JPH10194954A - Skin cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin cosmetic having excellent whitening, skin irritation- preventive, aging-preventive and complexion improving effects by including a specific hematogenic accelerator or cell activator, and a specific biphenyl compound. SOLUTION: This skin cosmetic is obtained by including, as a hematogenic accelerator or cell activator, at least one kind selected from Japanese green gentian (Swertia japonica), vitamin E nicotinate, diisopropylamine dichloroacetate, γ-aminolactic acid, γ-amino-β-hydroxylactic acid, a placental extract, 2-8C α-hydroxycaroxylic acid, mevalonic acid, and mevalonic lactone, and at least one of biphenyl compounds of formula I (R<1> is CH3 , C2 H5 , etc.) and formula II (R<2> is H or a 1-8C alkyl), for example, dehydrodicresol, preferably in a quantity of 0.0001-20wt.% in conversion into extract in the whole quantity of the cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic which has an excellent whitening effect, and furthermore has an excellent anti-roughing effect, anti-aging effect and beautiful skin effect, and can keep the skin healthy.

[0002]

2. Description of the Related Art Conventionally, cosmetics for the purpose of preventing or treating skin spots and freckles, etc. include L-ascorbic acid and its derivatives, hydroquinone derivatives such as arbutin, kojic acid and the like. Are blended.

[0003] These substances have effects such as suppression of melanin production and pale bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, these substances, for example, in the case of L-ascorbic acid and its derivatives, often have insufficient storage stability and insufficient anti-inflammatory effects due to ultraviolet rays. Hydroquinone derivatives also have problems such as insufficient safety. As described above, it has been difficult to obtain a cosmetic that is excellent in overall whitening, such as a melanin generation inhibitory effect, a melanin pale bleaching effect, an anti-inflammatory effect, and safety.

On the other hand, it is known that a specific biphenyl compound has an inhibitory effect on tyrosinase activity and an inhibitory effect on melanin production (JP-A-6-145040 and JP-A-7-25743). However, even when it was used alone, the whitening effect was not satisfactory.

Accordingly, the present inventors have conducted intensive studies and have found that assemblage extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-, which are components having a blood circulation promoting or cell activating effect. A skin cosmetic comprising at least one selected from hydroxybutyric acid and salts thereof, placenta extract, α-hydroxycarboxylic acid having 2 to 18 carbon atoms, mevalonic acid, and lactone mevalonate, and at least one specific biphenyl compound is provided. , Suppresses the production of melanin due to UV damage, promotes excretion of melanin pigment, expresses a synergistically superior whitening effect, further prevents epidermal drying, promotes skin metabolism, and promotes skin aging due to UV damage. It has been shown to exhibit excellent skin roughness prevention, aging prevention and beautiful skin effects. And it has led to the completion of the present invention.

[0006] An object of the present invention is to provide a skin cosmetic composition which can exhibit an excellent whitening effect, and further exhibit excellent anti-roughness, anti-aging and beautiful skin effects.

[Means for Solving the Problems]

[0007] The present invention for achieving the above-mentioned object comprises a assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-
β-hydroxybutyric acid and salts thereof, placenta extract, at least one selected from α-hydroxycarboxylic acids having 2 to 18 carbon atoms, mevalonic acid, and lactone mevalonate, and the following general structural formulas (1) and (2): It is a skin cosmetic containing at least one selected from the biphenyl compounds represented.

[0008]

Embedded image

(However, R ¹ is CH ₃ , C ₂ H ₅ , C ₃ H
₇ , CH ₂ OH, C ₃ H ₆ OH, CH ₂ CH = CH ₂ are substituents)

[0010]

Embedded image

(Where R ² is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms)

[0012]

Embodiments of the present invention will be described below in detail.

The method for producing the assembly extract used in the present invention is not specified, but the outline is as follows.

[Method for producing assembly extract] Assembly (S
It is an extract obtained by digesting a dry and ground product of the whole flowering plant of W.iatonia japonica Makino in ethanol or aqueous ethanol and filtering off the resultant. In Examples, an extract obtained by the following method was used.

50 g of the milled assembly is added to 250 ml of aqueous ethanol (ethanol 90 wt%) at a temperature of 40-50.
After being digested at ℃ and filtered, the residue is digested again several times to obtain 1.5 l of extract. 100 ml of purified water was added to the residue which was concentrated under reduced pressure, and after aging for 1 week, the extract obtained by filtering off insolubles was concentrated under reduced pressure, and then ethanol was added to reduce the ethanol content of the extract to 4%.
It was adjusted to be 0 wt% to obtain 100 ml of an extraction solution. This is the assembly extract.

As the γ-amino-β-hydroxybutyrate used in the present invention, γ-amino-β-hydroxybutyric acid is converted to potassium hydroxide, sodium hydroxide or calcium hydroxide,
Potassium salt, sodium salt, calcium salt and magnesium salt of γ-amino-β-hydroxybutyric acid neutralized with magnesium hydroxide, and all of them promote blood circulation to the same extent as γ-amino-β-hydroxybutyric acid. It is known to have an action or a cell activating action.

The placenta extract used in the present invention is a known substance, such as Nichirei placenta extract (Nichirei) or placenta liquid (Kultrichter).
Etc.

The α-hydroxycarboxylic acid used in the present invention is not particularly limited as long as it has 2 to 18 carbon atoms. For example, glycolic acid, lactic acid, sodium lactate, citric acid, sodium citrate , Malic acid, tartaric acid, α-hydroxyoctanoic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, etc., among which those having 2 to 8 carbon atoms are preferable.

The mevalonic acid and lactone mevalonate used in the present invention are known substances. Mevalonic acid is described in, for example, JP-A-63-216484 and JP-A-6-216484.
It can be produced by a microorganism fermentation method described in JP-A-3-216484, JP-A-63-216484, JP-A-63-216484 and the like. It is also easily synthesized by chemical synthesis. Mevalonic acid lactone, which is a derivative of mevalonic acid, is easily converted to mevalonic acid by hydrolysis.

In the present invention, the assembly extract, vitamin E-
Nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and salts thereof, placental extract, α having 2 to 18 carbon atoms
-At least one of hydroxycarboxylic acid, mevalonic acid and lactone mevalonate is blended. The content thereof is appropriately adjusted depending on the function and effect or the dosage form of the cosmetic, and the blending amount shown in Table 1 below is usually suitable. In addition, the compounding amount was based on the total weight of the cosmetic composition.

[0021]

[Table 1]

The biphenyl compound used in the present invention is a known substance, and specific examples thereof include dehydrodicresol, dehydrodiogenol, and tetrahydromagnolol (Journal of Organic Chemistry, Vol. 28, p. 1048). , 1963
Year; Journal of the Chemical Society of Japan, Vol. 87, No. 6, pp. 603, 19
66).

The compounding amount is preferably 0.0001 to 20% by weight, more preferably 0.001 to 5% by weight, in terms of extract, in the total amount of the cosmetic. 0.0001% by weight
If the amount is less than 20%, a sufficient effect cannot be obtained, and if the amount exceeds 20% by weight, the effect of the increased amount may not be increased.

In the cosmetic of the present invention, in addition to the above-mentioned raw materials, a dye, a fragrance, a preservative, a surfactant, an antioxidant, a humectant and the like are appropriately compounded within a range in which the object of the present invention is achieved. be able to.

Examples of the dosage form of the cosmetic of the present invention include creams, emulsions, lotions, packs and the like. For example, in the case of an emulsion or the like, this cosmetic can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.

[0026]

The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. The skin color lightness recovery test method, wrinkle formation suppression test method (aging prevention effect), rough skin improvement effect measurement method, and sensory test (beautiful skin effect) described in the examples are as follows.

The names of the biphenyl compounds in the examples are described as follows according to the difference between R1 and R2 in the above general formula. Biphenyl compound 1 (R ¹ ; CH ₃ ), biphenyl compound 2 (R ¹ ; C ₂ H ₅ ), biphenyl compound 3 (R ¹ ; C ₃ H ₇ ), biphenyl compound 4 (R ¹ ; C
H ₂ OH), biphenyl compound 5 (R ¹ ; C ₃ H ₆ O
H), biphenyl compound 6 (R ¹ ; CH ₂ CH ＝ C
H ₂ ), biphenyl compound 7 (R ² ; CH ₃ ), biphenyl compound 8 (R ² ; C ₂ H ₅ ), biphenyl compound 9
(R ² ; C ₃ H ₇ ), biphenyl compound 10 (R ² ; i
so-C ₃ H ₇ ), biphenyl compound 11 (R ² ; C ₈
H ₁₇ ) and biphenyl compound 12 (R ² ; H).

(1) Skin Lightness Recovery Test Method The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region twice as much as the minimum erythema dose, and a sample-applied portion and a non-applied portion were set, and the skin of each skin was set. The reference lightness (V ₀ value, V ₀ ′ value) was measured. Subsequently, the sample was applied to the application site twice a day for 15 times.
After continuous application for three weeks, the lightness (Vn value, Vn ') of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
Was measured, and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V value)
Was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation was shown as an average value of the evaluation points after 3 weeks for 20 subjects.

(2) Inhibition test of wrinkle formation by hairless mouse Hairless mouse (HR / ICR, 6 weeks old at the start of experiment)
Using 0 animals, 80 μl of the sample was applied to the back. Two hours later, the sample on the skin surface is wiped off with 70% ethanol, and six health line lamps (Toshiba, SE20) are prepared, and the irradiation amount at one time is adjusted to 1 MED or less to UV-B. Light irradiation was performed, and immediately after that, the sample was applied.
This operation was performed five times a week for 16 weeks. UV-Radiometer (TOKY)
OOPTICAL, UVR-305 / 365D)
It measured using. After completion of the test, the frequency of wrinkles was visually evaluated by the following criteria (wrinkle index). The test results are shown as the average of the evaluation points.

(3) Measurement Test Method for Improvement of Rough Skin The effect of continuous application for four weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of a sample was applied to the test site of the lower leg of the subject twice a day twice a day, and the skin condition before and after the start of the test was determined according to the following criteria. The lower right leg served as a control without the application of the sample. By comparing the judgment results of the test site and the control site before and after the test, when the skin dryness is improved by two or more steps (for example, + →
−, ++ → ±) is defined as “valid”, the case where the signal is improved by one step is “slightly valid”, and the case where there is no change is “invalid”.
The test results are shown by the number of subjects who became “effective” and “slightly effective”.

(4) Sensory Test Twenty test subjects evaluated the characteristics of the sample after continuously using the sample for 10 days. The evaluation was based on the questionnaire items for smoothness, whitening effect, and elasticity. The number of respondents who answered that "whitening effect was felt", "skin became smoother", and "skin became tight" was shown. .

Examples 1 to 19, Comparative Examples 1 to 21 Assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-aminobutyric acid, γ
-Amino-β-hydroxybutyric acid, a salt thereof, a placental extract, a component having a blood circulation promoting action or a cell activating action selected from α-hydroxycarboxylic acids having 2 to 18 carbon atoms, mevalonic acid and lactone mevalonate, The biphenyl compound was blended in the composition shown in Table 2, and a skin cream was prepared based on the following preparation method. The above-mentioned test was performed for each, and the results are shown in Tables 3, 4, 5, and 6. composition

[0033]

[Table 2]

[0034]

[Table 3]

[0035]

[Table 4]

[0036]

[Table 5]

[0037]

[Table 6]

Preparation Method (A) (B) is uniformly dissolved at 70 ° C., (B) is poured into (A) while stirring (A), and emulsified and dispersed. Prepare by cooling.

Properties The skin creams of Examples 1 to 19 of the present invention showed good results in the above tests. On the other hand, Comparative Examples 1 to 21
The skin cream of Example 1 did not show a sufficient effect, and was inferior to the examples of the present invention.

Example 20 Skin Lotion A skin lotion of the present invention having the composition shown in Table 7 was prepared by the following method. composition

[0041]

[Table 7]

Preparation method Each component of (A) and (B) is mixed and dissolved, and (B)
Was added to (A) and mixed and stirred.

Properties The skin lotion of Example 20 showed good results in the above tests.

[0044]

Industrial Applicability As described above, the present invention provides a skin cosmetic which is particularly excellent in whitening effect, furthermore, exhibits excellent skin roughness prevention effect, anti-aging effect and beautiful skin effect, and can keep skin healthy. It is clear to offer.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 D W

Claims (1)

[Claims] 1. Assembly extract, vitamin E-nicotinate, diisopropylamine dichloroacetate, γ-
At least one selected from the group consisting of aminobutyric acid, γ-amino-β-hydroxybutyric acid and salts thereof, placenta extract, α-hydroxycarboxylic acid having 2 to 18 carbon atoms, mevalonic acid, and lactone mevalonate; A skin cosmetic containing at least one selected from the biphenyl compounds represented by the general formulas (1) and (2). Embedded image (However, R ¹ is CH ₃ , C ₂ H ₅ , C ₃ H ₇ , CH ₂ O
H, C ₃ H ₆ OH and CH ₂ CH CH ₂ are substituents.) (However, R ² is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms)