JPH10509322A - 核酸変異体および病原体の迅速な検出および同定 - Google Patents

核酸変異体および病原体の迅速な検出および同定

Info

Publication number
JPH10509322A
JPH10509322A JP8516227A JP51622796A JPH10509322A JP H10509322 A JPH10509322 A JP H10509322A JP 8516227 A JP8516227 A JP 8516227A JP 51622796 A JP51622796 A JP 51622796A JP H10509322 A JPH10509322 A JP H10509322A
Authority
JP
Japan
Prior art keywords
cleavage
nucleic acid
dna
stranded
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP8516227A
Other languages
English (en)
Japanese (ja)
Inventor
イー． ダールバーグ，ジェームス
アイ． リャミチェフ，ヴィクター
アン ディー． ブロー，メアリー
シー． オールデンバーグ，メアリー
エム． ハイスラー，ローラ
フォーズ，ランス
マイケル オリーヴ，デイヴィッド
Original Assignee
サード ウェーヴ テクノロジーズ，インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/484,956 external-priority patent/US5843654A/en
Priority claimed from US08/520,946 external-priority patent/US6372424B1/en
Application filed by サード ウェーヴ テクノロジーズ，インコーポレーテッド filed Critical サード ウェーヴ テクノロジーズ，インコーポレーテッド
Publication of JPH10509322A publication Critical patent/JPH10509322A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP8516227A 1994-11-09 1995-11-09 核酸変異体および病原体の迅速な検出および同定 Ceased JPH10509322A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US33716494A 1994-11-09 1994-11-09
US08/337,164 1994-11-09
US40260195A 1995-03-09 1995-03-09
US08/402,601 1995-03-09
US08/484,956 1995-06-07
US08/484,956 US5843654A (en) 1992-12-07 1995-06-07 Rapid detection of mutations in the p53 gene
US08/520,946 1995-08-30
US08/520,946 US6372424B1 (en) 1995-08-30 1995-08-30 Rapid detection and identification of pathogens
PCT/US1995/014673 WO1996015267A1 (fr) 1994-11-09 1995-11-09 Detection et identification rapides de variants de l'acide nucleique et d'agents pathogenes

Publications (1)

Publication Number Publication Date
JPH10509322A true JPH10509322A (ja) 1998-09-14

Family

ID=27502560

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8516227A Ceased JPH10509322A (ja) 1994-11-09 1995-11-09 核酸変異体および病原体の迅速な検出および同定

Country Status (5)

Country Link
EP (1) EP0788557A4 (fr)
JP (1) JPH10509322A (fr)
AU (2) AU4234796A (fr)
CA (1) CA2203627C (fr)
WO (1) WO1996015267A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011072222A (ja) * 2009-09-29 2011-04-14 Kitasato Otsuka Biomedical Assay Kenkyusho:Kk 標的核酸の検出方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5922575A (en) * 1994-04-18 1999-07-13 Mayo Foundation For Medical Education & Research Mutations in the katG gene useful for detection of M. tuberculosis
WO1998023774A1 (fr) * 1996-11-29 1998-06-04 Third Wave Technologies, Inc. Agents de clivage ameliores
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
DK1634890T3 (da) * 1996-01-24 2009-03-09 Third Wave Tech Inc Invasiv klövning af nukleinsyrer
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
GB9918150D0 (en) * 1999-08-03 1999-10-06 Univ Sheffield Nuclease variant
US7060436B2 (en) 2000-06-17 2006-06-13 Third Wave Technologies, Inc. Nucleic acid accessible hybridization sites
EP1399562A2 (fr) * 2000-07-19 2004-03-24 PHARMACIA & UPJOHN COMPANY Sequence nucleotidique complete du gene de la proteine ribosomale de staphylococcus aureus, s20, et methodes d'identification de substances antibacteriennes
WO2016012508A1 (fr) * 2014-07-23 2016-01-28 Steffen Mergemeier Procédé de détection d'une septicémie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489149B1 (fr) * 1990-06-27 2001-10-17 Princeton University Sondes de detection de p53 mutant
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5422253A (en) * 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011072222A (ja) * 2009-09-29 2011-04-14 Kitasato Otsuka Biomedical Assay Kenkyusho:Kk 標的核酸の検出方法

Also Published As

Publication number Publication date
AU4234796A (en) 1996-06-06
CA2203627A1 (fr) 1996-05-23
EP0788557A1 (fr) 1997-08-13
WO1996015267A1 (fr) 1996-05-23
CA2203627C (fr) 2000-06-06
EP0788557A4 (fr) 2003-08-06
AU4444699A (en) 1999-10-14

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