JPS5490196A - Novel 1,n6-etheno-2-iodo-adenosine-3',5'-cyclic phosphoric acid,its salt,and their preparation - Google Patents
Novel 1,n6-etheno-2-iodo-adenosine-3',5'-cyclic phosphoric acid,its salt,and their preparationInfo
- Publication number
- JPS5490196A JPS5490196A JP15654077A JP15654077A JPS5490196A JP S5490196 A JPS5490196 A JP S5490196A JP 15654077 A JP15654077 A JP 15654077A JP 15654077 A JP15654077 A JP 15654077A JP S5490196 A JPS5490196 A JP S5490196A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- phosphoric acid
- compound
- etheno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 title abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- QSKPIOLLBIHNAC-UHFFFAOYSA-N 2-chloro-acetaldehyde Chemical compound ClCC=O QSKPIOLLBIHNAC-UHFFFAOYSA-N 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000003005 anticarcinogenic agent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1,N6-Etheno-2-iodo-adenosine-3',5'-cylic phosphoric acid of formula I: (Z1 is H, alkali metal, or organic ammonium group) or its salt.
USE: Biochemical reagents, e.g. a reagent for measuring phosphodiesterase activity, anticarcinogens, coronary vasodilators, blood platelet agglutination suppressants, diuretics, and antiallergic agants, having fluorescence.
PROCESS: A compound of formula II or its salt is reacted with I2 or an iodide of the formula Z2I (Z2 is H or alkali metal) in an aqueous solution at 5W50°C preferably 15W25°C for 0.5W24hr to give the compound of formula I or its salt. The compound of formula II is obtained by reaction of a compound of formula A: (X is 3-β-D-ribofuranosyl-3',5'-cyclic phosphoric acid) with chloroacetaldehyde, followed by hydrolysis and cyclization.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15654077A JPS5490196A (en) | 1977-12-27 | 1977-12-27 | Novel 1,n6-etheno-2-iodo-adenosine-3',5'-cyclic phosphoric acid,its salt,and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15654077A JPS5490196A (en) | 1977-12-27 | 1977-12-27 | Novel 1,n6-etheno-2-iodo-adenosine-3',5'-cyclic phosphoric acid,its salt,and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5490196A true JPS5490196A (en) | 1979-07-17 |
Family
ID=15630019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15654077A Pending JPS5490196A (en) | 1977-12-27 | 1977-12-27 | Novel 1,n6-etheno-2-iodo-adenosine-3',5'-cyclic phosphoric acid,its salt,and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5490196A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019517593A (en) * | 2016-06-29 | 2019-06-24 | ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー | Substituted Thienopyrrolopyrimidine Ribonucleosides for Therapeutic Use |
| JP2019522057A (en) * | 2016-08-02 | 2019-08-08 | ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for use in therapy |
-
1977
- 1977-12-27 JP JP15654077A patent/JPS5490196A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019517593A (en) * | 2016-06-29 | 2019-06-24 | ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー | Substituted Thienopyrrolopyrimidine Ribonucleosides for Therapeutic Use |
| JP2019522057A (en) * | 2016-08-02 | 2019-08-08 | ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for use in therapy |
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