on the wiring unit 4.

In this embodiment, one type of sensor is provided in the sensor section 3. However, the present invention is not limited to this, and a plurality of types of sensors may be provided. Examples of the sensor that can be mounted on the catheter of the present invention include, in addition to the enzyme electrode type sensor, an ISFET, a flow sensor, a pH sensor, a gas sensor, and the like.

Sensor part 3 and wiring part 4 in the present invention
Is provided on the outer wall of the catheter body 2. Therefore, even when the outer diameter of the catheter is as thin as about 1 mm, the inside of the catheter body 2 can be used for bodily fluid collection, drug solution transport, and the like without being hindered by the sensor unit 3 and the wiring unit 4. . There is also an advantage that the sensor unit 3 and the wiring unit 4 can be formed with high accuracy.

The wiring section 4 in this embodiment is provided spirally around the catheter body 2. By forming the wiring portion 4 in this manner, a motion having a degree of freedom can be secured. In particular, when the catheter is bent at an acute angle, stress is less likely to be applied. However, the shape of the wiring portion 4 is not limited to a spiral shape. FIG. 3 shows another example of the catheter of the present invention. In the catheter 1 'shown in FIG. 3, the wiring portion 4' is provided in a wavy shape on the outer wall of the main body 2 ', and the shape maintains the flexibility of the catheter 1'.

The wiring portion 4 is not particularly limited as long as it can transmit an electric signal from the sensor 3, but is preferably formed of a conductive thin film pattern or a metal wire. When formed in a conductive thin film pattern, as the conductive material, a conductive polymer such as polyacetylene, aluminum,
Metals like copper, silver, platinum, gold, indium oxide,
There are carbon, etc., but silver, gold,
Platinum or the like is suitable. The film thickness is preferably from 0.1 to 100 μm, and particularly preferably from 1 to 50 μm.
When the wiring part 4 is formed by a conductive thin film pattern, there is an advantage that the wiring part 4 can be formed integrally with the substrate of the sensor 3.

On the other hand, when the wiring portion 4 is formed of a metal wire,
As the material of the metal wire, there are aluminum, copper, silver, platinum, gold, and the like. In general, a silver wire, a gold wire, and the like for substrate wiring and semiconductor components can be used. The diameter of the metal wire is preferably 0.5 to 500 μm, particularly 5 to 10 μm.
It is preferably 0 μm. When a metal wire is used as the wiring part 4, it is preferable to wind the metal wire around the catheter body as shown in FIG. In this embodiment, the wiring section 4 is composed of two conductors, but the present invention is not limited to this, and may be composed of a plurality of conductors.

The insulating section 5 is provided to protect the wiring section 4. In the catheter 1 in FIG. 1, the insulating portion 5 is formed entirely in a region including the wiring portion 4, but the present invention is not limited to this, and the wiring portion 4 is selectively formed as shown in FIG. It may be formed so as to cover.

The material for forming the insulating portion 5 is not particularly limited as long as it has an insulating property. Such materials include polyester, polyvinyl alcohol, methylcellulose, polyurethane, segmented polyurethane, polyvinyl chloride, aramid, silicone, etc., but have biocompatibility in consideration of long-term indwelling in blood vessels and the like. For example, a segmented polyurethane is desirable.

It is preferable that the insulating portion 5 is formed as thin as possible as long as the covering of the wiring portion 4 is not hindered. Specifically, it is preferable to form a thin film having a thickness of 0.1 to 20 μm, particularly 1 to 10 μm. According to the catheters 1 and 1 ′ of the present invention described above, when a substance to be detected is present at a predetermined position in the body, electron transfer occurs due to an oxidation-reduction reaction of the substance to be detected by an enzyme, and the concentration of the substance to be detected is reduced. The corresponding electric signal is transmitted through the wiring unit 4.

Next, a method for producing the catheter of the present invention will be described. Preferred methods of providing the wiring portion on the catheter body include (1) a method of winding a metal wire around the outer wall of the catheter body, (2) a method of forming a conductive thin film pattern directly on the outer wall of the catheter body, and (3) ) A method of forming a conductive thin film pattern on an insulating film and covering the entire outer wall of the catheter together with the insulating film.

The method (1) may be performed by winding a metal wire around the outer wall of the catheter body in a conventional manner. Preferred methods of (2) include a method using a positive resist, a method using a negative resist, an electroless plating method using a catalyst solution, a method using a plate on which a conductive substance is formed, and There is a method of discharging fine particle ink.

In the method (1), first, a positive resist is applied to the outer wall of the catheter body. The positive resist is applied to the entire region including a portion corresponding to the wiring portion or a substrate of the wiring portion and the sensor portion (hereinafter, referred to as a sensor substrate). The application method is not particularly limited, and the application can be performed by, for example, a dip coat or a dispenser.

After the application of the positive resist, the wiring portion or the pattern of the wiring portion and the sensor substrate are exposed by laser drawing and then developed to expose those patterns. By performing laser drawing, a fine pattern can be accurately formed. When a sensor having a substrate is used, it is preferable to integrally expose the wiring portion and the pattern of the sensor substrate from the viewpoint of connection reliability and simplification of the manufacturing process. Exposure and development may be appropriately performed according to the type of the positive resist used.

Next, a conductive thin film is formed so as to cover the exposed pattern portion. Since the formation of the conductive thin film is performed on a three-dimensional surface, it is preferably performed by vapor deposition, sputtering, electroless plating, or the like. These methods may be performed by a conventional method. However, in the case of performing vapor deposition, it is preferable to rotate the catheter about the longitudinal direction using a jig or the like to form a uniform thin film.

The thickness of the conductive thin film is preferably from 0.1 to 100 μm, particularly preferably from 1 to 50 μm.
Examples of the material of the conductive thin film include a conductive polymer such as polyacetylene, metals such as aluminum, copper, silver, platinum, and gold; indium oxide; and carbon. , Gold, platinum and the like are preferred. After forming the conductive thin film in this manner, the remaining positive resist is removed by a conventional method.

In the method (1), first, a metal thin film is formed on the outer wall of the catheter body. The formation of the metal thin film may be performed in the same manner as described above. The metal thin film may be formed so as to include at least the wiring portion or a portion corresponding to the wiring portion and the sensor substrate, and may be formed on the entire outer wall of the catheter body. After forming the metal thin film, a negative resist is applied. Like the metal thin film, the negative resist may be applied so as to include at least the wiring portion or the portion corresponding to the wiring portion and the sensor substrate, and may be applied to the entire outer wall of the catheter body.

Next, the pattern of the wiring portion or the wiring portion and the sensor substrate is exposed by laser drawing and developed, thereby exposing the metal thin film in portions other than those patterns. In the case of forming a sensor having a substrate, it is preferable to integrally expose the wiring portion and the pattern of the sensor substrate. Exposure and development may be appropriately performed according to the type of the negative resist used. The exposed metal thin film can be removed by etching. Etching may be performed by a conventional method. In addition, since the remaining negative resist can be used as an insulating part as it is,
The removal step is not particularly required.

In the method (1), first, a catalyst solution for electroless plating is applied to the outer wall of the catheter body so as to form a wiring portion or a pattern of the wiring portion and the sensor substrate.
As the catalyst solution, tin chloride, palladium chloride, or the like can be used. The coating method may be any method as long as the catalyst solution can be coated in a desired pattern. For example, the method can be performed using a dispenser, an ink jet, or the like. After the application of the catalyst solution, electroless plating is performed by an ordinary method.

In the method of (1), first, on a conductive substrate,
A pattern made of an insulating material is formed so as to constitute a part other than the wiring part or a part other than the wiring part and the sensor part. As the conductive substrate, for example, a stainless plate, a copper plate, an iron plate, or the like can be used, and a substrate having a hardness or a thickness that does not easily deform is preferable.

The pattern made of an insulating material can be formed by, for example, photolithography.
It is preferable that the thickness of the insulating material is 0.1 to 20 μm, particularly 1 to 10 μm. As the insulating material, a photosensitive polymer resin or a protein material such as casein or gelatin can be used.

Next, a conductive substance is formed in a portion where the pattern made of the insulating material is not formed. The conductive material can be formed by, for example, electrodeposition (including electrolytic plating), and the thickness of the conductive material is 0.1 to 100 μm.
In particular, it is preferable to perform the process so that the thickness is 1 to 20 μm. As the conductive substance, gold, silver, platinum, nickel, copper, or the like can be used.

After the conductive material is formed, an insulating adhesive material is formed thereon. The insulating adhesive material can be formed by, for example, a method of electrodepositing a charged adhesive material, and the thickness of the adhesive material is 0.1 to 10%.
It is preferable to carry out the process so as to have a thickness of 0.1 μm, especially 0.1 to 3 μm. Acrylic or urethane-based polymers can be used as the insulating adhesive material.

After the insulating material, the conductive material, and the insulating adhesive material are formed on the conductive substrate as described above, they are pressed as a plate onto the outer wall of the catheter body,
Transcribe. At this time, it is common to rotate the catheter body with the plate fixed, but the plate may be rotated with the catheter body fixed. By this crimping and transfer,
A wiring portion made of a conductive material or a pattern of the wiring portion and the sensor portion is formed on the outer wall of the catheter main body via the adhesive material.

This method is suitable for a case where a sensor substrate is formed integrally with a wiring portion, and an enzyme or the like is fixed on the substrate to form a sensor. In addition, according to the method, since the thin wiring can be laminated by performing the transfer a plurality of times, it is particularly effective when a plurality of sensor functions are integrated on a small area such as a catheter.

The method of (1) may be performed by applying the discharged metal ultrafine particle ink to the outer wall of the catheter body so as to form a wiring portion or a pattern of the wiring portion and the sensor portion. The ejection of the metal ultrafine particle ink can be performed by an ink jet, a spray gun, or the like, and the thickness of the metal ultrafine particle ink is 0.1 to 20 μm, particularly 0.1 to 10 μm.
It is preferable to carry out so as to be μm.

When the wiring portion is provided by the method (1) or (2), a step of covering the wiring portion with an insulating material is required thereafter. The coating of the insulating material may be performed by an ordinary method. For example, after dip-coating or spray-coating an insulating resin in a solution state, heat drying, light, UV, EB
(Electron beam) or the like to cover the resin. As an insulating resin for coating, a resin in which an acrylic resin, a urethane resin, or the like is dissolved can be used.

The wiring portion can also be covered by attaching an insulating polymer film. As the insulating polymer film, a film made of PET, PP, PE, urethane, or the like can be used. The adhesion of the polymer film can be performed by a method of pressure bonding using an adhesive, a pressure-sensitive adhesive, or the like, or by heat fusion, but is preferably performed by heat fusion because of the simplicity of the process.

The coating of the wiring portion may be performed on the entire region including the wiring portion (see FIG. 1) or may be performed only on the wiring portion (see FIG. 4). In order to selectively cover the wiring part, for example, a catheter is placed so that the wiring part is immersed in a plating bath filled with a solution-like insulating material holding a charge, and a voltage is applied to the wiring part. Good.

In the method (3), first, an insulating polymer film is prepared, and a conductive ink is applied thereon so as to form a wiring pattern. As the insulating polymer film, those which can be used in the method (1) or (2) can be used. As conductive ink,
An ink containing a conductive component such as a gold paste or a silver paste can be used. The application of the conductive ink can be performed by roll coating, screen printing, inkjet, a dispenser, or the like. At this time, it is preferable to apply the conductive ink so that the thickness of the conductive ink is 0.1 to 100 μm, particularly 0.5 to 50 μm.

Next, a polymer film coated with a conductive ink is attached to the outer wall of the catheter body. When attaching a polymer film, an adhesive or a pressure-sensitive adhesive is applied to the film side and / or
Alternatively, it can be performed by a method of applying the coating on the catheter side and press-fitting, heat fusion, or the like, but is preferably performed by heat fusion because of the simplicity of the process.

The method (3) has the advantage that the wiring pattern can be formed and the insulating coating on the outer wall of the catheter body at one time, and there is no difficulty in applying the wiring pattern on the three-dimensional surface. It has the advantage that. Further, it can be preferably performed when an existing sensor is used without forming a sensor substrate.

After the wiring portion is provided on the outer wall of the catheter body by the method described above, the sensor is formed next.
When a sensor substrate is provided together with the wiring portion in the above method, a desired sensor is formed on the sensor substrate. For example, when an enzyme electrode type sensor is employed as a sensor, an enzyme solution containing an enzyme modified and mixed with a mediator is dropped on a sensor substrate using a dispenser or the like (fixation by SH group, physical adsorption). If necessary, the enzyme can be immobilized using a fixing agent. This step may be performed before the formation of the insulating portion.

On the other hand, when only the wiring portion is provided without providing the sensor substrate in the above method, a sensor is formed at the end of the wiring portion, or a desired sensor is connected to the end of the wiring portion. In the former case, for example, a sensor can be formed by dropping an enzyme solution onto one end of the wiring portion. Sensors that can be used in the latter case include, for example, ISFETs, pH sensors, gas sensors, flow sensors, and the like. The method of connecting the sensor to the wiring portion and the method of fixing the sensor to the outer wall of the catheter body may be performed by a conventional method.

[0053]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but the scope of the present invention is not limited to these Examples.

Example 1 In this example, a catheter having a configuration as shown in FIG. 1 except for the sensor portion was manufactured. A gold paste ink (5 μm in thickness) was printed on a 10 μm-thick polypropylene film by a gravure printing method so as to form a wiring pattern. The wiring pattern consists of two 100 µm lines with a width of 6 mm.
They were arranged in parallel.

The obtained film was cut into a length of 1,000 mm and a width of 6.3 mm in the longitudinal direction of the wiring pattern, coated on a commercially available catheter, and heat-sealed at a temperature of 200 ° C. Finally, a commercially available ISFET was connected to the end of the wiring section and fixed on the catheter.

(Example 2) Stainless steel plate (thickness: 0.5 m)
m), a positive photoresist was applied so as to have a thickness of 3 μm, and then the pattern of the wiring portion was exposed by laser drawing. The pattern of the wiring portion was the same as in Example 1.

After the exposure, development was performed to expose the stainless plate in the pattern of the wiring portion. Electrodeposition (100 mA, 1 min) was performed on the stainless steel plate to form a gold pattern (thickness: 2 μm) on the exposed portion. Further, electrodeposition was performed to form an acrylic pressure-sensitive adhesive on the gold pattern.
A commercially available catheter was placed on the plate prepared as described above, and the catheter was rotated once while applying a load to transfer the gold pattern.

Next, using a capillary having an outer diameter of 100 μm, a ferrocene-modified glucose oxidase solution was dropped and spotted from one end of one of the wires under a microscope to form a sensor portion having a length of 1 mm. The enzyme was immobilized by air-drying at 50 ° C. for 30 seconds after dropping. The catheter was dip-coated with a polyvinyl alcohol solution except for a 2 mm wiring portion from the end including the sensor portion, and dried at 50 ° C. for 2 hours to form an insulating layer having a thickness of 3 μm.

[0059]

According to the present invention, it is possible to obtain a catheter with a sensor that can have a wiring portion with high accuracy and can be used for injecting a chemical solution or the like inside.

[Brief description of the drawings]

FIG. 1 is a perspective view of a catheter according to an example of the present invention.

FIG. 2 is a partially enlarged cross-sectional view of the catheter of FIG.

FIG. 3 is a perspective view of a catheter according to another example of the present invention.

FIG. 4 is a partial cross-sectional view of a catheter according to another example of the present invention.

[Explanation of symbols]

 1, 1 '... catheter 2, 2' ... catheter body 3, 3 '... sensor 31 ... working electrode 31a ... substrate 31b ... enzyme fixing part 32 ... reference electrode 4, 4' ... wiring part 5, 5 ', 5 ''… Insulation part

Claims (15)

[Claims] 1. A catheter having a catheter body, a sensor section and a wiring section provided on an outer wall of the catheter body section, and an insulating section covering the wiring section. 2. The catheter according to claim 1, wherein the sensor section has a substrate made of a conductive material, and the substrate and the wiring section are provided integrally. 3. The catheter according to claim 1, wherein the sensor section is provided on the wiring section. 4. A method for manufacturing a catheter having a catheter body, a sensor section and a wiring section provided on an outer wall of the catheter body, and an insulating section covering the wiring section, wherein at least the wiring section is provided. A method for producing a catheter, characterized in that the catheter is formed by a conductive thin film pattern. 5. A method of manufacturing a catheter having a catheter main body, a sensor section and a wiring section provided on an outer wall of the catheter main section, and an insulating section covering the wiring section, wherein a metal wire is connected to the catheter. A method for manufacturing a catheter, wherein the wiring portion is formed by winding the wiring portion around a main body portion. 6. After coating a positive resist on the outer wall of the catheter body, at least the wiring pattern is exposed by laser drawing and developed to expose the pattern, and then the exposed pattern portion is covered. The method for manufacturing a catheter according to claim 4, wherein the conductive thin film pattern is formed by forming a conductive thin film so that the positive resist is removed. 7. The method according to claim 1, wherein the conductive thin film is formed by vapor deposition, sputtering or electroless plating.
A method for manufacturing a catheter according to claim 6. 8. A metal thin film is formed on the outer wall of the catheter main body, and then a negative resist is applied. Then, at least a pattern of the wiring portion is exposed by laser drawing and developed to form a metal in a portion other than the pattern. The method for manufacturing a catheter according to claim 4, wherein the conductive thin film pattern is formed by exposing the thin film and thereafter removing the exposed metal thin film by etching. 9. The method according to claim 8, wherein the metal thin film is formed by vapor deposition, sputtering, or electroless plating. 10. The electroconductive thin film pattern is formed by applying a catalyst solution to an outer wall of the catheter main body so as to form at least a pattern of a wiring portion, and then performing electroless plating. The method for producing a catheter according to claim 4, wherein 11. An insulating polymer film is coated with conductive ink so as to form a wiring pattern, and then the obtained polymer film is adhered to an outer wall of the catheter body. The method for manufacturing a catheter according to claim 4, wherein the wiring portion and the insulating portion are formed. 12. A pattern made of an insulating material is formed on a conductive base material so as to constitute a portion other than a wiring portion or a portion other than a wiring portion and a sensor portion, and then, on a portion where the pattern is not formed. After forming the conductive material, an insulating adhesive material is further formed on the conductive material, and the plate is pressed against the outer wall of the catheter body to form the conductive thin film pattern. The method for producing a catheter according to claim 4, wherein the catheter is formed. 13. The method according to claim 1, wherein the conductive material and / or the adhesive material is formed by electrodeposition.
3. The method for producing a catheter according to 2. 14. The method for manufacturing a catheter according to claim 4, wherein the conductive thin film pattern is formed by applying the discharged ultrafine metal ink to an outer wall of the catheter body. 15. The method for manufacturing a catheter according to claim 4, wherein the insulating portion made of an insulating material having a charge is coated on the wiring portion by an electrodeposition method.