JPS5455581A - Synthetic method of 5-fluorouracil derivative - Google Patents

Synthetic method of 5-fluorouracil derivative

Info

Publication number
JPS5455581A
JPS5455581A JP11855977A JP11855977A JPS5455581A JP S5455581 A JPS5455581 A JP S5455581A JP 11855977 A JP11855977 A JP 11855977A JP 11855977 A JP11855977 A JP 11855977A JP S5455581 A JPS5455581 A JP S5455581A
Authority
JP
Japan
Prior art keywords
fluorouracil
dihydrofuran
tetrahydrofuryl
conducted
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11855977A
Other languages
Japanese (ja)
Inventor
Toshio Nakamura
Yasuo Hoshiide
Yoshio Hashimoto
Kenichi Suzuki
Yoji Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Kowa Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP11855977A priority Critical patent/JPS5455581A/en
Publication of JPS5455581A publication Critical patent/JPS5455581A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: The reaction between 5-fluorouracil and 2, 3-dihydrofuran is conducted in the presence of a tertiary amine and a nonmetal halide to prepare under mild conditions title compound used as a carcinostatic agent or synthetic intermediate.
CONSTITUTION: The reaction between 5-fluorouracil and 2, 3-dihydrofuran is conducted in the presence of a tertiary amine, most preferably pyridine, and a nonmetal halide such as silicon tetrachloride or phosphorus trichloride at 50-100°C under normal pressure to form 5-fluorouracil derivative of the formula (A is H, 2-tetrahydrofuryl), which is further treated with an acid such as hydrochloric or acetic aicd to give N1-(2-tetrahydrofuryl)-5-fluorouracil. This compound is used as low-txicity and orally administered carcinostatic agent
COPYRIGHT: (C)1979,JPO&Japio
JP11855977A 1977-10-04 1977-10-04 Synthetic method of 5-fluorouracil derivative Pending JPS5455581A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11855977A JPS5455581A (en) 1977-10-04 1977-10-04 Synthetic method of 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11855977A JPS5455581A (en) 1977-10-04 1977-10-04 Synthetic method of 5-fluorouracil derivative

Publications (1)

Publication Number Publication Date
JPS5455581A true JPS5455581A (en) 1979-05-02

Family

ID=14739579

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11855977A Pending JPS5455581A (en) 1977-10-04 1977-10-04 Synthetic method of 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS5455581A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102285972A (en) * 2011-08-08 2011-12-21 江苏大学 Process for preparing tegafur

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102285972A (en) * 2011-08-08 2011-12-21 江苏大学 Process for preparing tegafur

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