JPH1087464A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity having a high analgesic action, excellent in effect for reducing pains in the oral cavity such as stomatitis and dental caries and having a high degree of perfuming freedom by making the composition contain a solvent extract of Kawane. SOLUTION: This composition for the oral cavity is obtained by blending a solvent extract of Kawane, which is a root of Piper methysticum Forst. f. belonging to Piperaceae therewith. The blending amount is preferably 0.001-5wt.% based on the whole composition. The extraction is preferably performed by adding a solvent to the Kawane and extracting the Kawane by heating between a room temperature and the boiling point of each solvent for 0.5-24hr, especially 1-10hr. The composition can be used in various dosage form.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition which is excellent in alleviating pain in the oral cavity due to stomatitis, caries and the like.

[0002]

2. Description of the Related Art Pain in the oral cavity due to stomatitis, caries and the like is painful, and there is a high demand for an oral composition having an excellent action to reduce such pain.

[0003] Hitherto, various proposals have been made to utilize plants and plant-derived components for oral compositions. Cough oil, cysin and the like are used as active ingredients in toothaches, but these components are not fragrant. Oral stimulation is difficult to apply to oral products in terms of flavoring, and the range of applicable products was limited.

The present invention has been made in view of the above circumstances, and provides an oral composition having a high analgesic effect, an excellent effect of alleviating pain in the oral cavity due to stomatitis, caries and the like, and having a high degree of freedom in perfuming. The purpose is to do.

[0005]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive studies to achieve the above object, the present inventor found that the roots of Kawa which are used as favorite plants in Southeast Asia and the South Pacific region. The solvent extract has high analgesic effect, weak flavor and irritation, and an oral composition containing such a root extract of kawa root as an active ingredient can reduce pain in the oral cavity due to stomatitis, caries, etc. It has been found that it is excellent in fragrance and has a high degree of freedom of flavoring, and can be widely used in various dosage forms.

[0006] The use of taste plants in oral products is described, for example, in Japanese Patent Application Laid-Open No. 58-57320, in which areca nut seed is used as a plaque inhibitor, and in Japanese Patent Application Laid-Open No. 2-53717, betel is used as an inhibitor of inflammatory enzymes. It is described that they can be used as agents, respectively. However, the use of kawa root in oral products, and the fact that the resulting oral compositions having the above-mentioned excellent properties can be obtained by the present inventors, are new. It is knowledge.

[0007] Accordingly, the present invention provides an oral composition comprising a solvent extract of kawa root.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention can be prepared as dentifrice such as toothpaste and liquid dentifrice, oral ointment, mouthwash, troche, chewing gum, candy and the like. And a solvent extract of kawa root as an active ingredient.

[0009] The above-mentioned kawa root is made of the pepper family Piper m.
ethicum Forst. f. Is the root of

In the present invention, the solvent extract of kawa root may be a solvent extract of kawa root as a raw material, or a solvent extract of kawa root or an extraction residue thereof may be subjected to multiple solvent extractions. Extracts can also be used. When the solvent extraction is performed again using the solvent extract of the root of Kawata as a raw material, the extraction can also be performed by partitioning into polar and non-polar two solvents. These solvent extracts may be used alone or as a mixture.

There is no particular limitation on the solvent used in the above-mentioned extraction treatment, and either a polar solvent or a non-polar solvent can be used, and a single solvent or a mixed solvent may be used. Specifically, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene ,benzene,
Examples thereof include water, an acid solution, an alkali solution, a salt solution, and other aqueous solutions.

[0012] The extraction is preferably carried out by adding a solvent to the above raw materials and heating the mixture from room temperature to the boiling point of each solvent, usually for 0.5 to 24 hours, especially 1 to 10 hours.

Further, before or after the above-mentioned extraction treatment step, a deoiling oil step by steam distillation and a decolorizing step may be performed.

It is preferable that the solvent extract of kawa root is finally distilled off and then added to the oral composition. The amount of the extract is 0.001 to 5% (% by weight) of the whole composition. ,
The same applies hereinafter), and particularly preferably 0.01 to 3%. If the amount is less than 0.001%, a satisfactory effect may not be exhibited. If the amount exceeds 5%, stability or flavor of the composition may be impaired.

In the oral composition of the present invention, components used in ordinary oral compositions can be used as components other than those described above, and the added amounts of these components impair the effects of the present invention. Normal amounts can be used within the range not present.

In the case of dentifrices, for example, abrasives, binders,
Thickeners, surfactants, sweeteners, preservatives, flavors, coloring agents,
Various active ingredients other than those described above can be blended, and these ingredients can be mixed with water for production.

Here, as the abrasive, precipitated silica,
Silica-based abrasives such as silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate and anhydrate, calcium pyrophosphate, calcium carbonate,
Aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, synthetic resin-based abrasives and the like are preferably used (usually 5 to 70%).

As the binder, sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, sodium alginate, xanthan gum, carbopol, guar gum, montmorillonite, gelatin and the like are preferably used (usually in an amount of 0.1 to 5%).

Examples of the thickener include glycerin, sorbitol, propylene glycol, polyethylene glycol,
Xylit, maltit, lactite and the like are preferably used (normally blended amount 1 to 70%).

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like can be blended, and specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, and N-acyl sulfonate. Cosinate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin Fatty acid esters, pluronics, polyoxyethylene sorbitan monostearate and the like are preferably used (normally blended amount: 0.1 to 5%).

As sweeteners, sodium saccharin,
Stevioside, stevia extract, paramethoxycinnamic, aldehyde, neohesperidyl dihydrochalcone, perillartin and the like can be mentioned.

Examples of the preservative include paraoxybenzoate, sodium benzoate and the like.

As the fragrance, terpenes such as l-menthol, carvone, anethole, limonene and the like, and derivatives thereof are preferable.

As the coloring agent, Blue No. 1, Yellow No. 4, titanium dioxide and the like are preferable.

The various active ingredients include sodium fluoride, potassium fluoride, ammonium fluoride and primary fluoride.
Fluorides such as tin and sodium monofluorophosphate,
Water-soluble phosphoric acid compounds such as potassium phosphate and sodium salt of orthophosphoric acid, allantoinchlorohydroxyaluminum,
Hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper compounds such as copper gluconate, aluminum lactate, chloride Strontium, potassium nitrate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, dextranase, methanase, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, dihydrocholesterol, zinc citrate , Touki, bakaku, clove, rosemary, ogon,
Extracts such as safflower, α-bisabolol, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride, trichlorocarbanilide and the like.

[0026]

EFFECTS OF THE INVENTION The oral composition of the present invention has a strong analgesic effect, is excellent in alleviating pain in the oral cavity due to stomatitis, caries and the like, and has a high degree of freedom in perfuming due to its weak flavor. And can be widely used in various dosage forms.

[0027]

EXAMPLES The present invention will now be described specifically with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples, all percentages are by weight.

[Experimental Examples] As shown in Table 1, each solvent was distilled off from the extract obtained by solvent extraction of various raw materials, and the resulting solution was used as a test solution (aqueous solution or suspension containing 1% solids). The evaluation was performed by the following method. Table 1 shows the results.

Evaluation method: Three panels feeling pain due to stomatitis were rinsed with 20 ml of the test solution for 30 seconds, spit out, and the intensity of the flavor immediately after and the intensity of the analgesic effect 15 minutes later were determined according to the following criteria. The scores were evaluated, and the results were shown by the evaluation as shown in Table 1 from the total score of the three panels. -Rating criteria for the strength of the flavor and the strength of the analgesic effect Strength Rating Strong 3 Weak 2 Slight 1 None 0

[0030]

[Table 1]

From the results shown in Table 1, it was confirmed that all the Kawa root extracts had a weak flavor and a high analgesic effect.

Next, an embodiment will be described. Note that, in each example, the above No. Those obtained by distilling off each solvent from the solvent extracts of the roots 1 to 4 were used.

Example 1 Toothpaste Calcium carbonate 50.00% Glycerin 20.00 Carrageenan 0.50 Carboxymethylcellulose 1.00 Lauryldiethanolamide 1.00 Sucrose monolaurate 2.00 Fragrance 1.00 Saccharin 0.0 10 Experimental Example No. 1 extract 0.50 water balance 100.00

Example 2 Toothpaste Dibasic calcium phosphate dihydrate 50.00% Glycerin 20.00 Carboxymethylcellulose 2.00 Sodium lauryl sulfate 2.00 Fragrance 1.00 Saccharin sodium 0.10 2 extract 0.50 water balance 100.00

Example 3 Toothpaste Aluminum hydroxide 45.00% Gelling silica 2.00 Sorbit 25.00 Carboxymethylcellulose 1.00 Sodium lauryl sulfate 2.00 Fragrance 1.00 Saccharin sodium 0.10 Experimental example No. . 3 extracts 0.50 water balance 100.00

Example 4 Toothpaste Precipitated silica 25.00% Glycerin 25.00 Sorbit 25.00 Lauroyl polyglycerin ester 1.00 Polyoxyethylene sorbitan monolaurate 2.00 Fragrance 1.00 Saccharin sodium 0.20 Experimental Example No. 4 extracts 0.30 water balance 100.00

[Example 5] Liquid dentifrice Aluminum hydroxide 25.00% Glycerin 40.00 Sorbit 15.00 Carboxymethyl cellulose 0.20 Propylene glycol 2.00 Sodium lauryl sulfate 1.50 Decaglyceryl monolaurate 1.00 Fragrance 1 .00 Saccharin sodium 0.10 Experimental Example No. 1 extract 1.00 water balance 100.00

Example 6 Liquid Toothpaste Precipitable Silica 20.00% Glycerin 25.00 Sorbit 35.00 Xanthan Gum 0.20 Propylene Glycol 2.00 Sodium Lauryl Sulfate 1.50 Decaglyceryl Monolaurate 2.00 Fragrance 1. 00 Saccharin sodium 0.10 Experimental example no. 2 extract 0.80 water balance 100.00

Example 7 Oral Ointment Liquid Paraffin 15.00% Cetanol 10.00 Glycerin 20.00 Polyoxyethylene Sorbitan Fatty Acid Ester 5.00 Fragrance 0.50 Saccharin Sodium 0.10 3 extracts 1.00 water balance 100.00

Example 8 Mouthwash Ethanol 20.00% Fragrance 1.00 Polyoxyethylene hydrogenated castor oil 0.30 Sodium monofluorophosphate 0.10 Saccharin sodium 0.05 4 extracts 0.20 water balance 100.00

Example 9 Gargle Tablets Sodium Bicarbonate 54.00% Citric Acid 17.00 Anhydrous Sodium Sulfate 12.80 Dibasic Sodium Phosphate 10.00 Polyethylene Glycol 3.00 Sodium Monofluorophosphate 0.10 0.10 experiment perfume 2.00 oleate No. 1 extract 1.00 total 100.00

Example 10 Lozenge Glucose 35.00% Palatinose 35.00 Gum Arabic 6.00 Fragrance 1.00 2 extract 0.10 water balance 100.00

Example 11 Candy Sugar 50.00% Candy Sugar 33.00 Organic Acid 2.00 Fragrance 0.20 3 extracts 0.05 water balance 100.00

[0044] Example 12 Chewing gum sugar 53.40% gum base 20.00 Glucose 10.00 Starch syrup 16.00 flavor 0.50 Experiment No. 4 extracts 0.10 total 100.00

[0045] Example 13 Chewing gum sugar 55.00% gum base 20.00 Corn Syrup 12.00 syrup 12.30 flavor 0.50 Experiment No. 1 extract 0.20 total 100.00

Claims (1)

[Claims] 1. An oral composition comprising a solvent extract of kawa root.