JPH1175889A - 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法 - Google Patents

光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法

Info

Publication number
JPH1175889A
JPH1175889A JP15130798A JP15130798A JPH1175889A JP H1175889 A JPH1175889 A JP H1175889A JP 15130798 A JP15130798 A JP 15130798A JP 15130798 A JP15130798 A JP 15130798A JP H1175889 A JPH1175889 A JP H1175889A
Authority
JP
Japan
Prior art keywords
lactic acid
optically active
trifluoromethyl
trifluoromethyl lactic
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15130798A
Other languages
English (en)
Japanese (ja)
Other versions
JPH1175889A5 (de
Inventor
Eiji Sato
栄治 佐藤
Kanehiko Enomoto
兼彦 榎本
Toshitaka Uragaki
俊孝 浦垣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Rayon Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Rayon Co Ltd filed Critical Mitsubishi Rayon Co Ltd
Priority to JP15130798A priority Critical patent/JPH1175889A/ja
Priority to PCT/JP1998/003160 priority patent/WO1999004028A1/ja
Publication of JPH1175889A publication Critical patent/JPH1175889A/ja
Publication of JPH1175889A5 publication Critical patent/JPH1175889A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP15130798A 1997-07-15 1998-06-01 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法 Pending JPH1175889A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP15130798A JPH1175889A (ja) 1997-07-15 1998-06-01 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法
PCT/JP1998/003160 WO1999004028A1 (fr) 1997-07-15 1998-07-14 Procede de preparation d'un acide alpha-trifluoromethylacetique optiquement actif et des esters antipodes dudit acide, et methode de purification dudit acide

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9-189525 1997-07-15
JP18952597 1997-07-15
JP15130798A JPH1175889A (ja) 1997-07-15 1998-06-01 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007061892A Division JP2007202563A (ja) 1997-07-15 2007-03-12 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法

Publications (2)

Publication Number Publication Date
JPH1175889A true JPH1175889A (ja) 1999-03-23
JPH1175889A5 JPH1175889A5 (de) 2005-09-29

Family

ID=26480602

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15130798A Pending JPH1175889A (ja) 1997-07-15 1998-06-01 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法

Country Status (2)

Country Link
JP (1) JPH1175889A (de)
WO (1) WO1999004028A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002095495A (ja) * 2000-09-20 2002-04-02 Mitsubishi Rayon Co Ltd 光学活性アミノアルコール誘導体の製造方法
JP2003079392A (ja) * 2001-09-10 2003-03-18 Mitsubishi Rayon Co Ltd 光学活性α−トリフルオロメチル乳酸の製造方法
JP2010524878A (ja) * 2007-04-18 2010-07-22 インテンディス ゲゼルシャフト ミット ベシュレンクテル ハフツング 非ステロイド抗炎症剤及びその中間体の製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2235851T3 (es) * 1999-02-23 2005-07-16 Lonza Ag Procedimiento para la preparacion de derivados de acido 3,3,3-trifluorometil-2-alquilpropionico opticamente activos.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0578277A (ja) * 1991-03-04 1993-03-30 Nikko Kyodo Co Ltd 3,3,3−トリフルオロ乳酸の製造方法及び光学純度の向上法
GB9607458D0 (en) * 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002095495A (ja) * 2000-09-20 2002-04-02 Mitsubishi Rayon Co Ltd 光学活性アミノアルコール誘導体の製造方法
JP2003079392A (ja) * 2001-09-10 2003-03-18 Mitsubishi Rayon Co Ltd 光学活性α−トリフルオロメチル乳酸の製造方法
JP2010524878A (ja) * 2007-04-18 2010-07-22 インテンディス ゲゼルシャフト ミット ベシュレンクテル ハフツング 非ステロイド抗炎症剤及びその中間体の製造方法

Also Published As

Publication number Publication date
WO1999004028A1 (fr) 1999-01-28

Similar Documents

Publication Publication Date Title
Koul et al. Enzymatic resolution of naproxen
JP3794702B2 (ja) キラル−α−第3級カルボン酸エステルの酵素的調製法
EP0912755B1 (de) Die bioauflösung auf n-acylazetidin-2-carbonsäuren
CA2018562C (en) Process for the enzymatic cleavage of vinyl 2-aryl-propionates
US5658796A (en) Optical resolution of alkyl chroman-2-carboxylates
US6121025A (en) Process for producing optically active 3-quinuclidinol derivatives
JP3819082B2 (ja) 光学活性3−n置換アミノイソ酪酸類およびその塩ならびにそれらの製造方法
US6440721B2 (en) Method for preparing an R- or S-form of α-substituted heterocyclic carboxylic acid and a counter enantiomeric form of α-substituted heterocyclic carboxylic acid ester thereto using enzyme
WO1999004028A1 (fr) Procede de preparation d'un acide alpha-trifluoromethylacetique optiquement actif et des esters antipodes dudit acide, et methode de purification dudit acide
US6455302B1 (en) Method for optically resolving a racemic α-substituted heterocyclic carboxylic acid using enzyme
EP0474250A2 (de) Enzymatisches Verfahren zur Trennung von optischen Isomeren der Racemischen 1,2-Diolen
JP2007202563A (ja) 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法
JP2003299495A (ja) 光学活性3−メチルグルタル酸モノエステルの製造方法
EP0783039B1 (de) Verfahren zur herstellung optisch aktiver 2-alkoxycyclohexanolderivate
EP0952227B1 (de) Verfahren zur biologischen Racematspaltung
CA2231456A1 (en) Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
JP4565672B2 (ja) 光学活性β−シアノイソ酪酸類及びその製造方法
US5861304A (en) Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic esters
JP3024361B2 (ja) 光学活性ピロリジン類の製造法
JP4476963B2 (ja) 光学活性3−n置換アミノイソ酪酸類およびその塩ならびにそれらの製造方法
JP4746019B2 (ja) 光学活性β−シアノイソ酪酸類及びその製造方法
JP2006001862A (ja) 3−シアノグルタル酸モノエステル類及びその製造方法
WO1995022620A1 (en) Enzymatic resolution of substituted 2-methyl-propionic acid
JPH06237788A (ja) アセチレンアルコール類の製造法
JPH08113550A (ja) 光学活性3−ヒドロキシヘキサン酸類の製造方法

Legal Events

Date Code Title Description
A521 Written amendment

Effective date: 20050422

Free format text: JAPANESE INTERMEDIATE CODE: A523

A621 Written request for application examination

Effective date: 20050422

Free format text: JAPANESE INTERMEDIATE CODE: A621

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060822

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20070109