JPS51148013A - Stable insulin preparation for nosal administration - Google Patents

Stable insulin preparation for nosal administration

Info

Publication number: JPS51148013A
Authority: JP; Japan
Prior art keywords: nosal; administration; insulin preparation; stable insulin; stable
Prior art date: 1975-06-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP5493176A

Other languages

English (en)

Japanese (ja)

Inventor

Shinichiro Hirai

Toshiaki Ikenaga

Etsu Matsuzawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-13

Filing date

1976-05-13

Publication date

1976-12-18

1976-05-13 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1976-12-18 Publication of JPS51148013A publication Critical patent/JPS51148013A/ja

Status Pending legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
238000004321 preservation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Biochemistry (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP5493176A 1975-06-13 1976-05-13 Stable insulin preparation for nosal administration Pending JPS51148013A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2535175A GB1554157A (en)	1975-06-13	1975-06-13	Stable insulin preparation for intra nasal administration

Publications (1)

Publication Number	Publication Date
JPS51148013A true JPS51148013A (en)	1976-12-18

Family

ID=10226264

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP5493176A Pending JPS51148013A (en)	1975-06-13	1976-05-13	Stable insulin preparation for nosal administration

Country Status (5)

Country	Link
JP (1)	JPS51148013A (fr)
BE (1)	BE841870A (fr)
DE (1)	DE2620483A1 (fr)
FR (1)	FR2313914A1 (fr)
GB (1)	GB1554157A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005532365A (ja) *	2002-06-18	2005-10-27	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	改善された安定性を有する酸性インスリン調製物
JP2007077151A (ja) *	2005-09-12	2007-03-29	Mcneil Ppc Inc	噴霧可能な個人用潤滑剤
JP2009292820A (ja) *	2003-12-08	2009-12-17	Cpex Pharmaceuticals Inc	インスリン治療のための薬学的組成物及びその供給装置
JP2016530930A (ja) *	2013-08-05	2016-10-06	マンカインドコーポレイション	通気装置及び方法

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3064888D1 (en) *	1979-04-30	1983-10-27	Hoechst Ag	Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
US4783441A (en) *	1979-04-30	1988-11-08	Hoechst Aktiengesellschaft	Aqueous protein solutions stable to denaturation
DE2917535C2 (de) *	1979-04-30	1986-10-30	Hoechst Ag, 6230 Frankfurt	Gegen Denaturierung beständige Insulinlösungen
EP0083619A1 (fr) *	1981-07-17	1983-07-20	Nordisk Insulinlaboratorium	Preparation therapeutique d'insuline aqueuse stable et son procede de preparation
DE3443877A1 (de) *	1984-06-09	1985-12-12	Hoechst Ag	Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung
JPS61267528A (ja) *	1984-11-26	1986-11-27	Yamanouchi Pharmaceut Co Ltd	吸収促進剤を含有するカルシトニン経鼻剤
EP0200383A3 (fr) *	1985-04-15	1987-09-02	Eli Lilly And Company	Procédé pour administrer l'insuline
DK179286D0 (da) *	1986-04-18	1986-04-18	Nordisk Gentofte	Insulinpraeparat
CA1291036C (fr) *	1986-04-23	1991-10-22	Edwin I. Stoltz	Administration de medicaments par voie nasale
EP0351651B1 (fr) *	1988-07-21	1993-09-15	F. Hoffmann-La Roche Ag	Préparation à base d'insuline
JP3219096B2 (ja) *	1990-05-10	2001-10-15	ニコメドファーマエイエス	ｎ―グリコフロール類及びｎ―エチレングリコール類を含有する医薬製剤
US6524557B1 (en)	1994-12-22	2003-02-25	Astrazeneca Ab	Aerosol formulations of peptides and proteins
CN1088580C (zh)	1994-12-22	2002-08-07	阿斯特拉公司	气溶胶药物制剂
EP3228320B1 (fr)	2008-10-17	2019-12-18	Sanofi-Aventis Deutschland GmbH	Combinaison d'une insuline et d'un antagoniste glp 1
EP3202394A1 (fr)	2009-07-06	2017-08-09	Sanofi-Aventis Deutschland GmbH	Préparations aqueuses de l´insuline contenant de la méthionine
PT2554183T (pt)	2009-11-13	2018-07-09	Sanofi Aventis Deutschland	Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
PE20121316A1 (es)	2009-11-13	2012-10-05	Sanofi Aventis Deutschland	Composicion farmaceutica que comprende un agonista de glp-1 y metionina
US20140148384A1 (en)	2010-08-30	2014-05-29	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
ITRM20110390A1 (it) *	2011-07-21	2013-01-22	Eramo Alessandra D	Prodotto per stimolare la produzione endogena di mediatori dell'infiammazione.
CN108079281A (zh)	2011-08-29	2018-05-29	赛诺菲-安万特德国有限公司	用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL62232C (fr) *		1900-01-01
US3096249A (en) *	1960-05-10	1963-07-02	Samuel J Prigal	Emulsion composition

1975
- 1975-06-13 GB GB2535175A patent/GB1554157A/en not_active Expired
1976
- 1976-05-08 DE DE19762620483 patent/DE2620483A1/de not_active Withdrawn
- 1976-05-13 JP JP5493176A patent/JPS51148013A/ja active Pending
- 1976-05-14 BE BE167069A patent/BE841870A/fr not_active IP Right Cessation
- 1976-05-14 FR FR7614706A patent/FR2313914A1/fr active Granted

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005532365A (ja) *	2002-06-18	2005-10-27	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	改善された安定性を有する酸性インスリン調製物
JP2011006492A (ja) *	2002-06-18	2011-01-13	Sanofi-Aventis Deutschland Gmbh	改善された安定性を有する酸性インスリン調製物
JP2009292820A (ja) *	2003-12-08	2009-12-17	Cpex Pharmaceuticals Inc	インスリン治療のための薬学的組成物及びその供給装置
JP2007077151A (ja) *	2005-09-12	2007-03-29	Mcneil Ppc Inc	噴霧可能な個人用潤滑剤
JP2016530930A (ja) *	2013-08-05	2016-10-06	マンカインドコーポレイション	通気装置及び方法

Also Published As

Publication number	Publication date
BE841870A (fr)	1976-11-16
DE2620483A1 (de)	1976-12-23
FR2313914B1 (fr)	1979-04-13
GB1554157A (en)	1979-10-17
FR2313914A1 (fr)	1977-01-07

Publication	Publication Date	Title
JPS51148013A (en)	1976-12-18	Stable insulin preparation for nosal administration
JPS5231839A (en)	1977-03-10	Drug for cosmetics and permanent wave in combination
JPS542316A (en)	1979-01-09	Solid pharmaceutical composition containing nifedipene
JPS539739A (en)	1978-01-28	#-trifluoromethyl-##-isoproxybenzoic acid anilide, its preparation and its use
JPS5218811A (en)	1977-02-12	Preparation of aqueous solution of fat- soluble substances
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JPS5231826A (en)	1977-03-10	Miticides
JPS5373554A (en)	1978-06-30	2, 10-dehydro-4-homobrendane and its preparation
JPS5283603A (en)	1977-07-12	N2-substituted-omega-amidino-alpha-amino acid derivative and acid addition salt thereof
JPS5294496A (en)	1977-08-09	Preparing of fr-29644 substance
JPS52143221A (en)	1977-11-29	Novel preparations for rectal administration