DK0831911T3 - Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist - Google Patents

Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist

Info

Publication number: DK0831911T3
Authority: DK; Denmark
Prior art keywords: angiotensin; receptor antagonist; spironolactone; combination therapy; heart failure
Prior art date: 1995-06-07

Application number

DK96919173T

Other languages

Danish (da)

English (en)

Inventor

Todd E Maclaughlan

Joseph R Schuh

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-05

Publication date

2002-07-22

1996-06-05 Application filed by Searle & Co filed Critical Searle & Co

2002-07-22 Application granted granted Critical

2002-07-22 Publication of DK0831911T3 publication Critical patent/DK0831911T3/da

Links

239000002333 angiotensin II receptor antagonist Substances 0.000 title abstract 4
238000002648 combination therapy Methods 0.000 title abstract 3
229960002256 spironolactone Drugs 0.000 title abstract 3
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 title abstract 3
206010007559 Cardiac failure congestive Diseases 0.000 title abstract 2
206010019280 Heart failures Diseases 0.000 title abstract 2
229940123413 Angiotensin II antagonist Drugs 0.000 title 1
102000003979 Mineralocorticoid Receptors Human genes 0.000 abstract 3
108090000375 Mineralocorticoid Receptors Proteins 0.000 abstract 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
229940044551 receptor antagonist Drugs 0.000 abstract 3
239000002464 receptor antagonist Substances 0.000 abstract 3
229940126317 angiotensin II receptor antagonist Drugs 0.000 abstract 2
KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
-1 3,5-dibutyl-1H-1,2,4-triazol-1-yl Chemical group 0.000 abstract 1
206010003445 Ascites Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010016654 Fibrosis Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
230000007882 cirrhosis Effects 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)

DK96919173T 1995-06-07 1996-06-05 Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist DK0831911T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48608995A	1995-06-07	1995-06-07
PCT/US1996/009342 WO1996040258A2 (en)	1995-06-07	1996-06-05	Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure

Publications (1)

Publication Number	Publication Date
DK0831911T3 true DK0831911T3 (da)	2002-07-22

Family

ID=23930539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96919173T DK0831911T3 (da)	1995-06-07	1996-06-05	Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist

Country Status (16)

Country	Link
US (1)	US20040102423A1 (2)
EP (1)	EP0831911B1 (2)
JP (1)	JPH11509838A (2)
KR (1)	KR19990022723A (2)
CN (1)	CN1192696A (2)
AT (1)	ATE216261T1 (2)
AU (1)	AU6158096A (2)
BR (1)	BR9608505A (2)
CA (1)	CA2224222A1 (2)
CZ (1)	CZ291268B6 (2)
DE (1)	DE69620756T2 (2)
DK (1)	DK0831911T3 (2)
ES (1)	ES2175098T3 (2)
IL (1)	IL122246A (2)
PT (1)	PT831911E (2)
WO (1)	WO1996040258A2 (2)

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AU2009305669A1 (en)	2008-10-16	2010-04-22	The Regents Of The University Of California	Fused ring heteroaryl kinase inhibitors
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
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JP5789252B2 (ja)	2009-05-07	2015-10-07	インテリカイン，エルエルシー	複素環式化合物およびその使用
US8980899B2 (en)	2009-10-16	2015-03-17	The Regents Of The University Of California	Methods of inhibiting Ire1
JP5951600B2 (ja)	2010-05-21	2016-07-13	インフィニティーファーマシューティカルズ，インコーポレイテッド	キナーゼ調節のための、化合物、組成物および方法
WO2012064973A2 (en)	2010-11-10	2012-05-18	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP3238722B1 (en)	2011-01-10	2019-03-13	Infinity Pharmaceuticals, Inc.	Solid forms of isoquinolinones
CA2821985C (en)	2011-01-11	2019-07-09	Dimerix Bioscience Pty Ltd	Combination therapy
TWI592411B (zh)	2011-02-23	2017-07-21	英特爾立秦有限責任公司	激酶抑制劑之組合及其用途
CN102816126A (zh) *	2011-06-07	2012-12-12	中国药科大学	具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途
US9056877B2 (en)	2011-07-19	2015-06-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP2734520B1 (en)	2011-07-19	2016-09-14	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
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WO2013077921A2 (en)	2011-09-02	2013-05-30	The Regents Of The University Of California	Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CA2886240A1 (en)	2012-09-26	2014-04-03	The Regents Of The University Of California	Modulation of ire1
RU2702908C2 (ru)	2012-11-01	2019-10-14	Инфинити Фармасьютикалз, Инк.	Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US9481667B2 (en)	2013-03-15	2016-11-01	Infinity Pharmaceuticals, Inc.	Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3964507A1 (en)	2013-10-04	2022-03-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN106456628A (zh)	2014-03-19	2017-02-22	无限药品股份有限公司	用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2015160975A2 (en)	2014-04-16	2015-10-22	Infinity Pharmaceuticals, Inc.	Combination therapies
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
WO2016141182A1 (en)	2015-03-03	2016-09-09	Yee Richard W	Compositions and methods for treating ocular diseases
CN114230571B (zh)	2015-09-14	2025-07-08	无限药品股份有限公司	异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
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1996
- 1996-06-05 AU AU61580/96A patent/AU6158096A/en not_active Abandoned
- 1996-06-05 DE DE69620756T patent/DE69620756T2/de not_active Expired - Fee Related
- 1996-06-05 IL IL12224696A patent/IL122246A/en not_active IP Right Cessation
- 1996-06-05 BR BR9608505A patent/BR9608505A/pt not_active Application Discontinuation
- 1996-06-05 JP JP9501683A patent/JPH11509838A/ja not_active Abandoned
- 1996-06-05 WO PCT/US1996/009342 patent/WO1996040258A2/en not_active Ceased
- 1996-06-05 CZ CZ19973848A patent/CZ291268B6/cs not_active IP Right Cessation
- 1996-06-05 ES ES96919173T patent/ES2175098T3/es not_active Expired - Lifetime
- 1996-06-05 PT PT96919173T patent/PT831911E/pt unknown
- 1996-06-05 EP EP96919173A patent/EP0831911B1/en not_active Expired - Lifetime
- 1996-06-05 AT AT96919173T patent/ATE216261T1/de not_active IP Right Cessation
- 1996-06-05 CN CN96196086A patent/CN1192696A/zh active Pending
- 1996-06-05 KR KR1019970709165A patent/KR19990022723A/ko not_active Ceased
- 1996-06-05 DK DK96919173T patent/DK0831911T3/da active
- 1996-06-05 CA CA002224222A patent/CA2224222A1/en not_active Abandoned
2002
- 2002-10-15 US US10/271,362 patent/US20040102423A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1996040258A3 (en)	1997-01-23
US20040102423A1 (en)	2004-05-27
ATE216261T1 (de)	2002-05-15
IL122246A (en)	2004-06-01
ES2175098T3 (es)	2002-11-16
EP0831911A2 (en)	1998-04-01
CZ291268B6 (cs)	2003-01-15
BR9608505A (pt)	1999-07-06
AU6158096A (en)	1996-12-30
CZ384897A3 (cs)	1998-05-13
CA2224222A1 (en)	1996-12-19
JPH11509838A (ja)	1999-08-31
PT831911E (pt)	2002-09-30
WO1996040258A2 (en)	1996-12-19
EP0831911B1 (en)	2002-04-17
DE69620756D1 (de)	2002-05-23
KR19990022723A (ko)	1999-03-25
DE69620756T2 (de)	2002-11-14
IL122246A0 (en)	1998-04-05
CN1192696A (zh)	1998-09-09

Publication	Publication Date	Title
BR9608505A (pt)	1999-07-06	Terapia de combinação dos antagonistas espironolactona e angiotensina ii para o tratamento de insuficiència cardíaca congestiva
WO1996040255A3 (en)	1997-01-23	Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldosterone antagonist
NZ310730A (en)	2001-01-26	Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for treatment of congestive heart failure
AU640417B2 (en)	1993-08-26	Substituted 5-((tetrazolyl)alkenyl)imidazoles
WO2004082599A3 (en)	2006-02-16	Combination of an aldosterone receptor antagonist and an anti-diabetic agent
NZ330889A (en)	2000-03-27	Cycloalkyl substituted imidazoles and their use in treating CSB/RK/p38 kinase mediated diseases
MY110205A (en)	1998-02-28	Imidazolyl-alkenoic acids.
IE902139L (en)	1990-12-14	Imidazolyl alkenoic acids
PT85312A (en)	1987-08-01	Process for the preparation of angiotension ii receptor blocking imidazoles and of pharmaceutical
EP0437103A3 (en)	1991-07-24	Substituted 5-(alkyl)carboxamide imidazoles
AU8844491A (en)	1992-03-30	Renal-selective biphenylalkyl 1h-substituted-1,2,4-triazole angiotensin ii antagonists for treatment of hypertension
RO118870B1 (ro)	2003-12-30	Monometansulfonat de acid (e)-alfa-[2-n-butil-1-[(4-carboxifenil)metil]-1h-imidazol-5-il]metilen-2-tiofenpropionic, procedee de preparare şi compoziţii farmaceutice
AU7905001A (en)	2002-02-13	Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
NZ235959A (en)	1991-09-25	Substituted n-(imidazolyl) alkyl alanine derivatives and pharmaceutical compositions
ZA912656B (en)	1992-03-25	Substituted benzimidazoles having angiotensin 11 receptor antagonisn
MXPA05010507A (es)	2005-11-16	Combinacion de un antagonista del receptor de aldosterona y un agente antiobesidad.
HU9402429D0 (en)	1994-10-28	Pyrazolopyrimidin derivatives as angiotensin ii receptor antagonists
MX9709976A (es)	1998-03-31	Terapia de combinacion con espironolactona y antagonista de angiotensina ii para el tratamiento de fallas cardiacas congestivas.
MX9709978A (es)	1998-03-31	Terapia de combinacion de antagonista de aldosterona epoxi-esteroidal y antagonista de angiotensina ii para tratamiento de insuficiencia cardiaca congestiva.
TW200501937A (en)	2005-01-16	Combination of an aldosterone receptor antagonist and an anti-diabetic agent
MY108525A (en)	1996-10-31	Substituted imidazoles.
AU2003202486A1 (en)	2003-06-12	Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for the treatment of congestive heart failure