JPH11509838A - 充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療 - Google Patents

充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療

Info

Publication number: JPH11509838A
Authority: JP; Japan
Prior art keywords: group; receptor antagonist; angiotensin; groups; alkyl
Prior art date: 1995-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

JP9501683A

Other languages

English (en)

Japanese (ja)

Other versions

JPH11509838A5 (2

Inventor

イー．マックローラン，トッド

アール．シュー，ジョゼフ

Original Assignee

ジー．ディー．サールアンドカンパニー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-05

Publication date

1999-08-31

1996-06-05 Application filed by ジー．ディー．サールアンドカンパニー filed Critical ジー．ディー．サールアンドカンパニー

1999-08-31 Publication of JPH11509838A publication Critical patent/JPH11509838A/ja

2005-05-12 Publication of JPH11509838A5 publication Critical patent/JPH11509838A5/ja

Status Abandoned legal-status Critical Current

Links

LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical class C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 title claims abstract description 34
239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract description 33
238000002648 combination therapy Methods 0.000 title claims abstract description 30
206010019280 Heart failures Diseases 0.000 title claims abstract description 24
206010007559 Cardiac failure congestive Diseases 0.000 title claims abstract description 20
229940123413 Angiotensin II antagonist Drugs 0.000 title description 8
150000001875 compounds Chemical class 0.000 claims abstract description 80
229940044551 receptor antagonist Drugs 0.000 claims abstract description 48
239000002464 receptor antagonist Substances 0.000 claims abstract description 48
102000003979 Mineralocorticoid Receptors Human genes 0.000 claims abstract description 41
108090000375 Mineralocorticoid Receptors Proteins 0.000 claims abstract description 41
229960002256 spironolactone Drugs 0.000 claims abstract description 28
229940126317 angiotensin II receptor antagonist Drugs 0.000 claims abstract description 24
206010020772 Hypertension Diseases 0.000 claims abstract description 20
239000004593 Epoxy Substances 0.000 claims abstract description 9
208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 8
238000011282 treatment Methods 0.000 claims abstract description 7
125000000714 pyrimidinyl group Chemical group 0.000 claims abstract description 5
125000001425 triazolyl group Chemical group 0.000 claims abstract description 4
-1 imidazoly Chemical group 0.000 claims description 141
125000000217 alkyl group Chemical group 0.000 claims description 48
239000005557 antagonist Substances 0.000 claims description 44
238000000034 method Methods 0.000 claims description 32
229910052760 oxygen Inorganic materials 0.000 claims description 30
230000002378 acidificating effect Effects 0.000 claims description 28
239000001301 oxygen Substances 0.000 claims description 27
229910052717 sulfur Inorganic materials 0.000 claims description 27
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
125000003118 aryl group Chemical group 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 26
125000004432 carbon atom Chemical group C* 0.000 claims description 21
229910052757 nitrogen Inorganic materials 0.000 claims description 21
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 20
125000000623 heterocyclic group Chemical group 0.000 claims description 20
125000004434 sulfur atom Chemical group 0.000 claims description 20
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 17
125000005842 heteroatom Chemical group 0.000 claims description 17
150000004678 hydrides Chemical class 0.000 claims description 17
PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims description 16
PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims description 16
229960002478 aldosterone Drugs 0.000 claims description 16
239000003814 drug Substances 0.000 claims description 16
229910052799 carbon Inorganic materials 0.000 claims description 15
125000004122 cyclic group Chemical group 0.000 claims description 15
125000000753 cycloalkyl group Chemical group 0.000 claims description 15
239000002934 diuretic Substances 0.000 claims description 14
229940079593 drug Drugs 0.000 claims description 14
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 13
125000003710 aryl alkyl group Chemical group 0.000 claims description 13
239000011593 sulfur Substances 0.000 claims description 13
ZPFRAPVRYLGYEC-UHFFFAOYSA-N 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one Chemical compound COC1=CC(OC)=CC(OC)=C1CCC(=O)C1=CC=C(O)C=C1 ZPFRAPVRYLGYEC-UHFFFAOYSA-N 0.000 claims description 12
239000004072 C09CA03 - Valsartan Substances 0.000 claims description 12
239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 12
GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 12
125000003368 amide group Chemical group 0.000 claims description 12
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
229960002198 irbesartan Drugs 0.000 claims description 12
YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 12
RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 12
229960004699 valsartan Drugs 0.000 claims description 12
125000001072 heteroaryl group Chemical group 0.000 claims description 11
125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 11
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
125000003342 alkenyl group Chemical group 0.000 claims description 10
125000001544 thienyl group Chemical group 0.000 claims description 10
108010083387 Saralasin Proteins 0.000 claims description 9
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 9
125000003545 alkoxy group Chemical group 0.000 claims description 9
125000005843 halogen group Chemical group 0.000 claims description 9
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 9
125000000304 alkynyl group Chemical group 0.000 claims description 8
125000001188 haloalkyl group Chemical group 0.000 claims description 8
125000004441 haloalkylsulfonyl group Chemical group 0.000 claims description 8
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
125000002541 furyl group Chemical group 0.000 claims description 7
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
125000004076 pyridyl group Chemical group 0.000 claims description 7
229920006395 saturated elastomer Polymers 0.000 claims description 7
125000001424 substituent group Chemical group 0.000 claims description 7
ZBOYJODMIAUJHH-SANMLTNESA-N (2s)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid Chemical compound C=1C(OC)=C(CN2[C@@H](CCCC2)C(O)=O)C(OC)=CC=1OCC(C=1C)=CC=CC=1C1=CC=CC=C1 ZBOYJODMIAUJHH-SANMLTNESA-N 0.000 claims description 6
KLVDUSUYBDMJKR-SANMLTNESA-N (6s)-1-[(4-amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4h-imidazo[4,5-c]pyridine-6-carboxylic acid Chemical compound C1=C(N)C(C)=CC(CN2C=3C[C@H](N(CC=3N=C2)C(=O)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C(O)=O)=C1 KLVDUSUYBDMJKR-SANMLTNESA-N 0.000 claims description 6
ZHWGRXBJGUEATA-UHFFFAOYSA-N 2-[[4-[[2-butyl-6-[methylcarbamoyl(pentyl)amino]benzimidazol-1-yl]methyl]phenyl]carbamoyl]-3,6-dichlorobenzoic acid Chemical compound C12=CC(N(C(=O)NC)CCCCC)=CC=C2N=C(CCCC)N1CC(C=C1)=CC=C1NC(=O)C1=C(Cl)C=CC(Cl)=C1C(O)=O ZHWGRXBJGUEATA-UHFFFAOYSA-N 0.000 claims description 6
FLOKGHWIQFCIJW-UHFFFAOYSA-N 2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid Chemical compound CCCCC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 FLOKGHWIQFCIJW-UHFFFAOYSA-N 0.000 claims description 6
AHZXSVWCNDLJER-UHFFFAOYSA-N 4-[butyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyrimidine-5-carboxylic acid Chemical compound N=1C=NC=C(C(O)=O)C=1N(CCCC)CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 AHZXSVWCNDLJER-UHFFFAOYSA-N 0.000 claims description 6
UIYUUEDFAMZISF-FTBISJDPSA-N 6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;(2s)-3-methyl-2-[pentanoyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NNN=N1 UIYUUEDFAMZISF-FTBISJDPSA-N 0.000 claims description 6
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 6
102000008873 Angiotensin II receptor Human genes 0.000 claims description 6
108050000824 Angiotensin II receptor Proteins 0.000 claims description 6
239000002080 C09CA02 - Eprosartan Substances 0.000 claims description 6
239000002081 C09CA05 - Tasosartan Substances 0.000 claims description 6
239000002053 C09CA06 - Candesartan Substances 0.000 claims description 6
239000005537 C09CA07 - Telmisartan Substances 0.000 claims description 6
ZUMPSVPHCDJCMD-UHFFFAOYSA-N abitesartan Chemical compound C1CCCC1(C(O)=O)CN(C(=O)CCCC)CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ZUMPSVPHCDJCMD-UHFFFAOYSA-N 0.000 claims description 6
YBZYNINTWCLDQA-UHKVWXOHSA-N acetic acid;(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1h-imidazol-5-yl)prop Chemical compound O.CC(O)=O.C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 YBZYNINTWCLDQA-UHKVWXOHSA-N 0.000 claims description 6
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 6
125000004391 aryl sulfonyl group Chemical group 0.000 claims description 6
229960000932 candesartan Drugs 0.000 claims description 6
229960004349 candesartan cilexetil Drugs 0.000 claims description 6
GNRPOJRPMDCDDL-UHFFFAOYSA-N chembl1668123 Chemical compound CCCCC1=NC=2CN3C(CC4)CCC4N3C(=O)C=2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 GNRPOJRPMDCDDL-UHFFFAOYSA-N 0.000 claims description 6
229950006523 cilexetil Drugs 0.000 claims description 6
125000004093 cyano group Chemical group *C#N 0.000 claims description 6
VTDCYOLLYVAJSY-UHFFFAOYSA-N cyclohexyl propan-2-yl carbonate Chemical compound CC(C)OC(=O)OC1CCCCC1 VTDCYOLLYVAJSY-UHFFFAOYSA-N 0.000 claims description 6
230000001882 diuretic effect Effects 0.000 claims description 6
IDAWWPOAHPVPMY-UHFFFAOYSA-N elisartan Chemical compound CCCCC1=NC(Cl)=C(C(=O)OC(C)OC(=O)OCC)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 IDAWWPOAHPVPMY-UHFFFAOYSA-N 0.000 claims description 6
229960004563 eprosartan Drugs 0.000 claims description 6
OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims description 6
ZEUXAIYYDDCIRX-UHFFFAOYSA-N losartan carboxylic acid Chemical compound CCCCC1=NC(Cl)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 ZEUXAIYYDDCIRX-UHFFFAOYSA-N 0.000 claims description 6
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical class [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 6
125000006413 ring segment Chemical group 0.000 claims description 6
229960001379 saralasin acetate Drugs 0.000 claims description 6
229960000651 tasosartan Drugs 0.000 claims description 6
ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 claims description 6
229960005187 telmisartan Drugs 0.000 claims description 6
XUHRVZXFBWDCFB-QRTDKPMLSA-N (3R)-4-[[(3S,6S,9S,12R,15S,18R,21R,24R,27R,28R)-12-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-3-(2-carboxyethyl)-18-(hydroxymethyl)-28-methyl-9,15,21,24-tetrakis(2-methylpropyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-27-yl]amino]-3-[[(2R)-2-[[(3S)-3-hydroxydecanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CCCCCCC[C@H](O)CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)CC XUHRVZXFBWDCFB-QRTDKPMLSA-N 0.000 claims description 5
108010088950 Tensins Proteins 0.000 claims description 5
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 5
125000000457 gamma-lactone group Chemical group 0.000 claims description 5
125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims description 5
125000004414 alkyl thio group Chemical group 0.000 claims description 4
150000001408 amides Chemical class 0.000 claims description 4
125000005135 aryl sulfinyl group Chemical group 0.000 claims description 4
125000000392 cycloalkenyl group Chemical group 0.000 claims description 4
150000002148 esters Chemical class 0.000 claims description 4
239000012634 fragment Substances 0.000 claims description 4
125000000842 isoxazolyl group Chemical group 0.000 claims description 4
125000002950 monocyclic group Chemical group 0.000 claims description 4
125000004430 oxygen atom Chemical group O* 0.000 claims description 4
230000036961 partial effect Effects 0.000 claims description 4
125000000335 thiazolyl group Chemical group 0.000 claims description 4
HHFYOGBTLFTWQX-XWGVYQGASA-N (2s,4s)-4-(4-carboxyphenoxy)-1-[(2s)-2-[4-[(2-sulfobenzoyl)amino]imidazol-1-yl]octanoyl]pyrrolidine-2-carboxylic acid Chemical compound O([C@@H]1CN([C@@H](C1)C(O)=O)C(=O)[C@H](CCCCCC)N1C=C(NC(=O)C=2C(=CC=CC=2)S(O)(=O)=O)N=C1)C1=CC=C(C(O)=O)C=C1 HHFYOGBTLFTWQX-XWGVYQGASA-N 0.000 claims description 3
GGKXIITZBSPCQP-IZIWAXSGSA-N (2s,4s,5s)-5-[[(2s)-2-[[(2s)-2-benzyl-3-tert-butylsulfonylpropanoyl]amino]-3-(1h-imidazol-5-yl)propanoyl]amino]-n-butyl-6-cyclohexyl-4-hydroxy-2-propan-2-ylhexanamide Chemical compound C([C@@H]([C@@H](O)C[C@H](C(=O)NCCCC)C(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)CS(=O)(=O)C(C)(C)C)C1CCCCC1 GGKXIITZBSPCQP-IZIWAXSGSA-N 0.000 claims description 3
125000004502 1,2,3-oxadiazolyl group Chemical group 0.000 claims description 3
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims description 3
125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims description 3
125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims description 3
UKEZYWUWLICNPR-UHFFFAOYSA-N 2,6-dibutyl-5-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-1h-pyrimidin-4-one Chemical compound N1C(CCCC)=NC(=O)C(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C2=NNN=N2)=C1CCCC UKEZYWUWLICNPR-UHFFFAOYSA-N 0.000 claims description 3
LQRYGEQNLPCYDT-FPYGCLRLSA-N 2-[4-[[2-[(e)-but-1-enyl]-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound CC\C=C\C1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C(O)=O)C=C1 LQRYGEQNLPCYDT-FPYGCLRLSA-N 0.000 claims description 3
UUPNFNCKGJOLQE-UHFFFAOYSA-N 2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C(O)=O)C=C1 UUPNFNCKGJOLQE-UHFFFAOYSA-N 0.000 claims description 3
OLQFKFSAJNUOPT-UHFFFAOYSA-N 2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound C1=C2N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C(O)=O)C(CCCC)=NC2=CC=C1NC(=O)NC1CCCCC1 OLQFKFSAJNUOPT-UHFFFAOYSA-N 0.000 claims description 3
DLMNZGAILMQDHA-UHFFFAOYSA-N 2-[propyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyridine-3-carboxylic acid Chemical compound N=1C=CC=C(C(O)=O)C=1N(CCC)CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 DLMNZGAILMQDHA-UHFFFAOYSA-N 0.000 claims description 3
YILJWHUIUCRKEU-UHFFFAOYSA-N 2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine Chemical compound CCCCC1=NC2=CC=CN=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 YILJWHUIUCRKEU-UHFFFAOYSA-N 0.000 claims description 3
AWZMTWHHQXOWQR-UHFFFAOYSA-N 2-ethyl-4-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methoxy]-5,6,7,8-tetrahydroquinoline Chemical compound C=12CCCCC2=NC(CC)=CC=1OCC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 AWZMTWHHQXOWQR-UHFFFAOYSA-N 0.000 claims description 3
MGSBGAVGFLLRDU-UHFFFAOYSA-N 2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-5-[2-(2,2,2-trifluoroacetyl)pyrrol-1-yl]imidazole-4-carboxylic acid Chemical compound CCCC1=NC(N2C(=CC=C2)C(=O)C(F)(F)F)=C(C(O)=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 MGSBGAVGFLLRDU-UHFFFAOYSA-N 0.000 claims description 3
NAGGAAHTUXEGFG-UHFFFAOYSA-N 5,7-diethyl-1-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-3,4-dihydro-1,6-naphthyridin-2-one;hydrochloride Chemical compound Cl.O=C1CCC=2C(CC)=NC(CC)=CC=2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 NAGGAAHTUXEGFG-UHFFFAOYSA-N 0.000 claims description 3
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

JP9501683A 1995-06-07 1996-06-05 充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療 Abandoned JPH11509838A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US48608995A	1995-06-07	1995-06-07
US08/486,089		1995-06-07
PCT/US1996/009342 WO1996040258A2 (en)	1995-06-07	1996-06-05	Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure

Publications (2)

Publication Number	Publication Date
JPH11509838A true JPH11509838A (ja)	1999-08-31
JPH11509838A5 JPH11509838A5 (2)	2005-05-12

Family

ID=23930539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9501683A Abandoned JPH11509838A (ja)	1995-06-07	1996-06-05	充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療

Country Status (16)

Country	Link
US (1)	US20040102423A1 (2)
EP (1)	EP0831911B1 (2)
JP (1)	JPH11509838A (2)
KR (1)	KR19990022723A (2)
CN (1)	CN1192696A (2)
AT (1)	ATE216261T1 (2)
AU (1)	AU6158096A (2)
BR (1)	BR9608505A (2)
CA (1)	CA2224222A1 (2)
CZ (1)	CZ291268B6 (2)
DE (1)	DE69620756T2 (2)
DK (1)	DK0831911T3 (2)
ES (1)	ES2175098T3 (2)
IL (1)	IL122246A (2)
PT (1)	PT831911E (2)
WO (1)	WO1996040258A2 (2)

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JP2007500677A (ja) *	2003-07-31	2007-01-18	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	アンギオテンシンｉｉ受容体アンタゴニストの使用
JP2008517072A (ja) *	2004-10-20	2008-05-22	ザレジェンツオブザユニバーシティーオブカリフォルニア	可溶性エポキシド加水分解酵素の改良された阻害剤

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1996
- 1996-06-05 WO PCT/US1996/009342 patent/WO1996040258A2/en not_active Ceased
- 1996-06-05 CZ CZ19973848A patent/CZ291268B6/cs not_active IP Right Cessation
- 1996-06-05 KR KR1019970709165A patent/KR19990022723A/ko not_active Ceased
- 1996-06-05 AT AT96919173T patent/ATE216261T1/de not_active IP Right Cessation
- 1996-06-05 BR BR9608505A patent/BR9608505A/pt not_active Application Discontinuation
- 1996-06-05 JP JP9501683A patent/JPH11509838A/ja not_active Abandoned
- 1996-06-05 ES ES96919173T patent/ES2175098T3/es not_active Expired - Lifetime
- 1996-06-05 CN CN96196086A patent/CN1192696A/zh active Pending
- 1996-06-05 CA CA002224222A patent/CA2224222A1/en not_active Abandoned
- 1996-06-05 EP EP96919173A patent/EP0831911B1/en not_active Expired - Lifetime
- 1996-06-05 DE DE69620756T patent/DE69620756T2/de not_active Expired - Fee Related
- 1996-06-05 IL IL12224696A patent/IL122246A/en not_active IP Right Cessation
- 1996-06-05 AU AU61580/96A patent/AU6158096A/en not_active Abandoned
- 1996-06-05 DK DK96919173T patent/DK0831911T3/da active
- 1996-06-05 PT PT96919173T patent/PT831911E/pt unknown
2002
- 2002-10-15 US US10/271,362 patent/US20040102423A1/en not_active Abandoned

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JP2007500677A (ja) *	2003-07-31	2007-01-18	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	アンギオテンシンｉｉ受容体アンタゴニストの使用
JP2008517072A (ja) *	2004-10-20	2008-05-22	ザレジェンツオブザユニバーシティーオブカリフォルニア	可溶性エポキシド加水分解酵素の改良された阻害剤

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Publication number	Publication date
IL122246A (en)	2004-06-01
DE69620756T2 (de)	2002-11-14
KR19990022723A (ko)	1999-03-25
EP0831911B1 (en)	2002-04-17
CN1192696A (zh)	1998-09-09
DK0831911T3 (da)	2002-07-22
BR9608505A (pt)	1999-07-06
WO1996040258A2 (en)	1996-12-19
PT831911E (pt)	2002-09-30
ATE216261T1 (de)	2002-05-15
IL122246A0 (en)	1998-04-05
EP0831911A2 (en)	1998-04-01
CZ384897A3 (cs)	1998-05-13
US20040102423A1 (en)	2004-05-27
WO1996040258A3 (en)	1997-01-23
DE69620756D1 (de)	2002-05-23
CA2224222A1 (en)	1996-12-19
ES2175098T3 (es)	2002-11-16
AU6158096A (en)	1996-12-30
CZ291268B6 (cs)	2003-01-15

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2006-05-11

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Effective date: 20060410

Publication	Publication Date	Title
JPH11509838A (ja)	1999-08-31	充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療
RU2166330C2 (ru)	2001-05-10	Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона
US20040067915A1 (en)	2004-04-08	Method to treat cardiofibrosis with a combination of an angiotensin II antagonist and spironolactone
US20040053903A1 (en)	2004-03-18	Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and an epoxy-steroidal aldosterone antagonist
TWI874399B (zh)	2025-03-01	心縮功能障礙之治療
IL300775A (en)	2023-04-01	Treatment methods with myosin modulator
RU2384346C2 (ru)	2010-03-20	Фармацевтические композиции, содержащие nep-ингибиторы, ингибиторы эндогенной эндотелинпродуцирующей системы и антагонисты at1-рецептора
RU2362561C2 (ru)	2009-07-27	Фармацевтическая композиция, включающая селективный агонист имидазолинового рецептора i1 и блокатор рецептора ангиотензина ii
AU2003202486B2 (en)	2005-06-16	Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for the treatment of congestive heart failure
AU4264200A (en)	2000-09-07	Spironolactone and angiotensin II antagonist combination therapy for treatment of congestive heart failure
HK1096293B (en)	2009-07-31	Pharmaceutical composition comprising a selective i1 imidazoline receptor agonist and an angiotensin ii receptor blocker

JPH11509838A - 充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンｉｉ拮抗物質との組合わせ治療 - Google Patents

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