JPH1085573A - Preparation method of mixed solution of electrolyte and non-electrolyte - Google Patents

Abstract

(57) [Summary] [PROBLEMS] In a batch type mixing apparatus, it is possible to easily prevent a decrease in the concentration of an electrolyte solution at the first preparation, and to prevent an electrolyte and a non-electrolyte from decreasing at the beginning of a plurality of preparations. Is to obtain a mixed solution containing the same. SOLUTION: Water is supplied to a mixing tank 15 of a mixing device 1,
Water is circulated through the pipe 20 and stirred, and the dialysate A
The electrolyte agent 101 is continuously added and mixed, and the electric conductivity of the aqueous solution is measured by the conductivity meter 24 to prepare an aqueous electrolyte solution having a predetermined concentration. The glucose (non-electrolyte) drug 102 is continuously added and mixed while the aqueous electrolyte solution is stirred, and the electric conductivity of the mixed aqueous solution is measured to prepare a mixed aqueous solution (agent A) containing a predetermined concentration of the electrolyte and the non-electrolyte. And then discharge. The above series of steps is repeated a plurality of times. In the first mixing, before adding the electrolyte medicine 101 to water and mixing, the mixed solution prepared by the first and subsequent mixing is the same amount as that contained in the residual liquid unavoidably remaining in the mixing device 1 after discharge. Of glucose.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for preparing a mixed solution obtained by mixing a predetermined concentration of an electrolyte and a non-electrolyte in an aqueous solvent such as water. INDUSTRIAL APPLICABILITY The present invention is used particularly in the food industry and the pharmaceutical industry, and is particularly effectively used in the preparation of a dialysate in the medical field.

[0002]

2. Description of the Related Art Conventionally, in the food industry and the pharmaceutical industry, for example, an electrolyte such as salt or sodium carbonate and a non-electrolyte such as sugar or alcohol are often used after being dissolved in water or other aqueous polar solvent. Also in the medical field, an aqueous solution in which sodium chloride as an electrolyte, glucose as a non-electrolyte, and other trace components are dissolved is used as a dialysis solution for dialysis treatment.

[0003] In the production of these products, a method of adding and mixing a predetermined amount of an electrolyte and a non-electrolyte to a predetermined amount of a solvent has been conventionally performed. Therefore, there is a problem that it is difficult to prepare a mixed solution having an accurate concentration due to an increase in the amount of the solution due to the above.

Therefore, while measuring the solute concentration of the solution,
By adding and mixing solutes, it is possible to prepare a mixed solution having an accurate concentration.
For mixing, it is necessary to be able to measure the solute concentration of the solution in real time.

Conventionally, there are various methods for measuring the concentration of an electrolyte solution such as sodium chloride. However, there are many advantages, such as a simple and easy-to-use apparatus, little variation in measured values, and high reliability. A method widely used for this purpose is a method of measuring the electric conductivity of a solution using an electric conductivity meter. The method for measuring the electric conductivity of this solution is to use the change in electric conductivity where the electric conductivity of water increases linearly with the amount of the electrolyte when the electrolyte is added to water or the like. Measures the concentration. By previously determining the relationship between the electrolyte concentration of the solution and the electric conductivity of the solution (calibration curve), the electrolyte concentration of the solution can be measured in real time with respect to the addition and mixing of the electrolyte. .

On the other hand, as a method for measuring the concentration of a non-electrolyte solution such as glucose, the measurement of the refractive index and the degree of polarization of the solution is known. However, these methods are complicated in measuring equipment, difficult to handle, and reliable. It has disadvantages such as low performance and the measured value is likely to fluctuate depending on sample preparation, and is not suitable for measuring the non-electrolyte concentration of the solution in real time with addition and mixing.

[0007] The present inventors have intensively studied a method for measuring the non-electrolyte concentration of a solution in order to make it possible to prepare a mixed solution having an accurate concentration obtained by mixing an electrolyte and a non-electrolyte. As a result, conventionally, the method of measuring the solute concentration by measuring the electric conductivity of a solution can be applied to an electrolyte, and for a non-electrolyte such as glucose that does not dissociate ions, the concentration of the solute cannot be measured by the electric conductivity measurement. It has been found that as the non-electrolyte is added to the electrolyte solution, the electric conductivity of the solution decreases in a fixed relation with an increase in the amount of the non-electrolyte added. Therefore,
If the correlation (calibration curve) between the electric conductivity of the mixed solution and the concentration of the non-electrolyte is determined in advance for a system in which the electrolyte and the non-electrolyte are the same, the electric conductivity of the mixed solution is measured, and the non-electrolyte concentration is determined. And found that it can be measured in real time, and recently filed an application entitled "Method for Measuring Non-Electrolyte Concentration in Electrolyte Solution" (Japanese Patent Application No. 7-70274).

FIG. 7 is a graph showing a change in electrical conductivity when glucose is added to an aqueous solution of an electrolyte except glucose in the dialysate A, and FIG. 8 is a mixed aqueous solution obtained by adding glucose to an aqueous solution of an electrolyte. 5 is a graph showing the correlation between the electrical conductivity and the glucose concentration at the time of FIG.

The electrolyte components of the dialysate A except glucose are sodium chloride (NaCl) and potassium chloride (KC).
l), calcium chloride (CaCl ₂ .2H ₂ O), magnesium chloride (MgCl ₂ ), sodium acetate (CH ₃
The COONa), NaCl: KCl: CaCl 2 · 2H
₂ O: MgCl ₂ .6H ₂ O: CH ₃ COONa = 19
33: 47: 69: 32: 258.

Approximately 289 g of this electrolyte component was added to water 1 at 20 ° C.
Dissolve uniformly in liter (A agent electrolyte concentration 4.4m
ol / l), 1 liter of the resulting aqueous solution was placed in a glass container, and about 13.4 g of powdered glucose was added thereto (glucose concentration: about 74 mmol / l), and the mixture was stirred and mixed uniformly, and then subjected to electric conductivity. The electric conductivity of the mixed aqueous solution was measured using a meter. The electrical conductivity of the mixed aqueous solution initially decreases with time, but becomes a constant value after a predetermined time has elapsed. Thereafter, about 13.4 g of glucose was further added to the container (glucose concentrations of about 148, 188, 221.3).
And 296 mmol / l), respectively, and the electric conductivity of the mixed aqueous solution was measured, and the graphs of FIGS. 7 and 8 were obtained.

FIG. 7 shows that the electric conductivity of the mixed aqueous solution decreases as the amount of added glucose increases, and FIG. 8 shows that the decrease in the electric conductivity is linearly related to the increase in the glucose concentration of the mixed aqueous solution. It can be seen that the relationship exists.

Therefore, if a calibration curve (correlation) between the electric conductivity of the mixed aqueous solution and the glucose concentration is determined in advance for the mixed aqueous solution obtained by adding glucose to the aqueous solution of the electrolyte component of the dialysate A agent, the electric power of the mixed aqueous solution can be obtained. From the measurement of conductivity, the glucose concentration of the mixed aqueous solution can be measured immediately and accurately in real time. Therefore, it is possible to accurately prepare an aqueous solution of the dialysate A at a predetermined concentration in which the electrolyte and the non-electrolyte (glucose) are mixed.

For preparing a mixed solution, for example, a dialysate A using such a concentration measuring method, a mixing tank, water supply means for supplying water to the mixing tank, and electrolyte supply means for supplying electrolyte to the mixing tank are provided. And using a mixing device provided with a non-electrolyte supply means for supplying a non-electrolyte to the preparation tank and a stirring means, a discharge means and an electric conductivity meter provided in the preparation tank, as follows. it can.

First, the mixing tank is supplied with water and filled, and the water is stirred by the stirring means. While the electrolyte is continuously added and mixed by the electrolyte supply means under the stirring, the electric conductivity of the electrolyte aqueous solution mixed with the electrolyte is measured by the electric conductivity meter, and the electrolyte concentration of the aqueous solution is detected,
The addition of the electrolyte is stopped when a predetermined electrolyte concentration is detected. As a result, an aqueous electrolyte solution having a predetermined concentration is obtained. Then, while stirring the obtained electrolyte aqueous solution, glucose was continuously added to and mixed with the non-electrolyte supply means,
The electric conductivity of the mixed aqueous solution in which glucose is dissolved is measured by the electric conductivity meter, the glucose concentration of the mixed aqueous solution is detected, and the addition of glucose is stopped when a predetermined glucose concentration is detected. Thereby, a mixed aqueous solution containing a predetermined concentration of electrolyte and a predetermined concentration of glucose is obtained. Thereafter, the mixed aqueous solution (agent A) thus prepared is discharged from the preparation tank by a discharging means, and is mixed with an electrolyte solution having a predetermined concentration (aqueous sodium hydrogen carbonate solution (agent B)) prepared by another device. In order to combine the dialysis solution and the dialysis solution, the dialysis solution is supplied to a preparation storage tank or the like and is adjusted to a dialysate or a dialysate stock solution having a predetermined concentration.

[0015]

By the way, the above-mentioned operation of preparing the dialysate A in the dialysis solution, that is, (a) supply of water to the preparation tank, and (b) continuous addition and mixing of electrolyte to water. And preparing an aqueous electrolyte solution having a predetermined concentration by measuring the electric conductivity of the aqueous solution, (c) continuously adding and mixing glucose to the aqueous electrolyte solution, and preparing an electrolyte having a predetermined concentration by measuring the electric conductivity of the mixed aqueous solution. For the preparation of the mixed aqueous solution (agent A) containing the non-electrolyte and (d) the series of steps of discharging the mixed aqueous solution from the mixing tank, once the operation is started, the series of steps is repeated a plurality of times, and a plurality of steps are performed Formulation of Next, when the compounding operation is restarted, each part of the compounding device, such as the compounding tank and the pipeline attached thereto, is sterilized and washed, and then the above-mentioned operations (a) and thereafter are started.

According to the operation method of such a dispensing device, at the time of the first dispensing operation, when the dispensing operation is started, the residual liquid remaining after discharging the mixed aqueous solution prepared in the previous operation is left in the dispensing device. However, at the time of the second and subsequent preparations, the remaining liquid of the mixed aqueous solution of the previous preparation is inevitably remaining in the preparation apparatus. When water is supplied to the preparation tank, stirred, and the electrolyte is added and mixed, A situation occurs in which the residual liquid is combined with the liquid.

When the electric conductivity of the electrolyte aqueous solution to which the residual liquid is combined is measured, even if the electrolyte concentration is the same,
The reading of the conductivity meter is lower by the amount of glucose contained in the residual liquid. Therefore, a calibration curve of the electric conductivity and the electrolyte concentration of the aqueous electrolyte solution is prepared according to the second and subsequent preparations, and used for measuring the electrolyte concentration to prepare the aqueous electrolyte solution. There was a problem that the concentration of the prepared mixed aqueous solution (agent A) was lower in the first time than in the second time and thereafter.

An object of the present invention is to easily prevent a decrease in the electrolyte concentration of the electrolyte solution in the first preparation,
Provided is a method for preparing a mixed solution that enables a stable mixed solution containing a predetermined concentration of an electrolyte and a predetermined concentration of a non-electrolyte without a decrease in electrolyte concentration from the first to the last preparation. It is to be.

[0019]

The above object is achieved by a method for preparing a mixed solution according to the present invention. In summary, the present invention provides a preparation tank, a solvent supply means for supplying an aqueous polar solvent to the preparation tank, an electrolyte supply means for supplying an electrolyte to the preparation tank, and a non-electrolyte supply for supplying a non-electrolyte to the preparation tank. Mixing of an electrolyte and a non-electrolyte using a mixing device including a means, a stirring means provided in the mixing tank, a discharging means provided in the mixing tank, and an electric conductivity meter provided in the mixing tank. A method for preparing a solution, comprising: (a) supplying a solvent to a preparation tank; and (b) continuously adding and mixing an electrolyte to the supplied solvent by an electrolyte supply means under stirring by a stirring means while conducting electric conduction. An electric conductivity of the electrolyte solution mixed with the electrolyte is measured by a rate meter, and an electrolyte solution of a predetermined concentration is prepared by detecting an electrolyte concentration of the electrolyte solution. (C) Then, the electrolyte solution is kept stirring. , This is non-electric While continuously adding and mixing the non-electrolyte by the electrolyte supply means, by measuring the electric conductivity of the mixed solution obtained by mixing the non-electrolyte with the electric conductivity meter, and detecting the non-electrolyte concentration of the mixed solution, Preparing a mixed solution containing a predetermined concentration of electrolyte and a predetermined concentration of non-electrolyte, and (d) discharging the mixed solution by a discharge means after that;
In a method for preparing a mixed solution of an electrolyte and a non-electrolyte, a series of steps (b), (c) and (d) is repeated a plurality of times,
In the first preparation of the plurality of preparations of the mixed solution, after the step (a) and before the step (b), the water supplied to the preparation tank is mixed by the first and subsequent preparations. A method for preparing a mixed solution of an electrolyte and a non-electrolyte, comprising charging the same amount of non-electrolyte as the non-electrolyte mass contained in the residual liquid inevitably remaining in the mixing device after discharging the prepared mixed solution. It is.

According to the present invention, the stirring means can be a circulating means including a circulating path attached to the mixing tank, and the electric conductivity meter is installed in the circulating path. Further, the solvent is water, the electrolyte is an electrolyte agent containing sodium chloride as a main component, and the non-electrolyte is a glucose agent.

In another aspect of the present invention, in the first preparation of the plurality of preparations of the mixed solution, the mixed solution is supplied to the preparation tank after the step (a) and before the step (b). Instead of adding the same amount of non-electrolyte as the non-electrolyte mass contained in the residual liquid inevitably remaining in the mixing device after discharging the mixed solution prepared at the time of the second and subsequent preparations, The concentration set value of the electric conductivity meter, which detects the electrolyte concentration of the electrolyte solution by measuring the electric conductivity, inevitably remains in the mixing device after discharging the mixed solution prepared by the first and subsequent preparations. It is characterized in that it is changed and set by a variation amount corresponding to the non-electrolyte component contained in the residual liquid.

Still another aspect of the present invention is a first preparation tank, a solvent supply means for supplying an aqueous polar solvent to the first preparation tank, and an electrolyte supply means for supplying an electrolyte to the first preparation tank. A first stirring means provided in the first mixing tank, a first electric conductivity meter provided in the first mixing tank, and a first discharging means provided in the first mixing tank. A second mixing tank; a non-electrolyte supply unit for supplying a non-electrolyte to the second mixing tank; a second stirring unit provided in the second mixing tank; and a second mixing tank. A method of preparing a mixed solution of an electrolyte and a non-electrolyte using a mixing device provided with a second electric conductivity meter and a second discharging means provided in a second mixing tank, wherein ) Supplying a solvent to the first preparation tank, and (b)
While continuously adding and mixing the electrolyte to the supplied solvent by the electrolyte supply means under stirring by the first stirring means,
The first electric conductivity meter measures the electric conductivity of the electrolyte solution mixed with the electrolyte, and detects the electrolyte concentration of the electrolyte solution to prepare an electrolyte solution having a predetermined concentration. Is discharged by the first discharge means and supplied to the second preparation tank. (D) Then, the non-electrolyte is continuously supplied to the supplied electrolyte solution by the non-electrolyte supply means under stirring by the second stirring means. While mixing
By measuring the electric conductivity of the mixed solution obtained by mixing the non-electrolyte with the second electric conductivity meter and detecting the non-electrolyte concentration of the mixed solution, the non-electrolyte contains the predetermined concentration of the electrolyte and the predetermined concentration of the non-electrolyte Mixing the mixed solution, and (e) discharging the mixed solution by the second discharging means after that (a),
This is a method for preparing a mixed solution of an electrolyte and a non-electrolyte, characterized by repeating a series of steps (b), (c), (d), and (e) a plurality of times.

[0023]

Embodiments of the present invention will be described below in detail with reference to the drawings.

Embodiment 1 FIG. 1 is a block diagram showing a mixing apparatus used for carrying out the method for preparing a mixed solution of the present invention. The present mixing apparatus is an apparatus which is suitably used for preparing a dialysate, particularly the agent A, but can also be widely used for preparing other types of mixed solutions.

As shown in FIG. 1, the mixing apparatus 1 comprises a mixing tank 15 and a storage means 11 such as a hopper for storing a powdery electrolyte drug 101 which is an electrolyte component excluding glucose in the solution A of the dialysate. And a storage means 12 such as a hopper storing powdery glucose 102 as a non-electrolyte component.
And the storage means 11 and 12 are each provided with the supply device 1
It is connected to the mixing tank 15 via 3 and 14. A conduit 16 for supplying bacteria-free water such as R / O water (reverse osmosis membrane treated water) is connected to the mixing tank 15 via an electromagnetic valve 17. A pump 19 is connected via a line 18. In this pump 19, the aqueous solution discharged from the mixing tank 15 is returned to the mixing tank 15 again,
A circulating pipeline 20 is connected to a pipeline 21 for feeding the prepared mixed aqueous solution (agent A) in the blending tank 15 to a blending storage tank or a dialysis device (not shown). An electromagnetic valve 22 and an electric conductivity meter 24 are installed in the pipe 20, and an electromagnetic valve 23 is installed in the pipe 21.

To mix the dialysate A with the mixing device 1, first, the solenoid valve 17 is opened and R / O water is introduced into the mixing tank 15 through the pipe 16. The amount of water depends on the mixing tank 1
The weight is measured by a measuring means 25 such as a float switch provided in 5. When the amount of water is measured, the valve 22 is opened and the valve 23 is opened.
With the pump closed, the pump 19 is operated to circulate the water in the mixing tank 15 via the pipes 18 and 20 and stir the water.

Subsequently, the electrolyte medicine 101 is supplied from the hopper 11.
Is continuously supplied into the mixing tank 15 via the supply device 13. The electrolyte drug 101 is an electrolyte component mainly composed of sodium chloride excluding glucose in the agent A of the dialysate, and includes sodium chloride (NaCl) and potassium chloride (K).
Cl), calcium chloride (CaCl ₂ · 2H ₂ O), magnesium chloride (MgCl ₂ ), sodium acetate (CH
₃ COONa) _{a, NaCl: KCl: CaCl 2 ·} 2
H ₂ O: MgCl ₂ .6H ₂ O: CH ₃ COONa = 1
It is a powdered drug containing 933: 47: 69: 32: 258.

The electrolyte agent 101 is stirred and mixed in the mixing tank 15 by circulating water. Therefore, if the electric conductivity of the aqueous electrolyte solution flowing in the conduit 20 is measured by the electric conductivity meter 24 installed in the conduit 20, based on a calibration curve between the electric conductivity of the aqueous solution and the electrolyte concentration, The electrolyte concentration of the aqueous solution can be measured. According to the instruction of the electric conductivity meter 24, the electrolyte medicine 101 is added to the preparation tank 15
The electrolyte solution is appropriately supplied to the inside, and when the predetermined electrolyte concentration is detected, the supply of the electrolyte agent 101 is stopped, whereby an aqueous electrolyte solution having a predetermined concentration containing sodium chloride as a main component is prepared.

When an aqueous electrolyte solution having a predetermined concentration is prepared in the preparation tank 15, the powdery glucose drug 102 is then transferred from the hopper 12 under stirring by the flow of the aqueous electrolyte solution.
The supply device 14 supplies a predetermined amount to the mixing tank 15. The aqueous electrolyte solution and glucose in the mixing tank 15 are sufficiently stirred by being circulated by the pump 19 through the pipe 20 to form a mixed aqueous solution in which glucose is dissolved in the aqueous electrolyte solution. By measuring the electric conductivity of the mixed aqueous solution flowing in the pipe 20 by the electric conductivity meter 24 installed in the pipe 20, for example, as shown in FIG. The glucose concentration of the mixed aqueous solution can be measured from the calibration curve of the electric conductivity and the glucose concentration of the mixed aqueous solution when glucose is added to the concentrated aqueous electrolyte solution.

In this manner, a mixed aqueous solution containing a predetermined concentration of glucose in a predetermined concentration of an aqueous electrolyte solution (agent A)
Is prepared in the mixing tank 15, the valve 22 is then closed and the valve 23 is opened, whereby the mixed aqueous solution in the mixing tank 15 is discharged to the pipe 21 and flows through the pipe 21. And supplied to a mixing storage tank (not shown). An aqueous electrolyte solution (agent B) composed of sodium bicarbonate having a predetermined concentration prepared by another device is supplied to the preparation storage tank, and a dialysate having a predetermined concentration or a dialysate stock solution is prepared.

As described above, the preparation of the A agent as described above, that is, (a) supply of water to the preparation tank 15, (b)
Continuous addition and mixing of an electrolyte into water, preparation of an aqueous electrolyte solution having a predetermined concentration by measuring the electric conductivity of the aqueous solution, (c) continuous addition and mixing of glucose to the aqueous electrolyte solution, and electricity generation of the mixed aqueous solution The preparation of a mixed aqueous solution (agent A) containing a predetermined concentration of electrolyte and a predetermined concentration of glucose based on the measurement of conductivity, and (d) a series of processes of discharging the mixed aqueous solution from the preparation tank include a series of steps. When the blending operation is to be resumed, and then the blending operation is to be resumed, sterilization and cleaning of each part of the mixing device, such as the blending tank and the pipelines attached to the blending tank, are performed, and then the operations described in (a) and below are performed. To start.

From the operation method of the mixing apparatus 1, the first
At the time of the second dispensing, at the start of the dispensing operation, there is no possibility that the remaining liquid remaining after discharging the mixed aqueous solution dispensed in the previous mixing is left in the mixing device 1, but at the time of the second and subsequent dispensing, The residual liquid of the mixed aqueous solution in the previous round is inevitably left in the mixing device 1, especially the pipe line 20 and the like. When water is supplied to the mixing tank 1, circulated and stirred, and the electrolyte is added and mixed, A situation occurs in which the residual liquid is combined.

When the electric conductivity ρ (mS / cm) of the aqueous electrolyte solution to which the residual liquid was combined was measured, the electric conductivity was affected by glucose contained in the residual liquid, and the electrolyte concentration C (mmol / l) Are the same, the electric conductivity of the aqueous electrolyte solution to which the residual liquid cannot be adjusted is lower by the amount of glucose contained. In other words, the relationship between the electric conductivity and the electrolyte concentration changes from the straight line L1 in FIG. 2 in the first formulation to the straight line L2 in the second and subsequent formulations, and the relationship between the same electrolyte concentration C0 and the second The indicated value ρ = ρ2 of the electric conductivity meter at the time of the subsequent dispensing is lower than the indicated value ρ = ρ1 at the time of the first dispensing.

Now, for the sake of simplicity, FIG.
The straight line L2 is a calibration curve of the electric conductivity and the electrolyte concentration of the aqueous electrolyte solution prepared according to the second and subsequent preparations, and the indicated value ρ2 of the electric conductivity meter corresponds to the required electrolyte concentration C0 of the aqueous solution. Let it be electrical conductivity. Then, this calibration curve L2 was used to measure the electrolyte concentration of the aqueous electrolyte solution, and when the electrolyte was added so that the indicated value of the electric conductivity meter for the aqueous electrolyte solution at the first preparation was ρ = ρ2, the aqueous solution was added. Is apparently the required electrolyte concentration C0, but the actual electrolyte concentration is C0 ', which is lower than C0, and the predetermined electrolyte concentration C0 cannot be accurately obtained.

Therefore, in this embodiment, the mixed aqueous solution (A
In the first of the multiple preparations, the water supplied to the preparation tank 15 is mixed with the water before the electrolyte is added to and mixed with the water. The same amount of glucose contained in the residual liquid unavoidably remaining in the mixing device 1 after discharging the mixed solution prepared at the time of the subsequent preparation is added to the mixing device 1, and thereafter, the electrolyte is continuously added to the water. While adding and mixing, the electric conductivity of the aqueous solution is measured, and the electrolyte concentration is determined using the calibration curve L2.

According to this, while the same amount of glucose is contained as in the second and subsequent preparations, the electrolyte concentration of the aqueous electrolyte solution in the first preparation is measured, so that the first preparation is performed. The electrolyte concentration of the aqueous electrolyte solution is accurately determined. Therefore, if the supply of the electrolyte agent 101 is stopped at the time when the predetermined electrolyte concentration C0 is detected based on the electric conductivity ρ = ρ2, the concentration containing sodium chloride as the main component in the first preparation is accurate. Can be prepared. Thus, a mixed aqueous solution in which a predetermined concentration of electrolyte and a predetermined concentration of glucose are dissolved can be prepared by the subsequent addition and mixing of glucose.

According to the method of this embodiment, 5 parts of the dialysate
FIG. 3 shows changes in the respective concentrations of Na and glucose when blended. The amount of glucose charged during the first preparation of the aqueous electrolyte solution was set to 35 g from the empirical value measured in the past by the present inventors regarding the residual liquid remaining in the mixing device 1 after discharging the prepared mixed aqueous solution. As a comparative example, the dialysate A was prepared five times by the method of preparing an aqueous electrolyte solution without charging glucose during the first preparation. FIG. 4 shows changes in the concentrations of Na and glucose at that time.

As shown in FIGS. 3 and 4, according to the method of the present embodiment, the electrolyte and the non-electrolyte having a predetermined concentration with no decrease in the electrolyte concentration from the first to the fifth preparations are prepared. Was able to be obtained in a stable manner.

Embodiment 2 In this embodiment, in order to prevent a decrease in the electrolyte concentration of the electrolyte aqueous solution at the time of the first preparation, the first preparation was carried out in the following manner.
The set value of the concentration detection of the electric conductivity meter with respect to the electrolyte aqueous solution was set higher by the concentration fluctuation amount due to the non-electrolyte component contained in the residual solution inevitably remaining in the mixing device 1 at the time of the first and subsequent preparations.

That is, referring to FIG. 2, the relational line L1 is adopted as a calibration curve at the time of the first preparation, and the set value of the indicated value of the electric conductivity meter with respect to the electrolyte concentration C0 required for the aqueous solution is ρ = ρ1.

According to this, the set value of the electrolyte concentration of the electric conductivity meter in the electric conductivity meter at the time of the first preparation is set to be higher by the concentration decrease due to the non-electrolyte in the residual solution at the time of the second preparation and thereafter. Therefore, the electrolyte concentration of the aqueous electrolyte solution at the time of the first preparation can be determined accurately. Therefore, if the supply of the electrolyte agent 101 is stopped at the time when the predetermined electrolyte concentration C0 is detected based on the electric conductivity ρ = ρ1, in the first preparation, the predetermined concentration of the aqueous electrolyte solution containing sodium chloride as a main component is prepared. It can be prepared accurately. This makes it possible to prepare a mixed solution in which the predetermined concentration of glucose is dissolved in the predetermined concentration of the aqueous electrolytic solution by the subsequent addition and mixing of glucose.

FIG. 5 shows changes in the concentrations of Na and glucose when the dialysate A was mixed five times by the method of this embodiment.
Shown in The density setting value at the time of the first preparation is 216.5 ms.
/ Cm, the density setting value at the time of the second and subsequent preparations is 212.
0 mS / cm was set.

Example 3 In this example, the configuration of the mixing apparatus itself was changed in order to prevent the electrolyte concentration of the aqueous solution from decreasing at the time of the first preparation.
FIG. 6 is a configuration diagram showing a mixing device used for performing the preparation method of the present embodiment.

The mixing device 1 is a device for mixing a dialysate similar to that shown in the first embodiment, particularly, the agent A. In this embodiment, the mixing tank 15A is added to the electrolyte drug 101 and the non-electrolyte drug is mixed. The difference is that 15B is provided for each (glucose drug) 102. Therefore, in this mixing device,
Members having the same functions as those of the mixing device of the first embodiment are denoted by the same reference numerals, and detailed description thereof will be omitted.

In order to mix the dialysate A with the mixing apparatus 1, first, the solenoid valve 17 is opened, and R / O water is introduced into the mixing tank 15A through the conduit 16. The amount of water is measured by a measuring means 2 such as a float switch provided in the mixing tank 15A.
Weigh at 5A. When the amount of water is measured, the valve 22 is opened,
By operating the pump 19A with the valve 31 closed, the water in the mixing tank 15A is circulated through the pipes 18A and 20A and stirred.

Subsequently, the electrolyte medicine 101 is supplied from the hopper 11.
Is continuously supplied into the mixing tank 15A via the supply device 13. The electrolyte medicine 101 is stirred and mixed in the mixing tank 15A by the circulating water. Accordingly, the electric conductivity meter 24A installed in the conduit 20A causes the conduit 20A
If you measure the electrical conductivity of the aqueous electrolyte solution flowing inside,
Based on the calibration curve of the electric conductivity of the aqueous solution and the electrolyte concentration,
The electrolyte concentration of the aqueous solution can be measured. According to the instruction of the electric conductivity meter 24A, the electrolyte agent 101 is appropriately supplied into the mixing tank 15A, and the supply of the electrolyte agent 101 is stopped when a predetermined electrolyte concentration is detected. Is prepared at a predetermined concentration.

When a predetermined concentration of the aqueous electrolyte solution is prepared in the preparation tank 15A, the valve 31 is opened and the valve 22 is closed.
The pump 19A is operated. Thereby, the mixing tank 15
The electrolyte aqueous solution in the mixing tank 15A having the predetermined concentration is introduced into B. When the float switch 25B detects that a predetermined amount of the aqueous electrolyte solution has been introduced into the mixing tank 15B, the operation of the pump 19A is stopped, and the valve 31 is closed. The aqueous electrolyte solution introduced into the mixing tank 15B opens the valve 23 and closes the valve 32,
B circulates through the pipes 18C and 20B.

Next, the powdered glucose drug 102 is supplied from the hopper 12 by the supply device 14 to the mixing tank 15B by a predetermined amount under stirring by the flow of the aqueous solution. The aqueous electrolyte solution and glucose in the mixing tank 15B are sufficiently stirred by being circulated and flowed through the pipe 20B by the pump 19B to form a mixed aqueous solution in which glucose is dissolved in the aqueous electrolyte solution. The glucose concentration in the mixed aqueous solution in the mixing tank 15B is measured by an electric conductivity meter 24B installed in a pipe 20B.

In this way, a mixed aqueous solution containing the predetermined concentration of glucose in the predetermined concentration of the aqueous electrolyte solution (agent A)
Is prepared in the mixing tank 15B, the valve 32 is then opened,
By closing the valve 23, the mixed aqueous solution in the mixing tank 15B is discharged to the pipe 21 and flows through the pipe 21 to be supplied to a mixing storage tank (not shown). As above,
An aqueous electrolyte solution (agent B) composed of sodium bicarbonate having a predetermined concentration prepared by another device is supplied to the preparation storage tank, and a dialysate having a predetermined concentration or a dialysate stock solution is prepared.

According to the mixing using such a mixing device 1, the pipe 20 of the mixing tank 15A for preparing the aqueous electrolyte solution is prepared.
Since the residual liquid containing glucose does not remain in A and the like, the electric conductivity of the aqueous electrolyte solution prepared in the preparation tank 15A is not limited to the first preparation, but also to the second and subsequent preparations. No reduction due to Therefore, the electric conductivity of the aqueous solution is measured by the electric conductivity meter 24A, and the calibration curve L1 shown in FIG. 2 is used to accurately determine the electrolyte concentration of the aqueous electrolyte solution in the first to final preparations. At a density C0.

In each of the above embodiments, the dialysate A
Although the description has been made taking the preparation of an agent as an example, the present invention is not limited to this, and can be widely applied in the field of preparing a mixed solution of an electrolyte and a non-electrolyte, including the pharmaceutical industry and the food industry.

[0052]

As described above, according to the present invention,
A mixture containing an electrolyte of a predetermined concentration and a non-electrolyte of a predetermined concentration, in which the electrolyte concentration of the electrolyte solution in the first preparation is easily prevented from decreasing and the electrolyte concentration does not decrease from the first preparation to the final preparation. A solution can be obtained stably.

[Brief description of the drawings]

FIG. 1 is a configuration diagram showing a mixing apparatus used in an embodiment of a mixed solution preparation method of the present invention.

FIG. 2 is an explanatory diagram showing a principle of preventing a decrease in electrolyte concentration of an aqueous electrolyte solution at the time of a first preparation in the method of FIG.

FIG. 3 is a graph showing changes in the concentrations of the electrolyte and glucose in the dialysate A prepared by the method of FIG.

FIG. 4 is a graph showing changes in the concentrations of electrolyte and glucose in the dialysate A prepared by the method of the comparative example.

FIG. 5 is a graph showing changes in the concentrations of the electrolyte and glucose of the dialysate A prepared by the method in another example of the present invention.

FIG. 6 is a configuration diagram showing a mixing device used in still another embodiment of the present invention.

FIG. 7 is a graph showing a change in electric conductivity when glucose is added to an aqueous solution of an electrolyte component excluding glucose of the dialysate A agent.

FIG. 8 is a graph showing a correlation between the electric conductivity of the aqueous solution of FIG. 7 and the glucose concentration.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Mixing device 11,12 Storage means 13,14 Supply device 15 Mixing layer 16,18,20,21 Pipeline 17,22,23 Valve 19 Pump 24 Electric conductivity meter 25 Water meter 101 Electrolyte drug 102 Glucose drug

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Yoshihiro Suzima 613, Oaza Kitaiso, Sayama-shi, Saitama Toadenba Industrial Co., Ltd. Toa Denpa Kogyo Co., Ltd.Sayama Plant (72) Inventor Toshiyuki Naka 613 Kitairiso, Oaza, Sayama City, Saitama Prefecture Toa Denpa Kogyo Co., Ltd. Sayama Plant

Claims (12)

[Claims] A mixing tank; a solvent supply unit for supplying an aqueous polar solvent to the mixing tank; an electrolyte supply unit for supplying an electrolyte to the mixing tank; a non-electrolyte supply unit for supplying a non-electrolyte to the mixing tank; Mixing of a mixed solution of an electrolyte and a non-electrolyte by using a mixing device provided with a stirring means provided in the mixing tank, a discharge means provided in the mixing tank, and an electric conductivity meter provided in the mixing tank. A method comprising: (a) supplying a solvent to a preparation tank; and (b) continuously adding and mixing an electrolyte to the supplied solvent by an electrolyte supply means under stirring by a stirring means, using an electric conductivity meter. By measuring the electric conductivity of the electrolyte solution mixed with the electrolyte, and detecting the electrolyte concentration of the electrolyte solution, an electrolyte solution having a predetermined concentration is prepared. (C) Then, while stirring the electrolyte solution, Non-electrolyte supply While continuously adding and mixing the non-electrolyte by the step, the electric conductivity of the mixed solution obtained by mixing the non-electrolyte is measured by the electric conductivity meter, and the non-electrolyte concentration of the mixed solution is detected, thereby obtaining the predetermined concentration. (A), (b), (c), and (d), wherein the mixed solution containing the electrolyte and the non-electrolyte at a predetermined concentration is prepared, and then the mixed solution is discharged by the discharging means. In the method for preparing a mixed solution of an electrolyte and a non-electrolyte, wherein the step is repeated a plurality of times, the first preparation of the plurality of preparations of the mixed solution is performed after the step (a) and before the step (b). The same amount of non-electrolyte as the non-electrolyte mass contained in the residual liquid inevitably remaining in the mixing device after discharging the mixed solution prepared by the first and subsequent preparations in the water supplied to the preparation tank And an electrolyte characterized by Formulation of the mixed solution of the electrolyte. 2. The method for preparing a mixed solution according to claim 1, wherein said stirring means comprises a circulation means including a circulation path attached to a preparation tank. 3. The method according to claim 2, wherein the electric conductivity meter is installed in the circulation path. 4. The method according to claim 1, wherein the solvent is water, the electrolyte is an electrolyte agent containing sodium chloride as a main component, and the non-electrolyte is a glucose agent. 5. A preparation tank, a solvent supply means for supplying an aqueous polar solvent to the preparation tank, an electrolyte supply means for supplying an electrolyte to the preparation tank, a non-electrolyte supply means for supplying a non-electrolyte to the preparation tank, Mixing of a mixed solution of an electrolyte and a non-electrolyte by using a mixing device provided with a stirring means provided in the mixing tank, a discharge means provided in the mixing tank, and an electric conductivity meter provided in the mixing tank. A method comprising: (a) supplying a solvent to a preparation tank; and (b) continuously adding and mixing an electrolyte to the supplied solvent by an electrolyte supply means under stirring by a stirring means, using an electric conductivity meter. By measuring the electric conductivity of the electrolyte solution mixed with the electrolyte, and detecting the electrolyte concentration of the electrolyte solution, an electrolyte solution having a predetermined concentration is prepared. (C) Then, while stirring the electrolyte solution, Non-electrolyte supply While continuously adding and mixing the non-electrolyte by the step, the electric conductivity of the mixed solution obtained by mixing the non-electrolyte is measured by the electric conductivity meter, and the non-electrolyte concentration of the mixed solution is detected, thereby obtaining the predetermined concentration. (A), (b), (c), and (d), wherein the mixed solution containing the electrolyte and the non-electrolyte at a predetermined concentration is prepared, and then the mixed solution is discharged by the discharging means. Repeating the process a plurality of times, in the method of preparing a mixed solution of an electrolyte and a non-electrolyte, in the first preparation of the plurality of preparations of the mixed solution, the electrolyte concentration of the electrolyte solution by measuring the electrical conductivity The concentration set value of the electric conductivity meter to be detected,
An electrolyte characterized in that the mixed solution prepared in the first and subsequent preparations is changed and set by a variation amount corresponding to a non-electrolyte component contained in a residual liquid inevitably remaining in the mixing device after discharging the mixed solution. For preparing a mixed solution of water and non-electrolyte. 6. The method for preparing a mixed solution according to claim 5, wherein said stirring means comprises a circulation means including a circulation path attached to a preparation tank. 7. The method according to claim 6, wherein the electric conductivity meter is installed in the circulation path. 8. The method according to claim 5, wherein the solvent is water, the electrolyte is an electrolyte agent containing sodium chloride as a main component, and the non-electrolyte is a glucose agent. 9. A first preparation tank, a solvent supply means for supplying an aqueous polar solvent to the first preparation tank, an electrolyte supply means for supplying an electrolyte to the first preparation tank, and a first preparation tank. , A first electric conductivity meter provided in the first mixing tank, a first discharging means provided in the first mixing tank, and a second mixing tank. A non-electrolyte supplying means for supplying a non-electrolyte to the second mixing tank; a second stirring means provided in the second mixing tank; and a second stirring means provided in the second mixing tank.
(A) a method for preparing a mixed solution of an electrolyte and a non-electrolyte, which is performed using a mixing device provided with an electric conductivity meter and a second discharge means provided in a second mixing tank. (B) While the electrolyte is continuously added to and mixed with the supplied solvent by the electrolyte supply means under stirring by the first stirring means, the solvent is supplied by the first electric conductivity meter. Measuring the electrical conductivity of the electrolyte solution mixed with the electrolyte, and detecting the electrolyte concentration of the electrolyte solution to prepare an electrolyte solution having a predetermined concentration; (c)
The electrolyte solution is discharged by the first discharge means and supplied to the second preparation tank. (D) Then, the non-electrolyte is supplied to the supplied electrolyte solution by the non-electrolyte supply means under stirring by the second stirring means. While continuously adding and mixing, the electric conductivity of the mixed solution obtained by mixing the non-electrolyte is measured by the second electric conductivity meter, and the non-electrolyte concentration of the mixed solution is detected, whereby a predetermined concentration of the non-electrolyte is detected. Preparing a mixed solution containing an electrolyte and a non-electrolyte at a predetermined concentration, and (e) discharging the mixed solution by a second discharging means after that, (a), (b),
A method for preparing a mixed solution of an electrolyte and a non-electrolyte, comprising repeating a series of steps (c), (d), and (e) a plurality of times. 10. The first stirring means comprises a circulation means including a circulation path attached to the first mixing tank, and the second stirring means comprises a circulation means including a circulation path attached to the second mixing tank. The method for preparing a mixed solution according to claim 9, comprising: 11. The method according to claim 10, wherein the electric conductivity meter is installed in the circulation path. 12. The method according to claim 9, wherein the solvent is water, the electrolyte is an electrolyte agent containing sodium chloride as a main component, and the non-electrolyte is a glucose agent.