JPH1176392A - Patch - Google Patents

Abstract

(57) [Problem] To provide a patch with low irritation, which satisfactorily holds a liquid component in an adhesive layer. SOLUTION: The adhesive is formed by forming an adhesive layer on one side of a support, and the adhesive layer has a weight average molecular weight of 25.
A patch comprising at least 100,000 acrylate polymer and a liquid plasticizer compatible with the polymer. Preferably, the acrylate polymer is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch which is applied to a skin surface to protect the skin surface, and is used for continuous administration of a drug through the skin to the body.

[0002]

2. Description of the Related Art Various types of skin, such as patches for protecting skin surfaces such as healthy skin and wound skin, and patches for use in the administration of drugs for percutaneous administration through the skin into the body, etc., have been used. A surface-applied external preparation has been developed. Because these agents are applied on the skin surface, in addition to the ease of handling at the time of application and the ability to follow the movement of the skin surface, in addition to the suppression of irritation due to keratin damage to the skin, that is, low irritation Is required.

[0003] Among them, with respect to handling properties and low irritation to the skin, the composition of the adhesive itself is changed to appropriately reduce the skin adhesive force, or a liquid component such as water or an oil component is added to the adhesive layer. There may be mentioned a method in which a water-containing gel or oily gel is added to give a soft feeling to the pressure-sensitive adhesive layer. Further, in this method, it is known that a pressure-sensitive adhesive is cross-linked by using a cross-linking agent to give a cohesive force, and a liquid component is retained in the pressure-sensitive adhesive layer. The cross-linking agent reacts with a functional group of the pressure-sensitive adhesive, for example, a carboxyl group, a hydroxyl group, or an amino group at a plurality of locations, and as a result, the pressure-sensitive adhesive layer has a network structure to hold the liquid component. In this reaction, when the liquid component, additive, drug, etc. have a functional group capable of reacting with the cross-linking agent, the cross-linking agent has a lower molecular weight than the adhesive due to the difference in diffusivity. It is common to react with some of these, and in many cases it is. As a result, since the pressure-sensitive adhesive is not cross-linked by the cross-linking agent, the liquid component is not retained in the pressure-sensitive adhesive, and in addition, the liquid component, the additive, the drug, and the like have no problem.

[0004]

SUMMARY OF THE INVENTION The present invention is to solve the above-mentioned problems, and an object of the present invention is to provide a patch having a low-irritating property, which satisfactorily holds a liquid component in an adhesive layer. Is to do.

[0005]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have studied a method of retaining a liquid component without using a crosslinking agent. As a result, the weight average molecular weight of the pressure-sensitive adhesive was 2.5 million. It has been found that the above problems can be solved by using the above-mentioned acrylate polymer, and the present invention has been completed.

That is, the present invention has the following features. (1) a patch comprising a pressure-sensitive adhesive layer formed on one surface of a support, wherein the pressure-sensitive adhesive layer is composed of an acrylate polymer having a weight average molecular weight of 2.5 million or more and a liquid plastic which is compatible with the polymer. An adhesive patch comprising an adhesive. (2) The patch according to the above (1), wherein the weight average molecular weight of the acrylate polymer is 5,000,000 or more. (3) The patch according to the above (1) or (2), wherein the acrylate polymer is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component. (4) The patch according to any one of the above (1) to (3), wherein the content of the liquid plasticizer is 10 to 100 parts by weight based on 100 parts by weight of the acrylate polymer. (5) The patch according to any one of the above (1) to (4), wherein the liquid plasticizer is a fatty acid ester composed of a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms. . (6) the pressure-sensitive adhesive layer further contains a transdermally absorbable drug
The patch according to any one of (1) to (5).

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The patch of the present invention is obtained by forming a pressure-sensitive adhesive layer on one surface of a support. The support used in the present invention is not particularly limited, but one in which the content is not reduced by the loss of the liquid plasticizer or drug from the back surface through the support, that is, these components are impermeable. Certain materials are preferred. Specifically, a film made of polyester, nylon, polyvinyl chloride, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polytetrafluoroethylene, an ionomer resin, or the like, a metal foil, or a laminate film of these or the like can be given. . Among these, in order to improve the adhesiveness (anchoring force) between the support and the pressure-sensitive adhesive layer, the support is a laminate film of a non-porous film and a porous film made of the above material, and the porous film side It is preferable to form a pressure-sensitive adhesive layer.

The porous film is not particularly limited as long as the anchoring property of the pressure-sensitive adhesive layer is good, and examples thereof include paper, woven fabric, non-woven fabric, and mechanically perforated sheet. Cloths and non-woven fabrics are preferred. The thickness of the porous film is from 10 to 500 μm in consideration of improvement of anchoring force and flexibility of the patch, and about 10 to 200 μm for a thin patch such as a plaster type or an adhesive tape type. In the case of a woven or non-woven fabric, the basis weight is 5
To 30 g / m ^2, preferably preferably in terms of that improvement of anchoring force to 8 to 20 g / m ^2.

The pressure-sensitive adhesive layer formed on one side of the support contains an acrylate polymer as a pressure-sensitive adhesive and a liquid plasticizer compatible with the polymer. Acrylate-based polymer has a weight average molecular weight of 2.5 million or more,
When the high molecular weight acrylate polymer is used as an adhesive, the liquid plasticizer is held in the adhesive layer by the cohesive force of the adhesive. If the molecular weight is less than 2.5 million, the cohesive force of the adhesive polymer is inferior,
The liquid plasticizer is not retained in the pressure-sensitive adhesive layer, and blooms on the surface of the pressure-sensitive adhesive layer to deteriorate the adhesiveness. The upper limit of the weight average molecular weight of the polymer is about 10,000,000.

[0010] Emulsion polymerization, bulk polymerization, and suspension polymerization are employed for the production of such a polymer having a weight average molecular weight of 2.5 million or more. However, since the adjustment of the weight average molecular weight is relatively easy, the emulsification polymerization is carried out. Polymerization is preferably employed.

The weight-average molecular weight referred to in the present invention is a value obtained by dissolving a polymer in a measuring solvent such as tetrahydrofuran or dimethylsulfoxide, and detecting the polymer by gel permeation chromatography (GPC) using a differential refraction system. .

As the acrylate-based polymer,
The weight average molecular weight is not less than 2.5 million, is not particularly limited as long as it can be compatible with the liquid plasticizer described below,
Preferably, it is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component. As the alkyl (meth) acrylate, specifically, the alkyl group is butyl, pentyl, hexyl, heptyl, octyl,
Nonyl, decyl, undecyl, dodecyl, tridecyl and the like, and alkyl (meth) acrylates which are linear or branched alkyl groups having 4 or more carbon atoms, and used alone or in combination of two or more. Is done.

The monomer copolymerizable with the above-mentioned alkyl (meth) acrylate includes, for example, (meth)
Monomers having a carboxyl group such as acrylic acid, itaconic acid, maleic acid, and maleic anhydride; styrenesulfonic acid, allylsulfonic acid, sulfopropyl (meth) acrylate, (meth) acryloyloxynaphthalenesulfonic acid, acrylamidomethylpropanesulfonic acid, etc. A monomer having a sulfonic acid group; a monomer having a hydroxyl group such as hydroxyethyl (meth) acrylate and hydroxypropyl (meth) acrylate; (meth) acrylamide, dimethyl (meth) acrylamide, N-butyl (meth) (Meth) acrylic acid derivatives having an amide group such as acrylamide and N-methylol (meth) acrylamide; (meth) acrylic acid aminoethyl ester, (meth) acrylic acid dimethylaminoethyl ester, ( Data) (meth) acrylic acid aminoalkyl esters of acrylic acid t- butyl aminoethyl ester; (meth) acrylic acid methoxyethyl ester,
(Meth) acrylic acid ethoxyethyl ester, (meth)
(Meth) acrylic acid alkoxyalkyl esters such as tetrahydrofurfuryl acrylate; (meth)
(Meth) acrylic acid alkoxyalkylene glycol esters such as methacrylic acid methoxyethylene glycol ester, (meth) acrylic acid methoxydiethylene glycol ester, (meth) acrylic acid methoxypolyethylene glycol ester, and (meth) acrylic acid methoxypolypropylene glycol ester; Acrylonitrile; vinyl acetate, vinyl propionate, N-vinyl-2-pyrrolidone, methylvinylpyrrolidone, vinylpyridine, vinylpiperidone, vinylpyrimidine, vinylpiperazine, vinylpyrazine, vinylpyrrole, vinylimidazole, vinylcaprolactam, vinyloxazole, vinylmorpholine, etc. And the like. These compounds are used alone or in combination of two or more. The copolymerization amount of these monomers is appropriately set according to the weight average molecular weight of the obtained copolymer.

The pressure-sensitive adhesive is other than an acrylate polymer, for example, a rubber-based material such as natural rubber or synthetic rubber,
If it is a silicone-based polymer, the compatibility with the liquid plasticizer is insufficient, or the solubility and release of the drug are poor.

The liquid plasticizer contained in the pressure-sensitive adhesive layer plasticizes the pressure-sensitive adhesive layer to impart a soft feeling, thereby reducing skin irritation. The liquid plasticizer used in the present invention is not particularly limited as long as it is a liquid at room temperature, exhibits a plasticizing action, and is compatible with the above-mentioned acrylate-based polymer. sex,
It is preferable to improve storage stability. Specifically, a higher fatty acid having 12 to 16 carbon atoms and a higher fatty acid having 1 carbon atom
Fatty acid esters comprising lower monohydric alcohols having 4 to 4 carbon atoms; fatty acids having 8 to 10 carbon atoms; glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, and polypropylene glycol; olive oil, castor oil, squalene, and lanolin Oils and the like; ethyl acetate, ethyl alcohol, dimethyl decyl sulfoxide, methyl octyl sulfoxide, dimethyl sulfoxide, dimethyl formamide, dimethyl acetamide, dimethyl lauryl amide, dodecyl pyrrolidone, isosorbitol, and other organic solvents; liquid surfactant; diisopropyl adipate ,
Conventionally known plasticizers such as phthalic acid esters and diethyl sebacate; hydrocarbons such as liquid paraffin;
Ethoxylated stearyl alcohol, glycerin ester, isopropyl myristate, isotridecyl myristate, ethyl laurate, N-methylpyrrolidone, ethyl oleate, oleic acid, diisopropyl adipate, diisopropyl palmitate, octyl palmitate, 1,3-propanediol , Glycerin and the like. Of course, of these, those that are liquid at room temperature are used. These may be used alone or in combination of two or more.

Among the above liquid plasticizers, a higher fatty acid having 12 to 16 carbon atoms and a higher fatty acid having 1 to 12 carbon atoms are preferred in view of compatibility with an adhesive, appropriate skin adhesion, and no volatilization in a heating step. 4
Fatty acid esters composed of lower monohydric alcohols are preferred. As higher fatty acids having 12 to 16 carbon atoms, for example,
Examples thereof include lauric acid, myristic acid, and palmitic acid. Examples of the lower monohydric alcohol having 1 to 4 carbon atoms include methyl alcohol, ethyl alcohol, propyl alcohol, and isopropyl alcohol.
Particularly preferred is isopropyl myristate.

The content of the liquid plasticizer is preferably from 10 to 100 parts by weight of the acrylate polymer.
100 parts by weight, more preferably 60 to 100 parts by weight. When the content is less than 10 parts by weight, the plasticization of the pressure-sensitive adhesive layer may be insufficient and skin irritation may not be reduced. In some cases, the liquid plasticizer cannot be held in the pressure-sensitive adhesive layer even by force, and blooming may occur on the surface of the pressure-sensitive adhesive layer, resulting in poor adhesion.

The pressure-sensitive adhesive layer may further contain a transdermally absorbable drug. The percutaneously absorbable drug used in the present invention is appropriately selected depending on the purpose of treatment. Examples thereof include corticosteroids, analgesics and anti-inflammatory agents, hypnotic sedatives, tranquilizers, antihypertensives, and antihypertensive diuretics. Drugs, antibiotics, anesthetics, antibacterial agents, antifungal agents, vitamins, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improvers, antiemetic agents, antitumor agents, biopharmaceuticals, etc. And transdermally absorbable drugs. These drugs are used in combination of two or more as necessary. Among them, it is preferable to use a hydrophobic drug (dissolution amount of 0.4 g or less in 100 g of water) from the viewpoint of uniform dispersibility in the pressure-sensitive adhesive layer and transdermal absorption.

The content of these drugs is appropriately set according to the kind of the transdermally absorbable drug and the purpose of administration, but is preferably 1 to 40% by weight, more preferably 3 to 40% by weight in the pressure-sensitive adhesive layer.
30% by weight. When this content is less than 1% by weight,
If the release of a therapeutically effective amount of the drug cannot be expected, and if it exceeds 40% by weight, the therapeutic effect is limited and economically disadvantageous.

The thickness of the pressure-sensitive adhesive layer is preferably from 10 to 200 μm, more preferably from 30 to 100 μm, in consideration of the adhesiveness and the necessary amount of the drug and its utilization when the drug contains a transdermally absorbable drug. It is.

The patch of the present invention has a weight average molecular weight of 50.
More than 100,000 acrylate polymer and liquid plasticizer (and transdermally absorbable drug for prevention or treatment of various diseases) are mixed with a solvent if necessary. On top, the thickness after drying is preferably 10 to 2
The adhesive layer is formed by coating and drying to form a pressure-sensitive adhesive layer so as to have a thickness of 00 μm, more preferably 30 to 100 μm, and transferring the pressure-sensitive adhesive layer to one surface of a support.

When the patch of the present invention contains a transdermally absorbable drug in a patch for coating used for protection of the skin surface, such as a plaster, a dressing, etc., for example, prevention and treatment of various diseases It can be suitably used as a patch for performing the following.

The patch of the present invention contains a liquid plasticizer in an acrylate polymer having good adhesiveness.
The adhesiveness of the pressure-sensitive adhesive layer is appropriately reduced, and the pressure-sensitive adhesive layer is plasticized to give a soft feeling to achieve low irritation. In the present invention, a high molecular weight acrylate polymer having a weight average molecular weight of 2.5 million or more is used as the pressure-sensitive adhesive, but since this polymer has a high cohesive force, the conventional pressure-sensitive adhesive is not subjected to a crosslinking treatment. In both cases, the liquid plasticizer can be held in the pressure-sensitive adhesive layer only by the cohesive force of the pressure-sensitive adhesive. Therefore, the patch of the present invention simultaneously satisfies the skin adhesiveness and the low irritation, which is an opposite property. Also, no matter what functional group the liquid plasticizer or drug has, the original effect can be exhibited.

[0024]

EXAMPLES The present invention will be described in detail with reference to the following examples, but the present invention is not limited to these examples. In the following text, all parts mean parts by weight.

EXAMPLE 1 75 parts of 2-ethylhexyl acrylate, 20 parts of isobutyl acrylate, 5 parts of acrylic acid, 0.06 part of 1-dodecanethiol and 0.2 part of ammonium peroxodisulfate
Parts of an acrylic acid alkyl ester-based pressure-sensitive adhesive obtained by emulsion polymerization in an aqueous solution (weight average molecular weight 500
) And 40 parts of isopropyl myristate were mixed in ethyl acetate to obtain an adhesive layer solution. This solution was applied onto a polyester separator so that the thickness after drying was 60 μm, and dried at 100 ° C. for 3 minutes to form an adhesive layer. This adhesive layer was coated with a polyester nonwoven fabric (8 g / m 2
² ) / Polyester film (2 μm thick) was transferred to the nonwoven fabric surface of the laminated film to obtain a patch.

Comparative Example 1 2-ethylhexyl acrylate 7 in an inert gas atmosphere
5 parts, 20 parts of isobutyl acrylate, 5 parts of acrylic acid and 0.2 part of azobisisobutyronitrile are solution-polymerized in ethyl acetate in 60 parts of an acrylic acid alkyl ester-based pressure-sensitive adhesive 60 parts (weight average molecular weight 2,000,000 ) And 40 parts of isopropyl myristate were mixed in ethyl acetate to obtain a solution for an adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 2 A patch was obtained in the same manner as in Example 1 except that isopropyl myristate was not used.

Comparative Example 3 A patch was obtained in the same manner as in Comparative Example 1, except that isopropyl myristate was not used.

Reference Example 50 parts of the pressure-sensitive adhesive obtained in Comparative Example 1, trifunctional isocyanate (trade name: Coronate HL, manufactured by Nippon Polyurethane Co., Ltd.)
0.2 parts and 40 parts of isopropyl myristate were mixed in ethyl acetate to obtain a pressure-sensitive adhesive layer solution. Using this solution, a patch was obtained in the same manner as in Example 1.

Example 2 50 parts of the pressure-sensitive adhesive obtained in Example 1, 40 parts of isopropyl myristate, and 10 parts of metoprolol were mixed in ethyl acetate to obtain a solution for a pressure-sensitive adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 4 50 parts of the adhesive obtained in Comparative Example 1, 40 parts of isopropyl myristate, and 10 parts of metoprolol were mixed in ethyl acetate to obtain a solution for an adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 5 90 parts of the pressure-sensitive adhesive obtained in Example 1 and metoprolol 10
The parts were mixed in ethyl acetate to obtain a solution for an adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 6 To 50 parts of the pressure-sensitive adhesive obtained in Comparative Example 1, 0.4 parts of trifunctional isocyanate (trade name: Coronate HL, manufactured by Nippon Polyurethane Co.), 40 parts of isopropyl myristate, and 10 parts of metoprolol were added to acetic acid. Mixing in ethyl gave a solution for the pressure-sensitive adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Example 3 75 parts of 2-ethylhexyl acrylate, 20 parts of isobutyl acrylate, 5 parts of acrylic acid, 0.06 part of 1-dodecanethiol and 0.1 part of ammonium peroxodisulfate
Of an acrylic acid alkyl ester-based pressure-sensitive adhesive obtained by emulsion polymerization of
) And 40 parts of isopropyl myristate were mixed in ethyl acetate to obtain an adhesive layer solution. Using this solution,
A patch was obtained in the same manner as in Example 1.

Comparative Example 7 A patch was obtained in the same manner as in Example 3, except that isopropyl myristate was not used.

Example 4 75 parts of 2-ethylhexyl acrylate, 20 parts of isobutyl acrylate, 5 parts of acrylic acid, 0.06 part of 1-dodecanethiol and 0.4 part of ammonium peroxodisulfate
Parts of an acrylic acid alkyl ester-based pressure-sensitive adhesive obtained by emulsion polymerization in an aqueous solution (weight average molecular weight 250
) And 40 parts of isopropyl myristate were mixed in ethyl acetate to obtain an adhesive layer solution. Using this solution,
A patch was obtained in the same manner as in Example 1.

Comparative Example 8 A patch was obtained in the same manner as in Example 4, except that isopropyl myristate was not used.

Example 5 An adhesive layer solution was obtained by mixing 50 parts of the adhesive obtained in Example 3, 40 parts of isopropyl myristate, and 10 parts of metoprolol in ethyl acetate. Using this solution, a patch was obtained in the same manner as in Example 1.

Example 6 An adhesive layer solution was obtained by mixing 50 parts of the adhesive obtained in Example 4, 40 parts of isopropyl myristate, and 10 parts of metoprolol in ethyl acetate. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 9 90 parts of the pressure-sensitive adhesive obtained in Example 3 and metoprolol 10
The parts were mixed in ethyl acetate to obtain a solution for an adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Comparative Example 10 90 parts of the pressure-sensitive adhesive obtained in Example 4, metoprolol 10
The parts were mixed in ethyl acetate to obtain a solution for an adhesive layer. Using this solution, a patch was obtained in the same manner as in Example 1.

Experimental Examples Using the patches obtained in Examples 1 to 6, Comparative Examples 1 to 10 and Reference Example (for those containing coronate HL, after storage at 70 ° C. for 2 days), The test was performed. 1. Skin Adhesion 10 cm ² of each sample obtained in Examples 1 to 6, Comparative Examples 1 to 10 and Reference Example was applied to the inner side of the upper arm of six volunteers, and the skin adhesion after 24 hours was visually determined. . The one that adhered best (good adhesion) was evaluated as 5, and the one that peeled remarkably was evaluated as 1. Table 1 shows the results.

[0043]

[Table 1]

As shown in Table 1, all the patches of Examples 1 to 6 had good skin adhesion. However, in the patches of Comparative Examples 1 and 4, isopropyl myristate was not retained in the pressure-sensitive adhesive layer because the cohesive force of the pressure-sensitive adhesive was poor, and blooming occurred at the interface of the separator, so that there was no adhesion. In the patch of Comparative Example 6, since metoprolol as a drug and coronate HL as a cross-linking agent reacted preferentially, isopropyl myristate was not retained in the pressure-sensitive adhesive layer and bloomed at the separator interface. There was no adhesion.

2. Exfoliation amount 50mm 12mm width inside the upper arm of 6 volunteers
Each sample cut to length was affixed for 6 hours and then peeled off. The sample was immersed in a staining solution having the following composition for 24 hours, washed with distilled water and stained for the exfoliated keratinocytes. However, since the dyeing solution used in this test soaked into the nonwoven fabric constituting the support, a patch using a 12 μm-thick polyester film as the support was prepared and used for this test. Examples 2, 5, and 6 and Comparative Examples 4 to 6 using metoprolol as a drug for transdermal absorption,
With respect to the patches of Nos. 9 and 10, exactly the same placebo preparations were prepared except that no metoprolol was blended, and used. Each stained sample was cut into a size of 12 mm × 5 mm, and a 1% sodium dodecyl sulfate aqueous solution 5
These samples were immersed in 24 ml for 24 hours to extract the dye from the adherent keratinocytes, and the absorbance (595 nm) of the extract was measured with a spectrophotometer. As a control sample, a sample not attached to the skin surface was used, and the same extraction operation was performed to measure the absorbance. The difference in absorbance between the sample and the control sample was defined as the amount of exfoliated keratinocytes. Table 2 shows the results. The greater the amount of exfoliated keratinocytes, the higher the absorbance. This absorbance is 1.0 or less, especially 0.5
The following is preferred. A good correlation was observed between the number of exfoliated keratinocytes counted by a stereomicroscope and the absorbance. <Staining solution composition> Gentian Violet 1.0% Brillian Green 0.5% Distilled water 98.5%

3. Pain degree Each sample cut to a size of 10 cm ² was attached to the inner side of the upper arm of six volunteers, and the pain at the time of peeling one hour later was measured. The average of the pain was evaluated based on the following criteria. Table 2 shows the results. 1: Painless 2: Painful 3: Slightly painful 4: Painful 5: Extremely painful

[0047]

[Table 2]

According to Table 2, all the patches of Examples 1 to 6 showed a small amount of exfoliating keratin and little pain at the time of exfoliation. However, the patches of Comparative Examples 2, 3, 5, and 7 to 10 had a large amount of exfoliation and felt pain when exfoliated. The patches of Comparative Examples 1, 4 and 6 could not be measured because blooming occurred at the separator interface.

4. Skin transfer rate The samples (10 cm ² ) of Examples 2, 5, 6 and Comparative Examples 4 to 6, 9, and 10 were applied to the inner side of the upper arm of a person for 8 hours, and after peeling, the drug was removed from the tape using methanol. A certain metoprolol was extracted and HPLC (detector: UV21
(0 nm), the content of the drug contained in the unpasted sample was defined as 100%, and the human skin transfer rate was calculated from the measured value. Table 3 shows the results. This transfer rate is preferably at least 10%, particularly preferably at least 30%.

[0050]

[Table 3]

From Table 3, it can be seen that the patches of Examples 2, 5, and 6 all had good migration rates, but the patches of Comparative Examples 5, 9, and 10 showed a higher migration rate than those of Examples. The rate was poor. In addition, the adhesive patches of Comparative Examples 4 and 6 could not be measured because the adhesive and isopropyl myristate remained at the application site.

[0052]

As is apparent from the above description, according to the present invention, the liquid plasticizer can be favorably retained in the pressure-sensitive adhesive layer without performing the cross-linking treatment. And a patch which simultaneously satisfies the low irritation property which is contradictory. Also, no matter what functional group the liquid plasticizer or drug has, the original effect can be exhibited.

 ──────────────────────────────────────────────────の Continued on the front page (72) Inventor Saburo Otsuka 1-1-2 Shimohozumi, Ibaraki-shi, Osaka Nitto Denko Corporation

Claims (6)

[Claims] 1. A patch comprising a support and a pressure-sensitive adhesive layer formed on one surface of the support, wherein the pressure-sensitive adhesive layer is compatible with an acrylate polymer having a weight average molecular weight of 2.5 million or more and the polymer. An adhesive patch comprising a liquid plasticizer. 2. The patch according to claim 1, wherein the weight average molecular weight of the acrylate polymer is 5,000,000 or more. 3. The acrylate-based polymer is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component.
The patch according to the above. 4. The adhesive patch according to claim 1, wherein the content of the liquid plasticizer is 10 to 100 parts by weight based on 100 parts by weight of the acrylate polymer. 5. The liquid plasticizer according to claim 1, wherein the liquid plasticizer is a fatty acid ester comprising a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms. The patch as described in the above. 6. The patch according to claim 1, wherein the pressure-sensitive adhesive layer further contains a transdermally absorbable drug.