JPH107552A5 - - Google Patents
Info
- Publication number
- JPH107552A5 JPH107552A5 JP1997060781A JP6078197A JPH107552A5 JP H107552 A5 JPH107552 A5 JP H107552A5 JP 1997060781 A JP1997060781 A JP 1997060781A JP 6078197 A JP6078197 A JP 6078197A JP H107552 A5 JPH107552 A5 JP H107552A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- sustained
- release formulation
- venlafaxine hydrochloride
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (8)
- 塩酸ベンラファキシン、微結晶セルロースおよびヒドロキシプロピルメチルセルロースを含有し、エチルセルロースおよびヒドロキシプロピルメチルセルロースでコーティングされた治療上有効量の細粒剤を充填した硬質ゼラチンカプセルからなることを特徴とする、塩酸ベンラファキシンの持続放出性製剤。
- 細粒剤が、約３７.３重量％の塩酸ベンラファキシン、約０.５重量％のヒドロキシプロピルメチルセルロース・タイプ２２０８および約６２.１７重量％の微結晶セルロースからなる請求項１記載の持続放出性製剤。
- フィルムコーティングがエチルセルロース（全重量の４.８１％）およびヒドロキシプロピルメチルセルロース（全重量の０.８５％）からなる請求項１記載の持続放出性製剤。
- フィルムコーティングがエチルセルロース（全重量の４.０４％）およびヒドロキシプロピルメチルセルロース（全重量の０.７１４％）からなる請求項１記載の持続放出性製剤。
- フィルムコーティングがエチルセルロース（全重量の２.４８％）およびヒドロキシプロピルメチルセルロース（全重量の０.４３７％）からなる請求項１記載の持続放出性製剤。
- エトキシ基の含有量が４４.０％〜５１.０％のエチルセルロース（全重量の８５％）と、メトキシ基の含有量が２８.０％〜３０.０％およびヒドロキシプロポキシ基の含有量が７.０％〜１２.０％のヒドロキシプロピルメチルセルロース（全重量の１５％）とからなるフィルムコーティング組成物。
- ３７.３重量％の塩酸ベンラファキシン、６２.１７重量％の微結晶セルロースおよび０.５重量％のヒドロキシプロピルメチルセルロース・タイプ２２０８を含有し、２４時間にわたって所望の放出速度を与える溶解プロフィールを有するコーティング細粒剤を与えるのに充分な量の、８５重量％のエチルセルロース・タイプＨＧ２８３４および１５重量％のヒドロキシプロピル−メチルセルロース・タイプ２９１０からなる混合物でコーティングされた細粒剤からなる毎日１回投与用の塩酸ベンラファキシンの持続放出性製剤。
- ２４時間にわたって、１５０ｎｇ／ｍｌまでのより低いピーク血清レベルおよび持続した治療上有効な血漿レベルを与える請求項７記載の塩酸ベンラファキシンの持続放出性製剤。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1400696P | 1996-03-25 | 1996-03-25 | |
| US60/014006 | 1996-03-25 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008064149A Division JP2008156374A (ja) | 1996-03-25 | 2008-03-13 | 持続放出性製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH107552A JPH107552A (ja) | 1998-01-13 |
| JPH107552A5 true JPH107552A5 (ja) | 2004-12-24 |
| JP4771565B2 JP4771565B2 (ja) | 2011-09-14 |
Family
ID=21762972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP06078197A Expired - Fee Related JP4771565B2 (ja) | 1996-03-25 | 1997-03-14 | 持続放出性製剤 |
| JP2008064149A Pending JP2008156374A (ja) | 1996-03-25 | 2008-03-13 | 持続放出性製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008064149A Pending JP2008156374A (ja) | 1996-03-25 | 2008-03-13 | 持続放出性製剤 |
Country Status (34)
| Country | Link |
|---|---|
| EP (2) | EP0797991B1 (ja) |
| JP (2) | JP4771565B2 (ja) |
| KR (1) | KR101096512B1 (ja) |
| CN (2) | CN1090018C (ja) |
| AR (1) | AR006519A1 (ja) |
| AT (1) | ATE257011T1 (ja) |
| AU (1) | AU727653B2 (ja) |
| BR (1) | BR9701304A (ja) |
| CA (1) | CA2199778C (ja) |
| CO (1) | CO4761054A1 (ja) |
| CY (1) | CY2442B1 (ja) |
| CZ (1) | CZ291637B6 (ja) |
| DE (1) | DE69727000T2 (ja) |
| DK (1) | DK0797991T3 (ja) |
| EG (1) | EG24198A (ja) |
| ES (1) | ES2210454T3 (ja) |
| HU (1) | HU224617B1 (ja) |
| IL (1) | IL120382A (ja) |
| IN (1) | IN187337B (ja) |
| NO (2) | NO320355B1 (ja) |
| NZ (1) | NZ314442A (ja) |
| PA (1) | PA8426401A1 (ja) |
| PE (1) | PE57198A1 (ja) |
| PL (2) | PL195564B1 (ja) |
| PT (1) | PT797991E (ja) |
| PY (1) | PY970019A (ja) |
| RU (1) | RU2176912C2 (ja) |
| SK (1) | SK281530B6 (ja) |
| SV (1) | SV1997000015A (ja) |
| TR (1) | TR199700190A2 (ja) |
| TW (1) | TW493993B (ja) |
| UA (1) | UA44904C2 (ja) |
| UY (1) | UY24613A1 (ja) |
| ZA (1) | ZA972403B (ja) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| PE57198A1 (es) * | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
| UA77145C2 (en) * | 1997-11-05 | 2006-11-15 | Wyeth Corp | Extended release dosage formulation |
| JP3379461B2 (ja) * | 1998-08-06 | 2003-02-24 | 三菱電機株式会社 | コア部材の積層金型装置、コア部材の積層方法および電動機 |
| IE990406A1 (en) | 1999-05-20 | 2000-12-27 | Elan Corp Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
| ATE367153T1 (de) * | 1999-05-20 | 2007-08-15 | Elan Corp Plc | Multipartikuläre arzneizusammensetzungen mit gesteuerter wirkstoffabgabe enthaltend selektive inhibitoren der serotoninwiederaufnahme |
| ES2162746B1 (es) * | 1999-10-21 | 2003-02-16 | Lipotec Sa | Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion. |
| FR2805462B1 (fr) * | 2000-02-24 | 2003-08-15 | Therabel Res | Nouvelle forme galenique orale a liberation prolongee de la molsidomine |
| US6482440B2 (en) * | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
| SK5762003A3 (en) * | 2000-10-19 | 2003-11-04 | Teva Pharma | Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof |
| SE0102887D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
| SE0102886D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
| SE0102888D0 (sv) * | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
| IL146462A (en) * | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
| HUP0104872A3 (en) * | 2001-11-13 | 2004-04-28 | Egis Gyogyszergyar Nyilvanosan | New polymorphic forms of venlafaxine, process for their preparation, pharmaceutical compositions containing them and their use |
| US6696496B2 (en) | 2002-03-28 | 2004-02-24 | Synthon Bv | Low water-soluble venlafaxine salts |
| AU2003219117A1 (en) * | 2002-03-28 | 2003-10-13 | Synthon B.V. | Extended release venlafaxine formulations |
| EP1485344A1 (en) | 2002-03-28 | 2004-12-15 | Synthon B.V. | Venlafaxine besylate |
| US20060246132A1 (en) * | 2003-02-07 | 2006-11-02 | Fjalar Johannsson | Sustained release formulations of venlafaxine |
| TW200503670A (en) * | 2003-03-28 | 2005-02-01 | Sandoz Ag | Venlafaxine compositions |
| EP1473030B2 (en) * | 2003-05-02 | 2014-05-14 | Dexcel Ltd. | Extended release Venlafaxine tablet formulation |
| IN2003MU00504A (ja) * | 2003-06-05 | 2005-05-13 | Alembic Ltd | |
| WO2004112756A1 (en) | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| ATE336988T1 (de) | 2003-07-30 | 2006-09-15 | Pharmathen Sa | Venlafaxine hydrochloridformulierungen mit verzögerter freisetzung |
| WO2005048979A2 (en) * | 2003-10-06 | 2005-06-02 | Torrent Pharmaceuticals Limited | Pharmaceutical composition having casing with multiple micro tablets |
| HUP0303382A2 (hu) * | 2003-10-10 | 2005-08-29 | EGIS Gyógyszergyár Rt. | Venlafaxin-hidroklorid-tartalmú pelletek |
| EP1523979A1 (en) * | 2003-10-13 | 2005-04-20 | Wyeth | Extended release pharmaceutical dosage form |
| EP1523981A1 (en) * | 2003-10-13 | 2005-04-20 | Wyeth | Extended release formulations of venlafaxine |
| DE10359154A1 (de) | 2003-12-16 | 2005-07-28 | Krka Tovarna Zdravil, D.D. | Verfahren zur Herstellung von Venlafaxin und Venlafaxinhydrochlorid der Form I |
| AU2004315136B2 (en) | 2004-02-04 | 2010-06-17 | Alembic Limited | Extended release coated microtablets of venlafaxine hydrochloride |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US7776358B2 (en) | 2004-07-22 | 2010-08-17 | Synthon Ip Inc. | Extended release venlafaxine besylate tablets |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| CN100463676C (zh) * | 2004-11-11 | 2009-02-25 | 成都康弘药业集团股份有限公司 | 一种盐酸文拉法辛控释片制剂及其制备方法 |
| ITFI20050206A1 (it) * | 2005-09-30 | 2007-04-01 | Valpharma Sa | Composizione farmaceutica a rilascio controllato di venlafaxina cloridrato, e processo per la sua preparazione |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| CA2648280C (en) * | 2006-04-03 | 2014-03-11 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
| NZ703464A (en) | 2006-04-26 | 2016-05-27 | Alphapharm Pty Ltd | Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| KR100791194B1 (ko) * | 2006-06-12 | 2008-01-02 | 코오롱제약주식회사 | 염산 벤라팍신의 경구 투여용 서방성 펠렛 및 그 제조방법 |
| JP6045347B2 (ja) * | 2010-02-03 | 2016-12-14 | ファーマ ツー ビー リミテッド | ラサギリンの持続放出性製剤およびその使用 |
| WO2011132008A2 (en) | 2010-04-22 | 2011-10-27 | EGIS Gyűgyszergyár Nyilvánosan Múködő Részvény társaság | Controlled release pharmaceutical composition |
| US9789093B2 (en) | 2011-01-31 | 2017-10-17 | Serotech, Llc | Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder |
| CN103893151B (zh) * | 2012-12-31 | 2018-04-27 | 石药集团中奇制药技术（石家庄）有限公司 | 一种盐酸文拉法辛缓释胶囊及其制备方法 |
| IL270654B2 (en) | 2017-05-17 | 2024-07-01 | Confluence Pharmaceuticals Llc | Formulations of homotaurines and salts thereof |
| CN114288273B (zh) * | 2022-02-11 | 2022-10-18 | 桂林华信制药有限公司 | 一种盐酸文拉法辛缓释胶囊及其生产工艺 |
| JP2023127913A (ja) * | 2022-03-02 | 2023-09-14 | 共和薬品工業株式会社 | ベンラファキシン塩酸塩含有顆粒 |
| JP2025120141A (ja) | 2024-02-03 | 2025-08-15 | 共和薬品工業株式会社 | ベンラファキシン塩酸塩含有徐放性顆粒の製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1561204A (en) * | 1977-06-01 | 1980-02-13 | Ici Ltd | Sustained release pharmaceutical composition |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| IE56324B1 (en) * | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
| US4761501A (en) * | 1983-10-26 | 1988-08-02 | American Home Products Corporation | Substituted phenylacetamides |
| IE60311B1 (en) | 1987-09-24 | 1994-06-29 | American Home Prod | Sustained release etodolac |
| US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| PT639374E (pt) * | 1993-06-28 | 2002-07-31 | American Home Prod | Novos tratamentos utilizado derivados fenetilo |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| PE57198A1 (es) * | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
-
1997
- 1997-03-04 PE PE00015497A patent/PE57198A1/es not_active IP Right Cessation
- 1997-03-05 PY PY199700970019A patent/PY970019A/es unknown
- 1997-03-05 AR ARP970100883 patent/AR006519A1/es unknown
- 1997-03-06 IL IL12038297A patent/IL120382A/xx unknown
- 1997-03-07 TW TW86102797A patent/TW493993B/zh not_active IP Right Cessation
- 1997-03-07 SK SK301-97A patent/SK281530B6/sk not_active IP Right Cessation
- 1997-03-10 SV SV1997000015A patent/SV1997000015A/es active IP Right Grant
- 1997-03-10 CO CO97012838A patent/CO4761054A1/es unknown
- 1997-03-11 EG EG18297A patent/EG24198A/xx active
- 1997-03-12 CA CA 2199778 patent/CA2199778C/en not_active Expired - Lifetime
- 1997-03-12 UA UA97031116A patent/UA44904C2/uk unknown
- 1997-03-13 PL PL368424A patent/PL195564B1/pl unknown
- 1997-03-13 RU RU97103563A patent/RU2176912C2/ru not_active IP Right Cessation
- 1997-03-13 TR TR97/00190A patent/TR199700190A2/xx unknown
- 1997-03-13 CZ CZ1997772A patent/CZ291637B6/cs not_active IP Right Cessation
- 1997-03-13 PL PL97318954A patent/PL188444B1/pl unknown
- 1997-03-14 NO NO19971206A patent/NO320355B1/no not_active IP Right Cessation
- 1997-03-14 HU HU9700589A patent/HU224617B1/hu not_active IP Right Cessation
- 1997-03-14 KR KR1019970008590A patent/KR101096512B1/ko not_active Expired - Lifetime
- 1997-03-14 BR BR9701304A patent/BR9701304A/pt not_active IP Right Cessation
- 1997-03-14 CN CN97109594A patent/CN1090018C/zh not_active Expired - Lifetime
- 1997-03-14 JP JP06078197A patent/JP4771565B2/ja not_active Expired - Fee Related
- 1997-03-14 PA PA8426401A patent/PA8426401A1/es unknown
- 1997-03-19 ZA ZA972403A patent/ZA972403B/xx unknown
- 1997-03-19 NZ NZ31444297A patent/NZ314442A/xx not_active IP Right Cessation
- 1997-03-20 AU AU16400/97A patent/AU727653B2/en not_active Expired
- 1997-03-21 PT PT97301937T patent/PT797991E/pt unknown
- 1997-03-21 DK DK97301937T patent/DK0797991T3/da active
- 1997-03-21 ES ES97301937T patent/ES2210454T3/es not_active Expired - Lifetime
- 1997-03-21 AT AT97301937T patent/ATE257011T1/de active
- 1997-03-21 EP EP19970301937 patent/EP0797991B1/en not_active Expired - Lifetime
- 1997-03-21 DE DE1997627000 patent/DE69727000T2/de not_active Expired - Lifetime
- 1997-03-21 EP EP14198408.8A patent/EP2881110A1/en not_active Withdrawn
- 1997-03-21 IN IN507CA1997 patent/IN187337B/en unknown
- 1997-07-10 UY UY24613A patent/UY24613A1/es not_active IP Right Cessation
-
2001
- 2001-12-14 CN CN01143869A patent/CN1403077A/zh active Pending
-
2004
- 2004-05-27 CY CY0400040A patent/CY2442B1/xx unknown
-
2005
- 2005-01-24 NO NO20050379A patent/NO20050379L/no not_active Application Discontinuation
-
2008
- 2008-03-13 JP JP2008064149A patent/JP2008156374A/ja active Pending
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