JPH11263732A - Skin preparation for external use containing mushroom extracts - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a safe humectant, agent for preventing lowering of immunity or skin preparation for external use, comprising a specific mushroom extract. SOLUTION: This agent comprises extracts of one or more kinds of mushrooms selected from Flammulina velutipes, Pleurotus eryngii, Lentinus edodes, Lyophyllum aggregattum, Pholiota nameko, Agaricus bisporus, Agaricus campestris, Agaricus blazei Merrill and Grifola frondosa. The agent can be utilized as a humectant and an agent for preventing lowering of immunity and further, effective in preventing and treating roughened skin and dried skin and can impart gloss and tenseness to skin. Damage of LC cell deeply concerns in immunodepression of skin and the extracts of the agent have effect normally retaining LC cell.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel and safe enokitake, eryngii, shiitake, shimeji, nameko,
The present invention relates to a moisturizer containing at least one extract selected from agaricus, agaricus, himetaketake, and maitake, a preventive agent for reducing immunity, and applications to various skin external preparations in the field of pharmaceuticals / quasi-drugs or cosmetics.

[0002] The field of application is generally applicable to various external preparations (including preparations used for animals), and specifically, ampules, capsules, pills, tablets, powders, granules , Solid, liquid, gel-like or foam-like 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics, 4) medicinal or / and cosmetic for scalp / hair (E.g., shampoos, rinses, treatments, permanent liquids, hair dyes, hair styling, hair tonics, hair growth / hair restoration, etc.), 5) bath agents for use in bath water, 6) other , Liquid odor and deodorant inhibitor, sanitary goods, sanitary cotton, wet tissue, etc.

[0003]

2. Description of the Related Art Human skin is covered with a stratum corneum, a thin biological defense membrane, and can live in a dry atmosphere without losing water because of the stratum corneum of the skin epidermis in contact with the outside world. Is present. That is, the stratum corneum is thin and supple, and the skin is adjusted in a normal state while keeping the body from losing water.

However, the skin causes some change or injury to the skin epidermis due to various factors (for example, temperature change, humidity change, light, contact with water, etc.), and its function is incomplete. The skin in which the stratum corneum is formed, that is, the so-called skin that has reached such a state, is hard, loses elasticity, and becomes dry and moist and dry. Also, in recent years, it has been said that such dry skin, especially Kasatsuki, may be one of the causes of atopic dermatitis.

Therefore, conventionally, various cosmetic raw materials have been applied and used in order to prevent or supplement these points. For example, oils and fats such as squalane are applied on the skin to form an oily film, which prevents the evaporation of water in the stratum corneum,
Attempts have also been made to supplement lipids between cells and the like, form a lipid membrane while retaining water between lipids, and prevent evaporation of water.

[0006] However, these alternative substances conventionally used are basically used only with the idea of preventing drying by being applied to the skin epithelium, so that a small amount of these substances are used. In such a case, the effect cannot be expected. Conversely, if the amount is too large, the oily and sticky feeling is produced, and it is hard to say that the feeling of use is good.

Therefore, in recent years, it is ideal to apply and reproduce on the skin a substance that is substantially the same as a component on the skin surface, and a natural moisturizing factor: NMF (Natural Moisturizing Fa
The stratum corneum component called ctar) has attracted attention and has been used. In addition, these natural moisturizing factors (hereinafter, NMF)
It is known that the stratum corneum component referred to as ") is an amino acid, organic acids such as lactic acid and salts thereof, pyrrolidonecarboxylic acid, urea and saccharides, and others.

[0008] The characteristics and characteristics of this NMF play a most important role in regulating the skin stratum corneum because it makes the skin stratum corneum hydrophilic and takes in water and has a water retention action. However, NMF causes elution due to prolonged contact with water and the like, leading to so-called dry skin, causing rough skin, scabble, cracks and reddish guinea pigs, reduced elasticity of the skin, and various skin troubles. It is said to be.

Therefore, recently, a substance having high hygroscopicity, such as water-soluble, is called a humectant, and is added to an external preparation for skin. Incidentally, currently used representative humectants include, for example, glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyethylene glycol, sodium lactate, hyaluronic acid and its salts, chondroitin sulfate and its salts, Water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, sodium lactate, collagen and its degradation products or their derivatives, chicken egg components, trehalose or its derivatives, bovine and human placenta extracts, thickeners (roasted gingham,
Carrageenan, tragacanth gum, pectin, mannan,
Xanthan gum, gelatin, casein, methylcellulose, ethylcellulose, alginic acid and its salts, polyvinylpyrrolidone, carboxyvinyl polymer, etc.) and plant extracts (aloe extract, oak extract, kyokatsu extract, kuzu extract, licorice extract, kohon extract, psycho extract, senkyu extract, Corn extract, ginseng extract, yokunin extract, etc.) are known.

[0010]

However, the above-mentioned humectants are poor in stability and solubility in the formulation system, and cause unpleasant odors and coloring due to sedimentation and decomposition, and their effects at the biological level are not sufficient. Further, some of them may cause rough skin and rash, and there is also a problem in terms of safety.

[0011]

In view of these circumstances, the present inventors have made various extracts useful as moisturizers as the theme of their development, and as a result, enokitake, eryngii,
It was confirmed that the extracts of Shiitake, Shimeji, Nameko, Tsukutake mushroom, Agaritake, Himematsutake and Maitake had a moisturizing effect. Further, when the evaluation was attempted from another viewpoint, the effect of preventing immunity reduction was further confirmed. Therefore, the present extract can be effectively used as a moisturizing agent and / or an agent for preventing immunity lowering, and is useful for prevention and treatment of dryness and roughness of the skin or scalp and prevention of immunity lowering induced by ultraviolet rays. The present invention has been completed by providing a safe external preparation for skin.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION "Enokitake: Enokitake" used in the present invention refers to enokitake (F. velutipes) belonging to the family Trimicolomataceae or the genus Flammulina.
Umbrella or handle, fruit body, mycelium, sclerotium.

[0013] "Eringy" means Pleurotaceae (Pleurot)
aceae), umbrella or stalk of Pleurotus, P. eryngii, fruiting body, mycelium, sclerotium.

"Shiitake: Shiitake mushroom" refers to the slime mushroom family
cbolomataceae), Genus Lentinus, Shiitake mushroom "L.
Ebobes Singer (= Cortinellus shiitake P. Henn.) "umbrella or handle, fruiting body, mycelium, sclerotium.

[0015] "Shimeji: occupied land" is a family of shimejime (Tricb).
olomataceae), Lyophyllum, Hon-shimeji
(L. shimeji), shaka shimeji (= Sembon shimeji) (L. shimeji)
fumosum), L. descastes, L. connatum, and Hypsizigu
s), Bunashimeji (H. marmoreus), Shirotamogitake (H.ulm)
arius) umbrella or handle, fruiting body, mycelium, sclerotium.

[0016] "Nameko: Smoothie" refers to the moegita family (St.
rophariaceae) and the nameco (P.
nameko), A. adiposa, A. aurivella, A. mushroom (P. lub)
rica), umbrella or handle of P. lenta, fruiting body, mycelium, sclerotia.

"Amanita mushroom" refers to an umbrella or handle, a fruit body, a mycelium, or a sclerotium of Agaricaceae, Agaricus, or A. bisporus.

"Agaricaceae" refers to agaricaceae (Agaricaceae)
ae), Agaricus (Agaricus), Agaricus (A.campestri
s), umbrella or stalk, fruiting body, mycelium, sclerotium of A. arvensis, A. aruprupibulbus.

"Himematsutake: Himematsutake, aka: Kawariharatake" refers to Agariaceae, Agaricaceae
(Agaricus), umbrella or handle of A. blazei Merrill, fruiting body, mycelium, sclerotium.

"Maitake: Maitake" is an umbrella or handle, fruiting body, mycelium, or fungal nucleus of Plyporaceae, Grifola maitake (G. frondosa).

The extracts of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agarita, himematsutake, and maitake used in the present invention include various parts (umbrella or handle, fruiting body, mycelium, fungal nucleus) What was squeezed after crushing. Or, as it is or after grinding,
It was extracted with a solvent.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

Also, enokitake, eryngii, shiitake,
Various extracts of shimeji, nameko, agaricus, agaricus, agaricus, himematsutake and maitake may be dried, concentrated, or diluted depending on the type and form of the moisturizer, immunosuppressant, and external preparation for skin. .

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added to the extent that the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The various extracts of the enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake and maitake mushrooms of the present invention can be directly incorporated into moisturizers, immunosuppressants and skin external preparations. Although not particularly specified, the humectant, the immunosuppressive preventive agent, the type and quality of the skin external preparation, the quality thereof and the expected degree of action slightly vary, and usually 0.01% by weight or more (hereinafter, referred to as
It is preferably 2 to 20%. If the amount is less than 0.01%, the effect cannot be expected sufficiently.

The humectant, the immunosuppressant, and the skin external preparation of the present invention may contain, in addition to the above-mentioned essential components, if necessary, pharmaceuticals, quasi-drugs, and the like as long as the effects of the present invention are not impaired. It can be produced by arbitrarily selecting and using components and additives used in preparations such as cosmetics.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane, and the like.

(4) Fatty Acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salts, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, gamma oryzanol, orotic acid, vitamin Ps ( Rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

It should be noted that additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsujirafuji (Kibo), Aono Ryukyuran, Fukurin Ryuetsuran, Acacia, Akasugi Fruit, Akavine, Akamegashiwa (Red Bud), Akane (Akane Grassroot), Akayajiou Jio (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Asuka), Azuki (Red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit , Avocado, flax, amateur (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Pterodactyla mushroom, Nepenthes (summer hay), Udo or Shishiudo (Qang, Independent, Tang Dynasty), Ume (Ume) or its flesh, Vladigashi, Oolong tea, Uwaurushi, Unshumikan (Chen skin), Estragon, Ezocogi (Ezo five) , Ezoki strawberry, Echinashi (Hymenoptera), Ebisugusa (Keiko), Elderberry fruit,
Elemi, Enju (Sophora oleracea, Sophora oleracea L.), Ogi-kibanaohagi (Astragalus radiata), Ouren (Orchid), Ookarasuri (Karonin), Ootsu-la-Fuji (Anti-self), Psyllium (Walker child, Wracker grass), Toucan (Haruko) ), Obananaokera okera (white ajutsu), Obayashishabushi fruit, Oo hawthorn hawthorn (Yamasato), Oohisasanoyuki, Sasanoyuki, barley
(Barley), oguruma (turning over), okra fruit, panax ginseng and horseshoe ginseng (carrots), hypericum, kogomebato hypericum perforatum, perforated periwinkle (brother cut grass), odorikosou (interrupted), onamimi (blue ears), onigurumi, heavenly grass , Onyuri Sasayuri Hakatayuri (Yuri),
Ononis, Halibut (hihayu), Ominaeshi (defeated), Dutch strawberry, Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, olive, oregano, orange fruit or pericarp, giant pheasant (ripened yellow), cacao seeds, oyster Or its leaves (persimmons), kagikazura (chou hook), cassia, casino fruit (kozumi), gajutsu (shajutsu), kashiwa (shaju), kasukaira, kanikusa (kinsato), kanokosou (yoshikone) ), Birch or weeping birch (birch), squash, capoknoki seed, kahoku sansho (shopper), gama (bamboo), chamomile roman chamomile, chamiyatsude (tsukusa),
CAMCAM / Duck, Duckweed (Gourd), Raspberry (Half-summer), Raspberry, Guarana Seed, Duckweed (Park), Kalaya, Karin (Gourd), Garcinia, Kawayanagi, Kawaratake, Kawarayugi, Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kantou, Canna, Raspberry, Kiwi fruit, Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum flower), Kisasage (Azumitsu), Rabbits (Yotei root), Pheasant (Kizumi), Kizuta, Kidachi aloe , Yellow mint, quina, linden (shincona, red linden), yellowfin (yellow), gymnema
Sylvesta, cabbage, immature cabbage, cucumber, Kiraja saponaria, Kiraya, kumquat fruit, betel,
Agrimony (Sesangaku), Guava Fruit, Guayule, Quercus Infectoria (Gallery), Kukui Nuts, Kuko (Gugi, Gyugia, Gygi Leaf, Skeletal Bark), Kusagi Kazura
(Tenmen winter), Kuzu (Kakkon), Camphor tree, Gooseberry fruit,
Gardenia, gardenia, black clover, kumazasa, black pine, horseradish, clara, bitter cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, buckthorn, black crocodile (rescue),
Kurobana Hikikoshi, cloves (cloves, cloves), kayai
(Kingaku, Kingakuho), Celosia (cow flower, rooster), Bayberry (laurel), Kenashisarutibara (Tokubukuryo, Yamakoi), Gentiana, Gennoshoko (Old grass), Koji /
Tachibana / Oveni mikan / Ponkan / Santara (Tachibana bark), Koushinbara (Monthly flower), Kosui mint, Kozo fruit, Koucha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Koulyan, Koendro fruit, Koganebana (Yellow Gon), Cowberry (Koshibachi), Coconut Fruit, Goshyu
(Goshuyu), gosho strawberry (covered bonko), pepper (pepper), copaiba balsam, coffee beans, kobushi magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame crab (gensan), Gomushi (Gomiko), Sanekazura, Binankazura, Matsubusa, Wheat (wheat), Rice, Rice bran (red bran, white bran), rice oil, Cola acuminata seed, Cola vera seed, Fenugreek fruit, Colombo, Konzulango, Kombu, Konjac, Comfrey (final barn grass), sisal, sisal asa, saxima buttonpul (weird spirit), cherry blossom (oshimazakura, yamazakura, oyamazakura, edhigashi, mamezakura, yamayamazakura, yoshino cherry tree,
Leaves / flowers / fruit / bark of Takanezakura, Kasumizakura, Choujizakura, Kohigan, Satozakura, Kanzakura)
(Cherry bark), cherry, pomegranate, sasa, sasanqua, sajimodaka (sawashatsu), sweet potato, sugar cane, sugar beet, sambu jujube (acid jujube), saffron (safflower, west safflower), pomelo fruit, sabonso, salmonberry fruit,
Drosophila pear (masa), salvia (sage), sawagyoukyo (yamachona), sawagurumi (sanguo), panax ginseng (seven carrots), sanshuyu (sanshuyu), sansho (sanshoyu), sunzukon (sanzukon) , Shea (carite), cyanoki fruit, Zion (Shion), squirrel (Shikunshi), perilla, Aodiso, Chirimenjiso, and catamendiso (Shiyoha,
Shiso), rosewood, linden, Chinese pine, Chinese forsythia (forsythia), sycamore (chrysanthemum), sycamore, potato, peonies (shakuyaku), shajin (shasan), janohige (wheaten winter), juzdama, palm fruit, ginger ( Ginger), shobu (irises, iris roots), shizuku fruit, white oak seeds, white walnut butterflies, white rhinoceros, white rhododendron flowers, white minant (Nantami), cinchona sacilla bra, cinnamon, watermelon (watermelon), honeysuckle (gold and silver) Flowers, shinobi winter), sorrel (acid pattern), swimberry fruit, stevia, strawberry fruit, horsetail (Thorn), stevia, plum fruit, pine cone, cone larch,
Vines, walnuts, hawthorn,
Dandelion, horse chestnut (malonie), pear fruit, snowy pear, elderflower, elderberry, juniper (juniper),
Yarrow (milfoil), rose,
Cornflower, mistletoe, mint, mint, horseradish, horseradish (stone iris), mallow, hirohasenega, senega, seri, celery, senkyu (kawakyu), sendan, senburi (drug), senna fruit or leaves , Senninsou (great tate), Soka (grass), buckwheat seeds, Soybean potato, Rhubarb (daioh), radish, soybean, daidai (orange peel, kikomi), takatodai (daigei), takawarabi (gull), dark sweet cherry Fruit, hollyhock, hollyhock (thyme, Hyakurika), hollyhock, tamarind seeds, onion, tamashiba (spicy), arachis or its root bark, tanjin (dansin), dandelion (gakko British) or shirobana dandelion, mokodandanpo, dammaru, cherry fruit , Chigaya or its roots (Chiyone), Chixetsu carrot (Bamboo ginseng), Chicory Korean ginseng (Gomiko), Korean ginseng (Ohaku), Korean ginseng (Wuyi), Korean ginseng (Ginseng), Korean ginseng (Ayo-leaf), Choeimaitake (Irei), Tsukimisou, Camellia, Camellia, Tsumekusa ), Commelina
(Duck shark), red bean (red azuki bean), red turtle (red bean), red vine (an apricot), red ginseng (four-leaf ginseng), tsuwabuki, daico, teuchigurumi, duberry fruit, tengusa, tendaiyaku (drug), touga (winter melon) , Capsicum (Hot Pepper), Touki (Toki), Calendula (Marigold), Maize or Maize Hair (Southern Hair), Spodoptera (Female Sadako), Toudorindo (Ryubile), Dokudami
(Juyaku), Tokon (sperm root), Toshishi, Mamedaoshi, Nashikazura, Eucommia (Tonaka, Tonakaha), Tomato, Tragant,
Triacanthus seed, Tormentilla, Dronoki, Trolo-mallow, Niseria berry fruit, Yam yam
(Yamayaku), Nagikadida (Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsumikan, Jujube (Dajutsu),
Naniwaiba (gold cherry), Narco lily (yellow), peanut (peanut), Nanten (minamitenmi), nigaki (makinoki), bitter mugwort (bitumen), nutmegium, kei nikkei (cinnamon bark), keishi (keishi), leek (Niriko), fruit and flower or foliage of elderberry (bone-attached tree), garlic (garlic), nulde (fivefold child), leeks, thistle (daiji), wild rose (fruit), yarrow, sawdust
(Mae Hu), Novara, Nomomo, Palm, Pineapple Fruit,
Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone Crushing), Hakusen (Rinosaur), Huckleberry Fruit, Hakobe (Regular), Hazel (Haruko), Hashiridoro (Rot Root), Basil, Lotus (Russian, Renko, parsley (Netherlands jelly), naked mussels, batata, hachiku madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimochimo), banana, hanahacka, vanilla bins, papaya, Stilt
(Rabbit malt grass), Habu grass, Paprika, Hamago / Mitsubahamago (vine thorns), Hamasuge (Kazukiko), Hamabishi (Situriko),
Hamanas (maikai flower), Hamabofu (beach storm), hamamelis, rose (rose), Parietaria, harunire (yubari, yubaishi, yuba), breadfruit, hioogi (sun-dried), lycopodium carrot (partisan), pecan nut, ganganbana (Ishiru,
Jinshasha, Hiokikoshi (prolonged life grass), Hishi (Hisami), Pistachio, Beet, Hitotsuba (Ishire), Hinata Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himegama Pimenta fruit, juniper, beakkyu, and hiyu fruit, beroud oyster, hirohaokinagusa (shiraoka), loquat (loquat, loquat leaf), betel wax (large clothes, betel nut), squash kazura (southern rattan), butterflies, coltsfoot Subsidiary winter leaf), Fujibakama (orchid grass), Fuji bean (flat beans), grape berries or pericarp, seeds and leaves, beech, Fuyumushinatsukutake mushroom (Cordyceps sinensis), Brazilian liquorice, black currant fruit, blackberry, plum fruit, furcellaria,
Blueberry (Prunus avium), prunes, blond psyllium, bundo (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruits, perbianberg, boysenberry fruits, boufu (windproof), spinach, physalis (Torone) , Honoki (Japanese magnolia, Park), Bokeh (Gourd), Hosovanaokera (Sojutsu), Hosobabarengiku,
Bodaiju (bodai tree), button (peony, peony skin), hop,
Jojoba, White berry fruit, Meisulten Nanshaw (Tenan star), Ephedra (mao), Macadamia nut, Macri
(Seaman grass), magwa (mulberry white skin, mulberry leaf), magnolia splengeri, matabi (mokuten tate), matsukasa, matsuba, matsuhod
(Bukuryo), mayolam (Hanaminka), malvanozadin (bitter), mulberry fruit, quince, mango, mangosteen, manshugulumi, mandarin fruit, mannentake (reishi), citrus plant fruit (komi), mishimasaiko (saiko), Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Myoga, Miracle Fruit Fruit, Myrrh, Mirobaran, Mukuge (Mokuge), Mukunoki, Mukuroji, Murasaki (purple root), Purple Sorghum, Mehaji (Mother mother grass), Mebokugi, Melaleuca, Melissa, Meliloth, Melon fruit, Moukomugi, Mosouchikku, Mokkou (wood incense), Maple blossom, Peach leaves (peach leaves), fruits and seeds (peach kernels), bean sprouts, morello cherry fruit, moroheiya (Burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower) ), Yagurumahakka, Alnus firma (vane wheel), Yachiyanagi, Fatsia Japonica
(Octagonal gold plate), mistletoe (parasitic willow), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yangmei), yamakomogi, eucalyptus, yukinoshita (tiger ear) Grass), Yucca flevifolia, Yuzu fruit, lily, yorigusa, European strawberry, mugwort (Aiba), lime fruit, rye, lacanca fruit, raspberry leaf and fruit, lavender, longan (longan meat), ryocha (green tea), apple fruit, Gentian, rubus suavisimus, sweet lettuce, red currant fruit, lemon fruit, lemongrass, forsythia,
Examples include lotus root, wax palm, lokon (reed: Root) loganberry fruit, logwood, rosemary (mannenrow), rosehip (novara), wasabi, and valetum (jiyu).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: brown alga; , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohigewari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike), Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

The axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include a cockscomb extract, a cow / human placenta extract, a pig / cattle stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig / cattle spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposition products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolites Yeast metabolites, yeast extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation of skim milk powder, trehalose or derivatives thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker p aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p Aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placenta extract, silk peptide, plant extract (mulberry, corn, waremoko,
Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, artea, keihi, mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, hemp yellow, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genenoshoko, Kakkon, Licorice, Gopiko, Aloe, Shouma, Safflower, Green Tea, Tea, Asenyaku).

(20) Melanin dye reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavengers SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, age extract extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3 butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, sodium lactate , Mini Sasanishiki extract etc.

(29) Agents for hair Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Topical stimulants Pepper tincture, nonylate vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid and derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(34) Antiseborrheic agents Pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(35) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(39) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal / plant proteins and their decomposed products, animal / Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the humectant, the immunosuppressant, and the external preparation for skin of the present invention is arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, emulsion, It can be used by blending it with creams, ointments, sheets, and other pharmaceuticals, quasi-drugs, and skin / hair cosmetics.

[0078] Specifically, for example, basic preparations such as medicinal preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, shampoos, rinses, hair treatments, and hair styling products , Perm agents, hair tonics, hair dyes, hair growth and hair restoration, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents, and other toothpastes , Mouth freshener ・
It can be applied to various products such as gargle, deodorant / deodorant, sanitary cotton, wet tissue, and can be used for general foods and drinks.

The method of adding to the moisturizing agent, the immunosuppressive preventive agent, and the external preparation for skin of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability. Just do it.

[0080]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) 100 g of each extract of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake and maitake were heated and extracted with purified water (about 80 ° C.) for about 5 hours. Filtration gives about 1.0 kg of extract (dry solids: about 0.1-2.5% by weight).

(Production Example 2) 100 g of various extracts of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake, and maitake were 50% each.
After immersion in ethanol solution and extraction at room temperature for 5 days and nights,
Filter the extract (dry solids: about 0.1-2.5% by weight) to about
Get 1.0kg.

(Production Example 3) 100 g of various extracts of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake, and maitake were 70% each.
Ethanol solution or 30% 1,3-butylene glycol solution,
Or a 60% propylene glycol solution or purified water (about 30
C.), extracted at room temperature for 5 days and nights, and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5% by weight).

(Test 1) Moisturizing Test (Test Method and Evaluation Method) 1) Apparatus for measuring water content of stratum corneum (high frequency IMPERDANCE METE)
R model IB 335, manufactured by IBS Co., Ltd.), and the electrical conductivity of the skin was measured with an electrode having an outer diameter of 6 mm and a center diameter of 1 mm. The measurement site is the inside of the forearm flexion side, and the electrical conductivity of the measurement site is measured in advance. Next, apply about 1 mL of each sample to the measurement site, and after 30 seconds, remove the excess sample,
Immediately thereafter, the electric conductivity was measured every 30 seconds for 5 minutes, and a moisture retention test was performed. In addition, for the sample of the moisturizing test, the extract (solid content concentration: 1.0% by weight) obtained in Production Example 1 of the present invention was used for the test. The test conditions are as follows: temperature: 22 to 24 ° C, relative humidity: 50 to
52%, and the results are shown in FIGS.

(Test Results) As shown in FIGS. 1 to 9, the various extracts of enokitake, shiitake, mushroom and agaric mushrooms of the present invention show a strong moisturizing effect,
It was confirmed that various extracts of Shimeji, Nameko, Himematsutake and Maitake have a moisturizing effect as compared with purified water.

(Test 2) Prevention Test of Immune Reduction Induced by Ultraviolet Rays It has recently been known that the immune function of the skin is reduced by ultraviolet rays (UVB). It is thought that the cause is that the Langerhans cells (hereinafter, referred to as LC cells) in the constituent cells are lost or deteriorated by UVB irradiation. still,
LC cells have the function of transmitting antigen or cancer cell information to immune system cells (T cells), and are thought to be deeply involved in the contact hypersensitivity reaction (Ueda, 9th SCCJ
Seminar text 10 (1996)). In this study, we investigated the protective effects of UV-induced contact hypersensitivity on the reduction of skin immunity (Horio et al .: Nisshinkai 105 (12), 1621 (1995), Uchida: Fragrance Journal 9, 29 (1991)) was measured and evaluated using the contact hypersensitivity reaction as an index.

(Test Method) a. The sample extract was concentrated under reduced pressure by evaporating the solvent under reduced pressure, and a hydrophilic petrolatum ointment containing 10% by weight in terms of solid content was produced and used by a conventional method. b. Measurement of edema swelling rate That is, the back of the mouse whose hair was shaved three days before with an electric clipper and an electric shaver was placed on the back of the mouse and exposed to ultraviolet light (UV B lamp manufactured by Toshiba F
L20S · E lamp) at 50 mJ / cm 2. Immediately thereafter, the test drug was applied to the irradiated site, and the same was applied the next day and the next two days, and the test was performed three times in total. Six hours after the final application, 0.2% (W / W) DNFB (1 Fluoro 2,4 dinitroben)
(Zene, manufactured by Wako Pure Chemical Industries, Ltd., dissolved in acetone: olive oil 4: 1)) was coated with 25 μL to sensitize. 7 days after the sensitization, 20 μL of 0.2% DNFB was applied to the auricle of one side of the mouse.
In the evaluation method, the left and right auricles were cut out with a punch (about 5 mm in diameter) 24 hours after the eruption, the weight of the cut out auricles was measured, and the difference was defined as the auricle swelling value. In addition, the animals which were not subjected to the ultraviolet irradiation and the test drug and were subjected to only the sensitizing operation (unirradiated group) were provided for comparison. In addition, eight 10-week-old C3H / HeN female mice were used per group.

(Test Results) As a result of observing the inflammation of the contact hypersensitivity reaction by the DNFB solution performed in this test method, the group irradiated with ultraviolet rays (control) was more inflamed than the group not irradiated with ultraviolet rays (unirradiated). Showed a tendency to decrease inflammation (decreased skin immune response). However, after irradiation with ultraviolet rays, the enokitake mushroom, eryngii, shiitake mushroom, shimeji mushroom, nameko mushroom, mushroom mushroom, agaric mushroom, himematsu mushroom,
The group to which the various extracts of Maitake were applied, as shown in FIG.
No reduction in inflammation was observed. From these results, it was confirmed that the various extracts of Enokitake, Eryngii, Shiitake, Shimeji, Nameko, Tsukutake, Agarita, Himematsutake, and Maitake of the present invention have a preventive effect on the reduction of immune response due to ultraviolet rays. In addition, skin immunosuppression involves LC cell damage, and the various extracts of the present invention have the effect of maintaining LC cells normally.
C cells secrete EGF (epidermal growth factor) and FGF (fibroblast growth factor) and are indispensable for maintenance of skin structure. Various extracts of the present invention are important for maintenance of skin structure. Can be suggested.

(Test 3) Safety test (1) Primary skin irritation test Various extracts of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agarita, himematsutake and maitake obtained in Production Examples 1 to 3 were dried. Prepared in purified water so that the solid concentration is about 1.0 W / V%,
Japanese white rabbit with shaved back (female, 3 per group, weight 2.
About 3 kg) of skin. Judgment is 24,48,72 after application
Erythema and edema were used as indicators by the primary irritation scoring method at time. The result is, in all animals,
No erythema and edema were observed, and the result was negative.

(Test 4) Safety Test (2) Skin Cumulative Irritation Test Various extracts of enokitake, eryngii, shiitake, shimeji, nameko, mushroom, agaric, himematsutake and maitake similarly obtained in Production Examples 1 to 3 Was prepared in purified water so that the dry solid content was about 1.0 W / V%, and the flank was shaved in a Hartley-type guinea pig (female, female).
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 mL / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 5) Safety test (3) Acute toxicity test Similarly, various extracts of enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake and maitake obtained in Production Examples 1 to 3 were decompressed. Powder obtained by concentration and drying (dry solid content about 1.0 W / V%)
Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old), which had been fasted for 4 hours before the test, in an amount of 2,000 mg / kg.
The appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days,
In addition, there was no abnormality in the dissection result. Therefore, LD50 is 2,
It was determined to be 000 mg / kg or more.

(Prescription Examples) Various moisturizing agents, immunosuppressants,
Manufacture of skin external preparation According to the above evaluation results, formulation examples are shown below. The formulation examples may be those manufactured by a conventional method in the manufacture of each product, and only the compounding amounts are shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 3.0 3. Jojoba oil 3.0 4. Cetyl alcohol 2.0 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Enokitake hot water extract B: Eryngii hot water extract C: Shiitake hot water extract D: Shimeji hot water Extract E: Nameko hot water extract F: Tsukutake mushroom hot water extract G: Agaricus hot water extract H: Himematsutake hot water extract I: Maitake hot water extract * Any one of A to I 8.0 11. Fragrance・ An appropriate amount of preservative 12.Purified water 100 residue

(Formulation Example 2) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Himematsutake hot water extract 3.0 7. Maitake hot water Extract 3.0 8. Flavors, preservatives appropriate amount 9. Purified water 100 residue

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Shimeji hot water extract 1.0 7. Nameko hot water extraction Liquid 1.5 8. Agaricus 30% 1,3-butylene glycol extract 1.0 9. Appropriate amount of fragrance and preservative

(Formulation Example 4) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Enokitake mushroom 50% ethanol extract 1.0 5. Eryngii hot water extract 2.0 6. Haratake extract Liquid 1.5 (Ethanol: 1,3-butylene glycol = 3: 1 extract) 7. Extract of Himematsutake hot water 1.5 8. pH adjuster qs 9. Preservative qs 10. Purified water 100

(Formulation Example 5) Shampoo weight% 1. Triethanolamine lauryl sulfate 6.0 2. Sodium polyoxyethylene lauryl ether sulfate 15.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Shimeji hot water extract 1.0 7. Nameko hot water extract 2.5 8. Maitake mushroom hot water extract 1.5 9. Appropriate amount of fragrance and preservatives 10. Purified water 100 residue

(Formulation Example 6) Rinse weight% 1. Stearyl trimethylammonium chloride 3.0 2. Cetostearyl alcohol 3.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Haratake 50% ethanol extract 1.0 6. Eryngii 50 % Ethanol extract 1.5 7. Maitake 50% 1,3-butylene glycol extract 1.5 8. pH adjuster qs 9. Preservative qs 10. Purified water 100

(Formulation Example 7) Hair liquid weight% 1. Ethanol 30.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. 30% mushroom extract 30% ethanol extract 1.0 6. Hararitake 50% ethanol extract 1.0 7. Himematsutake hot water extract 1.0 8. Preservatives appropriate amount 9. Purified water 100 residue

(Formulation Example 8) Hair tonic wt% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Enokitake mushroom 20% ethanol extract 1.0 5. Shiitake mushroom 50% phenolic alcohol 1.0 6. Agaric ethanol extract 1.0 7. Appropriate amount of fragrance and preservative

(Formulation Example 9) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Powdered agaricus hot water extraction powder 5.0 5. Himematsutake hot water extracted powder 2.0 6. Nameco 50 % Ethanol extracted powder 2.0

(Prescription example 10) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing an appropriate amount of a hot water extract of Himematsutake and a hot water extract of Maitake, an antibiotic, an anti-inflammation and the like, and attached to the wound. Further, the Himematsutake hot water extract and the Maitake mushroom hot water extract may be directly sprayed locally and covered with gauze or the like.

(Test 6) Use effect test The effect when the external preparation for skin of the present invention was actually used was examined. Use test is for those who suffer from rough skin and dry skin, and those who have no gloss or tension on their skin.
The test was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face and hands for 3 months after washing the face twice a day, morning and night, with 0 panelists. A control prepared by the same method except that various extracts of the present invention were removed from the emulsion was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Beautiful skin / moisturizing effect" Effective: Rough skin and dry skin were improved. Slightly effective: rough and dry skin slightly improved. Ineffective: No change from before use.

"Skin feel improving effect" Effective: Skin gloss / tension increased, and skin was improved. Slightly effective: Skin gloss and tension increased slightly, and skin was improved. Ineffective: No change from before use.

[0106]

[Table 1]

(Test results) The results are shown in Table 1, and the enokitake mushroom, eryngii mushroom, shiitake mushroom, shimeji mushroom, nameko mushroom,
It was confirmed that various extracts of Amanita mushroom, Agaritake, Himematsutake, and Maitake mushrooms significantly improved rough and dry skin and gave gloss and firmness to the skin.

[0108]

EFFECT OF THE INVENTION The moisturizer, immunosuppressant or skin external preparation containing at least one extract selected from the enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agaric, himematsutake and maitake mushrooms according to the present invention, It has a moisturizing effect and / or a preventive effect on lowering immunity, and can also prevent or improve rough and dry skin, and can also give the skin a gloss and firmness. Further, skin immunosuppression is closely related to LC cell damage, and the various extracts of the present invention have an effect of maintaining LC cells normally, and are safe for humans and animals.
The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

FIG. 1 is a diagram showing the water content of the stratum corneum of the enokitake mushroom extract of the present invention.

FIG. 2 is a graph showing the water content of the stratum corneum of the eryngii extract of the present invention.

FIG. 3 is a diagram showing the water content of the stratum corneum of the shiitake mushroom extract of the present invention.

FIG. 4 is a graph showing the water content of the stratum corneum of the shimeji extract of the present invention.

FIG. 5 is a graph showing the water content of the stratum corneum of the nameko extract of the present invention.

FIG. 6 is a graph showing the water content of the stratum corneum of the agaric extract of the present invention.

FIG. 7 is a diagram showing the water content of the stratum corneum of the agaric extract of the present invention.

FIG. 8 is a graph showing the water content of the stratum corneum of the Himematsutake extract of the present invention.

FIG. 9 is a graph showing the water content of the stratum corneum of the maitake extract of the present invention.

FIG. 10 is a graph showing the effect of various extracts of Enokitake mushroom, Eringi, Shiitake mushroom, Shimeji mushroom, Nameko mushroom, Tsukutake mushroom, Agaric mushroom, Himematsu mushroom and Maitake mushroom, on the immune-lowering-preventive action induced by ultraviolet rays.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/06 A61K 7/06 7/50 7/50

Claims (5)

[Claims] 1. A humectant comprising at least one extract selected from enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agarita, himematsutake and maitake. 2. An agent for preventing immunity, comprising one or more extracts selected from enokitake, eryngii, shiitake, shimeji, nameko, tsukutake, agarita, himematsutake, and maitake. 3. An external preparation for skin, comprising one or more humectants according to claim 1. 4. An external preparation for skin, comprising one or more of the immunosuppressive preventive agents according to claim 2. 5. An external preparation for skin, comprising at least one of the moisturizing agents and immunosuppressants according to claim 1 or 2.