JPH11507272A - 薬物粉末の静電堆積 - Google Patents

薬物粉末の静電堆積

Info

Publication number: JPH11507272A
Authority: JP; Japan
Prior art keywords: substrate; drug; charge; powder; emitter
Prior art date: 1995-06-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

JP9502067A

Other languages

English (en)

Japanese (ja)

Other versions

JPH11507272A5 (2

Inventor

プレチェア，ティモスィー，アレン

ダッタ，パビトラ

ポウクス，クリストファー，ジャスト

コイ，ランドール，ユージーンマク

Original Assignee

サーノフコーポレイション

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-06

Publication date

1999-06-29

1996-06-06 Application filed by サーノフコーポレイション filed Critical サーノフコーポレイション

1999-06-29 Publication of JPH11507272A publication Critical patent/JPH11507272A/ja

2004-09-02 Publication of JPH11507272A5 publication Critical patent/JPH11507272A5/ja

Status Ceased legal-status Critical Current

Links

239000003814 drug Substances 0.000 title claims abstract description 230
229940079593 drug Drugs 0.000 title claims abstract description 230
239000000843 powder Substances 0.000 title claims abstract description 68
238000004924 electrostatic deposition Methods 0.000 title claims description 13
239000000758 substrate Substances 0.000 claims abstract description 244
238000000034 method Methods 0.000 claims abstract description 53
238000000151 deposition Methods 0.000 claims abstract description 44
239000002245 particle Substances 0.000 claims abstract description 44
239000002775 capsule Substances 0.000 claims abstract description 13
239000000829 suppository Substances 0.000 claims abstract description 9
238000004519 manufacturing process Methods 0.000 claims abstract description 5
239000003826 tablet Substances 0.000 claims description 33
239000000463 material Substances 0.000 claims description 20
239000003989 dielectric material Substances 0.000 claims description 12
239000011324 bead Substances 0.000 claims description 11
230000000694 effects Effects 0.000 claims description 7
239000011159 matrix material Substances 0.000 claims description 4
238000007599 discharging Methods 0.000 claims description 3
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238000003860 storage Methods 0.000 abstract description 4
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
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239000002184 metal Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229960002744 mometasone furoate Drugs 0.000 description 2
WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 2
238000000879 optical micrograph Methods 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
239000006215 rectal suppository Substances 0.000 description 2
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239000000126 substance Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
239000006216 vaginal suppository Substances 0.000 description 2
BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
229920006370 Kynar Polymers 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
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229920000881 Modified starch Polymers 0.000 description 1
239000004368 Modified starch Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229910052770 Uranium Inorganic materials 0.000 description 1
238000005411 Van der Waals force Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
239000002131 composite material Substances 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
230000000875 corresponding effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
230000005684 electric field Effects 0.000 description 1
238000010894 electron beam technology Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000007373 indentation Methods 0.000 description 1
230000003434 inspiratory effect Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000002523 lectin Substances 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000011326 mechanical measurement Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
230000010355 oscillation Effects 0.000 description 1
239000003973 paint Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
238000007747 plating Methods 0.000 description 1
229920000307 polymer substrate Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
239000002759 woven fabric Substances 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A61M15/025—Bubble jet droplet ejection devices
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B05B5/047—Discharge apparatus, e.g. electrostatic spray guns using tribo-charging
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
- G03G15/00—Apparatus for electrographic processes using a charge pattern
- G03G15/04—Apparatus for electrographic processes using a charge pattern for exposing, i.e. imagewise exposure by optically projecting the original image on a photoconductive recording material
- G03G15/04036—Details of illuminating systems, e.g. lamps, reflectors
- G03G15/04045—Details of illuminating systems, e.g. lamps, reflectors for exposing image information provided otherwise than by directly projecting the original image onto the photoconductive recording material, e.g. digital copiers
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
- G03G15/00—Apparatus for electrographic processes using a charge pattern
- G03G15/22—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20
- G03G15/221—Machines other than electrographic copiers, e.g. electrophotographic cameras, electrostatic typewriters
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
- G03G15/00—Apparatus for electrographic processes using a charge pattern
- G03G15/22—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20
- G03G15/32—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head
- G03G15/321—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head by charge transfer onto the recording material in accordance with the image
- G03G15/323—Apparatus for electrographic processes using a charge pattern involving the combination of more than one step according to groups G03G13/02 - G03G13/20 in which the charge pattern is formed dotwise, e.g. by a thermal head by charge transfer onto the recording material in accordance with the image by modulating charged particles through holes or a slit
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Electrostatic Spraying Apparatus (AREA)

JP9502067A 1995-06-06 1996-06-06 薬物粉末の静電堆積 Ceased JPH11507272A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/471,889 US5714007A (en)	1995-06-06	1995-06-06	Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US08/471,889		1995-06-06
PCT/US1996/009882 WO1996039257A1 (en)	1995-06-06	1996-06-06	Electrostatically depositing a medicament powder

Publications (2)

Publication Number	Publication Date
JPH11507272A true JPH11507272A (ja)	1999-06-29
JPH11507272A5 JPH11507272A5 (2)	2004-09-02

Family

ID=23873389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9502067A Ceased JPH11507272A (ja)	1995-06-06	1996-06-06	薬物粉末の静電堆積

Country Status (7)

Country	Link
US (5)	US5714007A (2)
EP (1)	EP0828564A4 (2)
JP (1)	JPH11507272A (2)
KR (1)	KR19990022213A (2)
AU (1)	AU711460B2 (2)
CA (1)	CA2223251A1 (2)
WO (1)	WO1996039257A1 (2)

Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7008668B2 (en) *	1995-05-09	2006-03-07	Phoqus Pharmaceuticals Limited	Powder coating composition for electrostatic coating of pharmaceutical substrates
TR199701323T1 (xx) *	1995-05-09	1998-02-21	Colorcon Limited	Farmas�tik alttabakalar�n elektrostatik olarak kaplanmas� i�in toz kaplama kompozisyonu.
US5714007A (en)	1995-06-06	1998-02-03	David Sarnoff Research Center, Inc.	Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US6399143B1 (en)	1996-04-09	2002-06-04	Delsys Pharmaceutical Corporation	Method for clamping and electrostatically coating a substrate
GB9623634D0 (en) *	1996-11-13	1997-01-08	Bpsi Holdings Inc	Method and apparatus for the coating of substrates for pharmaceutical use
US6433154B1 (en)	1997-06-12	2002-08-13	Bristol-Myers Squibb Company	Functional receptor/kinase chimera in yeast cells
US6045753A (en) *	1997-07-29	2000-04-04	Sarnoff Corporation	Deposited reagents for chemical processes
US6004752A (en) *	1997-07-29	1999-12-21	Sarnoff Corporation	Solid support with attached molecules
FR2768123B1 (fr) *	1997-09-09	1999-11-26	Soc Generale Pour Les Techniques Nouvelles Sgn	Procede et dispositif de conditionnement de produits, tel des poudres, notamment magnetiques
IL138194A0 (en)	1998-03-04	2001-10-31	Delsys Pharmaceutical Corp	Medicament dry powder inhaler dispensing device
US6149774A (en)	1998-06-10	2000-11-21	Delsys Pharmaceutical Corporation	AC waveforms biasing for bead manipulating chucks
CN1312709A (zh)	1998-06-10	2001-09-12	德尔西斯药品公司	药用制品及其制备方法和装置
US6287595B1 (en)	1998-06-10	2001-09-11	Delsys Pharmaceuticals Corporation	Biomedical assay device
US6063194A (en)	1998-06-10	2000-05-16	Delsys Pharmaceutical Corporation	Dry powder deposition apparatus
US6142146A (en) *	1998-06-12	2000-11-07	Microdose Technologies, Inc.	Inhalation device
US6152130A (en) *	1998-06-12	2000-11-28	Microdose Technologies, Inc.	Inhalation device with acoustic control
DK1083952T3 (da) *	1998-06-12	2006-04-24	Microdose Technologies Inc	Apparat til uddeling af medicinalvarer og medikamenter
GB9814368D0 (en) *	1998-07-02	1998-09-02	Reckitt & Colmann Prod Ltd	Inhalation of aerosol actives
DE19830650C1 (de) *	1998-07-09	1999-08-12	Lohmann Therapie Syst Lts	Trockenkopierprozeß zur Herstellung flächiger, einzeldosierter Wirkstoffzubereitungen
US6652903B2 (en)	1998-07-09	2003-11-25	Lts Lohmann Therapie-Systeme Ag	Dry-copying method for producing flat, individually dosed preparations of active agents
SE512386C2 (sv) *	1998-07-30	2000-03-06	Microdrug Ag	Förfarande och anordning för klassificering av elektrostatiskt laddat pulverformigt material
JP2002525308A (ja)	1998-09-25	2002-08-13	デルシスファーマシューティカルコーポレイション	経口投与のための液状薬剤
US6378518B1 (en)	1998-10-30	2002-04-30	Richard George Miekka	Method for producing uniform small doses of finely divided substances
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CA2147260C (en) *	1992-10-19	1999-04-13	Mark Bernard Mecikalski	Dry powder inhaler
SE9203743D0 (sv) *	1992-12-11	1992-12-11	Astra Ab	Efficient use
US5437271A (en) *	1993-04-06	1995-08-01	Minnesota Mining And Manufacturing Company	Deagglomerators for dry powder inhalers
TW402506B (en) *	1993-06-24	2000-08-21	Astra Ab	Therapeutic preparation for inhalation
TR199701323T1 (xx) *	1995-05-09	1998-02-21	Colorcon Limited	Farmas�tik alttabakalar�n elektrostatik olarak kaplanmas� i�in toz kaplama kompozisyonu.
US5714007A (en)	1995-06-06	1998-02-03	David Sarnoff Research Center, Inc.	Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate

1995
- 1995-06-06 US US08/471,889 patent/US5714007A/en not_active Expired - Lifetime
1996
- 1996-06-06 US US08/659,501 patent/US6007630A/en not_active Expired - Fee Related
- 1996-06-06 AU AU63825/96A patent/AU711460B2/en not_active Ceased
- 1996-06-06 WO PCT/US1996/009882 patent/WO1996039257A1/en not_active Ceased
- 1996-06-06 KR KR1019970708692A patent/KR19990022213A/ko not_active Ceased
- 1996-06-06 JP JP9502067A patent/JPH11507272A/ja not_active Ceased
- 1996-06-06 EP EP96923264A patent/EP0828564A4/en not_active Withdrawn
- 1996-06-06 CA CA002223251A patent/CA2223251A1/en not_active Abandoned
- 1996-10-18 US US08/733,525 patent/US6074688A/en not_active Expired - Fee Related
1999
- 1999-12-30 US US09/475,453 patent/US6319541B1/en not_active Expired - Fee Related
2001
- 2001-10-23 US US10/047,183 patent/US6802313B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6319541B1 (en)	2001-11-20
AU6382596A (en)	1996-12-24
KR19990022213A (ko)	1999-03-25
US6007630A (en)	1999-12-28
US5714007A (en)	1998-02-03
US6802313B2 (en)	2004-10-12
EP0828564A1 (en)	1998-03-18
WO1996039257A1 (en)	1996-12-12
US6074688A (en)	2000-06-13
EP0828564A4 (en)	2000-05-10
US20020176926A1 (en)	2002-11-28
AU711460B2 (en)	1999-10-14
CA2223251A1 (en)	1996-12-12

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