JPH11302257A5 - - Google Patents
Info
- Publication number
- JPH11302257A5 JPH11302257A5 JP1998297011A JP29701198A JPH11302257A5 JP H11302257 A5 JPH11302257 A5 JP H11302257A5 JP 1998297011 A JP1998297011 A JP 1998297011A JP 29701198 A JP29701198 A JP 29701198A JP H11302257 A5 JPH11302257 A5 JP H11302257A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- chlorine
- hydrogen
- alkoxy
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19746287:1 | 1997-10-20 | ||
| DE19746287A DE19746287A1 (de) | 1997-10-20 | 1997-10-20 | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005254578A Division JP4691419B2 (ja) | 1997-10-20 | 2005-09-02 | 置換イソキノリン−３−カルボキサミド、その製法および薬剤としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11302257A JPH11302257A (ja) | 1999-11-02 |
| JPH11302257A5 true JPH11302257A5 (2) | 2005-10-27 |
| JP3782591B2 JP3782591B2 (ja) | 2006-06-07 |
Family
ID=7846053
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29701198A Expired - Lifetime JP3782591B2 (ja) | 1997-10-20 | 1998-10-19 | 置換イソキノリン−３−カルボキサミド、その製法および薬剤としてのその使用 |
| JP2005254578A Expired - Lifetime JP4691419B2 (ja) | 1997-10-20 | 2005-09-02 | 置換イソキノリン−３−カルボキサミド、その製法および薬剤としてのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005254578A Expired - Lifetime JP4691419B2 (ja) | 1997-10-20 | 2005-09-02 | 置換イソキノリン−３−カルボキサミド、その製法および薬剤としてのその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6093730A (2) |
| EP (2) | EP0911340B1 (2) |
| JP (2) | JP3782591B2 (2) |
| KR (1) | KR100618922B1 (2) |
| CN (1) | CN1117079C (2) |
| AR (1) | AR013696A1 (2) |
| AT (2) | ATE432940T1 (2) |
| AU (1) | AU755714B2 (2) |
| BR (1) | BR9804504B1 (2) |
| CA (2) | CA2250664A1 (2) |
| CZ (1) | CZ337298A3 (2) |
| DE (3) | DE19746287A1 (2) |
| DK (2) | DK1538160T3 (2) |
| ES (2) | ES2245471T3 (2) |
| HU (1) | HUP9802422A3 (2) |
| ID (1) | ID21115A (2) |
| IL (1) | IL126638A0 (2) |
| NO (1) | NO312365B1 (2) |
| NZ (1) | NZ332363A (2) |
| PL (1) | PL192354B1 (2) |
| PT (1) | PT911340E (2) |
| SG (1) | SG87776A1 (2) |
| TR (1) | TR199802106A2 (2) |
| ZA (1) | ZA989505B (2) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001275014A1 (en) * | 2000-05-30 | 2001-12-11 | Neurogen Corporation | Imidazoloisoquinolines |
| US6762318B2 (en) * | 2001-12-03 | 2004-07-13 | Novo Nordisk A/S | Glucagon antagonists |
| CN102552263A (zh) * | 2001-12-06 | 2012-07-11 | 法布罗根股份有限公司 | 提高内源性红细胞生成素(epo)的方法 |
| US8318703B2 (en) | 2001-12-06 | 2012-11-27 | Fibrogen, Inc. | Methods for improving kidney function |
| EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| WO2005007192A2 (en) * | 2003-06-06 | 2005-01-27 | Fibrogen, Inc. | Cytoprotection through the use of hif hydroxylase inhibitors |
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| CA2528232C (en) | 2003-06-06 | 2010-05-25 | Fibrogen, Inc. | Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| US20060276477A1 (en) * | 2005-06-06 | 2006-12-07 | Fibrogen, Inc. | Treatment method for anemia |
| AU2006259352A1 (en) | 2005-06-15 | 2006-12-28 | Fibrogen, Inc. | Use of HIF 1alfa modulators for treatment of cancer |
| JP5202327B2 (ja) * | 2005-12-09 | 2013-06-05 | アムジエン・インコーポレーテツド | プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 |
| EP2476669A1 (en) | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
| US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
| WO2007101204A1 (en) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Method of treating glaucoma |
| WO2007114612A1 (en) * | 2006-03-30 | 2007-10-11 | Lg Electronics Inc. | A method and apparatus for decoding/encoding a video signal |
| CN103497184A (zh) | 2006-04-04 | 2014-01-08 | 菲布罗根有限公司 | 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物 |
| BRPI0713350B1 (pt) | 2006-06-26 | 2022-04-12 | Akebia Therapeutics Inc | Composto, e, composição |
| EP2111399A2 (en) | 2006-12-18 | 2009-10-28 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| US8048892B2 (en) | 2006-12-18 | 2011-11-01 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| EP2142509B1 (en) | 2007-04-18 | 2013-12-04 | Amgen, Inc | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| EP2155680B1 (en) | 2007-04-18 | 2013-12-04 | Amgen, Inc | Indanone derivatives that inhibit prolyl hydroxylase |
| US8097620B2 (en) | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| ES2389063T3 (es) | 2007-05-04 | 2012-10-22 | Amgen, Inc | Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa |
| US8962530B2 (en) * | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| CN101497584B (zh) * | 2008-01-29 | 2010-12-22 | 首都医科大学 | 异喹啉-3-甲酰氨基酸苄酯及其制备和应用 |
| EP2294066B9 (en) | 2008-04-28 | 2015-03-11 | Janssen Pharmaceutica, N.V. | Benzoimidazoles as prolyl hydroxylase inhibitors |
| WO2010056767A1 (en) | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
| SI2455381T1 (sl) * | 2009-07-17 | 2014-08-29 | Japan Tobacco Inc. | Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina |
| NO2686520T3 (2) | 2011-06-06 | 2018-03-17 | ||
| US9206134B2 (en) * | 2011-07-22 | 2015-12-08 | Beijing Betta Pharmaceuticals Co. Ltd. | Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof |
| US9273034B2 (en) | 2011-10-25 | 2016-03-01 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
| AU2013229922B2 (en) | 2012-03-09 | 2017-09-28 | Kyntra Bio, Inc. | 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| KR20210130849A (ko) | 2012-07-16 | 2021-11-01 | 피브로겐, 인크. | 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 |
| EP2872487B1 (en) | 2012-07-16 | 2017-04-26 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| US9822135B2 (en) | 2012-10-30 | 2017-11-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | STAT3 dimerization inhibitors |
| CA2899024C (en) | 2013-01-24 | 2022-01-04 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| KR20210104173A (ko) | 2013-06-06 | 2021-08-24 | 피브로겐, 인크. | Hif 하이드록실라제 억제자의 약학적 제형 |
| SG10201910773VA (en) | 2013-06-13 | 2020-01-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
| SMT202000516T1 (it) | 2014-05-15 | 2020-11-10 | Insmed Inc | Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari |
| AU2016209126A1 (en) | 2015-01-23 | 2017-08-10 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| US11324734B2 (en) | 2015-04-01 | 2022-05-10 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| US20180243271A1 (en) * | 2015-05-28 | 2018-08-30 | Japan Tobacco Inc. | Method for Treating or Preventing Diabetic Nephropathy |
| EP3319976B1 (en) * | 2015-07-09 | 2021-09-01 | Insmed Incorporated | Compositions and methods for treating lung diseases and lung injury |
| AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| AR108325A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| CN111819190A (zh) * | 2018-01-09 | 2020-10-23 | 康奈尔大学 | 器官纤维化的预防和治疗 |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| WO2019213398A1 (en) | 2018-05-02 | 2019-11-07 | Insmed Incorporated | Methods for the manufacture of liposomal drug formulations |
| EP3790863A1 (en) | 2018-05-09 | 2021-03-17 | Akebia Therapeutics Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| EP3829623A4 (en) * | 2018-08-03 | 2022-10-19 | Cornell University | METHODS OF REDUCING ABNORMAL SCAR FORMATION |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| CN112979541B (zh) * | 2019-12-17 | 2022-11-11 | 浙江大学 | 一种基于n-(3-羟基吡啶-2-羰基)甘氨酸的抗肿瘤药物增敏剂及其应用 |
| CN116120340B (zh) * | 2021-11-15 | 2023-10-31 | 艾立康药业股份有限公司 | 一种吡啶并噁嗪类化合物及其制备方法、组合物和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| EP0548883A1 (de) * | 1991-12-24 | 1993-06-30 | Hoechst Aktiengesellschaft | Substituierte Pyridin-N-oxide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
| DE4233124A1 (de) * | 1992-10-02 | 1994-04-07 | Hoechst Ag | Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ES2101420T3 (es) * | 1993-11-02 | 1997-07-01 | Hoechst Ag | Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos. |
| EP0650961B1 (de) * | 1993-11-02 | 1997-03-05 | Hoechst Aktiengesellschaft | Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| NZ270267A (en) * | 1993-12-30 | 1997-03-24 | Hoechst Ag | 3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions |
| SE9400810D0 (sv) * | 1994-03-10 | 1994-03-10 | Pharmacia Ab | New use of Quinoline-3-carboxamide compounds |
| IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
-
1997
- 1997-10-20 DE DE19746287A patent/DE19746287A1/de not_active Withdrawn
-
1998
- 1998-10-16 NZ NZ332363A patent/NZ332363A/xx unknown
- 1998-10-16 EP EP98119591A patent/EP0911340B1/de not_active Expired - Lifetime
- 1998-10-16 AT AT05004047T patent/ATE432940T1/de active
- 1998-10-16 ID IDP981374A patent/ID21115A/id unknown
- 1998-10-16 PT PT98119591T patent/PT911340E/pt unknown
- 1998-10-16 ES ES98119591T patent/ES2245471T3/es not_active Expired - Lifetime
- 1998-10-16 DK DK05004047T patent/DK1538160T3/da active
- 1998-10-16 DE DE59814365T patent/DE59814365D1/de not_active Expired - Lifetime
- 1998-10-16 ES ES05004047T patent/ES2328156T3/es not_active Expired - Lifetime
- 1998-10-16 AT AT98119591T patent/ATE299148T1/de active
- 1998-10-16 DK DK98119591T patent/DK0911340T3/da active
- 1998-10-16 EP EP05004047A patent/EP1538160B1/de not_active Expired - Lifetime
- 1998-10-16 AR ARP980105164A patent/AR013696A1/es unknown
- 1998-10-16 DE DE59812907T patent/DE59812907D1/de not_active Expired - Lifetime
- 1998-10-18 IL IL12663898A patent/IL126638A0/xx unknown
- 1998-10-19 CA CA002250664A patent/CA2250664A1/en not_active Abandoned
- 1998-10-19 ZA ZA989505A patent/ZA989505B/xx unknown
- 1998-10-19 KR KR1019980043578A patent/KR100618922B1/ko not_active Expired - Lifetime
- 1998-10-19 JP JP29701198A patent/JP3782591B2/ja not_active Expired - Lifetime
- 1998-10-19 CZ CZ983372A patent/CZ337298A3/cs unknown
- 1998-10-19 BR BRPI9804504-0A patent/BR9804504B1/pt not_active IP Right Cessation
- 1998-10-19 AU AU89413/98A patent/AU755714B2/en not_active Expired
- 1998-10-19 TR TR1998/02106A patent/TR199802106A2/xx unknown
- 1998-10-19 US US09/174,558 patent/US6093730A/en not_active Expired - Lifetime
- 1998-10-19 HU HU9802422A patent/HUP9802422A3/hu unknown
- 1998-10-19 NO NO19984877A patent/NO312365B1/no not_active IP Right Cessation
- 1998-10-20 SG SG9804225A patent/SG87776A1/en unknown
- 1998-10-20 PL PL329274A patent/PL192354B1/pl unknown
- 1998-10-20 CA CA2251647A patent/CA2251647C/en not_active Expired - Lifetime
- 1998-10-20 CN CN98121000A patent/CN1117079C/zh not_active Expired - Lifetime
-
2005
- 2005-09-02 JP JP2005254578A patent/JP4691419B2/ja not_active Expired - Lifetime
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