JPS5452069A - Prostaglandin i2 analog compound and its preparation - Google Patents

Prostaglandin i2 analog compound and its preparation

Info

Publication number: JPS5452069A
Authority: JP; Japan
Prior art keywords: compound; alkyl; prostaglandin; preparation; analog compound
Prior art date: 1977-09-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP11613877A

Other languages

English (en)

Inventor

Masaki Hayashi

Yoshinobu Arai

Katsuichi Shimoji

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ono Pharmaceutical Co Ltd

Original Assignee

Ono Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-29

Filing date

1977-09-29

Publication date

1979-04-24

1977-09-29 Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd

1977-09-29 Priority to JP11613877A priority Critical patent/JPS5452069A/ja

1978-09-22 Priority to DE19782841360 priority patent/DE2841360A1/de

1978-09-27 Priority to GB7838358A priority patent/GB2007218B/en

1978-09-27 Priority to IT28156/78A priority patent/IT1099217B/it

1978-09-28 Priority to FR7827768A priority patent/FR2404637A1/fr

1979-04-24 Publication of JPS5452069A publication Critical patent/JPS5452069A/ja

Status Pending legal-status Critical Current

Links

-1 Prostaglandin i2 analog compound Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000004702 methyl esters Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000002040 relaxant effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP11613877A 1977-09-29 1977-09-29 Prostaglandin i2 analog compound and its preparation Pending JPS5452069A (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
JP11613877A JPS5452069A (en)	1977-09-29	1977-09-29	Prostaglandin i2 analog compound and its preparation
DE19782841360 DE2841360A1 (de)	1977-09-29	1978-09-22	Prostaglandin-i tief 2 -analoge
GB7838358A GB2007218B (en)	1977-09-29	1978-09-27	Prostaglandin 1 anologues
IT28156/78A IT1099217B (it)	1977-09-29	1978-09-27	Analoghi di prostaglandine i2
FR7827768A FR2404637A1 (fr)	1977-09-29	1978-09-28	Analogues de prostaglandines et compositions pharmaceutiques les contenant

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP11613877A JPS5452069A (en)	1977-09-29	1977-09-29	Prostaglandin i2 analog compound and its preparation

Publications (1)

Publication Number	Publication Date
JPS5452069A true JPS5452069A (en)	1979-04-24

Family

ID=14679665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP11613877A Pending JPS5452069A (en)	1977-09-29	1977-09-29	Prostaglandin i2 analog compound and its preparation

Country Status (5)

Country	Link
JP (1)	JPS5452069A (ja)
DE (1)	DE2841360A1 (ja)
FR (1)	FR2404637A1 (ja)
GB (1)	GB2007218B (ja)
IT (1)	IT1099217B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55500346A (ja) *	1978-03-13	1980-06-19

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58164512A (ja) *	1982-03-25	1983-09-29	Ono Pharmaceut Co Ltd	プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤

1977
- 1977-09-29 JP JP11613877A patent/JPS5452069A/ja active Pending
1978
- 1978-09-22 DE DE19782841360 patent/DE2841360A1/de not_active Withdrawn
- 1978-09-27 IT IT28156/78A patent/IT1099217B/it active
- 1978-09-27 GB GB7838358A patent/GB2007218B/en not_active Expired
- 1978-09-28 FR FR7827768A patent/FR2404637A1/fr active Granted

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55500346A (ja) *	1978-03-13	1980-06-19

Also Published As

Publication number	Publication date
IT1099217B (it)	1985-09-18
FR2404637B1 (ja)	1982-02-05
GB2007218B (en)	1982-08-04
IT7828156A0 (it)	1978-09-27
FR2404637A1 (fr)	1979-04-27
GB2007218A (en)	1979-05-16
DE2841360A1 (de)	1979-04-05

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