JPH10316559A - Patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a plaster having excellent pasting operability by laminating a tacky adhesive layer composed of a tacky adhesive base composed mainly of a styrene-isoprene-styrene block copolymer on one surface of a supporting material. SOLUTION: This plaster is produced by laminating a tacky adhesive layer on one surface of a supporting material composed of a woven fabric or a nonwoven fabric. The tacky adhesive layer is composed of a tacky adhesive base containing a styrene-isoprene-styrene block copolymer as a main component, a drug, a tackifying resin and a liquid paraffin. The solution viscosity of the tacky adhesive base is 1,500-2,000 cps (25 deg.C, 25 wt.% toluene solution) and the amounts of the tackifying resin and the liquid paraffin are 85-160 pts.wt. and 180-270 pts.wt. based on 100 pts.wt. of the tacky adhesive base, respectively. A plaster stably keeping excellent tacky adhesive force and applicability over a long period can be produced by using a tacky adhesive base having a solution viscosity falling within the above range.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a patch having excellent patching properties.

[0002]

2. Description of the Related Art Patches are generally composed of a pressure-sensitive adhesive layer containing a drug and a support, so that the drug present in the pressure-sensitive adhesive layer can be efficiently absorbed into the body through the skin, and an excellent patch can be obtained. Is required.

The pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer includes:
For example, a pressure-sensitive adhesive composition comprising a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softener is known (JP-A-60-223880). However, when the pressure-sensitive adhesive composition is applied to a support made of a woven or nonwoven fabric, the pressure-sensitive adhesive composition tends to sink into the support over time, and as a result, there is a problem that the adhesive strength is reduced. .

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a patch which has a stable sticking property over a long period of time.

[0005]

The patch of the present invention comprises an adhesive base, a drug and a tackifier having a styrene-isoprene-styrene block copolymer as a main component on one surface of a support made of a woven or nonwoven fabric. It is characterized in that an adhesive layer made of resin and liquid paraffin is laminated.

Hereinafter, the present invention will be described in detail. The adhesive base has a styrene-isoprene-styrene block (hereinafter, referred to as SIS) copolymer as a main component. The solution viscosity of the adhesive base is limited to 1,500-2,000 cps. When the solution viscosity is less than 1,500 cps, the pressure-sensitive adhesive layer easily sinks into the support over time, and as a result, the adhesive strength decreases. The solution viscosity is 2,000 c
If it exceeds ps, the coating becomes difficult because the viscosity becomes too high. The solution viscosity is a value measured at 25 ° C. and a 25% by weight toluene solution according to JIS K7117.

[0007] Commercially available SIS copolymers include, for example, "Califlex TR Series" manufactured by Shell Chemical Company.
And the like.

In order to adjust the viscosity of the SIS copolymer, a styrene-isoprene block copolymer may be added, and two or more styrene-isoprene block copolymers may be added.

The tackifying resin is not particularly limited, but examples thereof include a rosin resin, a polyterpene resin,
Coumarone-indene resin, petroleum resin, terpene-phenol resin, alicyclic saturated hydrocarbon resin and the like can be mentioned.
Of these, alicyclic saturated hydrocarbon resins are preferably used because they exhibit a tackifying effect without excessively reducing the cohesive force of the adhesive base.

When the amount of the tackifying resin used is large, the adhesive force tends to change with time, and the peeling force becomes strong, causing pain at the time of peeling. Since the initial adhesive strength is reduced, it is preferably 85 to 160 parts by weight, more preferably 90 to 150 parts by weight, based on 100 parts by weight of the adhesive base.

The above liquid paraffin is used as a softener. The amount of liquid paraffin used, although the change in adhesive strength with time is small, the adhesive layer becomes hard and the peeling strength increases, and when it increases, the liquid paraffin bleeds out,
Since the sticking property is deteriorated, the amount is preferably 180 to 270 parts by weight, more preferably 190 to 250 parts by weight, based on 100 parts by weight of the adhesive base.

If necessary, other additives may be added to the pressure-sensitive adhesive layer within a range that does not impair the cohesive strength or adhesive force of the pressure-sensitive adhesive layer. Examples of such additives include, for example,
Softeners such as liquid polybutene, mineral oil, lanolin, liquid polyisoprene, and liquid polyacrylate; antioxidants such as dibutylhydroxytoluene; and fillers such as titanium oxide.

The drug is not particularly limited as long as it penetrates the skin and exhibits a medicinal effect. For example, nonsteroidal antipyretic and antiphlogistic analgesics such as ketoprofen, flurbiprofen, piroxicam and salicylic acid; prednisolone And steroidal anti-inflammatory drugs such as dexamethasone; vasodilators such as isosorbide dinitrate and nitroglycerin;
Antihypertensive / Arrhythmic, Antihypertensive, Antitussive expectorant, Antineoplastic, Local anesthetic, Hormonal, Asthma / Nasal allergy treatment, Antihistamine, Anticoagulant, Antispasmodic, Cerebral circulation / metabolic improver, Antidepressant / Examples include anxiolytics, vitamin D preparations, hypoglycemic agents, antiulcer agents, hypnotics, antibiotics and the like.

The content of the above-mentioned drug varies depending on the kind of the drug, the purpose of use of the patch and the like. However, when the content is small, sufficient skin permeability cannot be obtained and the therapeutic effect is reduced, and when the content is large, crystals are formed in the adhesive layer. 0.1 to 30% by weight in the pressure-sensitive adhesive layer is preferable since the adhesiveness is reduced due to precipitation.

The support is not particularly limited as long as it is a woven or non-woven fabric having flexibility and imparting self-supporting property to the patch, and examples thereof include flannel, cotton, silk, polyolefin, polyester and nylon. And rayon or the like. The properties of the woven or nonwoven fabric are not particularly limited, and for example, any of a thin and coarse gauze-like one and a thick one with a thickness of about 2 mm can be used.

A resin foam may be laminated on the surface of the woven or nonwoven fabric opposite to the surface on which the pressure-sensitive adhesive layer is laminated. Examples of the resin foam include polyethylene, ethylene-vinyl acetate copolymer and mixtures thereof; polypropylene;
Resin foams such as polyvinyl chloride are exemplified.

In order to improve the adhesion between the support and the pressure-sensitive adhesive layer, a corona treatment is applied to the pressure-sensitive adhesive laminated surface of the support,
Plasma discharge treatment or the like may be performed, or an anchor coat agent may be applied.

If the thickness of the support is too small, the self-supporting property of the patch becomes insufficient and it becomes difficult to handle. If the thickness is too large, the flexibility of the patch becomes insufficient and the skin becomes uncomfortable.
A range of 0.01 to 7 mm is preferred.

The patch of the present invention is obtained by spreading the above-mentioned pressure-sensitive adhesive layer on one side of a support to form a layer.
When the thickness of the pressure-sensitive adhesive layer is too small, the amount of the skin absorbed by the drug and the adhesive strength are insufficient, and when the thickness is too large, the flexibility of the patch is insufficient and the skin feels uncomfortable. preferable.

In order to protect the surface of the adhesive layer of the patch of the present invention until use, it is usually preferable to have a release paper on the sticking surface. As the release paper, those obtained by subjecting a polyethylene terephthalate film to a silicon treatment, those obtained by subjecting a paper to a polyethylene lamination and then a silicon treatment, and the like are suitably used. The thickness of the release paper is 10
00 μm or less, more preferably 20 to 200 μm.
μm.

As a method for producing the adhesive patch of the present invention, an ordinary method for producing an adhesive tape can be applied. For example, solvent coating method,
Typical examples include a hot melt coating method and the like, an emulsion coating method, a method using electron beam crosslinking, and the like. In order to produce the patch of the present invention by a solvent coating method, for example, an adhesive base, a tackifying resin, a drug, a softener and other various compounding agents are dissolved or dispersed in an appropriate solvent, and the obtained solution or dispersion is obtained. The liquid is applied directly to the surface of the support and dried to form an adhesive layer. Alternatively, this solution or dispersion may be coated on a protective release paper, and the pressure-sensitive adhesive layer obtained after drying may be adhered to a support.

In order to apply the patch of the present invention by a hot melt method, for example, an adhesive base, a tackifier resin, a drug, a softener and other various additives are mixed by heating and then mixed. The liquid is directly applied to the surface of the support and solidified by cooling to form an adhesive layer. This pressure-sensitive adhesive layer is brought into close contact with a protective release paper to obtain a target adhesive patch. Alternatively, the melt may be temporarily applied on release paper, and the pressure-sensitive adhesive layer obtained after cooling and solidifying may be adhered to a support.

[0023]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to only these examples.

Example 1 100 parts by weight of an SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.) was dissolved in 850 parts by weight of cyclohexane, and an alicyclic saturated hydrocarbon resin ("Arakawa Chemical Co., Ltd.") was added thereto. Archon P85 ") 127
Parts by weight, 227 parts by weight of liquid paraffin (manufactured by Nikko Chemical Co., Ltd.), and 4 parts by weight of dibutylhydroxytoluene (manufactured by Orient Chemical Co., Ltd .; hereinafter, referred to as “BHT”) are added, thoroughly stirred and completely dissolved, and the solid content A 35% adhesive base solution was obtained. To the obtained adhesive base solution, 14 parts by weight of isosorbide dinitrate (manufactured by Chugoku Kayaku Co., Ltd .; hereinafter, referred to as "ISDN") was added to obtain a uniform coating solution as a whole.

The above coating solution is coated on a release paper obtained by treating a 38 μm-thick polyethylene terephthalate (PET) film with silicon and dried at 60 ° C. for 30 minutes in a gear oven to form an adhesive layer. After doing
The pressure-sensitive adhesive layer was laminated on a rayon-polyolefin nonwoven fabric having a thickness of 0.45 mm to prepare a patch having a pressure-sensitive adhesive layer thickness of 200 μm.

Example 2 100 parts by weight of SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.), 750 parts by weight of cyclohexane, alicyclic saturated hydrocarbon resin 1
00 parts by weight, liquid paraffin 200 parts by weight and BHT4
After obtaining an adhesive base solution in the same manner as in Example 1 except that the weight part was used, ISDN was added to the obtained adhesive base solution.
12 parts by weight were added to obtain a uniform coating liquid. A patch was prepared in the same manner as in Example 1 except that this coating liquid was used.

Example 3 100 parts by weight of SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.), 940 parts by weight of cyclohexane, alicyclic saturated hydrocarbon resin 1
50 parts by weight, liquid paraffin 250 parts by weight and BHT5
After obtaining an adhesive base solution in the same manner as in Example 1 except that the weight part was used, ISDN was added to the obtained adhesive base solution.
26 parts by weight were added to obtain a coating solution which was entirely uniform. The above-mentioned coating solution is applied on a release paper obtained by subjecting a 38 μm-thick PET film to a silicon treatment and dried in a gear oven at 60 ° C. for 30 minutes to form an adhesive layer. It was laminated on a 2 mm polyester nonwoven fabric to prepare a patch having a pressure-sensitive adhesive layer thickness of 200 μm.

Example 4 100 parts by weight of SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.), 850 parts by weight of cyclohexane, alicyclic saturated hydrocarbon resin 1
27 parts by weight, 227 parts by weight of liquid paraffin and BHT5
After obtaining an adhesive base solution in the same manner as in Example 1 except that the weight part was used, ISDN was added to the obtained adhesive base solution.
14 parts by weight were added to obtain a uniform coating liquid.

The above-mentioned coating solution is applied to a release paper formed by subjecting a 38 μm-thick PET film to silicon treatment and dried in a gear oven at 60 ° C. for 30 minutes to form an adhesive layer. A two-layer support obtained by laminating a rayon-polyolefin nonwoven fabric having a thickness of 0.45 mm on a polyethylene foam having a thickness of 2.5 mm by a thermal lamination method was laminated on the nonwoven fabric side to prepare a patch having an adhesive layer thickness of 200 μm.

Comparative Example 1 A patch was prepared in the same manner as in Example 1 except that "Califlex 1117" manufactured by Shell Chemical Co., Ltd. was used as the SIS copolymer.

Comparative Example 2 A patch was prepared in the same manner as in Example 1 except that “Califlex 1112” manufactured by Shell Chemical Company was used as the SIS copolymer.

Comparative Example 3 A patch was prepared in the same manner as in Example 1, except that "Califlex 1111" manufactured by Shell Chemical Company was used as the SIS copolymer.

Comparative Example 4 100 parts by weight of SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.), 670 parts by weight of cyclohexane, and alicyclic saturated hydrocarbon resin 7
An adhesive base solution was obtained in the same manner as in Example 1 except that 5 parts by weight, 180 parts by weight of liquid paraffin, and 3 parts by weight of BHT were used. Then, ISDN7 was added to the obtained adhesive base solution.
A part by weight was added to obtain a coating solution which was uniform throughout. Using this coating liquid, a patch was prepared in the same manner as in Example 1.

Comparative Example 5 100 parts by weight of SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.), 1040 parts by weight of cyclohexane, 100 parts by weight of alicyclic saturated hydrocarbon resin, 350 parts by weight of liquid paraffin, BHT
After obtaining an adhesive base solution in the same manner as in Example 1 except that 7 parts by weight was used, ISD was added to the obtained adhesive base solution.
N17 parts by weight was added to obtain a coating solution that was uniform throughout. Using this coating liquid, a patch was prepared in the same manner as in Example 1.

(Comparative Example 6) 100 parts by weight of SIS copolymer ("Califlex 1117" manufactured by Shell Chemical Co., Ltd.), 675 parts by weight of cyclohexane, saturated alicyclic hydrocarbon resin 2
30 parts by weight, 110 parts by weight of liquid paraffin and BHT3
After obtaining an adhesive base solution in the same manner as in Example 1 except that the weight part was used, ISDN was added to the obtained adhesive base solution.
7 parts by weight were added to obtain a coating solution that was uniform throughout. Using this coating liquid, a patch was prepared in the same manner as in Example 1.

The adhesive base and the patch obtained in the above Examples and Comparative Examples were evaluated for the performance in the following items, and the results are shown in Table 1. (1) Solution viscosity According to JIS K7117, 2
The solution viscosity of the 5% toluene solution at 25 ° C. was measured using a B-type viscometer. (2) Adhesive force (tack, ball rolling method) The adhesive force of the patch was measured in accordance with JIS Z0237. The size of the test piece was 2.5 cm in width × 5 cm in length, and the number described in the Pharmaceutical Manufacturing Guidelines for the ball stopped on the adhesive surface was measured. Immediately after production and at 60 ° C
The patch was measured after being stored for a week. (3) Peeling force A 180-degree peeling test was performed on the patch in accordance with JIS Z0237. The size of the test piece was 2.5 cm width x
The length was 5 cm.

[0037]

[Table 1]

As is evident from Table 1, the patches of the examples are excellent in adhesive strength stability and sticking property.

[0039]

The patch of the present invention is constituted as described above. The adhesive is prepared by setting the solution viscosity (25 ° C., 25% toluene solution) of the adhesive base to 1,500 to 2,000 cps. Excellent force stability and sticking properties.

Claims (1)

[Claims] 1. A pressure-sensitive adhesive layer comprising a styrene-isoprene-styrene block copolymer as a main component, a drug, a tackifying resin, and liquid paraffin is provided on one surface of a support made of a woven or nonwoven fabric. A laminated patch, wherein the solution viscosity of the adhesive base is 1,500 to 2,000.
cps (25 ° C., 25% by weight toluene solution), the amount of the tackifying resin is 85 to 160 parts by weight, and the amount of the liquid paraffin is 1 to 100 parts by weight of the adhesive base.
A patch characterized by being 80 to 270 parts by weight.