JPS5498785A - Preparation of 5-fluorouracil derivative - Google Patents

Preparation of 5-fluorouracil derivative

Info

Publication number
JPS5498785A
JPS5498785A JP373178A JP373178A JPS5498785A JP S5498785 A JPS5498785 A JP S5498785A JP 373178 A JP373178 A JP 373178A JP 373178 A JP373178 A JP 373178A JP S5498785 A JPS5498785 A JP S5498785A
Authority
JP
Japan
Prior art keywords
fluorouracil
preparation
dihydrofuran
tetrahydrofuryl
sicl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP373178A
Other languages
Japanese (ja)
Inventor
Hiroshi Fukatsu
Tetsuji Miyano
Ikuo Iwatsuki
Ikuo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP373178A priority Critical patent/JPS5498785A/en
Publication of JPS5498785A publication Critical patent/JPS5498785A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the title compound useful as carcinostatics in a high yield, by reacting 5-fluorouracil with 2,3-dihydrofuran in the presence of inexpensive SiCl4 and N,N-dimethylformamide.
CONSTITUTION: 5-Fluorouracil is reacted with 2,3-dihydrofuran in the presence of SiCL4 and N,N-dimethylformamide in an aprotic anhydrous organic solvent, e.g. dichloromethane or chloroform, at room temperature to give 1-(2'-tetrahydrofuryl)- 5-fluorouracil and 1,3-bis(2'-tetrahydrofuryl)-5-fluorouracil. The desired compound can be selected depending on the proportion of the raw materials.
COPYRIGHT: (C)1979,JPO&Japio
JP373178A 1978-01-19 1978-01-19 Preparation of 5-fluorouracil derivative Pending JPS5498785A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP373178A JPS5498785A (en) 1978-01-19 1978-01-19 Preparation of 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP373178A JPS5498785A (en) 1978-01-19 1978-01-19 Preparation of 5-fluorouracil derivative

Publications (1)

Publication Number Publication Date
JPS5498785A true JPS5498785A (en) 1979-08-03

Family

ID=11565396

Family Applications (1)

Application Number Title Priority Date Filing Date
JP373178A Pending JPS5498785A (en) 1978-01-19 1978-01-19 Preparation of 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS5498785A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016010305A1 (en) 2015-09-04 2017-03-09 Mazda Motor Corporation automatic transmission

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016010305A1 (en) 2015-09-04 2017-03-09 Mazda Motor Corporation automatic transmission

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