JPH10273424A - Cosmetic for hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic having an excellent unhairing- preventing effect, an excellent trichogenous effect, and an excellent effect for preventing the itch and dandruff of scalp and further excellent in safety by compounding a specific essential oil and a specific amineoxide. SOLUTION: This cosmetic contains (A) an essential oil ingredient capable of being used as a refreshing agent [e.g. a menthol compound (e.g. l-menthol) and/or a camphor (e.g. d-camphor)] and (B) dimethylamine oxide of the formula. In the objective composition, the ingredients A and B are preferably contained in 0.001-5.0 wt.% and 0.0001-20.0 wt.%, respectively, based on the whole cosmetic. The ingredients may be administered at a daily dose of 0.001-100 mg per kg of a general adult body with two to four portions a day.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention belongs to the technical field of scalp hair cosmetics (hereinafter referred to as hair cosmetics). More specifically, it belongs to the technical field of hair cosmetics having excellent effects and excellent safety, and the hair cosmetics of the present invention are used particularly in the field of pharmaceuticals, quasi-drugs or cosmetics. .

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, products that can improve the current state of hair loss and the like by preventing dandruff and kayumi on the scalp depending on the scalp condition have been developed. Various troubles on the scalp
In today's aging society, social stress is increasing, and the demand for hair cosmetics corresponding to the scalp trouble is increasing rapidly. In general, the causes of baldness and hair loss on the head, thinning of hair, scalp Kayumi and dandruff are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, generation of lipid peroxide, hair follicles Blood flow to the skin and stress. In addition, when sufficient hair follicles cannot be supplied with nutrients when growing strong and strong hair, fine hair and thin hair may be caused. Decreased blood flow to the hair follicles leads to nutritional deficiency and reduced excretion of waste products.

[0003] From such a viewpoint, it is necessary to improve keratin turnover and excessive sebum secretion in the scalp.
It is an essential point in at least improving the decrease in blood flow function in the scalp and solving problems of the scalp and hair. Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin such as cepharanthin. It contains a function enhancer and the like, and is used for prevention and treatment of baldness, hair loss, and hair thinning.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into the cosmetic for hair. There is a tendency to have a feeling and redness,
Naturally, the amount was limited.

The problem to be solved by the present invention is to provide a cosmetic for hair which has excellent effects and is also excellent in safety.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining a specific essential oil component and a specific amine oxide in combination, it has an excellent hair loss preventing effect, a hair growth effect, a scalp Kayumi and dandruff preventing effect, and is also excellent in safety. The present inventors have found that a cosmetic for hair is provided and completed the present invention.

That is, the present invention relates to an essential oil component which can be used as a cooling agent and a dimethylamine oxide represented by the following formula (I):

Embedded image And a hair cosmetic composition comprising:

In the present invention, it is preferable that the essential oil component is menthols and / or camphors in view of the effect.

[0009]

Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exerts an intended effect by being combined with an essential oil component that can be used as a refreshing agent and the above-mentioned dimethylamine oxide (I).

The essential oil component which can be incorporated in the cosmetic for hair of the present invention is not particularly limited as long as it is an ingredient which is incorporated in cosmetics as a refreshing agent, and examples thereof include menthols, camphors, peppermint oil, clove oil and the like. Can be mentioned.

Among these essential oil components, it is preferable to select menthols and / or camphors as essential oil components in order to more effectively exert the intended effects of the present invention.

In the present invention, examples of menthols include l-menthol and dl-menthol. These menthols can be extracted from western mint and the like by an ordinary method, and are of course commercially available.

In the present invention, examples of the camphors include d-camphor and dl-camphor. The camphors can be extracted from camphor tree, majorana and the like by an ordinary method, and are of course commercially available. Of these essential oil components, any one of them can be used alone in the cosmetic for hair of the present invention, but two or more of them can be used in combination.

The amount of the essential oil component in the cosmetic for hair of the present invention is 0.001% by weight or more and 5.0% by weight or less, and 0.01% by weight or less based on the total amount of the cosmetic for hair.
At least 2.0% by weight is preferred.

If the amount is less than 0.001% by weight based on the total weight of the cosmetic for hair, a sufficient effect is not exerted, which is not preferable. If the amount is more than 5.0% by weight, there is a tendency for inconvenience in the preparation. There is a possibility that a problem may arise from the aspect of safety, such as intensification and further skin irritation.

The dimethylamine oxide (I) to be blended in the hair cosmetic of the present invention together with the essential oil component can be produced according to a generally known method for producing an amine oxide. If an example is shown, it can be manufactured generally according to the following steps.

[0017]

Embedded image Usually, the dimethylamine oxide (I) thus produced is incorporated into the cosmetic for hair of the present invention through a purification step by a generally known purification method such as a recrystallization method.

The amount of dimethylamine oxide (I) in the hair cosmetic of the present invention is 0.0001% by weight or more and 20.0% by weight or less based on the total amount of the hair cosmetic. It is preferably from 05% by weight to 5.0% by weight.

If the amount is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be exerted, which is not preferable. The tendency to cause inconvenience becomes stronger,
Further, it is not preferable from the point that skin irritation occurs.

In this way, the combination of the anti-inflammatory component and the dimethylamine oxide (I) has an excellent effect of preventing hair loss and hair growth, and an effect of preventing scalp kayumi and dandruff. The present invention also provides a hair cosmetic composition which is excellent in safety. Incidentally, in the hair cosmetic of the present invention, the medicinal component usually blended in the hair cosmetic, for the purpose of exerting the general effect of the medicinal component, the intended effect of the present invention Can be blended as long as is not impaired.

For example, amino acids such as serine, methionine and arginine; vitamins such as vitamin B ₆ and biotin; pantothenic acid or derivatives thereof; and female hormones such as esladiol are incorporated into the cosmetic for hair of the present invention. Can also. In addition, plant extracts usually incorporated into hair cosmetics, for example, Altea extract, yokuinin extract, iodine extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishi Extract, Mannan Wax Extract, Kossaiho Extract, Enishida Extract, Gentian Extract, Tanjin Extract, Loofah Extract, Fennel Extract, Pine Extract, Kujin Extract, Touki Extract, Safflower Extract, Barberry Extract , Betel nut extract, eucalyptus extract, sprouts extract, moxa extract, gossip extract, psycho extract, tea extract, licorice extract, hops extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract Extract, cashew extract, cuckoo extract, squid extract, saffron extract, rosemary extract, sage extract The mallow extract or the like may be formulated into the present invention for hair cosmetics.

Zinc or a derivative thereof; lactic acid or an alkyl ester thereof; organic acids such as citric acid;
Protease inhibitors such as tranexamic acid; olive oil,
Oils such as squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, Antibacterial agents, dyes, ethanol, water, and the like can be appropriately compounded within a range that does not impair the intended effects of the present invention.

The form of the cosmetic for hair of the present invention is not particularly limited as long as it can be applied to the outer skin such as a liquid, an emulsion or an ointment. Of the present invention can be prepared. Further, the cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The cosmetic for hair of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. In addition, the purpose shown here is an example,
The diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0026]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.

1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The test subjects were male and 10 persons in each group of Comparative Example and Example. The test application period is four months,
The sample was applied to the scalp twice to four times a day. Immediately before application and 3 months after application, subject 1
Fifty hairs were randomly removed from the crown for each name, the roots of the removed hairs were observed under a microscope, and the follicle resting period rate (%) was calculated from the state of the roots. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.

<Evaluation criteria> Remarkable effect: Hair root telogen rate decreased by 30% or more Effective: Hair root telogen rate decreased by 20% or more Weak effect: Hair root telogen rate decreased by 10% or more No effect: Hair root telogen Reduction rate of less than 10% The evaluation of the hair-growth effect is as follows.
% Is valid, and the others are invalid.

2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The test subjects were male, and the male and female subjects in the comparative example and the example were each 10 persons. The test period was six months, the first two months were a period during which no sample was applied, and the last four months were a period during which the sample was applied. During the sample application period, apply the sample 2 times a day.
Each time, 2 to 4 ml of the sample was applied to the scalp. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.

The display of the number of hair removals during each period is based on the data of the number of hair removals eight times in total during the two months when the sample is not applied and the data of the number of hair removals eight times in the latter two months of the period during which the sample is applied. The results were summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation.

The effect was judged as follows from the difference between the average values in each period. <Judgment criteria> ++: The number of removed hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs decreased by 10 or more. The effect was slightly recognized. −: The number of hair loss was less than 10 hairs, and the hair loss was ineffective.
Is valid when the value exceeds the limit, and invalid for the others.

3. Test for dandruff and itching prevention effect The dandruff and itching prevention effect was examined after the test period for each subject's scalp dandruff and itching, and the degree of dandruff and itching were compared. The test subjects were men, especially complaining of dandruff and itching, and 10 subjects in each group of Comparative Examples and Examples. The sample was applied for a period of 3 months, during which time the hair was washed once a day with the same shampoo containing no drug, and the sample was applied to the scalp twice a day, twice a day.
After the test, the degree of dandruff and itching of each subject was represented by the following scores.

<Danmark score> 3: Significantly dandruff 2: Many dandruff 1: Slightly dandruff 0: Almost no dandruff

<Itching score> 3: Strong itching 2: Itching 1: Slight itching 0: No itching

Examples 1 to 6 and Comparative Examples 1 to 5 Lotions of the components shown in Table 1 (Examples 1 to 6 and Comparative Examples 1 to 5) were prepared according to the production methods described below, and the above-mentioned tests were performed. Was done.

[0036]

[Table 1]

<Production Method> Each essential oil component was dissolved in 95% ethanol in the respective amounts, propylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, lactic acid, sodium lactate, and a fragrance (ethanol phase). Next, a dye was added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion.

The results of the above tests are shown in Table 2 (hair growth effect test), Table 3 (hair loss prevention effect test) and Table 4 (dandruff,
(Itching prevention effect test).

[Table 2]

[0039]

[Table 3]

[0040]

[Table 4]

From the above results, it can be seen that the lotion of the example in which any one of the above camphors and menthols is blended with dimethylamine oxide (I) has a remarkable hair-growth effect, a hair loss-preventing effect, and a dandruff-and-itch-preventing effect. Was accepted,
The hair growth lotion of Comparative Example, in which only one of these anti-inflammatory components and dimethylamine oxide (I) is blended, shows that even if these components are blended in a considerable amount, these effects are compared with the results of the above Examples. It was significantly inferior.

That is, in the hair cosmetic composition of the present invention in which the above camphors and menthols are combined with dimethylamine oxide (I), a synergistic hair-growth effect, a hair loss-preventing effect and a dandruff-and-itch-preventing effect are obtained. Was remarkably recognized. This is because the desired effects can be obtained in the cosmetic for hair of the present invention even with a small amount of the active ingredient, which is caused by adding a large amount of the above camphors and menthols.
This indicates that it is possible to prevent an unpleasant irritating feeling and redness of the application part and its peripheral part.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 7] Lotion (Blending components) Blending amount (% by weight) 95% ethanol 50.0 Dimethylamine oxide (I) 2.0 1-Menthol 0.5 dl-Camphor 0.5 Sodium pyrrolidonecarboxylate 5.0 Hardened castor oil ethylene oxide (40 mol) adduct 0.5 Succinic acid qs Perfume and pigment qs Purified water balance

<Production method> Dimethylamine oxide (I) and hydrogenated castor oil ethylene oxide (4%) in 95% ethanol
0 mol) The adduct, l-menthol, dl-camphor and perfume are dissolved, and then purified water is added with other components and dissolved therein.
A clear liquid lotion was obtained. When the above-mentioned test was carried out on the cosmetic for hair of the present invention, the effect of nourishing hair, the effect of preventing hair loss,
And the effect of preventing dandruff and Kayumi was remarkably recognized.

Example 8 Lotion (Blending Component) Blending amount (% by weight) 95% ethanol 90.0 Dimethylamine oxide (I) 5.0 dl-menthol 2.0 1,3-butylene glycol 1.0 Curing Castor oil ethylene oxide (50 mol) adduct 0.5 Sodium lauryl sulfate 0.3 Lactic acid qs Sodium lactate qs Flavors and pigments qs Purified water balance

<Production Method> A hydrogenated castor oil ethylene oxide (50 mol) adduct and a fragrance are dissolved in 95% ethanol, and then purified water is added. Then, other components are added, and the mixture is dissolved by stirring to form a transparent liquid lotion. Obtained. When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair growth effect, a hair loss preventing effect, and a dandruff / kayumi preventing effect were remarkably recognized.

Example 9 Emulsion Type Hair Cosmetic (Ingredients) Amount (% by weight) (A phase) Hydrogenated castor oil ethylene oxide (60 mol) adduct 2.0 Glycerin 5.0 Dipropylene glycol 15. 0 1,3-butylene glycol 3.0 polyethylene glycol 2.0 (phase B) cetyl isooctanoate 10.0 squalane 10.0 petrolatum 2.0 ethyl paraben 2.0 dimethylamine oxide (I) 2.0 l- Menthol 0.5 (C phase) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Purified water 9.35 (D phase) Purified water 4.0 (E phase) Potassium hydroxide 0.12 Purified water 3 .0

<Production Method> The phases A and B were each heated and dissolved at 60 ° C., mixed, and treated with a homomixer to prepare a gel. Phase D was gradually added to the gel and dispersed with a homomixer. The phase C dissolved in this dispersion is added, the phase E dissolved last is added, and the mixture is emulsified with a homomixer.
A W-type emulsion type cosmetic for hair was obtained. When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff / kayumi-preventing effect were remarkably recognized.

[0049]

Industrial Applicability According to the present invention, there is provided a hair cosmetic composition having an excellent hair loss preventing effect, a hair growth effect, an effect of preventing scalp kazumi and dandruff, and having excellent safety.

Claims (2)

[Claims] An essential oil component which can be used as a cooling agent and dimethylamine oxide represented by the following formula (I): A hair cosmetic composition comprising: 2. The dimethylamine oxide according to claim 1, wherein the essential oil component that can be used as a cooling agent is menthols and / or camphors.