JPH11279069A - Active oxygen eliminating agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an active oxygen eliminating agent or a skin beautifying cosmetic composition from new and safe plants. SOLUTION: This active oxygen eliminating agent or skin beautifying cosmetic composition comprises one or more kinds of plant extracts selected from among extracts of plant parts of Haematoxylon campechianum L., Lindera strychnifolia (Sieb.et Zucc.)F. Vill., Arctostaphylos uva-ursi (L). Spreng., Lycium chinense Mill., Perilla frutescens Britton var. acuta Kudo, Rubus suavissimus S.Lee, Nelumbo nucifera Gaertner and Lavandula vera D.C. The agent has excellent active oxygen eliminating action and further can improve a roughened skin and impart gloss and tenseness to the skin. Furthermore, the agent can be also utilized for general foods and beverages.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an active oxygen scavenger containing one or more plant extracts selected from Akaminoki, Yaku, Uwaurushi, Jicoppi, Perilla, Tencha, Lotus and Lavender, and a pharmaceutical / non-pharmaceutical product. The present invention relates to the application to various skin cosmetic compositions in the field of cosmetics or cosmetics.

[0002] The field of application is that it can be used in various cosmetic skin cosmetic compositions, for example, external preparations (including preparations used for animals) in general.
Capsule, pill, tablet, powder, granule, solid,
1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics in liquid, gel or foam form, 4) Bath agents to be poured into bath water, 5) Other liquid odor・ Deodorants, sanitary goods, sanitary cotton, wet tissue, etc.

[0003]

2. Description of the Related Art In recent years, the production of active oxygen in a living body and various effects (diseases) caused thereby have been reported. Generally, this active oxygen is also called Activated oxygens, and includes O ²⁻ , H ₂ O ₂ , .OH, and chemiluminescence.
They are roughly classified into species, all of which have strong bactericidal action and are regarded as important substances involved in the self-defense of living organisms.

For example, when an enemy (antigen) such as a bacterium, a virus, or a foreign substance invades the living body, neutrophils, monocytes, and macrophages, which are phagocytes in the blood, start phagocytosis. Active oxygen is produced to dissolve foreign substances phagocytosed in the endoplasmic reticulum of the phagocytic cells. It exerts a bactericidal action on external enemies and plays a role of protecting it from external enemies. In other words, it has the function of eliminating antigenic substances before the immune function works.

[0005] However, if the active oxygen for self-protection is produced and secreted in excess, even normal cells are lysed and stimulated, resulting in various damage reactions. Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) ) And brain trauma, it is said to cause blood flow impairment due to thrombus and the like, and to cause ischemic state in blood vessels due to rapid transient atrophy, thereby causing oxygen deprivation. Therefore, in this state, it is said that xanthine dehydrogenase in the blood vessel is converted to xanthine oxidase, which generates a large amount of active oxygen in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage I have.

[0006] Regarding the relationship between the skin and active oxygen, for example, since skin is an organ in direct contact with the outside world, active oxygen is excessively exposed to skin by ultraviolet rays or radiation while being susceptible to environmental factors. When the state is maintained, it reacts with the unsaturated fatty acids of the phospholipids of the biological membrane to generate lipid peroxide. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation, and the like, and also causes skin inflammation, edema, wrinkles, and the like. Further, as a disease due to excess active oxygen, from a cosmetic point of view, for example, herpetic dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis,
It causes eczema, atopic dermatitis, etc.

[0007] Accordingly, there is a need for a substance capable of eliminating excessive active oxygen present in a living body. In order to prevent or improve various diseases so far, for example, in a living body of animals and plants, superoxide dismutase ( SOD), catalase, glutathioperoxidase, and other tocopherols (vitamin E), oryzanol, plant extracts (hamamelis, clove, melissa, emmaiso,
Birch, sage, rosemary, age, basil,
Ginkgo, psycho, peonies, hanger, calyx, lysium, giant goose, carrot, licorice, ginger) and the like were used.

[0008]

However, the active oxygen-scavenging substance described above has poor stability and solubility in the formulation system, and produces an unpleasant odor and color due to sedimentation and decomposition.
The effect at the biological level was not sufficient, and there was also a problem in terms of safety such as skin irritation, which was not satisfactory.

[0009]

In view of these circumstances, the inventors of the present invention have developed a useful plant having an active oxygen scavenging (SOD) effect as a theme of development, and as a result, amamioki, eel yak, uwaurushi, dicopi, perilla, One or more plant extracts selected from tencha, lotus, and lavender have been confirmed to significantly eliminate and suppress active oxygen, and are also capable of improving rough skin and giving gloss and firmness to the skin. The present invention has been accomplished by providing a highly active oxygen scavenger and a skin beautiful cosmetic composition containing the same.

In the present invention, "Akaminoki: Logwood" refers to legumes (Leguminosae) and Akaminoki (H).
Plants of aematoxylon: Akamatoki (Haematoxylon campe)
chianum L.).

[0011] The term "eelgrass: crow drug, Tendai crow drug" used in the present invention means "Lindera strychn", a plant belonging to the family camphoraceae (Lauraceae) or the genus Lindner (Lindera).
ifolia (Sieb.et Zucc.) F.Vill. (= Benzoin strychnifo
lium (Sieb.et Zucc.) O.Kuntze) "is used.

"Uwaurushi: Laceae" refers to the ericaceae (Ericaceae) and the genus Arxostophilus (Arctostap).
hylos) plant: Arctostaphylos uva-ursi
(L) .Spreng.) Leaves.

"Zicoppi: skin bark" refers to Solanaceae (Sola)
naceae), a plant of the genus Lycium: Lycium chin
ense Mill.) is used.

"Perilla: Shiso" refers to the Labiatae family (Labiata).
e) Perilla plant: Perilla frutes
leaves and branches of cens Britton var. acuta Kudo) or other closely related plants (Labiatae).

"Tencha: Tengcha" refers to the rose family (Compos
itae), a plant of the genus Rubus (Rubus): Tencha (Rubus)
suavissimus S. Lee) leaves or branches and leaves are used.

"Lotus: lotus" means "Nymphaea"
ceac), a plant of the genus Lotus (Nelumbo): Lotus "Nelumbo nuci"
fera Gaertner (= Nelumbium speciosum Willd.) "

"Lavender" is a Labiatae (Labiata)
e), a plant of the genus Lavendula (Lavandula): Lavender "Lavandula vera DC (= L.angustifolia, = L.spica, =
L. officinalis) ”flowers, head flowers, and spikes.

The various plant extracts used for the present invention, such as red aster, eel, uruwa, jikkopi, perilla, tencha, lotus, and lavender, refer to various parts of each plant (whole plant, flower, head flower, spike, leaf) , Branches, leaves and leaves, rhizomes, root bark, roots, etc. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

The plant extracts of Akaminoki, Yaku, Uwaurushi, Zikoppi, Perilla, Tencha, Lotus and Lavender are dried, concentrated or concentrated depending on the type and form of the active oxygen scavenger and the beautiful skin cosmetic composition to be applied. Dilution or the like may be arbitrarily performed and adjusted.

Although the production method is not particularly limited, it is usually sufficient if it is in the range of the boiling point of the solvent at normal temperature to normal pressure, and after extraction, filtration or ion exchange resin is used.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, purification treatment such as deodorization and decolorization may be added as far as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Each of the plant extracts of the present invention, Akaminoki, Yaku, Uwaurushi, Zikoppi, Perilla, Tencha, Lotus and Lavender, can be incorporated into active oxygen scavengers and cosmetic skin care compositions. Although it is not something, active oxygen scavenger, kind, quality of beauty skin cosmetic composition,
It varies slightly depending on the expected degree of action, usually 0.01
% By weight or more (hereinafter represented by weight%), preferably 3 to 20%
% Is good. If the amount is less than 0.01%, the effect cannot be expected sufficiently.

The active oxygen scavenger and the skin cosmetic composition of the present invention may contain, in addition to the above-mentioned essential components, if necessary, pharmaceuticals, quasi-drugs, and the like within a range that does not impair the effects of the present invention.
It can be produced by arbitrarily selecting and using components and additives used in preparations such as cosmetics.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salts, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These can be processed in a conventional manner (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, and the processing to be performed later. However, usually, water and a water-soluble organic solvent (eg, ethanol) are used. , Propylene glycol, 1,3-butylene glycol, etc.).
However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsujirafuji (Kibo), Aono Ryukyuran, Fukurin Ryuetsuran, Acacia, Akasugi Fruit, Akavine, Akamegashiwa (Red Bud), Akane (Akane Grassroot), Akayajiou Jio (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Asuka), Azuki (Red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit , Avocado, flax, amateur (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Usenitachioi, tsubogusa (summer hay), udo or shishido (qang, indigenous, tangdoku), ume (crow plum) or its pulp, urajirogashi, oolong tea, unshu mandarin (chenkin), estragon, eleuthero, ezoki strawberry , Echinashi (Echinacea vulgaris), Enokitake (Enoki mushroom), Ebisugusa (Keiko), Elderberry fruit, Elemi, Eringy (Pre-rotus Erinji), Endu (Gossip, Sophora rice), Ogi-kibananagi (Chrysalis),
Ouren (yellow), giant crow squirrel (karonin), giant skull (self-defense), psyllium (vegetative child, vegetative grass), toucan hazel (Haruko), obanokera okera (white jitsu), obayashishabushi fruit, o hawthorn hawthorn ) 、 Ohisasanoyuki, Sasanoyuki, barley (barley), oguruma
(Turning over), okra fruit, Panax ginseng, Panax ginseng
(Ginseng), St. John's wort, St. John's wort, St. John's wort Yu), Ominaeshi (losing sauce), Dutch strawberry, Dutch mustard (Watercress), Dutch jelly, Dutch honeybee, olive, oregano, orange fruit or pericarp, cayca sylvestris (ripe yellow), cacao seeds, oysters or leaves (persimmon) ), Kagikazura (Hook of Choto), Cassia, Kasinaki fruit (Kozomi), Kajutsu (Shazajutsu), Kashiwa (Kazuki), Kasukaira, Kanixa (Kinsato), Kanokosou (Kisakune), Birch or Shidare kamba ( Birch), pumpkin, capoknoki seed, kahoku sansho (shopper), gama (bamboo), chamomile
Roman chamomile, Camellia japonica (weeds), Kamkamu / Kamo-duck, Rasuri (flowers), Rasubisaku (midsummer), Rasacea, Guarana seeds, Karaho (Pop), Karaya, Karin
(Gourd), Garcinia, Kawayanagi, Kawatake, Kawarayomugi (Inchinko), Kansui (Kansu), Licorice (Licorice),
Kantala Asa, Candelilla, Canto, Canna, Raspberry, Kiwi Fruit, Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum), Kisage (Azusa), Gigi
(Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachi mint, Kina, Kinoki (Shincona, Akakinoki), Yellowfin (Huangbashi), Gymnema sylvesta, Cabbage, Cabbage immature, Cucumber, Kiraja saponaria, Kiraya, Kumquat fruit , Betel, golden hibiscus (Senaku rub), guava fruit, guayule, Quercus infectria (gallicate), kukui nuts, wolfberry (Gugi, gugiko, gugi leaf), Kusagi Kazura (Tenmen winter), Kuzu (Kuzukuzu),
Camphor tree, gooseberry fruit, gardenia, gardenia, blackberry, kumazasa, black pine, horseshoe
(Bitterness), cranberry fruit, chestnut or its astringent skin, curculigo-latifolia fruit, grapefruit, buckthorn, black crocodile (rescue rescue), black crab,
Cloves (cloves, cloves), scallops (codlings, codlings), celosia (cow flowers, rooster), bay laurel (laurel), kenashisarutoribara (tokubukuryo, mountain return), gentian, gennoshoko (old tomato), koji / tachibana / Oveni mikan / Ponkan / Santara (Tachibana skin), Koushinbara (Monthly flower), Kouzi mint, Kozo fruit, Kocha (tea),
Kouhone (river bone), kouhon (straw and kara straw), kouriang, cilantro fruit, koganebana (yellow gon), cowberry
(Koshibachi), coconut fruit, goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), copaiba balsam, coffee beans, kobushi magnolia (spicy), burdock (burdock, burdock), kobotur, sesame ( Sesame seeds), Sesame seeds (Ginseng), Gomishi (Gomiko), Sanekazura Binankazura,
Matsubusa, wheat (wheat), rice, rice bran (red bran, white bran), rice oil, cola acuminata seed, cola vera seed, fenugreek fruit, colombo, conzulango, kelp, konjac, comfrey (finnari grass), sisal , Sisal Asa, Sakisima Button (Sacred Spirits), Sakura (Oshimazakura,
Leaves, flowers, fruits, bark (cherry bark), cherries, yamazakura, oyamazakura, edhigashi, mamezakura, miyamazakura, yoshino cherry tree, takanezakura, kasumizakura, chojizakura, kohigan, satozakura, kanzakura)
Pomegranate, Sasa, Sazanka, Sadomodaka (Sawaka), Sweet potato, Sugar cane, Sugar beet, Sunabet jujube
(Acid jujube), saffron (red safflower, western safflower), pomelo fruit, savonso, salmonberry fruit, sarasinosa (maso), salvia (sage), sawagikyo (yamachona), sawagurumi (yamawomo), sanshinjinjin (37 ginseng), sanshuyu (sanshuyu), sansho (sansho), sanzukon (yamazune), shea (carite), cyanoki fruit, shiitake mushroom (shiitake),
Zion (Shien), Red squirrel, Shikunshi (Shikishi), Rosewood, Shinanoki, Shinanohonoki, Chinese Forsythia,
Shimanagi (chrysanthemum), shimeji (hinshimeji, shakashimeji, hatakeshimeji, ossiloyshimeji, bunashimeji, shirotamogitake), shimotsusou, potato, peonies
(Shakuyaku), shajin (shasan), scabbard (wheat season), juzdama, palm fruit, ginger, ginger, shobu,
Iris roots), shokuzuku fruit, birch oak seeds, seeds of white butterfly, white blossoms, white blossoms, white blossoms, white blossoms, white blossoms, white clover, cinnamon,
Watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acidic pattern), swimberry fruit, stevia, strawberry fruit, horsetail (Qingi), stevia, plum fruit, pine cone, pine larch, pine tree Walnuts, hawthorn, dandelion,
Horse chestnut (malonie), pear fruit, prunus edulis, elderberry (elder), northern pear (juniper, juniper), yarrow (milfoil), yellow valley, euonymus japonica, Horseradish, Sekisho (Iris), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Senkyu (River Kyu), Sendan, Senburi (Drug), Senna fruit or leaf, Senninsou (Large Tate), Souka (grass), Buckwheat seed, Soybean potato, Rhubarb (Daio), Radish, Soybean, Daidai (Orange skin, Kikomi), Takatodai (Daiki), Takawarabi
(Gull), dark sweet cherry fruit, hollyhock, lycopodium thyme (thyme, Hyakurika), larvae, tamarind seeds, onion, tamshiba (spicy), arano or its root bark, tanjin (dansin), dandelion (gakuko) or shirobana dandelion・ Moko dandelion, dammar, cherry fruit, ginger or its root (chinese radish), chikusetsu carrot (bamboo ginseng), chicory, ginseng (gomiko), ginseng dai (large yellow), ginseng radish (buoy), ginseng (ginseng) ), Artemisia (Aiba), Choreimaitake (Irei), Tsukimiso, Tsukuritake (Mushroom), Camellia, Camellia, Tumexa (lacquer primrose), Commelina
(Ducklings), red bean (red azuki bean), red turtle (red bean), red vine (blancho), red ginseng (four-leaf ginseng), tsuwabuki, deiko, teuchigurumi, duberry fruit, tengusa, red pepper, red pepper. , Touki (Toki), Calendula (Marigold), Maize or Maize Hair (Nanban Hair), Toad Moth (Female Sadako), Torindo (Ryubile), Dokudami (Juyaku), Tokon (Spirit), Toshishi Mamedaoshi Nesashizu, Eucommia (Tonaka, Tonakanoha), Tomato, Traganto, Triacanthus Seed, Tormentilla, Dronoki, Troloaoi, Niseria Berry Fruit, Nagaimo Yamanoimo (Yakuyaku), Nagiikada (Butcha Bloom), Naginata Koju, Nazuna,
Rape, Natsumikan, Jujube (large jujube), Naniwaibara (Kanekurako), Nameko, Narco lily (Yellow), Peanut (peanut), Nanten (Namitenmi), Nigaki (Maki), Nigayomagi (Bittersweet), Nikuzuku, Kei Fruits, flowers or foliage of Nikkei (Keshi bark), Keishi (Keishi), Chinese chive (Nirako), Elderberry (bone-attached tree), Garlic (Garlic), Nurde (Fivefold), Leek, Nori Thistle
(Ohi), Noibara (real fruit), Yarrow, Japanese radish (Maehu), Nobara, Nomomo, Palm, Pineapple fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone crushing), Hakusen (White ring skin), Huckleberry fruit, chickweed (reddish), hazel (haruko), hasidorokoro (roth root), basil, parsley (holland jelly),
Naked mussels, batata, bees and medaka (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), adlay (yokuinin), hanasuge (chimbo), banana, hanamacka, vanilla bins, papaya, japonicus (rat), hub grass , Paprika, hamago mitsubahamagou (vine thorns), hamasuge (kosuke), hamabishi (situriko), hamanas (maikai flower), hamabafu (beach storm), hamamelis, rose (rose), haratake (haratake, hirotakeharatake) , Parietaria, Harunire (yu bark, Yu white bark, Yuba), Breadfruit, Ginkgo biloba (sun dried), Ginkgo biloba ginseng (party party), Pecan nut, Giganbana (Shirubi, Suzuka Hana), Hikikoshi (Longevous grass) ), Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Ishire), Hinata Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Higama ), Himematsutake (Kawariharatake, Hilo matsutake), Pimenta fruit,
Juniper, juniper, hyouju fruit, below mallow,
Hiroha okinagusa (Hakuto Okina), loquat (loquat, loquat leaf), betel nut (large clothing, arelocha), sprout kazura (southern rattan), butterbur,
Coltsfoot (winter flower, winter leaf), fujibakama (orchid grass), wisteria bean (flat beans), grape fruit or pericarp, seeds, leaves, beech,
Fumushinashikutaketake (Cordyceps), Brazilian Licorice,
Black currant fruit, blackberry, plum fruit, flucellaria, blueberry (Prunus avium), prune, blond psyllium, bundou (green bean), loofah, safflower (safflower), henneken, belladonna, berry fruit, Perbianberg, Boysenberry fruit , Boufu (windbreak), spinach, physalis (Torone), honoki (Japanese thick, magnolia), bokeh (wood gourd), bonsai bonsai (sojutsu), hosobabarengiku, bodaiju (bodaiju), button (peony, peony), hop , Jojoba, white berry fruit, hon-shimeji, meisurutennansha (Tennan star), maitake (maitake), ephedra (mao), macadamia nut, macri (sea grass), maguwa (mulberry white skin, mulberry leaf), magnolia. Spurengeri, Matatabi (Kiten Tate), Matsukasa, Matsuba, Matsuhodo (Bukuryo), Mayorum (Hanamint), Maru Nojazin (Bitterfruit), Mulberry Fruit, Quince, Mango, Mangosteen, Manshu Gurumi, Mandarin Fruit, Mannentake (Lingzhi), Fruits of Citrus Species (Kikumi), Mishima Saiko (Saiko), Mizokashi (Hanbe Lotus), Misohagi ( Chikuna), honeywort, honeybee, green peppermint, mimosa,
Ginger, miracle fruit fruits, myrrh, myrobaran, mugwort (woody geese), mukunoki, mukuroji, murasaki (purple root), murasaki maize, mehajiki (benefit mother grass), mebogi, melaleuca, melissa, melilot, melon fruit, makoyoko tree, moso-kook Incense), Maple blossoms, Peach leaves (peach leaves), fruits and seeds (peach seeds), bean sprouts, morello cherry fruits, moloheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflowers (cornflowers), cornflowers , Yashabushi (arrow wheel), willow willow, yatsude (octagonal gilded), mistletoe (parasitic willow), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed
(Land), alder (Yamaharu), bayberry (peel skin), sagebrush, eucalyptus, snowy citrus (tiger ear grass), yucca flebifolia, yuzu fruit, lily, yorigusa, European strawberry, mugwort, lime fruit, Rye, Lacanca fruit, Raspberry leaf / fruit, Lavender, Longan (longan meat), Ryokucha (green tea), Apple fruit, Gentian, Lubas suavisimus (Tenryu), Lettuce, Red currant fruit, Lemon fruit, Lemongrass, Forsythia
(Forsythia), astragalus, wax palm, rokon (reed: Akane)
Loganberry fruits, rosemary (mannan wax), rose hips (novara), wasabi, and valerium (jiyu) are examples.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu-konbuma , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas sp., Akayukimo, Dunaliella spp .: Dunaliella spp., Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo spp., Volvox spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Nagamimi spp., Isogrape spp .: Isogrape,
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

The axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include cockscomb extract, cow / human placenta extract, swine / cattle stomach, duodenum or intestine extract or its decomposed product, and swine / cattle spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin,
Hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolites: yeast metabolites, yeast extract, rice ferment extract, rice bran extract, euglena extract, trehalose or derivatives thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placenta extract, silk peptide, plant extract (mulberry, corn, waremoko,
Artemisia, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisou, hawthorn, eucalyptus, americana japonicus, altea, keihi, mankeishi, hamamelis, yamaguwa, life-extended grass, bellflower, toshishi, tsukkoshi, kyoto, makko, senkyu, dokka Psycho, Bohu,
Hamabofu, Ogon, Peonies, Gennoshoko, Licorice, Fivefold, Aloe, Ginger, Safflower, Asenyaku).

(20) Melanin pigment reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, age extract extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, lactic acid Sodium, Mini Sasanishiki extract, etc.

(29) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Topical stimulants Pepper tincture, nonylate vanillamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(34) Antiseborrheic agents Pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(35) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, cedarwood essential oil,
Citronella essential oil, Jasmine essential oil, Gingergrass essential oil, Cedar essential oil, Spearmint essential oil, Western mint essential oil, Daifeng essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Trubal sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil , Hinoki essential oil, Hiba essential oil, Sandalwood essential oil,
Petit glen essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, peruvian balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil And other vegetable flavors, and other synthetic flavors.

(39) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives and anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, enzymes, and the like are listed, and when used in combination therewith, various additive and synergistic effects can be expected.

The active oxygen scavenger and the skin cosmetic composition of the present invention may be in any dosage form, such as capsules, powders, granules, solids, liquids, gels, foams, emulsions, and creams. , Ointment, sheet and other pharmaceuticals, quasi-drugs,
It can be used by blending it into cosmetics for skin and hair.

Specifically, for example, external preparations, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, shampoos, rinses, hair treatments, and hairdressings , Perm agents, hair tonics, hair dyes, hair growth and hair restoration, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents, and other toothpastes , Mouth freshener ・
It can be applied to various products such as gargle, deodorant and deodorant, sanitary cotton, wet tissue, and can be used for general foods and drinks.

The method of adding the active oxygen scavenger of the present invention to the skin care cosmetic composition may be added in advance or during the production, and may be appropriately selected in consideration of workability. Good.

[0077]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) 100 g of each plant of Amanoki, Yaku, Uwaurushi, Jicoppi, Perilla, Tencha, Lotus and Lavender was heated and extracted with purified water (about 80 ° C.) for about 5 hours, and filtered. Extract (dry solids: about 0.05-2.
5% by weight).

(Production Example 2) 100 g of each of the plants of Amanoki, Yaku, Uwaurushi, Jicoppi, Perilla, Tencha, Lotus and Lavender were immersed in a 50% ethanol solution.
After extraction at room temperature for 5 days and nights, the mixture is filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.05 to 2.5% by weight).

(Production Example 3) 100 g of each of the plants of Akaminoki, Yaku, Uwaurushi, Jicoppi, Perilla, Tencha, Lotus and Lavender were put in 70% ethanol solution or 30%
Immerse in 3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C)
After extraction day and night, filter and extract (dry solids: about 0.05
~ 3.0% by weight).

(Test 1) Elimination of active oxygen (SOD-like activity)
Test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 was tested for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the NBT method of the Imana et al. (Experimental method for lipid peroxide, p. (Co., Ltd.).

"Test Method and Evaluation Method" a. After distilling off the solvent from the sample extract under reduced pressure, the solid content concentration in purified water
It was redissolved to a concentration of 0.1% by weight and used for the test. b. Measurement of elimination ability of active oxygen 0.05M sodium carbonate buffer (pH 10.2) 2.5m in a small test tube
l, 0.75 mM nitro blue tetrazolium (NBT), 3.0
mM xanthine, 3.0 mM disodium ethylenediaminetetraacetate, 0.15 W / V% bovine serum albumin, and 0.1 ml each of a sample solution (the solvent for the control) were added, and the mixture was kept at 25 ° C. for 10 minutes.
0.1 ml of an aqueous solution of xanthine oxidase (adjusted so that the change in absorbance of NBT in the control is about 0.3 / 20 minutes) was added, and the absorbance at 560 nm was measured. In addition, a sample containing purified water instead of a sample was used as a control, and a blank containing a reaction stop solution was set for each sample and control before adding xanthine oxidase. I asked. The results are shown in FIG.

[0083]

(Equation 1)

(Test Results) As shown in FIG. 1, it was confirmed that the plant extracts of the present invention, Akaminoki, Yaku, Uwaurushi, Zikoppi, Perilla, Tencha, Lotus and Lavender have excellent active oxygen scavenging effects. .

(Test 2) Safety test (1) Primary skin irritation test Each of the plant extracts obtained in Production Examples 1 to 3 was added to purified water such that the dry solid concentration was about 0.5 W / V%. It was applied to the skin of a Japanese white rabbit (female, 3 per group, weighing about 2.3 kg) whose back was shaved. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 3) Safety test (2) Skin cumulative irritation test Similarly, each of the plant extracts obtained in Production Examples 1 to 3 was purified to a dry solid concentration of about 0.5 W / V%. Prepared in water,
0.5m on the skin of Hartley-type guinea pig (female, 3 per group, body weight around 320g) with shaved flank once a day, 5 times a week
l / animal were applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. The result, in all animals,
No erythema and edema were observed over a period of 2 weeks, and the sample was determined to be negative.

(Test 4) Safety test (3) Acute toxicity test Similarly, powders obtained by concentrating and drying each plant extract obtained in Production Examples 1 to 3 (dry solid content: about 1.0 W / V%) was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old), which had been fasted for 4 hours before the test, in an amount of 2,000 mg / kg.
The appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days,
In addition, there was no abnormality in the dissection result. Therefore, LD ₅₀ is 2,00
It was determined to be 0 mg / kg or more.

(Formulation examples) Production of active oxygen scavenger and skin care cosmetic composition According to the above evaluation results, the formulation examples are shown below. Each formulation example is produced by a conventional method in the production of each product. Good, only the amount was shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Aqueous extract 50% ethanol extract B: Yaku 50% ethanol extract C: Uwaurushi 50% ethanol extract D: Zicopi 50% ethanol extract E: Perilla 50% ethanol extract F: Tencha 50% ethanol extract G: Lotus 50% ethanol extract H: Lavender 50% ethanol extract * Any one of A to H 7.0 11. Appropriate amount of fragrance and preservative 12.Purified water 100 residue

(Formulation Example 2) Peel-off pack (% by weight) 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Akaminoki 50% ethanol extract 2.0 7. Dicopi 50 % Ethanol extract 2.0 8. Flavors, preservatives appropriate amount 9. Purified water 100 residue

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Uwaurushi 50% ethanol extract 1.5 7. Tensha 50% Fluorene glycol extract 1.5 8. Lotus 50% 1,3-butylene glycol extract 1.5 8. Appropriate perfume and preservative 9. Purified water 100

(Formulation Example 4) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Aminoki 50% ethanol extract 0.5 5. Yak 50% 1,3-butylene glycol extract Liquid 1.5 6. Pterodactyl extract 1.5 (Ethanol: 1,3-butylene glycol = 3: 1 extract) 7. Dicopi 70% ethanol extract 1.5 8. pH adjuster qs 9. Preservative qs 10. Purified water 100 Residue

(Formulation Example 5) Shampoo wt% 1. Triethanolamine lauryl sulfate 6.0 2. Sodium polyoxyethylene lauryl ether sulfate 15.0 3.1,3-butylene glycol 4.0 4. Lauric acid diethanolamide 2.0 5. Disodium edetate 0.1 6. Perilla 30% ethanol extract 2.0 7. Yak 50% ethanol extract 2.0 8. Lavender 50% 1,3-butylene glycol extract 2.0 9. Appropriate perfume, preservative 10. Purified water 100

(Formulation Example 6) Rinse weight% 1. Stearyltrimethylammonium chloride 3.0 2. Cetostearyl alcohol 3.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Yaku 50% ethanol extract 1.5 6. Uwaurushi 50 % Ethanol extract 1.5 7. pH adjuster qs 8. preservative qs 9. Purified water 100

(Formulation Example 7) Hair liquid weight% 1. Ethanol 30.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Tencha 70% ethanol extract 1.0 6. Lotus 50% ethanol extract 1.0 7. Lavender 30% ethanol extract 1.0 8. Preservative appropriate amount 9. Purified water 100 residue

(Formulation Example 8) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Akaminoki 50% ethanol extract 1.0 5. Yaku ethanol extract 1.0 6. Tencha 50% ethanol extract 1.0 7. Lotus 50% ethanol extract 1.0 8. Appropriate amount of flavor and preservative 9. Purified water 00

(Formulation Example 9) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Dicopi 70% ethanol extracted powder 5.0 5. Uyak hot water extracted powder 2.0 6. Lavender 50% ethanol extracted powder 2.0

(Formulation Example 10) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution containing a mixture of yak 50% ethanol extract / has 50% ethanol extract, antibiotics, anti-inflammation, etc., and attached to the wound. I do. Also, yak
The 50% ethanol extract and the lotus 50% ethanol extract may be directly applied locally and covered with gauze or the like.

(Test 5) Use effect test The effect of the skin care cosmetic composition of the present invention actually used was examined. Use test is for those who suffer from rough skin,
Or, for those who are suffering from shiny and unskinned skin, 30 to 50 years old, 10 each
The test was carried out by applying an appropriate amount of the emulsion of Formulation Example 1 to the face twice a day, in the morning and at night, after washing the face for three months. As a control, a preparation prepared by removing a plant extract of the present invention from the emulsion in the same manner was used. The evaluation was performed according to the following criteria.
And the numbers in the table represent the number of people. No one complained of skin abnormalities during the use period.

"Beautiful skin effect" Efficacy: Skin roughness or skin gloss / tension increased, and skin was improved. Slightly effective: rough skin or slightly increased gloss / tension and slightly improved skin. Ineffective: No change from before use.

[0101]

[Table 1]

(Test Results) As shown in Table 1, the plant extracts of the present invention, Akaminoki, Yaku, Uwaurushi, Zikoppi, Perilla, Tencha, Lotus, and Lavender, significantly improved the roughness of the skin. It was confirmed to give tension.

[0103]

EFFECT OF THE INVENTION The active oxygen scavenger or skin cosmetic composition containing at least one plant extract selected from the group consisting of Akaminoki, Yaku, Uwaurushi, Zikoppi, Perilla, Tencha, Lotus and Lavender is excellent in the present invention. It has an active oxygen elimination effect, can further improve rough skin, and can give the skin a gloss and firmness, and is safe for humans and animals. The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a view showing the active oxygen scavenging effect of each of the plant extracts of Amaranthus, Yaku, Uwaurushi, Jicoppi, Perilla, Tencha, Lotus and Lavender of the present invention.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 K W U 7/06 7/06 7/48 AED 7/48 AED 7/50 7/50

Claims (2)

[Claims] (1) a member selected from the group consisting of red arbor, eel yak, uwaurushi, jikkopi, perilla, tencha, lotus, and lavender
An active oxygen scavenger comprising at least one plant extract. 2. A cosmetic skin care composition comprising the active oxygen scavenger according to claim 1.