JPH1175889A5 - - Google Patents
Info
- Publication number
- JPH1175889A5 JPH1175889A5 JP1998151307A JP15130798A JPH1175889A5 JP H1175889 A5 JPH1175889 A5 JP H1175889A5 JP 1998151307 A JP1998151307 A JP 1998151307A JP 15130798 A JP15130798 A JP 15130798A JP H1175889 A5 JPH1175889 A5 JP H1175889A5
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- lactic acid
- trifluoromethyl lactic
- bacterial cell
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Description
（式中、Ｒは置換又は非置換の炭素原子数１〜12の炭化水素基である。）で表されるラセミ体α−トリフルオロメチル乳酸エステルを、エステル不斉加水分解能力を有する酵素、酵素固定化物、微生物、菌体培養液、又は菌体処理物の存在下で不斉加水分解させ、得られる光学活性α−トリフルオロメチル乳酸又はその未反応対掌体エステルを加水分解して得られる対掌体光学活性α−トリフルオロメチル乳酸を晶析する光学活性α−トリフルオロメチル乳酸の製造方法。
（２）上記（１）記載の方法で得られる光学活性α−トリフルオロメチル乳酸を再結晶し、結晶を回収する光学活性α−トリフルオロメチル乳酸の製造方法。
(wherein R is a substituted or unsubstituted hydrocarbon group having 1 to 12 carbon atoms), in the presence of an enzyme, an immobilized enzyme, a microorganism, a bacterial cell culture solution, or a treated bacterial cell product having the ability to asymmetrically hydrolyze esters, and then hydrolyzing the resulting optically active α-trifluoromethyllactic acid or its unreacted enantiomer ester to crystallize the enantiomer, optically active α-trifluoromethyllactic acid.
(2) A method for producing optically active α-trifluoromethyl lactic acid, which comprises recrystallizing the optically active α-trifluoromethyl lactic acid obtained by the method described in (1) above and recovering the crystals.
Claims (2)
で表されるラセミ体α−トリフルオロメチル乳酸エステルを、エステル不斉加水分解能力を有する酵素、酵素固定化物、微生物、菌体培養液、又は菌体処理物の存在下で不斉加水分解させ、得られる光学活性α−トリフルオロメチル乳酸又はその未反応対掌体エステルを加水分解して得られる対掌体光学活性α−トリフルオロメチル乳酸を晶析する光学活性α−トリフルオロメチル乳酸の製造方法。 General formula (I):
in the presence of an enzyme, an immobilized enzyme, a microorganism, a bacterial cell culture solution, or a treated bacterial cell product, which has the ability to asymmetrically hydrolyze an ester, and then the obtained optically active α-trifluoromethyl lactic acid or its unreacted enantiomer ester is hydrolyzed to crystallize the enantiomer, optically active α-trifluoromethyl lactic acid.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15130798A JPH1175889A (en) | 1997-07-15 | 1998-06-01 | Production method and purification method of optically active α-trifluoromethyl lactic acid and its enantiomer ester |
| PCT/JP1998/003160 WO1999004028A1 (en) | 1997-07-15 | 1998-07-14 | PROCESS FOR PREPARING OPTICALLY ACTIVE α-TRIFLUOROMETHYLLACTIC ACID AND ANTIPODE ESTERS THEREOF AND METHOD OF PURIFICATION THEREOF |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9-189525 | 1997-07-15 | ||
| JP18952597 | 1997-07-15 | ||
| JP15130798A JPH1175889A (en) | 1997-07-15 | 1998-06-01 | Production method and purification method of optically active α-trifluoromethyl lactic acid and its enantiomer ester |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007061892A Division JP2007202563A (en) | 1997-07-15 | 2007-03-12 | Method for producing and purifying optically active α-trifluoromethyl lactic acid and its enantiomer ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH1175889A JPH1175889A (en) | 1999-03-23 |
| JPH1175889A5 true JPH1175889A5 (en) | 2005-09-29 |
Family
ID=26480602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15130798A Pending JPH1175889A (en) | 1997-07-15 | 1998-06-01 | Production method and purification method of optically active α-trifluoromethyl lactic acid and its enantiomer ester |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH1175889A (en) |
| WO (1) | WO1999004028A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1155138B1 (en) * | 1999-02-23 | 2005-01-05 | Lonza AG | Method for preparing optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives |
| JP4711367B2 (en) * | 2000-09-20 | 2011-06-29 | 三菱レイヨン株式会社 | Method for producing optically active amino alcohol derivative |
| JP4775925B2 (en) * | 2001-09-10 | 2011-09-21 | 三菱レイヨン株式会社 | Process for producing optically active α-trifluoromethyl lactic acid |
| MX2009011253A (en) * | 2007-04-18 | 2009-12-02 | Intendis Gmbh | Process for the manufacture for non-steroidal anti-inflammatory agents and intermediates thereof. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0578277A (en) * | 1991-03-04 | 1993-03-30 | Nikko Kyodo Co Ltd | Production of 3,3,3-trifluorolactic acid and method for improving optical purity |
| GB9607458D0 (en) * | 1996-04-10 | 1996-06-12 | Zeneca Ltd | Enzymatic process for stereoselective preparation of therapeutic amides |
-
1998
- 1998-06-01 JP JP15130798A patent/JPH1175889A/en active Pending
- 1998-07-14 WO PCT/JP1998/003160 patent/WO1999004028A1/en not_active Ceased
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