JPH11500330A - 抗菌性医療装置及び方法 - Google Patents

抗菌性医療装置及び方法

Info

Publication number: JPH11500330A
Authority: JP; Japan
Prior art keywords: triclosan; medical device; polymeric material; polyurethane; weight
Prior art date: 1995-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP8522425A

Other languages

English (en)

Japanese (ja)

Inventor

スティーヴンディーパチェッティー

エメットエルボンド

リサビージュンゲアー

Original Assignee

ヴィタフォアコーポレイション

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-18

Filing date

1996-01-18

Publication date

1999-01-12

1996-01-18 Application filed by ヴィタフォアコーポレイション filed Critical ヴィタフォアコーポレイション

1999-01-12 Publication of JPH11500330A publication Critical patent/JPH11500330A/ja

Status Pending legal-status Critical Current

Links

230000000845 anti-microbial effect Effects 0.000 title claims abstract description 13
238000000034 method Methods 0.000 title claims description 18
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 81
229960003500 triclosan Drugs 0.000 claims abstract description 80
239000004599 antimicrobial Substances 0.000 claims abstract description 33
229920002635 polyurethane Polymers 0.000 claims abstract description 30
239000004814 polyurethane Substances 0.000 claims abstract description 30
239000004014 plasticizer Substances 0.000 claims abstract description 11
229940123208 Biguanide Drugs 0.000 claims abstract description 4
229940100890 silver compound Drugs 0.000 claims abstract description 4
150000003379 silver compounds Chemical class 0.000 claims abstract description 4
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims abstract 2
239000000463 material Substances 0.000 claims description 30
244000005700 microbiome Species 0.000 claims description 12
239000002861 polymer material Substances 0.000 claims description 8
229920005989 resin Polymers 0.000 claims description 8
239000011347 resin Substances 0.000 claims description 8
229920000570 polyether Polymers 0.000 claims description 7
239000004721 Polyphenylene oxide Substances 0.000 claims description 6
238000005192 partition Methods 0.000 claims description 6
238000002156 mixing Methods 0.000 claims description 5
125000001931 aliphatic group Chemical group 0.000 claims description 4
230000002401 inhibitory effect Effects 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
230000000813 microbial effect Effects 0.000 claims description 4
238000012546 transfer Methods 0.000 claims description 4
230000012010 growth Effects 0.000 claims description 2
210000001124 body fluid Anatomy 0.000 claims 2
229920005749 polyurethane resin Polymers 0.000 claims 1
239000000758 substrate Substances 0.000 claims 1
238000013270 controlled release Methods 0.000 abstract description 2
239000003814 drug Substances 0.000 description 23
229940079593 drug Drugs 0.000 description 22
208000015181 infectious disease Diseases 0.000 description 19
229920000642 polymer Polymers 0.000 description 18
238000012360 testing method Methods 0.000 description 14
238000001125 extrusion Methods 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
DSUFPYCILZXJFF-UHFFFAOYSA-N 4-[[4-[[4-(pentoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamoyloxy]butyl n-[4-[[4-(butoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamate Chemical compound C1CC(NC(=O)OCCCCC)CCC1CC1CCC(NC(=O)OCCCCOC(=O)NC2CCC(CC3CCC(CC3)NC(=O)OCCCC)CC2)CC1 DSUFPYCILZXJFF-UHFFFAOYSA-N 0.000 description 7
230000008961 swelling Effects 0.000 description 7
238000011068 loading method Methods 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000008188 pellet Substances 0.000 description 6
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 5
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 5
229960003260 chlorhexidine Drugs 0.000 description 5
238000000576 coating method Methods 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000012377 drug delivery Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000007943 implant Substances 0.000 description 4
238000002513 implantation Methods 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
241000894006 Bacteria Species 0.000 description 3
206010040047 Sepsis Diseases 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
230000005923 long-lasting effect Effects 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
230000000704 physical effect Effects 0.000 description 3
238000012545 processing Methods 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
239000000126 substance Substances 0.000 description 3
JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
229910021612 Silver iodide Inorganic materials 0.000 description 2
241000295644 Staphylococcaceae Species 0.000 description 2
239000000654 additive Substances 0.000 description 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
230000008901 benefit Effects 0.000 description 2
150000004283 biguanides Chemical class 0.000 description 2
239000006161 blood agar Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000013329 compounding Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
210000003743 erythrocyte Anatomy 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
230000007774 longterm Effects 0.000 description 2
230000006510 metastatic growth Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
244000045947 parasite Species 0.000 description 2
238000005191 phase separation Methods 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
239000004332 silver Substances 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
229940045105 silver iodide Drugs 0.000 description 2
NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
229920001169 thermoplastic Polymers 0.000 description 2
229920002803 thermoplastic polyurethane Polymers 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
230000002792 vascular Effects 0.000 description 2
ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
206010059866 Drug resistance Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
241000283977 Oryctolagus Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000004433 Thermoplastic polyurethane Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
230000010065 bacterial adhesion Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000006482 condensation reaction Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000009513 drug distribution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
OYQYHJRSHHYEIG-UHFFFAOYSA-N ethyl carbamate;urea Chemical compound NC(N)=O.CCOC(N)=O OYQYHJRSHHYEIG-UHFFFAOYSA-N 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000009477 glass transition Effects 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
238000001631 haemodialysis Methods 0.000 description 1
239000012760 heat stabilizer Substances 0.000 description 1
230000000322 hemodialysis Effects 0.000 description 1
230000000004 hemodynamic effect Effects 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000009545 invasion Effects 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000002932 luster Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
230000037311 normal skin Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
235000016236 parenteral nutrition Nutrition 0.000 description 1
238000005453 pelletization Methods 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920001228 polyisocyanate Polymers 0.000 description 1
239000005056 polyisocyanate Substances 0.000 description 1
239000002952 polymeric resin Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000009738 saturating Methods 0.000 description 1
CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 description 1
229940071536 silver acetate Drugs 0.000 description 1
LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
229910001958 silver carbonate Inorganic materials 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 description 1
CLDWGXZGFUNWKB-UHFFFAOYSA-M silver;benzoate Chemical compound [Ag+].[O-]C(=O)C1=CC=CC=C1 CLDWGXZGFUNWKB-UHFFFAOYSA-M 0.000 description 1
MNMYRUHURLPFQW-UHFFFAOYSA-M silver;dodecanoate Chemical compound [Ag+].CCCCCCCCCCCC([O-])=O MNMYRUHURLPFQW-UHFFFAOYSA-M 0.000 description 1
LTYHQUJGIQUHMS-UHFFFAOYSA-M silver;hexadecanoate Chemical compound [Ag+].CCCCCCCCCCCCCCCC([O-])=O LTYHQUJGIQUHMS-UHFFFAOYSA-M 0.000 description 1
239000000344 soap Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Surgery (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Materials For Medical Uses (AREA)

JP8522425A 1995-01-18 1996-01-18 抗菌性医療装置及び方法 Pending JPH11500330A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37429095A	1995-01-18	1995-01-18
US08/374,290		1995-01-18
PCT/US1996/000842 WO1996022114A1 (fr)	1995-01-18	1996-01-18	Instrument medical antimicrobien et procede associe

Publications (1)

Publication Number	Publication Date
JPH11500330A true JPH11500330A (ja)	1999-01-12

Family

ID=23476119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8522425A Pending JPH11500330A (ja)	1995-01-18	1996-01-18	抗菌性医療装置及び方法

Country Status (5)

Country	Link
EP (1)	EP0804256A1 (fr)
JP (1)	JPH11500330A (fr)
AU (1)	AU4763696A (fr)
CA (1)	CA2210119A1 (fr)
WO (1)	WO1996022114A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7993390B2 (en)	2002-02-08	2011-08-09	Boston Scientific Scimed, Inc.	Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8105520B2 (en)	2002-02-08	2012-01-31	Boston Scientific Scimed, Inc,	Implantable or insertable medical device resistant to microbial growth and biofilm formation
US9597067B2 (en)	2002-10-04	2017-03-21	Ethicon, Inc.	Packaged antimicrobial medical device and method of preparing same
US10245025B2 (en)	2012-04-06	2019-04-02	Ethicon, Inc.	Packaged antimicrobial medical device having improved shelf life and method of preparing same

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5772640A (en) *	1996-01-05	1998-06-30	The Trustees Of Columbia University Of The City Of New York	Triclosan-containing medical devices
AUPN596595A0 (en) *	1995-10-13	1995-11-09	Priscott, Paul Kenneth	Improvements in polymeric materials for use in medical applications
AU712132B2 (en) *	1995-10-13	1999-10-28	Paul Kenneth Priscott	Improvements in implantable medical devices
DE19812160C1 (de) *	1998-03-20	1999-07-08	Bayer Ag	Formkörper aus wirkstoffhaltigen thermoplastischen Polyurethanen
GB9810565D0 (en) *	1998-05-18	1998-07-15	Valpar Ind Ltd	Antimicrobial Plastic tubing
US6238575B1 (en) *	1998-07-29	2001-05-29	Microban Products Company	Antimicrobial treatment of enclosed systems having continuous or intermittent fluid flow
WO2000028814A1 (fr) *	1998-11-12	2000-05-25	Bayer Aktiengesellschaft	Amides de polyether sequence contenant des substances actives
DE19852192C2 (de) *	1998-11-12	2003-04-24	Bayer Ag	Wirkstoffhaltige aromatische Copolyester
JP2002535090A (ja) *	1999-01-28	2002-10-22	ユニオン・カーバイド・ケミカルズ・アンド・プラスティックス・テクノロジー・コーポレイション	潤滑性医療装置
US6224579B1 (en) *	1999-03-31	2001-05-01	The Trustees Of Columbia University In The City Of New York	Triclosan and silver compound containing medical devices
ATE328479T1 (de) *	2000-09-21	2006-06-15	Ciba Sc Holding Ag	Mischungen aus phenolischen und anorganischen materialien, die antimikrobielle aktivität zeigen
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1996
- 1996-01-18 AU AU47636/96A patent/AU4763696A/en not_active Abandoned
- 1996-01-18 JP JP8522425A patent/JPH11500330A/ja active Pending
- 1996-01-18 CA CA 2210119 patent/CA2210119A1/fr not_active Abandoned
- 1996-01-18 EP EP96903614A patent/EP0804256A1/fr not_active Withdrawn
- 1996-01-18 WO PCT/US1996/000842 patent/WO1996022114A1/fr not_active Ceased

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US10245025B2 (en)	2012-04-06	2019-04-02	Ethicon, Inc.	Packaged antimicrobial medical device having improved shelf life and method of preparing same
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Also Published As

Publication number	Publication date
WO1996022114A1 (fr)	1996-07-25
AU4763696A (en)	1996-08-07
CA2210119A1 (fr)	1996-07-25
EP0804256A1 (fr)	1997-11-05

Publication	Publication Date	Title
JPH11500330A (ja)	1999-01-12	抗菌性医療装置及び方法
WO1996022114A9 (fr)	1996-10-03	Instrument medical antimicrobien et procede associe
EP0379269B1 (fr)	1994-03-30	Articles médicaux anti-infectieux et lubrifiés et leur procédé de préparation
US5013306A (en)	1991-05-07	Anti-infective and antithrombogenic medical articles and method for their preparation
US5707366A (en)	1998-01-13	Anti-infective and antithrombogenic medical articles and method for their preparation
US6843784B2 (en)	2005-01-18	Triclosan and silver compound containing medical devices
US4925668A (en)	1990-05-15	Anti-infective and lubricious medical articles and method for their preparation
Jansen et al.	1992	In-vitro efficacy of a central venous catheter (‘Hydrocath’) loaded with teicoplanin to prevent bacterial colonization
EP1343547B1 (fr)	2009-04-15	Dispositifs medicaux antimicrobiens
CN101801449B (zh)	2013-09-18	具有无菌屏障的福利导尿管
US7597903B2 (en)	2009-10-06	Method and composition for producing catheters with antibacterial property
CN107921283A (zh)	2018-04-17	包括阿来西定的伤口护理产品
JP5021704B2 (ja)	2012-09-12	生体適合性ポリマー
Schierholz et al.	1997	Development of a new CSF-shunt with sustained release of an antimicrobial broad-spectrum combination
Schierholz et al.	1998	Investigation of a rifampin, fusidic-acid and mupirocin releasing silicone catheter
Li et al.	1999	In vitro antimicrobial activity of a new antiseptic central venous catheter
US8821906B2 (en)	2014-09-02	Biocompatible polymer
WO2025006879A1 (fr)	2025-01-02	Agents pharmaceutiques actifs composés dans des compositions polymères thermoplastiques et procédés de fabrication
KR20260030828A (ko)	2026-03-06	열가소성 중합체 조성물 중의 배합 활성 약제학적 제제 및 제조 방법
Szycher	2015	Polyurethanes: Antimicrobial
Szycher	2012	-Antimicrobial Polyurethanes