JPH10327766A - Feed composition for treatment of urolithiasis and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition attaining therapeutic effect on urolithiasis in a short time, effective for preventing the nutritional deficiency caused by the administration of the feed and capable of keeping the fattening period and production efficiency by including a water-soluble vitamin and sodium chloride and/or potassium chloride at respectively specific ratios based on a fatty acid calcium salt. SOLUTION: The objective composition is produced by including 0.1.-20 pts. wt. of a water-soluble vitamin and 1-80 pts.wt. of sodium chloride and/or potassium chloride based on 100 pts.wt. of a fatty acid calcium salt. It can be produced by adding 0.1-20 pts.wt. of a water-soluble vitamin and 1-80 pts.wt. of sodium chloride and/or potassium chloride to 80 pts.wt. of a hot molten fatty acid, adding 5-40 pts.wt. of calcium oxide to the mixture and mixing 5-50 pts.wt. of water into the product.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a fatty acid calcium, a water-soluble vitamin group, and sodium chloride and / or sodium chloride.
Or a feed composition having a therapeutic effect on urolithiasis combined with potassium chloride, and a method for producing the same, in particular, a feed composition for treating urolithiasis which does not affect rumen microorganisms and can efficiently supply an energy source And its manufacturing method.

[0002]

2. Description of the Related Art In recent years, with regard to fattening of cattle, a high-density breeding method has been pursued in order to improve productivity per unit area and to improve the efficiency of breeding management. Increasing the number of barleys and increasing barley to improve meat quality are being concentrated. Since such non-herbivore breeding has started, digestive disorders such as rumen acidosis, rumen keratosis, rumen gastritis, bloat, abomasum displacement, and hepatic abscess Have been reported, and laminitis and other limb disorders have been reported.

[0003] Since concentrated feed has a low cellulose content and is easily digested, it is a desirable method to use it as a source of energy necessary for production such as urination, pregnancy, and fattening, and to give it to livestock by adding an appropriate amount to roughage. When breeding and labor-saving management are pursued, reliance on concentrated feed is excessive, and the adverse effects of overfeeding are likely to appear. Urolithiasis is also considered one of them.

Urolithiasis, which frequently occurs in fattening cattle in Japan,
It is a phosphoric acid type containing magnesium ammonium phosphate as a main component, and is a disorder of the urinary system due to the deposition of stones. In the early stage, fine grayish white stones were observed on the pubic hair of bulls, and in severe cases, urination was difficult, complaining of anorexia, loss of appetite, loss of appetite, lumbar pain, urinary retention, etc., bladder rupture, uremia, etc. May cause death. A large amount of calculus precipitate is seen in urine. Urolithiasis usually occurs more often in young steers of 18 to 30 months of steers, and there is no difference in the age at which urolithiasis occurs.

[0005] In order to solve such problems, Japanese Patent Application Laid-Open No. 4-208227 discloses a therapeutic agent for preventing and treating urolithiasis comprising ammonium chloride and Virginia oak extract as main components. Discloses a preventive and therapeutic agent for urolithiasis for domestic animals containing a vulgaris extract and cyclodextrin, and JP-A-62-61921 describes a therapeutic agent for urolithiasis containing ammonium nitrate.

[0006] In addition, as a prophylactic / therapeutic agent for urolithiasis, Japanese Patent Application Laid-Open No. 6-298641 discloses a therapeutic and prophylactic agent for pet urolithiasis using edible carboxylic acid and edible oxycarboxylic acid or a salt thereof. JP-A-7-33678
JP-A-58-67624 discloses D as a urine acidifying agent.
A method for preventing cat urinary system syndrome using L-methionine, JP-A-64-66123 discloses a parenteral pharmaceutical composition containing a colloidal water-soluble polymerized alkanecarboxylic acid for treating urolithiasis. JP-A-61-140522 discloses an L-cysteic acid addition salt which inhibits phosphate stones, and JP-A-61-17517 discloses a urate containing a nonionic surfactant as an active ingredient. Drugs are described. JP-A-62-19153 describes a calculus breaking agent which causes a hydration reaction by using cement concrete, quick lime or the like as an expanding agent and develops an expanding pressure. A urinary stone disintegrating device including an ultrasonic operating element that exerts a urinary stone decomposing action inside a catheter is described.

[0007]

[SUMMARY OF THE INVENTION] However, ammonium chloride has been conventionally performed as a drug therapy alone or in vitamin B ₁ for the treatment of urolithiasis, administration of admixture with such as vitamin B _2, symptoms of stones And its effects vary, and the therapeutic effect is poor. This is because the use of these drugs reduces the number of rumen microorganisms, which play an extremely important role in the nutritional physiology of cattle, thereby reducing nutrient supply from bacterial cells and reducing the amount of food consumed by the cow itself. It is considered that the energy becomes insufficient and the effect cannot be obtained sufficiently. Insufficient energy and other nutrients also result in a prolonged fattening period and a significant decrease in productivity.

[0008] In the treatment of urolithiasis with the urajirogashi extract, it is difficult to obtain a large amount of the urajirogashi extract as a main raw material, and it is not practical because cattle violently avoid this mixed feed. Removal of stones by surgery leads to reduced productivity and a high likelihood of recurrence, and is not an appropriate treatment. As described above, fattening farmers aim to improve productivity and meat quality in order to cultivate international competitiveness, and to carry out stable management, there is an urgent need to improve and establish treatment methods for urolithiasis.

Accordingly, an object of the present invention is to provide an effect of treating urolithiasis in a short period of time and prevent nutrient deficiency caused by administration of a feed composition for treating urolithiasis.
An object of the present invention is to provide a feed composition for treating urolithiasis which can maintain a fattening period and production efficiency, and a method for producing the same.

[0010]

The present invention provides the following feed composition for treating urolithiasis and a method for producing the same. (1) A feed for treating urolithiasis, comprising 0.1 to 20 parts by weight of a water-soluble vitamin and 1 to 80 parts by weight of sodium chloride and / or potassium chloride with respect to 100 parts by weight of fatty acid calcium. Composition. (2) 0.1 to 20 parts by weight of a water-soluble vitamin and 1 to 80 parts by weight of sodium chloride and / or potassium chloride are added to 80 parts by weight of a fatty acid melted by heating, and then calcium oxide 5 to 20 parts by weight is added. A method for producing a feed composition for treating urolithiasis according to the above (1), wherein 40 parts by weight are added and mixed, and then 5 to 50 parts by weight of water are added and mixed.

The fatty acid calcium used in the present invention is not particularly limited. For example, animal fats and oils such as beef tallow and lard; marine animal fats such as sardine oil, mackerel oil, shark liver oil, cod liver oil and whale oil;
Kiri oil, rapeseed oil, soybean oil, sunflower oil, safflower oil,
Fatty acid calcium produced by a direct method or a metathesis method using a fatty acid produced by hydrolyzing vegetable oils such as linseed oil, palm oil and palm kernel oil as a starting material.
The particle size of the fatty acid calcium is generally preferably 3 mm or less, and the larger one is preferably ground before molding. Also, since this fatty acid calcium is solid at normal temperature, it is blended compared to liquid oil,
Good workability at the time of salary.

As the water-soluble vitamin used in the present invention, commercially available water-soluble vitamins for food additives and feed additives can be used, and vitamin B ₁ , vitamin B ₂ , vitamin B ₆ and vitamin B ₁₂ , Niacin, pantothenic acid, folic acid, biotin and choline. These can be used alone or in combination of two or more. Among these, it is preferable to use at least one vitamin selected from the group consisting of vitamin B ₁ , vitamin B ₂ and vitamin B ₆ . The use amount of these vitamins is 0.1 to 20 parts by weight, preferably 1 to 15 parts by weight, based on 100 parts by weight of fatty acid calcium. When the amount is less than 0.1 part by weight, the effect as a therapeutic agent for urolithiasis is small. Further, even if the amount is more than 20 parts by weight, the improvement in the effect as a therapeutic agent for urolithiasis is small.

The sodium chloride or potassium chloride used in the present invention is not particularly limited, and generally commercially available ones can be used. These are used in an amount of 1 to 80 parts by weight, preferably 30 to 70 parts by weight, based on 100 parts by weight of the fatty acid calcium. If less than 1 part by weight,
The effect as a therapeutic agent for urolithiasis is small. Further, even if the amount is more than 80 parts by weight, the effect as a therapeutic agent for urolithiasis is small.

The feed composition for treating urolithiasis of the present invention can effectively prevent and treat urolithiasis by orally administering it to ruminants such as cattle. In this case, the weight gain of the administered animals is smooth and the fattening period and production efficiency do not decrease. It is presumed that the reason why the weight increase is favorable is that the number of rumen microbial cells does not decrease and nutrients derived from the cells are sufficiently supplied.

The method for producing a feed composition for treating urolithiasis of the present invention comprises the steps of:
0.1 to 20 parts by weight of the water-soluble vitamin, preferably 1
-15 parts by weight, and 1-80 parts by weight of sodium chloride and / or potassium chloride, preferably 30-70 parts by weight, and then 5-40 parts by weight of calcium oxide, preferably 10-35 parts by weight. Stir well. Further, 5 to 50 parts by weight, preferably 10 to 45 parts by weight of water is added, and the mixture is stirred well to cause the fatty acid and calcium oxide to react to generate fatty acid calcium, whereby a feed composition for treating urolithiasis can be obtained. After 1-2 hours, 70
It is preferable to dry with hot air at ８０80 ° C. for 3 to 4 hours.

When used as a therapeutic agent for urolithiasis, the feed composition of the present invention is administered in an amount of 5 to 300 g / day per 100 kg of body weight by the first or middle stage showing symptoms of urolithiasis.
Oral administration is preferably performed within a range of 10 to 250 g / day for 7 to 21 days. The basic feed used in the present invention is not particularly limited, and a commercially available mixed feed for beef cattle or the like is used. The amount used ranges from 8 to 12 kg / day / head.

[0017]

DETAILED DESCRIPTION OF THE INVENTION The present invention will be described more specifically with reference to formulation examples, comparative examples, and examples. << Basic feed >> A basic feed for fattening cattle was blended with the composition shown in Table 1.

[Table 1]

<< Samples for Comparative Examples >> Feed compositions were prepared with the compositions shown in Table 2 below as samples for the control, and these were designated as Samples 1 to 6, respectively.

[Table 2]

<< Samples for Examples >> Samples having the compositions shown in Table 3 were prepared. The obtained ones were designated as Samples 7 to 9.

[Table 3]

<< Samples for Examples >> A feed composition was prepared with the composition shown in Table 4 or Table 5 below, and
0 to 18. The method of preparation was such that after adding a water-soluble vitamin and sodium chloride and / or potassium chloride to 80 parts by weight of the fatty acid melted by heating, 30 parts by weight of calcium oxide was added, followed by thorough stirring. More water 40
The fatty acid and calcium oxide were allowed to react with each other by adding parts by weight and stirring well. One hour later, the mixture was dried with hot air at 80 ° C. for 3 hours to obtain a feed composition.

[0021]

[Table 4]

[0022]

[Table 5]

Example 1 and Comparative Example 1 << Therapeutic effect test by administration to urolithiasis cattle >> Using Specimens 1 to 18, a therapeutic effect test for urolithiasis was performed in the following manner. First, 54 10-month-old Holstein steers diagnosed with urolithiasis were tested and divided into 18 groups of 3 each. Samples 1 to 18 were each added to 20
Each group was gavage-administered orally to each group for 2 weeks before administration, and 4 days and 8 days after the start of administration, respectively.
Urine was collected after 4 days (end of preparation administration) and 21 days after (basal feed only). In addition, 4 kg of the basic feed shown in Table 1 and 4 kg of rice straw (cut to 2 cm) were used as a daily feed, and were fed during the test period. As a diagnostic method for the degree of urolithiasis,
Urine pH and urinary phosphate crystal level (UPV: Urinay)
Phosphate Volume) was measured. This is a method of judging the amount of urinary calculus mainly composed of phosphates (calcium salt and magnesium salt) based on the phosphate crystal value (UPV) in urine. The obtained results are shown in Tables 6 and 7 below.

The phosphate crystal value in urine (UPV)
Was measured as follows according to a hematocrit measurement method. 2M of 1M ammonia water is added to 2mL of the collected urine supernatant.
L and left for 30 minutes.
Centrifuged for minutes. After removing 9/10 volume of the supernatant and shaking the residue well, put into a hematoctic capillary,
Centrifuged at 3000 rpm for 10 minutes. The crystal height relative to the height of the entire sample in the hematoctic capillary was measured, and this was expressed as "%" as a phosphate crystal value (UPV) in urine. This analysis indicates that the higher the number, the more the stones in the urinary tract are dissolved and elute as phosphate during urination. Therefore, it means that the higher the phosphate crystal value, the higher the effect of treating urolithiasis.

[0025]

[Table 6] * Average value of three animals

[0026]

[Table 7] * Average value of three animals

As shown in Tables 6 and 7, the urine of urolithic cattle having a stone with phosphate as a nucleus had an alkaline pH before administration. 4 days, 8 days, 14 days,
The urine collected after 21 days has shifted its pH from alkaline to neutral and weakly acidic. The administration of the preparation of the example shortened the number of days required for the pH to shift from an alkaline to a neutral or weakly acidic range, compared to the administration of the preparation of the comparative example.

By administering the preparations of the examples, the phosphate crystal value (UPV) showed an increasing tendency as compared with that before the administration. In addition, the phosphate crystal value increased in a shorter period of time than when the preparation of the comparative example was administered. From the above results, it is considered that the administration of the preparation of the present invention to cattle with urolithiasis caused phosphate stones in the urine to dissolve and eluted in the urine, indicating that phosphate crystal values increased. Can be In addition, the urine p
It is considered that H was in the normal range, and the stone was improved to a state where calculus was hardly formed.

Example 2 and Comparative Example 2 << Tissue Weight Gain Test by Administration to Urolithiatous Cattle >> 54 Holstein steers with a body weight of about 500 kg were divided into 3 groups of 18 cows, and Samples 1 to 18 were weighed per 100 kg of body weight. 10 g was orally administered by gavage for 3 weeks, and the body weight was measured before administration, 14 days after administration, 21 days after administration (end of preparation administration), and 28 days after administration (basal feed only). The weight gain during the test was also measured. During the test period, 8 kg / day of basal feed and 4 kg of rice straw
/ Day salary. Table 8 shows the obtained results.

[0030]

[Table 8] * Average value of three animals is described. * Weight gain (kg / day) = (weight on day 28-weight on day 0) / 28 days

As can be seen from Table 8, in Examples in which Samples 10 to 18 were fed as compared with Comparative Examples, the body weight increased smoothly during the feeding period. In addition, since the body weight gain was higher than that of the comparative example, it is considered that the body weight gain was not reduced by administration of the preparation of the present invention. The reason why a steady increase in body weight is observed is presumed to be because the number of rumen microbial cells did not decrease and nutrients derived from the cells were sufficiently supplied.

[0032]

The feed composition for the treatment of urolithiasis according to the present invention is effective for the treatment of urolithiasis since it uses calcium fatty acids, vitamins and sodium chloride and / or potassium chloride in combination. . In addition, a decrease in the body weight gain is suppressed, and healthy fattening can be performed. The method for producing a feed composition for treating urolithiasis of the present invention can easily and efficiently produce the above feed composition.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Masahiko Miyama 2-545-302 Minamiyama, Kobe, Yamada-cho, Kita-ku, Kobe-shi, Hyogo (72) Inventor Tsuneori Yoshida 17-1 Ogita, Shimodori-Watari, Fukushima-shi, Fukushima

Claims (2)

[Claims] 1. A treatment for urolithiasis, comprising 0.1 to 20 parts by weight of a water-soluble vitamin and 1 to 80 parts by weight of sodium chloride and / or potassium chloride with respect to 100 parts by weight of a fatty acid calcium. Feed composition. 2. A method according to claim 1, wherein 0.1 to 20 parts by weight of a water-soluble vitamin and 1 to 80 parts by weight of sodium chloride and / or potassium chloride are added to 80 parts by weight of the molten fatty acid. The method for producing a feed composition for treating urolithiasis according to claim 1, wherein 5 to 40 parts by weight are added and mixed, and then 5 to 50 parts by weight of water are added and mixed.