JPS5536418A - 8-substituted adenosine derivative and its preparation - Google Patents
8-substituted adenosine derivative and its preparationInfo
- Publication number
- JPS5536418A JPS5536418A JP10965478A JP10965478A JPS5536418A JP S5536418 A JPS5536418 A JP S5536418A JP 10965478 A JP10965478 A JP 10965478A JP 10965478 A JP10965478 A JP 10965478A JP S5536418 A JPS5536418 A JP S5536418A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkoxy
- preparation
- protecting groups
- adenosine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 8-substituted adenosine Chemical class 0.000 title 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 3
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 abstract 1
- 102000055025 Adenosine deaminases Human genes 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is O, S or imino; R2 is alkoxy, OH or NH2; Y, Z are H or protecting groups).
EXAMPLE: Adenosine-8-carboxylic acid methyl ester.
USE: Reagent for biochemistry. For example, a synthetic substrate for the biochemical or pharmaceutical investigation of the activity of enzymes concerning the metabolism of nucleic acid-relating substance in living body, e.g. adenosinedeaminase, etc. Also useful as a synthetic intermediate of 3',5'-cyclic nucleotide.
PROCESS: Reaction of a compound II with an alkoxide affords an objective compound III (R2a is alkoxy; Y', Z' are H or protecting groups), which can be hydrolyzed with an acid to another objective compound IV. The compound IV can be converted to a compound IV wherein R2a is OH. A compound V is prepared by reacting the compound II with H2S.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10965478A JPS5536418A (en) | 1978-09-08 | 1978-09-08 | 8-substituted adenosine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10965478A JPS5536418A (en) | 1978-09-08 | 1978-09-08 | 8-substituted adenosine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5536418A true JPS5536418A (en) | 1980-03-14 |
Family
ID=14515759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10965478A Pending JPS5536418A (en) | 1978-09-08 | 1978-09-08 | 8-substituted adenosine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5536418A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11506107A (en) * | 1995-06-02 | 1999-06-02 | ネクスター ファーマスーティカルズ，インコーポレイテッド | Palladium-catalyzed nucleoside modification using nucleophiles and carbon monoxide |
-
1978
- 1978-09-08 JP JP10965478A patent/JPS5536418A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11506107A (en) * | 1995-06-02 | 1999-06-02 | ネクスター ファーマスーティカルズ，インコーポレイテッド | Palladium-catalyzed nucleoside modification using nucleophiles and carbon monoxide |
| JP2009057388A (en) * | 1995-06-02 | 2009-03-19 | Gilead Sciences Inc | Palladium-catalyzed nucleoside modification method using nucleophile and carbon monoxide |
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