JPH11507541A - 低酸素誘導因子−１および使用方法 - Google Patents
低酸素誘導因子−１および使用方法Info
- Publication number
- JPH11507541A JPH11507541A JP9502264A JP50226497A JPH11507541A JP H11507541 A JPH11507541 A JP H11507541A JP 9502264 A JP9502264 A JP 9502264A JP 50226497 A JP50226497 A JP 50226497A JP H11507541 A JPH11507541 A JP H11507541A
- Authority
- JP
- Japan
- Prior art keywords
- hif
- sequence
- dna
- nucleotide sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
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- Chemical & Material Sciences (AREA)
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- Peptides Or Proteins (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Optical Communication System (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrophonic Musical Instruments (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US08/480,473 | 1995-06-06 | ||
| US08/480,473 US5882914A (en) | 1995-06-06 | 1995-06-06 | Nucleic acids encoding the hypoxia inducible factor-1 |
| PCT/US1996/010251 WO1996039426A1 (en) | 1995-06-06 | 1996-06-06 | Hypoxia inducible factor-1 and method of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2008284139A Division JP2009077729A (ja) | 1995-06-06 | 2008-11-05 | 低酸素誘導因子−１および使用方法 |
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| JPH11507541A true JPH11507541A (ja) | 1999-07-06 |
| JPH11507541A5 JPH11507541A5 (2) | 2004-07-29 |
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| JP9502264A Pending JPH11507541A (ja) | 1995-06-06 | 1996-06-06 | 低酸素誘導因子−１および使用方法 |
| JP2008284139A Pending JP2009077729A (ja) | 1995-06-06 | 2008-11-05 | 低酸素誘導因子−１および使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2008284139A Pending JP2009077729A (ja) | 1995-06-06 | 2008-11-05 | 低酸素誘導因子−１および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5882914A (2) |
| EP (2) | EP0833840B1 (2) |
| JP (2) | JPH11507541A (2) |
| AT (1) | ATE355299T1 (2) |
| AU (1) | AU704384B2 (2) |
| CA (1) | CA2222279C (2) |
| DE (1) | DE69636936T2 (2) |
| IL (1) | IL118581A (2) |
| WO (1) | WO1996039426A1 (2) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007512847A (ja) * | 2003-12-03 | 2007-05-24 | アネシヴァ， インコーポレイテッド | Ｈｉｆオリコヌクレオチドデコイ分子 |
| JP2009077729A (ja) * | 1995-06-06 | 2009-04-16 | Johns Hopkins Univ School Of Medicine | 低酸素誘導因子−１および使用方法 |
| JP2016514950A (ja) * | 2013-01-25 | 2016-05-26 | エックスセル・バイオサイエンシズ・インコーポレイテッド | 標的細胞の選択的富化のための方法、組成物、キット、及びシステム |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0990042A1 (en) * | 1997-06-10 | 2000-04-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Regulatory sequences involved in hypoxia regulated gene expression and uses thereof |
| US7973156B2 (en) | 1997-08-21 | 2011-07-05 | Quark Pharmaceuticals Inc. | Hypoxia-regulated genes |
| US7074895B2 (en) | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
| DE69829857T2 (de) * | 1997-08-21 | 2006-02-02 | Quark Biotech, Inc., Pleasanton | Hypoxie-regulierte gene |
| AU757930B2 (en) | 1997-12-01 | 2003-03-13 | Roche Diagnostics Gmbh | Optimization of cells for endogenous gene activation |
| IL136454A0 (en) | 1997-12-04 | 2001-06-14 | Genzyme Corp | Compositions and methods for inducing gene expression |
| WO1999048916A2 (en) * | 1998-03-27 | 1999-09-30 | The Board Of Trustees Of The Leland Stanford Jr. University | Hypoxia-inducible human genes, proteins, and uses thereof |
| US6124131A (en) | 1998-08-25 | 2000-09-26 | The Johns Hopkins University School Of Medicine | Mutant hypoxia inducible factor-1 HIF-1 |
| JP2002525081A (ja) * | 1998-08-27 | 2002-08-13 | クォーク・バイオテク・インコーポレーテッド | 低酸素により調節される遺伝子転写に特徴的な配列 |
| SE9803891D0 (sv) * | 1998-11-13 | 1998-11-13 | Pharmacia & Upjohn Ab | Protein Variants |
| US6436654B1 (en) * | 1998-11-13 | 2002-08-20 | Pharmacia & Upjohn Ab | Methods for identifying compounds that modulate HIF-1α |
| JP4638098B2 (ja) * | 1999-06-14 | 2011-02-23 | キャンサー・リサーチ・テクノロジー・リミテッド | 癌治療 |
| WO2001023426A2 (en) * | 1999-09-30 | 2001-04-05 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| FR2801319A1 (fr) * | 1999-11-18 | 2001-05-25 | Inst Nat Sante Rech Med | Construction d'acide nucleique porteuse d'un systeme regulant l'expression d'un gene |
| US6893867B1 (en) | 1999-12-23 | 2005-05-17 | Keith A. Webster | Molecular switch for regulating mammalian gene expression |
| CA2400088A1 (en) * | 2000-02-22 | 2001-08-30 | Oxford Biomedica (Uk) Limited | Differential expression screening method |
| US20020048794A1 (en) * | 2000-08-07 | 2002-04-25 | Lorenz Poellinger | Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von Hippel-Lindau tumor suppressor protein |
| US20040101825A1 (en) * | 2001-09-26 | 2004-05-27 | Van Meir Erwin G. | Viruses targeted to hypoxic cells and tissues |
| US7285414B2 (en) * | 2000-09-26 | 2007-10-23 | Emory University | Viruses targeted to hypoxic cells and tissues |
| AU2002231223A1 (en) * | 2000-10-26 | 2002-05-06 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating hematologic malignancies and multiple drug resistance |
| US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
| US7176345B2 (en) * | 2001-03-20 | 2007-02-13 | Dana-Farber Cancer Institute, Inc. | Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US7919274B2 (en) | 2001-03-20 | 2011-04-05 | Dana-Farber Cancer Institute, Inc. | Light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US6855510B2 (en) | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
| US6660737B2 (en) | 2001-05-04 | 2003-12-09 | The Procter & Gamble Company | Medicinal uses of hydrazones |
| US6878729B2 (en) * | 2001-05-04 | 2005-04-12 | The Procter & Gamble Company | Medicinal uses of dihydropyrazoles |
| AU2002302252A1 (en) * | 2001-05-23 | 2002-12-03 | Angiogene Inc. | Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions |
| EP1403365B1 (en) * | 2001-06-05 | 2009-05-27 | Masahiro Hiraoka | Polypeptide unstabilizing protein in cells under aerobic conditions and dna encoding the same |
| US6838430B2 (en) | 2001-09-28 | 2005-01-04 | The Regents Of The University Of California | Use of HIF-1a variants to accelerate wound healing |
| FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
| AU2003208684A1 (en) * | 2002-03-05 | 2003-09-16 | Angiogenetics Sweden Ab | Critical hypoxia-inducible factor-1alpha residues, products and methods related thereto |
| WO2003085110A2 (en) * | 2002-04-05 | 2003-10-16 | Santaris Pharma A/S | Oligomeric compounds for the modulation hif-1alpha expression |
| CA2482904A1 (en) * | 2002-04-18 | 2003-10-23 | Lynkeus Biotech Gmbh | Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification |
| NZ520321A (en) * | 2002-07-19 | 2005-03-24 | Auckland Uniservices Ltd | Use of an agent adapted to inhibit HIF in use together with an antiangiogenic agent for treating tumours in a non- human animal |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| NZ540779A (en) * | 2002-11-01 | 2008-05-30 | Univ Pennsylvania | Compositions and methods for siRNA inhibition of HIF-1 alpha |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| US20050014264A1 (en) * | 2002-12-11 | 2005-01-20 | University Of Massachusetts | Method of introducing siRNA into adipocytes |
| JP4546454B2 (ja) | 2003-01-28 | 2010-09-15 | レクサーン・コーポレイション | Ｈｉｆ−１発現を抑制するアンチセンスオリゴヌクレオチド |
| EP1601325B1 (en) * | 2003-01-31 | 2009-09-02 | Rexahn Corporation | Antisense oligonucleotides that inhibit expression of hif-1 |
| CA2546649A1 (en) * | 2003-11-26 | 2005-06-16 | Entelos, Inc. | Treatment of rheumatoid arthritis with hypoxia-inducible factor 1.alpha. antagonists |
| WO2006009843A2 (en) * | 2004-06-18 | 2006-01-26 | The Johns Hopkins University | Negative regulation of hypoxia inducible factor 1 by os-9 |
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| JP3394040B2 (ja) * | 1989-06-23 | 2003-04-07 | ジェネンテック・インコーポレーテッド | ナトリウム排泄増加性蛋白質受容体ｂの組成物および合成法および使用法 |
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
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1995
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- 1996-06-06 EP EP07000451A patent/EP1806357A1/en not_active Withdrawn
- 1996-06-06 DE DE69636936T patent/DE69636936T2/de not_active Expired - Lifetime
- 1996-06-06 AT AT96922458T patent/ATE355299T1/de not_active IP Right Cessation
- 1996-06-06 JP JP9502264A patent/JPH11507541A/ja active Pending
- 1996-06-06 AU AU63326/96A patent/AU704384B2/en not_active Ceased
- 1996-06-06 WO PCT/US1996/010251 patent/WO1996039426A1/en not_active Ceased
- 1996-06-06 CA CA2222279A patent/CA2222279C/en not_active Expired - Lifetime
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1997
- 1997-08-20 US US08/915,213 patent/US6020462A/en not_active Expired - Lifetime
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1999
- 1999-01-22 US US09/235,217 patent/US6222018B1/en not_active Expired - Lifetime
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009077729A (ja) * | 1995-06-06 | 2009-04-16 | Johns Hopkins Univ School Of Medicine | 低酸素誘導因子−１および使用方法 |
| JP2007512847A (ja) * | 2003-12-03 | 2007-05-24 | アネシヴァ， インコーポレイテッド | Ｈｉｆオリコヌクレオチドデコイ分子 |
| JP2016514950A (ja) * | 2013-01-25 | 2016-05-26 | エックスセル・バイオサイエンシズ・インコーポレイテッド | 標的細胞の選択的富化のための方法、組成物、キット、及びシステム |
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| AU704384B2 (en) | 1999-04-22 |
| US6020462A (en) | 2000-02-01 |
| EP0833840A4 (en) | 2001-12-19 |
| DE69636936T2 (de) | 2007-10-31 |
| IL118581A0 (en) | 1996-10-16 |
| US6222018B1 (en) | 2001-04-24 |
| DE69636936D1 (de) | 2007-04-12 |
| IL118581A (en) | 2000-01-31 |
| CA2222279A1 (en) | 1996-12-12 |
| CA2222279C (en) | 2011-02-01 |
| US5882914A (en) | 1999-03-16 |
| WO1996039426A1 (en) | 1996-12-12 |
| EP0833840B1 (en) | 2007-02-28 |
| AU6332696A (en) | 1996-12-24 |
| ATE355299T1 (de) | 2006-03-15 |
| EP0833840A1 (en) | 1998-04-08 |
| JP2009077729A (ja) | 2009-04-16 |
| EP1806357A1 (en) | 2007-07-11 |
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