JPH10231237A - Liquid oral composition - Google Patents

Abstract

(57) [Problem] To provide a liquid oral composition which contains aluminum lactate in a stable manner and does not cause white turbidity or precipitation. (1) A liquid oral composition containing aluminum lactate, wherein a sugar alcohol is added in an amount effective for preventing cloudiness. (2)
The liquid oral composition according to (1), wherein the sugar alcohol is xylitol and / or sorbitol.
(3) The liquid oral composition according to (1) or (2), wherein the pH is 5.5 to 7.5.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition, and more particularly, to a liquid oral composition which does not cause white turbidity or sediment in the composition and which is excellent in usability.

[0002]

2. Description of the Related Art Among drugs incorporated in oral compositions, aluminum lactate is effective for prevention and treatment of oral diseases, and is known to have an effect of tightening gums or preventing hyperesthesia. . However, aluminum lactate has a weaker astringent effect on gingiva than aluminum allantoinate, so it was necessary to add a large amount of aluminum lactate in the composition to obtain a sufficient effect.

[0003] Under such circumstances, means for enhancing the astringent action of aluminum lactate so that a sufficient action can be obtained even when the amount used is reduced have been studied. For example, it is known to mix carboxymethylcellulose or sodium alginate together with aluminum lactate, or mix ascorbic acid or its sodium salt.

[0004] On the other hand, when aluminum lactate is mixed into the oral composition as described above, the pH becomes extremely acidic, and there is a problem that the stability of the composition is deteriorated and the usability is poor. Therefore, it has been studied to improve the astringent action of aluminum lactate and to improve the feeling of use. For example, when a water-soluble aluminum compound and a fluoride are combined at a constant concentration and a fixed blending ratio, P
It has been proposed that H be 5-10. It is also known that when sodium silicate is mixed with an oral composition containing aluminum lactate, an oral composition having excellent aging stability can be obtained.

However, when the stability of aluminum lactate in an oral composition is examined in more detail, it is found that the liquid form of aluminum lactate is more effective than that of powdery or pasty preparations. It has been found that the stability is further inferior, and since it is in a liquid state, white turbidity or sediment is generated, and the feeling of use is inferior due to the turbidity.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide a liquid composition for oral cavity as described above which is free from problems such as white turbidity and precipitates caused by blending aluminum lactate, and has an excellent feeling in use. A liquid oral composition.

[0007]

Means for Solving the Problems As a result of intensive studies, the present inventors have found that the following composition for liquid oral cavity satisfies the above-mentioned problems, and have reached the present invention. (1) A liquid oral composition containing aluminum lactate, wherein an effective amount of sugar alcohol for preventing cloudiness is added. (2) The composition for a liquid oral cavity according to (1), wherein the sugar alcohol is xylitol and / or sorbitol. (3) The liquid oral composition according to (1) or (2), wherein the pH is 5.5 or more and less than 7.5.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION According to the present invention, by adopting the constitutions (1) to (3) described above, a liquid oral cavity containing aluminum lactate which is free from cloudiness and sediment and excellent in usability is provided. To provide a composition for use.

Although the amount of aluminum lactate in the liquid oral composition of the present invention is not particularly limited, it may be an amount usually used in the oral composition.
% By weight.

[0010] In the present invention, the sugar alcohol acts to effectively prevent the formation of white turbidity and precipitates caused by mixing aluminum lactate with the liquid oral composition. And the amount of the sugar alcohol in the composition may be any effective amount that exhibits the effects of the present invention,
For example, 10% by weight or more, preferably 20% by weight in the composition
All that is required is the above. Some sugar alcohols are highly viscous. When such sugar alcohols are used in a large amount, the composition becomes sol-like, which is not preferable. It is.

The sugar alcohol of the present invention includes xylitol, sorbitol, mannitol, maltitol, lactitol, erythritol, glycerin, inositol and the like, and preferably xylitol and sorbitol.

Further, the pH of the liquid oral composition of the present invention is preferably less than 7.5. That is, as the pH of the composition becomes alkaline, the stability of the aluminum lactate in the composition deteriorates, and the generation of cloudiness and precipitates increases. Therefore, the amount of the sugar alcohol increases, and the viscosity of the composition increases. Sometimes. Further, since the composition of the present invention is used in the oral cavity, if it becomes too acidic, it may cause strong depletion of teeth and irritation to the oral mucosa. In such a case, adjusting the pH of the composition to a range of 5.5 to 7.5 may be mentioned.

When adjusting the pH, an appropriate amount of a component having a buffering action such as citric acid and its salts, tartaric acid, lactic acid, sodium borate, sodium hydroxide, phosphoric acid and its salts, sodium polyphosphate and sodium bicarbonate is added. Then, the pH may be set in the above range.

In preparing the liquid oral composition of the present invention, no special means is required, and aluminum lactate may be blended with the above-mentioned sugar alcohol in an ordinary liquid oral composition. Suitable solvents in the liquid oral composition of the present invention include water, ethanol, denatured alcohol and the like.

The liquid oral composition of the present invention includes various medicinal ingredients, wetting agents, foaming agents, thickeners, preservatives, brighteners, flavoring agents, coloring agents, etc., as long as the effects of the present invention are not impaired. Can be blended. Such components include, for example, propylene glycol, polyethylene glycol, polyvinylpyrrolidone, algal extract, carrageenan, carboxyvinyl polymer, carboxymethylcellulose, licorice extract, sodium alkyl sulfate, N
-Anionic surfactants such as sodium acylsarcosinate and N-acylglutamate: sucrose fatty acid ester, sugar alcohol fatty acid ester, polyoxyethylene sorbitan fatty ester, polyoxyethylene hydrogenated castor oil, fatty acid monoglyceride, sorbitan fatty ester, poly Nonionic surfactants such as oxyethylene higher alcohols, polyoxyethylene / polyoxypropylene copolymers, polyoxyethylene / polyoxypropylene fatty acid esters: zwitterionic surfactants such as N-alkyldiaminoethyleneglycine: cetylpyridinium chloride , Ionic surfactants such as benzethonium chloride and benzalkonium chloride: fucose, stevioside,
Xylitol, sorbitol, saccharin sodium,
Dipotassium glycyrrhizinate, menthol, thymol,
Carvacrol, anethole, eucalyptus oil, eugenol, triclosan, chlorhexidine gluconate,
Isopropylmethylphenol, parahydroxybenzoate, sodium benzoate, Blue No. 1, Yellow 4
And Red No. 102.

Further, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or a salt thereof, glycyrrhizic acid and its salt, glycyrrhetinic acid and its salt, tocophenol acetate, sorbic acid, alexidine, hinokitiol, alkylglycine, alkyldiamino Ethyl glycine salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin C, vitamin E, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble phosphate, quaternary ammonium compound, Contains natural resins such as sodium chloride, shellac and wax, phosphates such as monoalkyl phosphoric acid (C12), fluorinated oils such as perfluoropolyether, linear or cyclic polyphosphoric acid and salts thereof To do It can be. In the liquid oral composition of the present invention, it is preferable to use a combination of components having a flavor action such as menthol, peppermint oil, herbal oil, and spearmint oil in order to further enhance the feeling of use. The liquid oral composition of the present invention can be in the form of, for example, a liquid dentifrice, a mouthwash (mouthwash) or the like, and by performing brushing as necessary, the action of the various components blended, The effect can be sufficiently obtained.

[0017]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the present invention is limited thereto.

Example 1 Liquid oral compositions having the respective formulations shown in Table 1- (1) and Table- (2) below were prepared.
(1) and PH regulator in comparison (sodium hydroxide)
Prepared the pH. The appearance of the composition of each formulation was checked visually for the presence or absence of cloudiness and precipitation, and the transmittance (T% 600) at 600 nm was measured, and the stability was examined. (1) Test method Table 1- (1) and the prescription for comparison were filled in a 50 ml sample bottle, and the stability over time was observed at 80 ° C. Five days after the start of the test, the transmittance of each formulation was measured. The results are shown in Table 2.

[0019]

[0020]

(2) Test results

[0022]

From Table 2, it can be seen that in the formulation containing the sugar alcohol of the present invention, when kept at 80 ° C., no turbidity or precipitation was observed in any case up to 3 days. On the fifth day, the effect was different depending on the amount of the sugar alcohol (glycerin), but all showed superior stability as compared with the comparison. In addition, almost the same results were obtained with the formulation shown in Table 1- (2).

Example 2 (1) Test Method Stability when the liquid oral compositions shown in Table 3 were prepared, filled in 50 ml sample bottles, and left at 50 ° C. for 2 months. Was observed.

[0025]

(2) Test Results As shown in Table 3, the composition for liquid oral cavity of the present invention (N
o. 13-No. 17) was excellent in stability without any turbidity or precipitation after 2 months.

Example 3 The following liquid oral composition of the present invention was prepared and obtained. When 0.35% by weight of a pH adjuster is blended, the pH is 7.
It was 0.

[0028] When 0.7% by weight of a pH adjuster is blended, the pH is 7.4.
Met.

[0029] When 0.35% by weight of a pH adjuster is blended, the pH is 7.
It was 5.

[0030] When 0.4% by weight of a pH adjuster is blended, the pH is 7.4.
Met.

[0031] When 0.7% by weight of the pH adjuster is added, the pH is 7.8.
Met.

[0032] When the pH adjuster is added at 0.6% by weight, the pH is 7.0.
Met.

[0033] When the pH adjuster is added at 0.6% by weight, the pH is 7.0.
Met.

[0034] When the pH adjuster is added at 0.6% by weight, the pH is 7.0.
Met.

[0035]

According to the liquid oral composition of the present invention, aluminum lactate can be stably compounded by adding an effective amount of a sugar alcohol without causing cloudiness and precipitation in the composition, and with the lapse of time. It is possible to provide a liquid oral composition which is stable and excellent in use feeling.

Claims (3)

[Claims] 1. A liquid oral composition containing aluminum lactate, wherein a sugar alcohol in an amount effective for preventing cloudiness is added. 2. The liquid oral composition according to claim 1, wherein the sugar alcohol is xylitol and / or sorbitol. 3. The composition for a liquid oral cavity according to claim 1, wherein the pH is 5.5 to 7.5.