JPS5657767A - Preparation of pyrimidine derivative - Google Patents
Preparation of pyrimidine derivativeInfo
- Publication number
- JPS5657767A JPS5657767A JP13270379A JP13270379A JPS5657767A JP S5657767 A JPS5657767 A JP S5657767A JP 13270379 A JP13270379 A JP 13270379A JP 13270379 A JP13270379 A JP 13270379A JP S5657767 A JPS5657767 A JP S5657767A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- formula
- dialkoxyacrylic
- hydroxypyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001409 amidines Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
Abstract
PURPOSE: To obtain a 2-substituted-4-alkoxy-6-hydroxypyrimidine useful as an intermediate for an agricultural chemical and a medicine in one stage, by reacting a β,β-dialkoxyacrylic ester with a 1-substituted amidine or a salt thereof.
CONSTITUTION: A β,β-dialkoxyacrylic ester of formula I (R1 is 1W3C alkyl; R2 is 1W6C alkyl) is reacted with a 1-substituted amidine of formula II or II' (R3 is lower alkyl, lower alkoxyl, lower alkylthio, aryl or NH2; HA is an inorganic acid, e.g. hydrochloric, sulfuric or nitric acid, or an organic acid, e.g. acetic acid) or a salt thereof in an inert solvent, preferably a lower alcohol or an aprotic polar solvent, at 50W200°C for 0.5W30hr to give a 2-substituted 4-alkoxyl-6-hydroxypyrimidine of formula III in one stage readily.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13270379A JPS5657767A (en) | 1979-10-15 | 1979-10-15 | Preparation of pyrimidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13270379A JPS5657767A (en) | 1979-10-15 | 1979-10-15 | Preparation of pyrimidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5657767A true JPS5657767A (en) | 1981-05-20 |
Family
ID=15087574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13270379A Pending JPS5657767A (en) | 1979-10-15 | 1979-10-15 | Preparation of pyrimidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5657767A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011888A1 (en) * | 1993-10-28 | 1995-05-04 | F. Joh. Kwizda Gesellschaft M.B.H. | Process for preparing 3,4-diaryl-5-isoxazolyl acetic acid derivatives |
| EP0902019A4 (en) * | 1996-05-16 | 2002-03-27 | Nissan Chemical Ind Ltd | Processes for the preparation of pyrimidine compound |
-
1979
- 1979-10-15 JP JP13270379A patent/JPS5657767A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011888A1 (en) * | 1993-10-28 | 1995-05-04 | F. Joh. Kwizda Gesellschaft M.B.H. | Process for preparing 3,4-diaryl-5-isoxazolyl acetic acid derivatives |
| EP0902019A4 (en) * | 1996-05-16 | 2002-03-27 | Nissan Chemical Ind Ltd | Processes for the preparation of pyrimidine compound |
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