JPH11507016A - 貯蔵安定性ヘモグロビン溶液 - Google Patents

貯蔵安定性ヘモグロビン溶液

Info

Publication number
JPH11507016A
JPH11507016A JP8533458A JP53345896A JPH11507016A JP H11507016 A JPH11507016 A JP H11507016A JP 8533458 A JP8533458 A JP 8533458A JP 53345896 A JP53345896 A JP 53345896A JP H11507016 A JPH11507016 A JP H11507016A
Authority
JP
Japan
Prior art keywords
hemoglobin
composition
solution
storage
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8533458A
Other languages
English (en)
Japanese (ja)
Inventor
エイ． カーウィン，ブルース
エル． ルッカー，ダグラス
Original Assignee
ソマトジェン，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ソマトジェン，インコーポレイテッド filed Critical ソマトジェン，インコーポレイテッド
Publication of JPH11507016A publication Critical patent/JPH11507016A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP8533458A 1995-05-02 1996-05-01 貯蔵安定性ヘモグロビン溶液 Pending JPH11507016A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/433,896 1995-05-02
US08/433,896 US5929031A (en) 1995-05-02 1995-05-02 Storage stable hemoglobin solutions
PCT/US1996/006080 WO1996034889A1 (en) 1995-05-02 1996-05-01 Storage stable hemoglobin solutions

Publications (1)

Publication Number Publication Date
JPH11507016A true JPH11507016A (ja) 1999-06-22

Family

ID=23721974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8533458A Pending JPH11507016A (ja) 1995-05-02 1996-05-01 貯蔵安定性ヘモグロビン溶液

Country Status (7)

Country Link
US (1) US5929031A (de)
EP (1) EP0826004B1 (de)
JP (1) JPH11507016A (de)
AT (1) ATE203546T1 (de)
CA (1) CA2216382A1 (de)
DE (1) DE69614105T2 (de)
WO (1) WO1996034889A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964798B2 (en) 1993-11-16 2005-11-15 Baxter International Inc. Multi-layered polymer based thin film structure for medical grade products
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6018035A (en) * 1997-07-21 2000-01-25 Baxter International Inc. Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
US5981710A (en) * 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
US6204254B1 (en) 1997-09-12 2001-03-20 Baxter International, Inc. Biocompatible surfaces and a method for their preparation
KR100674690B1 (ko) * 1999-07-01 2007-01-25 시스멕스 가부시키가이샤 헤모글로빈 안정화수단
JP3466516B2 (ja) * 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6949384B2 (en) * 2001-12-21 2005-09-27 Spectromedical Inc. Method for monitoring degradation of Hb-based blood substitutes
US7449339B2 (en) * 1999-11-23 2008-11-11 Nir Diagnostics Inc. Spectroscopic method and apparatus for total hemoglobin measurement
FR2809624B1 (fr) * 2000-05-31 2002-08-02 Centre Nat Rech Scient Utilisation comme substitut sanguin d'une hemoglobine extracellulaire de poids moleculaire eleve
US6974447B2 (en) * 2001-04-17 2005-12-13 Baxter International Inc. High gas barrier receptacle and closure assembly
JP2004538264A (ja) 2001-04-18 2004-12-24 ノースフィールド ラボラトリーズ 安定化ヘモグロビン溶液の保管のための可撓性容器システム
EP1471821B1 (de) * 2002-01-15 2013-06-26 Board Of Regents, The University Of Texas System Zusammensetzungen zur reduzierung von lichtstreuung während therapeutischen und diagnostischen bilddarstellungsverfahren
DE60335608D1 (de) * 2002-02-27 2011-02-17 Pharmain Corp Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
CN1703233A (zh) * 2002-07-12 2005-11-30 米德列斯公司 防止蛋白氧化降解的方法和组合物
US7223604B1 (en) * 2002-09-27 2007-05-29 Science & Technology Corporation @ Unm Methods and kits for the detection of erythrocytes
US7135553B2 (en) * 2003-01-29 2006-11-14 Northfield Laboratories, Inc. Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
WO2005112977A2 (en) * 2004-04-23 2005-12-01 Pharmain, Ltd. Compositions for treatment with glucagon-like peptide, and methods of making and using the same
MXPA06011837A (es) 2004-04-27 2007-01-16 Baxter Int Sistema de reactor de tanque agitado.
JP2006164312A (ja) * 2004-12-02 2006-06-22 Hitachi Ltd 半導体装置およびそれを用いた磁気記録再生装置
WO2006096774A2 (en) * 2005-03-07 2006-09-14 Sangart, Inc. Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers
US20070196810A1 (en) * 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
JP2008195656A (ja) * 2007-02-14 2008-08-28 Nipro Corp 人工酸素運搬体製剤
US8609815B2 (en) 2010-09-02 2013-12-17 Sangart, Inc. Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
US9199026B2 (en) * 2011-01-07 2015-12-01 Somerset Group Enterprises, Inc. Modular extracorporeal systems and methods for treating blood-borne diseases
CA2897426A1 (en) 2012-01-09 2013-07-18 Somerset Group Enterprises, Inc. Modular extracorporeal systems and methods for treating blood-borne diseases
US9763889B2 (en) * 2015-06-29 2017-09-19 Billion King International Ltd. Oral delivery system for hemoglobin based oxygen carriers
US10052290B2 (en) * 2016-02-04 2018-08-21 Billion King International Ltd. Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers
WO2021204948A1 (en) * 2020-04-09 2021-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions to determine the quality of red blood cell units

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4727027A (en) * 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
CA2067371C (en) * 1990-08-06 1999-05-25 Richard L. Kandler Stable hemoglobin based composition and method to store same
US5352773A (en) * 1990-08-06 1994-10-04 Baxter International Inc. Stable hemoglobin based composition and method to store same
WO1992008478A1 (en) * 1990-11-20 1992-05-29 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
SE9301581D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation

Also Published As

Publication number Publication date
DE69614105T2 (de) 2002-03-21
WO1996034889A1 (en) 1996-11-07
CA2216382A1 (en) 1996-11-07
AU708264B2 (en) 1999-07-29
EP0826004B1 (de) 2001-07-25
DE69614105D1 (de) 2001-08-30
US5929031A (en) 1999-07-27
EP0826004A1 (de) 1998-03-04
AU5852096A (en) 1996-11-21
ATE203546T1 (de) 2001-08-15

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JPH11507016A (ja) 貯蔵安定性ヘモグロビン溶液
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