JPS5473774A - Isoxazoline-3-one derivative - Google Patents
Isoxazoline-3-one derivativeInfo
- Publication number
- JPS5473774A JPS5473774A JP13961277A JP13961277A JPS5473774A JP S5473774 A JPS5473774 A JP S5473774A JP 13961277 A JP13961277 A JP 13961277A JP 13961277 A JP13961277 A JP 13961277A JP S5473774 A JPS5473774 A JP S5473774A
- Authority
- JP
- Japan
- Prior art keywords
- isoxazoline
- formula
- derivative
- phenyl
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QXDOFVVNXBGLKK-UHFFFAOYSA-N 3-Isoxazolidinone Chemical class OC1=NOCC1 QXDOFVVNXBGLKK-UHFFFAOYSA-N 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- FUOSTELFLYZQCW-UHFFFAOYSA-N 1,2-oxazol-3-one Chemical compound OC=1C=CON=1 FUOSTELFLYZQCW-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-(3-Phenyl-2-propynyl)-5-phenyl-4-isoxazoline-3-one Chemical compound 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
NEW MATERIAL:An isoxazoline-3-one derivative of formula I: (R1 is H or lower alkyl group; R2 is aryl, heterocyclic group; R3 is lower alkyl, lower alkenyl, aralkenyl, lower alkynyl, or aralkynyl group).
EXAMPLE: 2-(3-Phenyl-2-propynyl)-5-phenyl-4-isoxazoline-3-one.
USE: Pharmaceuticals having anti-inflammatory, analgesic, and antipyretic actions.
PROCESS: A 3-hydroxyisoxazole is reacted with 1.0W2.0 moles of a halogen compound of formula III: (X is halogen, e.g. Cl, Br, I, etc.) in an inert solvent, e.g. benzene, methanol, etc., if necessary, in the presence of a base, e.g. potassium, sodium hydroxides, etc. at 0W150°C, preferably 20W130°C to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13961277A JPS5473774A (en) | 1977-11-21 | 1977-11-21 | Isoxazoline-3-one derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13961277A JPS5473774A (en) | 1977-11-21 | 1977-11-21 | Isoxazoline-3-one derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5473774A true JPS5473774A (en) | 1979-06-13 |
Family
ID=15249334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13961277A Pending JPS5473774A (en) | 1977-11-21 | 1977-11-21 | Isoxazoline-3-one derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5473774A (en) |
-
1977
- 1977-11-21 JP JP13961277A patent/JPS5473774A/en active Pending
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