JPH11511643A - 遺伝子工学処理された細胞の条件的形質転換 - Google Patents

遺伝子工学処理された細胞の条件的形質転換

Info

Publication number
JPH11511643A
JPH11511643A JP8514133A JP51413396A JPH11511643A JP H11511643 A JPH11511643 A JP H11511643A JP 8514133 A JP8514133 A JP 8514133A JP 51413396 A JP51413396 A JP 51413396A JP H11511643 A JPH11511643 A JP H11511643A
Authority
JP
Japan
Prior art keywords
cells
protein
sos
membrane
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8514133A
Other languages
English (en)
Japanese (ja)
Inventor
クラブツリー，ジェラルド・アール
スペンサー，デイビッド
ホルシンガー，レスリー
グリーフ，イザベラ
シュライバー，スチュアート
Original Assignee
ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニア・ユニバーシティ
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニア・ユニバーシティ, プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ filed Critical ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニア・ユニバーシティ
Publication of JPH11511643A publication Critical patent/JPH11511643A/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP8514133A 1994-10-25 1995-10-25 遺伝子工学処理された細胞の条件的形質転換 Granted JPH11511643A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32893194A 1994-10-25 1994-10-25
US08/328,931 1994-10-25
PCT/US1995/013776 WO1996012796A1 (en) 1994-10-25 1995-10-25 Conditional transformation of genetically engineered cells

Publications (1)

Publication Number Publication Date
JPH11511643A true JPH11511643A (ja) 1999-10-12

Family

ID=23283095

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8514133A Granted JPH11511643A (ja) 1994-10-25 1995-10-25 遺伝子工学処理された細胞の条件的形質転換

Country Status (4)

Country Link
EP (1) EP0785992A4 (de)
JP (1) JPH11511643A (de)
AU (1) AU3968595A (de)
WO (1) WO1996012796A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69938335T2 (de) * 1998-01-08 2009-04-23 The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto Methoden zur kontrolle der zelldifferenzierung und des zellwachstums durch verwendung eines fusionsproteins und eines wirkstoffes
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
EP1229924A4 (de) 1999-11-19 2004-12-15 Univ Leland Stanford Junior Gezielte bifunctionelle moleküle und darauf gegründete therapien
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
KR100611545B1 (ko) 2001-06-22 2006-08-10 에프. 호프만-라 로슈 아게 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체
EP2933334B1 (de) 2003-02-18 2019-09-18 Baylor College of Medicine Induzierte Aktivierung in dendritischen Zellen
EP2465510B1 (de) 2006-10-19 2018-11-28 Baylor College Of Medicine Verfahren und Zusammensetzungen zur Erzeugung einer Immunreaktion mittels CD40-Induktion sowie Strukturerkennungsrezeptoren und Adapter davon
US20100203067A1 (en) 2008-09-22 2010-08-12 Baylor College Of Medicine Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters
WO2011146862A1 (en) 2010-05-21 2011-11-24 Bellicum Pharmaceuticals, Inc. Methods for inducing selective apoptosis
US10634668B2 (en) 2012-09-13 2020-04-28 Takara Bio Usa, Inc. Modifiable chemical inducers of proximity and methods of using the same
US9434935B2 (en) 2013-03-10 2016-09-06 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof
US9944690B2 (en) 2013-03-14 2018-04-17 Bellicum Pharmaceuticals, Inc. Methods for controlling T cell proliferation
EP3004329B1 (de) 2013-06-05 2020-03-04 Bellicum Pharmaceuticals, Inc. Verfahren zur induktion von partieller apoptose mit caspasepolypeptiden
EP4491726A3 (de) 2013-06-11 2025-03-05 Takara Bio USA, Inc. Proteinangereicherte mikrovesikel und verfahren zur herstellung und verwendung davon
CA2937750A1 (en) 2014-02-14 2015-08-20 Bellicum Pharmaceuticals, Inc. Methods for activating t cells using an inducible chimeric polypeptide
EP3189148A4 (de) 2014-09-02 2018-05-02 Bellicum Pharmaceuticals, Inc. Co-stimulierung von chimären antigenrezeptoren durch myd88- und cd40-polypeptide
ES2904301T3 (es) 2014-11-03 2022-04-04 Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum Receptores de células T dirigidos contra Bob1 y usos de los mismos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2257734T3 (es) * 1992-05-18 2006-08-01 Genentech, Inc. Activacion de los receptores de oligomerizacion por medio de los ligandos de receptores fusionados.
PL310327A1 (en) * 1993-02-12 1995-12-11 Univ Leland Stanford Junior Adjustable transcription of target genes and other biological processes
AU696991B2 (en) * 1993-07-16 1998-09-24 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
JPH10507624A (ja) * 1994-08-18 1998-07-28 アリアド・ジーン・セラピューティクス・インコーポレーテッド 遺伝子発現、遺伝子産物機能および工学処理された宿主細胞の調節可能な除去

Also Published As

Publication number Publication date
EP0785992A4 (de) 1999-12-22
AU3968595A (en) 1996-05-15
WO1996012796A1 (en) 1996-05-02
EP0785992A1 (de) 1997-07-30

Similar Documents

Publication Publication Date Title
JPH11511643A (ja) 遺伝子工学処理された細胞の条件的形質転換
Paroush et al. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
US7008780B2 (en) Chimeric DNA-binding proteins
Aster et al. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jκ or nuclear localization sequences retain the ability to associate with RBP-Jκ and activate transcription
US6627405B1 (en) 53BP2 complexes
US7982002B2 (en) Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
JPH09502088A (ja) 細胞死レギュレータ
JP2001523977A (ja) Ａｐａｆ−１、ｃｅｄ−４ヒト相同体、カスパーゼ−３の活性化因子
US6521412B1 (en) HsReq*1 and hsReq*2proteins and use thereof to detect CDK2
CA2370098C (en) Human beta-trcp protein
JP2005507249A (ja) Ｇｌｕ−Ｐｒｏモチーフに結合する分子、それらを含む治療用組成物、そしてそれらの用途
AU733874B2 (en) Novel CREBa isoform
Husberg et al. Cellular localisation and nuclear export of the human bZIP transcription factor TCF11
US20030023034A1 (en) p27 (Kip1) -FKBP-12 protein complexes
CA2365020C (en) Ganp proteins
JP2002542774A (ja) タンパク質−タンパク質相互作用
Chan The role of cell cycle in the regulation of activation-induced T cell death
Zeng A protein that interacts with Rab11-GTP and may serve as its effector in vesicular transport
Motto Grb2-associated proteins in T-cell activation
Zhang Identification of Fyb as an interacting protein with CD45 in yeast two-hybrid screening
Wu Molecular studies of phospholipase C: Analysis of functional domains of norpA gene of Drosophila melanogaster
US20030032058A1 (en) Protein-protein interactions
Roulier Tec29 tyrosine kinase: Multiple functions in the development of Drosophila melanogaster
Gisser Interactions among a group of related proteins in the cellular slime mold'Dictyostelium discoideum'
WO2002055657A2 (en) Protein-protein interactions

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060606

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060905

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20061023

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081007

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090122

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090216

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090310

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090407

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120417

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees