DK1634890T3 - Invasiv klövning af nukleinsyrer - Google Patents
Invasiv klövning af nukleinsyrerInfo
- Publication number
- DK1634890T3 DK1634890T3 DK05016686T DK05016686T DK1634890T3 DK 1634890 T3 DK1634890 T3 DK 1634890T3 DK 05016686 T DK05016686 T DK 05016686T DK 05016686 T DK05016686 T DK 05016686T DK 1634890 T3 DK1634890 T3 DK 1634890T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- specific
- present
- acid sequences
- nucleic acids
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 7
- 238000003776 cleavage reaction Methods 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 230000007017 scission Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/599,491 US5846717A (en) | 1996-01-24 | 1996-01-24 | Detection of nucleic acid sequences by invader-directed cleavage |
| US08/682,853 US6001567A (en) | 1996-01-24 | 1996-07-12 | Detection of nucleic acid sequences by invader-directed cleavage |
| US08/756,386 US5985557A (en) | 1996-01-24 | 1996-11-29 | Invasive cleavage of nucleic acids |
| US08/758,314 US6090606A (en) | 1996-01-24 | 1996-12-02 | Cleavage agents |
| US08/759,038 US6090543A (en) | 1996-01-24 | 1996-12-02 | Cleavage of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1634890T3 true DK1634890T3 (da) | 2009-03-09 |
Family
ID=27541970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05016686T DK1634890T3 (da) | 1996-01-24 | 1997-01-22 | Invasiv klövning af nukleinsyrer |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1634890B1 (da) |
| JP (2) | JP3665648B2 (da) |
| AT (1) | ATE414793T1 (da) |
| AU (1) | AU731062B2 (da) |
| CA (1) | CA2243353C (da) |
| DK (1) | DK1634890T3 (da) |
| ES (1) | ES2317113T3 (da) |
| WO (1) | WO1997027214A1 (da) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759226B1 (en) | 2000-05-24 | 2004-07-06 | Third Wave Technologies, Inc. | Enzymes for the detection of specific nucleic acid sequences |
| US7045289B2 (en) | 1991-09-09 | 2006-05-16 | Third Wave Technologies, Inc. | Detection of RNA Sequences |
| US7150982B2 (en) | 1991-09-09 | 2006-12-19 | Third Wave Technologies, Inc. | RNA detection assays |
| US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US7527928B2 (en) | 1996-11-29 | 2009-05-05 | Third Wave Technologies, Inc. | Reactions on a solid surface |
| US7432048B2 (en) | 1996-11-29 | 2008-10-07 | Third Wave Technologies, Inc. | Reactions on a solid surface |
| US6913881B1 (en) | 1996-01-24 | 2005-07-05 | Third Wave Technologies, Inc. | Methods and compositions for detecting target sequences |
| AU781188B2 (en) * | 1996-01-24 | 2005-05-12 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US6780982B2 (en) * | 1996-07-12 | 2004-08-24 | Third Wave Technologies, Inc. | Charge tags and the separation of nucleic acid molecules |
| ES2375764T3 (es) * | 1996-11-29 | 2012-03-06 | Third Wave Technologies, Inc. | Endonucleasas fen-1, mezclas y procedimientos de escisión. |
| US7101672B2 (en) | 1998-05-05 | 2006-09-05 | Third Wave Technologies, Inc. | Target-dependent reactions using structure-bridging oligonucleotides |
| US6210880B1 (en) | 1997-09-19 | 2001-04-03 | Third Wave Technologies, Inc. | Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
| US6194149B1 (en) | 1998-03-03 | 2001-02-27 | Third Wave Technologies, Inc. | Target-dependent reactions using structure-bridging oligonucleotides |
| EP0983292A4 (en) | 1997-05-05 | 2005-05-18 | Third Wave Tech Inc | DEPENDENT REACTIONS OF TARGETS USING OLIGONUCLEOTIDES FOR BRIDGING STRUCTURES |
| DK0920539T3 (da) | 1997-05-30 | 2006-07-24 | Xenomics | Fremgangsmåder til detektion af nukleinsyresekvenser i urin |
| US8182991B1 (en) | 1997-11-26 | 2012-05-22 | Third Wave Technologies, Inc. | FEN-1 endonucleases, mixtures and cleavage methods |
| US7824859B2 (en) | 1999-10-29 | 2010-11-02 | Cytyc Corporation | Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase |
| US7118860B2 (en) | 1999-10-29 | 2006-10-10 | Stratagene California | Methods for detection of a target nucleic acid by capture |
| US7838225B2 (en) | 1999-10-29 | 2010-11-23 | Hologic, Inc. | Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase |
| US6528254B1 (en) * | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| JP2003528627A (ja) * | 2000-03-27 | 2003-09-30 | アプレラ コーポレイション | 改善された侵襲アッセイ |
| JP2004521606A (ja) * | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Ｒｎａの検出法 |
| WO2001098537A2 (en) | 2000-06-17 | 2001-12-27 | Third Wave Technologies, Inc. | Nucleic acid accessible hybridization sites |
| DE60125243T2 (de) | 2000-07-03 | 2007-05-31 | Applera Corp., Foster City | Polynukleotid-sequenzassay |
| AU2001297524A1 (en) * | 2000-11-15 | 2002-09-19 | Third Wave Technologies, Inc. | Fen endonucleases |
| JP3681729B2 (ja) * | 2001-02-15 | 2005-08-10 | タカラバイオ株式会社 | 塩基置換の検出方法 |
| US7485443B2 (en) | 2001-07-17 | 2009-02-03 | Northwestern University | Solid-phase reactions |
| US7303869B2 (en) | 2001-07-17 | 2007-12-04 | Northwestern University | Solid-phase reactions |
| US20040014067A1 (en) | 2001-10-12 | 2004-01-22 | Third Wave Technologies, Inc. | Amplification methods and compositions |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US7312033B2 (en) | 2002-11-14 | 2007-12-25 | Third Wave Technologies, Inc. | CFTR allele detection assays |
| US8206904B2 (en) | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
| ATE525469T1 (de) | 2002-12-18 | 2011-10-15 | Third Wave Tech Inc | Nachweis kleiner nukleinsäuren |
| US7297780B2 (en) | 2003-01-06 | 2007-11-20 | Third Wave Technologies, Inc. | Reactive functional groups for preparation of modified nucleic acid |
| US7700750B2 (en) | 2003-01-09 | 2010-04-20 | Third Wave Technologies, Inc. | Connexin allele detection assays |
| US20040161749A1 (en) | 2003-01-24 | 2004-08-19 | Hall Jeff G. | 3' end tagged oligonucleotides |
| JP5138230B2 (ja) | 2004-01-07 | 2013-02-06 | サード・ウェーブ・テクノロジーズ・インク | Ｃ型肝炎ウイルスの遺伝子型の決定方法 |
| US7462451B2 (en) | 2004-04-26 | 2008-12-09 | Third Wave Technologies, Inc. | Compositions for modifying nucleic acids |
| US7727721B2 (en) | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
| CA2608348A1 (en) | 2005-05-12 | 2006-11-23 | Third Wave Technologies, Inc. | Polymorphic ghsr nucleic acids and uses thereof |
| US7960357B2 (en) | 2005-10-07 | 2011-06-14 | California Institute Of Technology | PKR activation via hybridization chain reaction |
| US7482127B2 (en) | 2005-11-03 | 2009-01-27 | Third Wave Technologies, Inc. | Nucleic acid detection assays employing blocker oligonucleotides |
| US7674924B2 (en) | 2006-05-22 | 2010-03-09 | Third Wave Technologies, Inc. | Compositions, probes, and conjugates and uses thereof |
| EP2029774B1 (en) | 2006-06-01 | 2015-04-01 | Third Wave Technologies, Inc. | Detection of nucleic acids |
| US7759062B2 (en) | 2006-06-09 | 2010-07-20 | Third Wave Technologies, Inc. | T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection |
| AU2007307171B2 (en) | 2006-10-04 | 2012-01-19 | Third Wave Technologies, Inc. | Snap-back primers and detectable hairpin structures |
| US9217151B2 (en) | 2007-05-16 | 2015-12-22 | California Institute Of Technology | Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| EP2183394B1 (en) | 2007-09-07 | 2012-12-12 | Third Wave Technologies, Inc. | Methods and applications for target quantification |
| US8497364B2 (en) | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
| KR101419980B1 (ko) | 2008-03-15 | 2014-07-15 | 홀로직, 인크. | 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법 |
| EP2853601B1 (en) | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| ES2645418T3 (es) | 2011-12-22 | 2017-12-05 | Ibis Biosciences, Inc. | Amplificación de una secuencia de un ácido ribonucleico |
| CN104271771A (zh) * | 2012-06-20 | 2015-01-07 | 东丽株式会社 | 核酸的检测方法及核酸检测试剂盒 |
| WO2014158628A1 (en) | 2013-03-14 | 2014-10-02 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules |
| CN105229176A (zh) | 2013-03-15 | 2016-01-06 | 特罗瓦基因公司 | 尿液中核酸的检测 |
| US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
| JP6688318B2 (ja) | 2015-05-01 | 2020-04-28 | ジェン−プローブ・インコーポレーテッド | 多重侵入切断アッセイ |
| WO2018009463A2 (en) | 2016-07-05 | 2018-01-11 | California Institute Of Technology | Fractional initiator hybridization chain reaction |
| WO2018044939A1 (en) | 2016-08-30 | 2018-03-08 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
| CN111032209A (zh) | 2017-07-10 | 2020-04-17 | 简·探针公司 | 分析系统和方法 |
| CA3072452A1 (en) | 2017-08-11 | 2019-02-14 | Gen-Probe Incorporated | Compositions and methods for detecting staphylococcus aureus |
| US11662281B2 (en) | 2017-12-13 | 2023-05-30 | Gen-Probe Incorporated | Compositions and methods for biological sample processing |
| EP3724354A1 (en) | 2017-12-15 | 2020-10-21 | Gen-Probe Incorporated | Compositions and methods for detecting toxigenic clostridium difficile |
| EP3746225B1 (en) | 2018-01-29 | 2024-10-30 | Gen-Probe Incorporated | Analytical systems and methods |
| JP7470095B2 (ja) | 2018-07-10 | 2024-04-17 | ジェン－プローブ・インコーポレーテッド | 核酸を検出および定量するための方法およびシステム |
| US20220080425A1 (en) | 2018-12-31 | 2022-03-17 | Gen-Probe Incorporated | Tray for transfering solid reagents to a multi-well cartridge |
| WO2020154513A1 (en) | 2019-01-25 | 2020-07-30 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
| US12210028B2 (en) | 2019-05-03 | 2025-01-28 | Gen-Probe Incorporated | Receptacle delivery system |
| CN111172164B (zh) * | 2020-03-09 | 2022-11-15 | 中国药科大学 | 一种用于任意核酸编辑的组合物及方法 |
| CA3177256A1 (en) | 2020-10-21 | 2022-04-28 | Gen-Probe Incorporated | Fluid container management system |
| US11873485B2 (en) | 2021-01-26 | 2024-01-16 | California Institute Of Technology | Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas |
| CN113774141B (zh) * | 2021-09-30 | 2024-02-27 | 重庆大学 | 一种用于双位点顺反式突变检测的引物、探针组合物及其应用 |
| WO2023200406A2 (en) * | 2022-04-14 | 2023-10-19 | National University Of Singapore | Method of detecting a polynucleotide analyte |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| CA1337639C (en) * | 1989-08-01 | 1995-11-28 | Joseph Eugene Celebuski | Dna probe assay using neutrally charged probe strands |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| JP3595841B2 (ja) * | 1992-12-04 | 2004-12-02 | サーナ セラピューティクス，インコーポレイテッド | リボザイム増幅診断用薬 |
| US5422253A (en) * | 1992-12-07 | 1995-06-06 | Wisconsin Alumni Research Foundation | Method of site specific nucleic acid cleavage |
| US5541311A (en) * | 1992-12-07 | 1996-07-30 | Third Wave Technologies, Inc. | Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
| AU4234796A (en) * | 1994-11-09 | 1996-06-06 | Third Wave Technologies, Inc. | Rapid detection and identification of nucleic acid variants and pathogens |
-
1997
- 1997-01-22 WO PCT/US1997/001072 patent/WO1997027214A1/en not_active Ceased
- 1997-01-22 EP EP05016686A patent/EP1634890B1/en not_active Expired - Lifetime
- 1997-01-22 JP JP52698997A patent/JP3665648B2/ja not_active Expired - Fee Related
- 1997-01-22 DK DK05016686T patent/DK1634890T3/da active
- 1997-01-22 AU AU18364/97A patent/AU731062B2/en not_active Expired
- 1997-01-22 EP EP97903931A patent/EP0904286A4/en not_active Withdrawn
- 1997-01-22 ES ES05016686T patent/ES2317113T3/es not_active Expired - Lifetime
- 1997-01-22 AT AT05016686T patent/ATE414793T1/de active
- 1997-01-22 CA CA2243353A patent/CA2243353C/en not_active Expired - Lifetime
-
2004
- 2004-12-01 JP JP2004348955A patent/JP4295715B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2243353C (en) | 2010-03-30 |
| JP2002515737A (ja) | 2002-05-28 |
| JP3665648B2 (ja) | 2005-06-29 |
| JP2005160481A (ja) | 2005-06-23 |
| AU731062B2 (en) | 2001-03-22 |
| AU1836497A (en) | 1997-08-20 |
| JP4295715B2 (ja) | 2009-07-15 |
| WO1997027214A1 (en) | 1997-07-31 |
| EP0904286A1 (en) | 1999-03-31 |
| EP1634890A1 (en) | 2006-03-15 |
| CA2243353A1 (en) | 1997-07-31 |
| ES2317113T3 (es) | 2009-04-16 |
| EP1634890B1 (en) | 2008-11-19 |
| ATE414793T1 (de) | 2008-12-15 |
| EP0904286A4 (en) | 2004-01-14 |
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